Abstract：
INTRODUCTION:Premature development of atherosclerosis in systemic lupus erythematosus has been widely reported. Anti-lipoprotein lipase antibody may be one cause contributing to this disorder. OBJECTIVE:To assess the extent of coronary risk due to autoimmune antibodies in terms of carotid plaque in lupus patients. PATIENTS AND METHODS:We compared 114 documented lupus patients with 111 normal controls matched for sex and age. Anti-lipoprotein lipase (A-LPL), anti-oxidized low density lipoprotein (A-OXLDL), and anti-low density lipoprotein (A-LDL) were measured by enzme-linked immunoabsorbent assay. Low density lipoprotein-triglyceride (LDL-Trig) and high density lipoprotein-triglyceride (HDL-Trig) were also measured. Plaque was measured by bilateral carotid ultrasound. RESULTS:45.6% of patients tested positive for A-LPL, and 34.4% for A-OXLDL. 44% of normal controls tested positive for A-LPL, and 20% for A-OXLDL. Risk increased sharply in subgroups with increased antibody levels. Patients with A-LPL and A-OXLDL > 0.40 (n = 12) showed coronary risk correlations of: A-LPL x LDL-Trig = 0.7008, P = 0.0111; bilateral ultrasound vs total cholesterol = 0.62205, P = 0.0308; LDL-Trig vs myocardial infarction (MI) = 0.76562, P = 0.0037; total triglycerides vs MI = 0.78191, P = 0.0027); LDL-Trig/LDL-cholesterol vs MI = 0.80493, P = 0.0016; A-OXLDL vs USBL = 0.71930, P = 0.0084. Correlations of SLEDAI with risk variables were highly significant only in subgroups of elevated antibody levels (SLEDAI x A-OXLDL = 0.70366, P = 0.0107). CONCLUSION:A-LPL initiates the development of LDL mutations, followed by antibody production, plaque formation and coronary risk in some SLE patients.
journal_name
Rev Bras Reumatoljournal_title
Revista brasileira de reumatologiaauthors
Fesmire J,Wolfson-Reichlin M,Reichlin Mdoi
10.1590/s0482-50042010000500007subject
Has Abstractpub_date
2010-09-01 00:00:00pages
539-51issue
5eissn
0482-5004issn
1809-4570pii
S0482-50042010000500007journal_volume
50pub_type
杂志文章abstract：:Machrophage activation syndrome (MAS) is a rare and potentially fatal disease, commonly associated with chronic rheumatic diseases, mainly juvenile idiopathic arthritis. It is included in the group of secondary forms of haemophagocytic syndrome, and other causes are lymphoproliferative diseases and infections. Its mos...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2014.02.007
更新日期：2015-01-01 00:00:00
abstract：INTRODUCTION:Recent studies show an association between autoimmune thyroiditis and systemic sclerosis (SSc) and suggest that this condition may interfere with the ES phenotype. However these studies evaluate the autoimmune thyroiditis as a whole and none of them specifically addresses Hashimoto's thyroiditis (HT) in SS...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2014.04.001
更新日期：2014-09-01 00:00:00
abstract：OBJECTIVE:To investigate the feasibility of bone turnover markers (BTMs) for the assessment of bone metabolism in patients with systemic lupus erythematosus (SLE), according to the guidelines of the International Osteoporosis Foundation and the International Federation of Clinical Chemistry and Laboratory Medicine. ME...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2014.10.004
更新日期：2015-03-01 00:00:00
abstract：INTRODUCTION:TCF7L2 is a transcription factor involved in Wnt/beta-catenin signaling and which has a variant known to be consistently associated with type 2 diabetes risk and some studies have also indicated its association with risk of certain types of cancer. OBJECTIVE:Since this pathway may be involved in the patho...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
abstract：:Anti-TNF-α agents have emerged as a potent treatment for patients with rheumatoid arthritis unresponsive to conventional disease-modifying antirheumatic drugs. Increased susceptibility to infections induced by these drugs is the main complication of their use. Reactivation of hepatitis B virus (HBV) is one of the most...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
abstract：:Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, and its excess can lead to severe consequences. Those effects are known to be antagonized by TNF-alpha inhibitors. Etanercept is a fusion protein that inhibits TNF-alpha action. As TNF-alpha regulation is related to cellular differentiation of vari...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章,评审
doi：
更新日期：2012-01-01 00:00:00
abstract：:Rats are currently the most used laboratory animals to investigate osteoporosis. We report an efficient method of ovariectomy and compared this method with the two other operative methods of ovariectomy (i.e., midline dorsal skin incision and double dorsolateral approach, which are used commonly for inducing experimen...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-05-01 00:00:00
abstract：:The aim of this study was to determine the prevalence of osteopenia and osteoporosis in a female population, that had bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) in a specialized clinic in the south of Brazil. We conducted a cross-sectional study including 1,871 women that performed s...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2014.08.012
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Lactic acid is a byproduct of both muscle metabolism and the central nervous system. Changes in metabolism are related to various physiological and pathological conditions. The aim of this study was to determine the relationship between migraine and fibromyalgia with the levels of lactic acid in the blood. ...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2015.02.002
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVES:To determine the frequency of antibodies to chromatin components in juvenile systemic lupus erythematosus (JSLE), and to correlate the presence of these autoantibodies with clinical manifestations and disease activity. METHODS:Anti-chromatin (anti-CHR), anti-nucleosome core particle (anti-NCS) and anti-dsDN...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-10-01 00:00:00
abstract：:Psoriatic arthritis (PA) is an inflammatory seronegative arthritis of unknown origin. Classically, PA has five clinical forms, and asymmetric oligoarthritis is the most common type. We describe the case of a patient with PA refractory to disease-modifying drugs, who developed drug-induced hepatitis after chemoprophyla...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
abstract：:This article is a systematic review of the literature about the coexistence of cancer and autoimmune rheumatic diseases, their main associations, cancers and possible risk factors associated, with emphasis on existing population-based studies, besides checking the relation of this occur with the use of the drugs used ...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章,评审
