Abstract：
PURPOSE:The aim of the present study was to investigate the HLA phenotype in Dupuytren's contracture (DC) patients in order to verify the correlation of these alleles with risk factors for development of DC in the Brazilian population. METHODS:This was a case-controlled study of 25 DC patients and 443 healthy individuals with no history of HLA-associated diseases. HLA class I and class II typing was performed using the polymerase chain reaction sequence-specific primer method. RESULTS:The HLAB*18 phenotype was observed in 32% of the patients and 10.5% of controls. However, P values did not remain significant after correction. DISCUSSION:Although we observed an increased tendency of DC patients to possess the HLA-B*18 allele, the results were not statistically significant after correction. This allele was higher in patients of Italian and/or Spanish ethnicity, localities with frequencies higher than 18.0% and 14.0% respectively. Further investigation with a larger cohort of DC patients is required to confirm the potential role of HLA in this disease.
journal_name
Rev Bras Reumatoljournal_title
Revista brasileira de reumatologiaauthors
Usó SM,Sanson AC,Covolo-Santana Fde S,Marcos EV,Marques T,Cury Filho M,Ura Ssubject
Has Abstractpub_date
2014-01-01 00:00:00pages
38-43issue
1eissn
0482-5004issn
1809-4570pii
S0482-5004(14)00007-2journal_volume
54pub_type
杂志文章abstract：INTRODUCTION:The Brazilian Unified Health Care System (SUS) offers treatment for patients with RA through federal funding (Ministry of Health) and state co-financing. The Clinical Protocol and Therapeutic Guidelines for the treatment of rheumatoid arthritis describe the therapeutic regimen for the disease, including th...
journal_title：Revista brasileira de reumatologia
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abstract：:Systemic Sclerosis (SSc) is an autoimmune disease of multifactorial etiology, triggered by a combination of genetic and environmental factors. Its varied clinical expression results from the complex physiopathogenic interaction of three main elements: proliferative vasculopathy, immune dysregulation and abnormal depos...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章,评审
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journal_title：Revista brasileira de reumatologia
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更新日期：2012-01-01 00:00:00
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更新日期：2015-07-01 00:00:00
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pub_type： 杂志文章,评审
doi：
更新日期：2013-09-01 00:00:00
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journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1590/s0482-50042013000400010
更新日期：2013-08-01 00:00:00
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更新日期：2012-10-01 00:00:00
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更新日期：2011-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.rbr.2014.02.007
更新日期：2015-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.rbr.2014.04.003
更新日期：2014-07-01 00:00:00
abstract：INTRODUCTION:Very few studies carried out with Latin American populations on the demographic and clinical characteristics of patients diagnosed with early rheumatoid arthritis (RA) can be found in the literature. OBJECTIVE:To characterize a population of patients with early RA, prospectively followed, concerning demog...
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pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.rbr.2014.04.001
更新日期：2014-09-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2011-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.rbr.2014.08.012
更新日期：2015-05-01 00:00:00
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journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章,评审
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更新日期：2014-05-01 00:00:00
abstract：INTRODUCTION:Rheumatoid arthritis (RA) is a chronic systemic and progressive inflammatory disorder of the joints, which can result in deformity and functional disability. The diagnosis, treatment, and follow-up of patients with RA vary worldwide. The major societies of rheumatology, as well as governmental agencies in ...
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pub_type： 杂志文章
doi：
更新日期：2011-05-01 00:00:00
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更新日期：2010-03-01 00:00:00
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更新日期：2012-08-01 00:00:00
abstract：:Ankylosing spondylitis (AS) is a chronic rheumatic disease of young men that affects mainly the axial skeleton and is associated with HLA-B27 in 90% of the cases. Incidence of cardiovascular involvement in AS ranges between 10%-30%; conduction disturbances have been described in 1%-9% of the patients with AS. The majo...
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pub_type： 杂志文章
doi：
更新日期：2012-10-01 00:00:00
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更新日期：2015-05-28 00:00:00
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更新日期：2016-03-08 00:00:00
abstract：:Over the past decades, the role of exercise training in rheumatic diseases has been largely explored. Currently, physical activity is well known to benefit patients with osteoporosis, osteoarthritis, systemic lupus erythematosus, systemic sclerosis, idiopathic inflammatory myopathy, fibromyalgia and rheumatoid arthrit...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章,评审
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更新日期：2011-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2015-11-01 00:00:00
abstract：INTRODUCTION:Fibromyalgia (FM) is a chronic pain condition that causes impaired functional capacity, possibly through the adoption of sedentary behaviour. However, little is known regarding physical activity level and its relationship with physical performance in women with FM. OBJECTIVES:To compare physical activity ...
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更新日期：2013-05-01 00:00:00
abstract：:Psoriatic arthritis (PA) is an inflammatory seronegative arthritis of unknown origin. Classically, PA has five clinical forms, and asymmetric oligoarthritis is the most common type. We describe the case of a patient with PA refractory to disease-modifying drugs, who developed drug-induced hepatitis after chemoprophyla...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
