[Two pairs of brothers with juvenile idiopathic arthritis (JIA): case reports].

Abstract:

:This is a case report of juvenile idiopathic arthritis (JIA) in two pairs of brothers followed in the department of pediatric rheumatology, Universidade Federal da Bahia. Genetic involvement in JIA pathogenesis is clear and the risk of recurrence among siblings supports this contribution. An important landmark of this discovery involves the acknowledgment of major histocompatibility complex (MHC) polymorphism contribution to JIA development susceptibility. Despite many advances, the numerous available studies cannot explain several implicit mechanisms in JIA pathogenesis yet.

journal_name

Rev Bras Reumatol

authors

Robazzi TC,Rios G,Castro C

doi

10.1016/j.rbr.2013.05.006

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

75-8

issue

1

eissn

0482-5004

issn

1809-4570

pii

S0482-5004(14)00130-2

journal_volume

55

pub_type

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