doi：
更新日期：2014-03-01 00:00:00
abstract：OBJECTIVE:To translate and validate the Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST 2.0) into Brazilian Portuguese. METHODS:Certified translators translated and back-translated Quest. Content validity (CVI) was determined by 5 experts and, after the final version of B-Quest, a pre-test was ...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2014.04.003
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVE:To report the results of a retrospective cohort involving 139 patients with dermatomyositis, conducted from 1991 to 2011. METHODS:All patients met at least four of the five Bohan and Peter criteria (1975). RESULTS:The patients' mean age at disease onset was 41.7 ± 14.1 years, and mean disease duration was 7...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-12-01 00:00:00
abstract：:Osteoporosis is considered a common metabolic bone disease and its prevalence is increasing worldwide. In this context, physical activity has been used as a non-pharmacological tool for prevention and auxiliary treatment of this disease. The aim of this systematic review was to evaluate the effects of cycling and swim...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2015.09.010
更新日期：2016-02-17 00:00:00
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journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
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journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVE:We aimed to determine the value of ultrasonography (US) in the diagnosis of carpal tunnel syndrome (CTS). METHODS:Two hundred patients (400 hands) were submitted to wrist US to measure median nerve area (MNA), questioning on paresthesia and pain in the median nerve territory, Tinel and Phalen maneuvers. An M...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2014.12.002
更新日期：2015-07-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to investigate pharmacological treatment adherence of patients with juvenile idiopathic arthritis, attended in an outpatient pharmacy at a tertiary hospital in northeastern Brazil. METHODS:The analysis of adherence was performed along with caregivers, through a structured questionna...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2015.11.004
更新日期：2016-03-08 00:00:00
abstract：:Systemic lupus erythematosus juvenile (SLEJ) is a multi-systemic, chronic inflammatory disease, and with autoimmune features. Some clinical manifestations of this disease are similar to those found in Acquired Immunodeficiency Syndrome (AIDS). Coexistence of AIDS with SLEJ is rare, especially in the pediatric populati...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVE:To evaluate the serum levels of leptin and adiponectin in patients with systemic lupus erythematosus (SLE) and correlate their levels with disease activity, presence of autoantibodies and clinical manifestations. METHODS:52 women with SLE and 33 healthy women were evaluated. The patients were divided into tw...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2014.08.014
更新日期：2015-03-01 00:00:00
abstract：:Idiopathic inflammatory myopathies (IIM), which include dermatomyositis (DM) and polymyositis (PM), are chronic systemic diseases associated with high morbidity and functional disability. Current treatment is based on the use of glucocorticoids and immunosuppressive drugs, but a considerable number of patients is refr...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章,评审
doi：10.1016/s2255-5021(13)70010-5
更新日期：2013-02-01 00:00:00
abstract：:Case report of a 38-year-old female patient with systemic lupus erythematosus (SLE) who presented an acute arterial thromboembolic event in the right lower limb. Investigation showed the presence of antiphospholipid antibodies and sterile vegetation in the mitral valve, Libman-Sacks endocarditis (LSE). Possible causes...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2010-11-01 00:00:00
abstract：:Over the past decades, the role of exercise training in rheumatic diseases has been largely explored. Currently, physical activity is well known to benefit patients with osteoporosis, osteoarthritis, systemic lupus erythematosus, systemic sclerosis, idiopathic inflammatory myopathy, fibromyalgia and rheumatoid arthrit...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章,评审
doi：
更新日期：2011-09-01 00:00:00
abstract：:Ankylosing spondylitis (AS) is a chronic rheumatic disease of young men that affects mainly the axial skeleton and is associated with HLA-B27 in 90% of the cases. Incidence of cardiovascular involvement in AS ranges between 10%-30%; conduction disturbances have been described in 1%-9% of the patients with AS. The majo...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-10-01 00:00:00
abstract：INTRODUCTION:The Brazilian Unified Health Care System (SUS) offers treatment for patients with RA through federal funding (Ministry of Health) and state co-financing. The Clinical Protocol and Therapeutic Guidelines for the treatment of rheumatoid arthritis describe the therapeutic regimen for the disease, including th...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVE:To evaluate the use of the spectral Doppler (SDoppler) to quantify inflammatory activity and to detect nail echotextural differences in patients with psoriatic arthritis and onychomycosis. METHODS:Two patients, one with psoriatic arthritis but with no joint pain nor nail clinical change and the other with on...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2014.03.029
更新日期：2014-11-01 00:00:00
abstract：INTRODUCTION:Fibromyalgia (FM) is a chronic pain condition that causes impaired functional capacity, possibly through the adoption of sedentary behaviour. However, little is known regarding physical activity level and its relationship with physical performance in women with FM. OBJECTIVES:To compare physical activity ...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2013-05-01 00:00:00
abstract：INTRODUCTION:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic joint inflammation that often leads to significant disability. Several effective anti-TNF agents have been used, but some patients have shown an inadequate response. Rituximab is a therapeutic monoclonal antibody indicated ...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章,评审
doi：
更新日期：2014-05-01 00:00:00
abstract：PURPOSE:The aim of the present study was to investigate the HLA phenotype in Dupuytren's contracture (DC) patients in order to verify the correlation of these alleles with risk factors for development of DC in the Brazilian population. METHODS:This was a case-controlled study of 25 DC patients and 443 healthy individu...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
