Abstract:
INTRODUCTION:TCF7L2 is a transcription factor involved in Wnt/beta-catenin signaling and which has a variant known to be consistently associated with type 2 diabetes risk and some studies have also indicated its association with risk of certain types of cancer. OBJECTIVE:Since this pathway may be involved in the pathophysiology of other chronic inflammatory diseases such as rheumatoid arthritis, we aimed to investigate the effect of TCF7L2 polymorphism rs7903146 on rheumatoid arthritis severity in a Brazilian population. PATIENTS AND METHODS:This polymorphism was genotyped in 208 patients with rheumatoid arthritis and in 104 healthy controls. We also analyzed the association of this polymorphism to smoking history, functional status classification and radiological indicators of disease severity. RESULTS:The distribution of CC, CT and TT genotypes of SNP rs7903146 of the TCF7L2 gene was not different between patients and controls, and no association between the genotype and indicators of disease severity or smoking history was found. When data were evaluated using the dominant model, in which carriers of the CT and TT genotypes were grouped, an increase in the T allele was observed in patients positive for rheumatoid factor and erosions, although this was not significant. The frequency of T allele was also increased in patients with functional class II compared to class I (P = 0.032). CONCLUSION:It is possible that the small number of patients included in this study may have restrained additional findings. Further studies are therefore needed to investigate the role of TCF7L2 gene variants in the risk of rheumatoid arthritis and its severity.
journal_name
Rev Bras Reumatoljournal_title
Revista brasileira de reumatologiaauthors
Mota LM,Rabelo Fde S,Lima FA,Lima RA,Carvalho JF,Barra GB,Amato AAsubject
Has Abstractpub_date
2012-08-01 00:00:00pages
523-8issue
4eissn
0482-5004issn
1809-4570pii
S0482-50042012000400005journal_volume
52pub_type
杂志文章abstract:INTRODUCTION:Fibromyalgia is a rheumatic syndrome characterized by diffuse and chronic pain associated with fatigue, sleep disorders, anxiety, depression, memory loss, and dizziness. Although the physiological mechanisms that control fibromyalgia have not been precisely established, neuroendocrine, genetic or molecular...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2010-03-01 00:00:00
abstract::This is a case report of juvenile idiopathic arthritis (JIA) in two pairs of brothers followed in the department of pediatric rheumatology, Universidade Federal da Bahia. Genetic involvement in JIA pathogenesis is clear and the risk of recurrence among siblings supports this contribution. An important landmark of this...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2013.05.006
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To assess retrospectively the ocular changes in children and adolescents with juvenile systemic lupus erythematosus (JSLE) in a tertiary pediatric rheumatology service. METHODS:This study assessed 117 JSLE patients (85.5% female, 60.7% non-Caucasian), who met at least four criteria of the 1997 SLE classifica...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2011-12-01 00:00:00
abstract::This article is a systematic review of the literature about the coexistence of cancer and autoimmune rheumatic diseases, their main associations, cancers and possible risk factors associated, with emphasis on existing population-based studies, besides checking the relation of this occur with the use of the drugs used ...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章,评审
doi:
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVES:To determine the frequency of antibodies to chromatin components in juvenile systemic lupus erythematosus (JSLE), and to correlate the presence of these autoantibodies with clinical manifestations and disease activity. METHODS:Anti-chromatin (anti-CHR), anti-nucleosome core particle (anti-NCS) and anti-dsDN...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2012-10-01 00:00:00
abstract:INTRODUCTION:Recent studies show an association between autoimmune thyroiditis and systemic sclerosis (SSc) and suggest that this condition may interfere with the ES phenotype. However these studies evaluate the autoimmune thyroiditis as a whole and none of them specifically addresses Hashimoto's thyroiditis (HT) in SS...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2014.04.001
更新日期:2014-09-01 00:00:00
abstract::Camptocormia is a postural affliction characterised by abnormal flexion of the thoracolumbar spine, which appears upon standing, increases with walking, and disappears in the supine position. Only five cases of camptocormia secondary to idiopathic inflammatory myopathies have been described in the literature. In this ...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1590/s0482-50042013000400010
更新日期:2013-08-01 00:00:00
abstract::Psoriatic arthritis (PA) is an inflammatory seronegative arthritis of unknown origin. Classically, PA has five clinical forms, and asymmetric oligoarthritis is the most common type. We describe the case of a patient with PA refractory to disease-modifying drugs, who developed drug-induced hepatitis after chemoprophyla...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2010-05-01 00:00:00
abstract:INTRODUCTION:Fibromyalgia (FM) is a chronic pain condition that causes impaired functional capacity, possibly through the adoption of sedentary behaviour. However, little is known regarding physical activity level and its relationship with physical performance in women with FM. OBJECTIVES:To compare physical activity ...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:To analyze the frequency of psychiatric comorbidities in patients with systemic lupus erythematosus (SLE) using the systematic review method. METHODS:A systematic literature search was performed between April and July 2011 in the following databases: BIREME, PubMed and CAPES thesis database. This search prio...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章,评审
doi:
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To translate and validate the Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST 2.0) into Brazilian Portuguese. METHODS:Certified translators translated and back-translated Quest. Content validity (CVI) was determined by 5 experts and, after the final version of B-Quest, a pre-test was ...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2014.04.003
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:Some studies have reported that adding leflunomide (LEF) to the treatment of rheumatoid arthritis (RA) in patients who do not respond to methotrexate (MTX) improved efficacy but increased the risk of liver toxicity. This study aimed at assessing the incidence of liver toxicity in patients with active RA using...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2011-03-01 00:00:00
abstract::Machrophage activation syndrome (MAS) is a rare and potentially fatal disease, commonly associated with chronic rheumatic diseases, mainly juvenile idiopathic arthritis. It is included in the group of secondary forms of haemophagocytic syndrome, and other causes are lymphoproliferative diseases and infections. Its mos...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2014.02.007
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Premature development of atherosclerosis in systemic lupus erythematosus has been widely reported. Anti-lipoprotein lipase antibody may be one cause contributing to this disorder. OBJECTIVE:To assess the extent of coronary risk due to autoimmune antibodies in terms of carotid plaque in lupus patients. PA...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1590/s0482-50042010000500007
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the use of the spectral Doppler (SDoppler) to quantify inflammatory activity and to detect nail echotextural differences in patients with psoriatic arthritis and onychomycosis. METHODS:Two patients, one with psoriatic arthritis but with no joint pain nor nail clinical change and the other with on...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2014.03.029
更新日期:2014-11-01 00:00:00
abstract::Idiopathic chondrolysis of the hip is a rare condition of unknown etiology characterized by progressive destruction of the hyaline cartilage that covers the femoral head and acetabulum. Idiopathic chondrolysis of the hip has an insidious beginning and affects more often female adolescents. Patients report severe hip p...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2013-04-01 00:00:00
abstract:INTRODUCTION:Rheumatoid arthritis (RA) is a chronic systemic and progressive inflammatory disorder of the joints, which can result in deformity and functional disability. The diagnosis, treatment, and follow-up of patients with RA vary worldwide. The major societies of rheumatology, as well as governmental agencies in ...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:To investigate the feasibility of bone turnover markers (BTMs) for the assessment of bone metabolism in patients with systemic lupus erythematosus (SLE), according to the guidelines of the International Osteoporosis Foundation and the International Federation of Clinical Chemistry and Laboratory Medicine. ME...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2014.10.004
更新日期:2015-03-01 00:00:00
abstract:INTRODUCTION:The colored ultrasound images can better highlight the joint echotexture damage. OBJECTIVE:To detect echotexture changes in joints of patients with rheumatic diseases, through a color histogram, and to correlate the area measurements with the gray scale (GS). METHODS:Four patients with chondrocalcinosis,...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2014.12.016
更新日期:2015-05-28 00:00:00
abstract:INTRODUCTION:The Brazilian Unified Health Care System (SUS) offers treatment for patients with RA through federal funding (Ministry of Health) and state co-financing. The Clinical Protocol and Therapeutic Guidelines for the treatment of rheumatoid arthritis describe the therapeutic regimen for the disease, including th...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Lactic acid is a byproduct of both muscle metabolism and the central nervous system. Changes in metabolism are related to various physiological and pathological conditions. The aim of this study was to determine the relationship between migraine and fibromyalgia with the levels of lactic acid in the blood. ...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2015.02.002
更新日期:2015-11-01 00:00:00
abstract::Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, and its excess can lead to severe consequences. Those effects are known to be antagonized by TNF-alpha inhibitors. Etanercept is a fusion protein that inhibits TNF-alpha action. As TNF-alpha regulation is related to cellular differentiation of vari...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章,评审
doi:
更新日期:2012-01-01 00:00:00
abstract::The aim of this study was to determine the prevalence of osteopenia and osteoporosis in a female population, that had bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) in a specialized clinic in the south of Brazil. We conducted a cross-sectional study including 1,871 women that performed s...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2014.08.012
更新日期:2015-05-01 00:00:00
abstract:INTRODUCTION:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic joint inflammation that often leads to significant disability. Several effective anti-TNF agents have been used, but some patients have shown an inadequate response. Rituximab is a therapeutic monoclonal antibody indicated ...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章,评审
doi:
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To report the results of a retrospective cohort involving 139 patients with dermatomyositis, conducted from 1991 to 2011. METHODS:All patients met at least four of the five Bohan and Peter criteria (1975). RESULTS:The patients' mean age at disease onset was 41.7 ± 14.1 years, and mean disease duration was 7...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2012-12-01 00:00:00
abstract::Over the past decades, the role of exercise training in rheumatic diseases has been largely explored. Currently, physical activity is well known to benefit patients with osteoporosis, osteoarthritis, systemic lupus erythematosus, systemic sclerosis, idiopathic inflammatory myopathy, fibromyalgia and rheumatoid arthrit...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章,评审
doi:
更新日期:2011-09-01 00:00:00
abstract::Anti-TNF-α agents have emerged as a potent treatment for patients with rheumatoid arthritis unresponsive to conventional disease-modifying antirheumatic drugs. Increased susceptibility to infections induced by these drugs is the main complication of their use. Reactivation of hepatitis B virus (HBV) is one of the most...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2012-08-01 00:00:00
abstract::TNF blockade has been successful in the treatment of some rheumatic diseases such as spondyloarthritis. Many infectious complications have been reported with anti-TNF therapy, mainly bacterial, mycobacterial, viral and fungal infections. Entamoeba histolytica is an extracellular protozoan parasite that mainly causes c...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2013.09.004
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVES:To assess the association between hyperuricemia and different neuropsychiatric manifestations and stroke risk factors in systematic lupus erythematosus (SLE) patients. METHODS:This study was conducted on 204 SLE patients who were admitted to a tertiary referral center. A standardized questionnaire was compl...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2015.05.002
更新日期:2015-07-17 00:00:00
abstract::Systemic lupus erythematosus juvenile (SLEJ) is a multi-systemic, chronic inflammatory disease, and with autoimmune features. Some clinical manifestations of this disease are similar to those found in Acquired Immunodeficiency Syndrome (AIDS). Coexistence of AIDS with SLEJ is rare, especially in the pediatric populati...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2010-07-01 00:00:00