Leptin and adiponectin in patients with systemic lupus erythematosus: clinical and laboratory correlations.

Abstract:

OBJECTIVE:To evaluate the serum levels of leptin and adiponectin in patients with systemic lupus erythematosus (SLE) and correlate their levels with disease activity, presence of autoantibodies and clinical manifestations. METHODS:52 women with SLE and 33 healthy women were evaluated. The patients were divided into two groups, the first with active SLE and the second with inactive SLE. Patients with SLEDAI ≥3 were considered active. Serum levels of leptin (ng/ml) and adiponectin (μg/ml) were measured by enzyme immunoassay. RESULTS:There was a significant difference in leptin levels between SLE and controls (20.7 ± 17.1 vs. 8.0 ± 5.0 ng/mL, P <0.001), but no significant difference in adiponectin levels (87.5 ± 69.7 vs. 118.1 ± 70.6 pg/ml, P = 0.053). No significant difference in levels of leptin and adiponectin was noted between inactive and active SLE groups. There was a significant association between low levels of leptin and positivity for anticardiolipin (aCL) (P = 0.025) and lupus anticoagulant (LA) (p = 0.003) and a significant association between high levels of leptin and the presence of renal disease (p <0.001). However, there was no association between adiponectin levels with autoantibodies and clinical features in SLE patients. CONCLUSION:Patients with SLE had elevated leptin levels, with association with renal involvement. Leptin and adiponectin were not correlated with disease activity. Low levels of leptin have been associated with the presence of LA and aCL.

journal_name

Rev Bras Reumatol

authors

Barbosa Vde S,Francescantônio PL,Silva NA

doi

10.1016/j.rbr.2014.08.014

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

140-5

issue

2

eissn

0482-5004

issn

1809-4570

pii

S0482-5004(14)00212-5

journal_volume

55

pub_type

杂志文章
  • Leukopenia and thrombocytopenia induced by etanercept: two case reports and literature review.

    abstract::Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, and its excess can lead to severe consequences. Those effects are known to be antagonized by TNF-alpha inhibitors. Etanercept is a fusion protein that inhibits TNF-alpha action. As TNF-alpha regulation is related to cellular differentiation of vari...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章,评审

    doi:

    authors: Azevedo VF,Silva MB,Marinello DK,Santos FD,Silva GB

    更新日期:2012-01-01 00:00:00

  • Use of infliximab in a patient with rheumatoid arthritis and chronic hepatitis B.

    abstract::Anti-TNF-α agents have emerged as a potent treatment for patients with rheumatoid arthritis unresponsive to conventional disease-modifying antirheumatic drugs. Increased susceptibility to infections induced by these drugs is the main complication of their use. Reactivation of hepatitis B virus (HBV) is one of the most...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:

    authors: Doubrawa E,Ricca RA,Malucelli TO,Pizzol VI,Barros DH,Paiva ES

    更新日期:2012-08-01 00:00:00

  • Ultrasound Color histogram assessment allows better view of echotexture damage.

    abstract:INTRODUCTION:The colored ultrasound images can better highlight the joint echotexture damage. OBJECTIVE:To detect echotexture changes in joints of patients with rheumatic diseases, through a color histogram, and to correlate the area measurements with the gray scale (GS). METHODS:Four patients with chondrocalcinosis,...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:10.1016/j.rbr.2014.12.016

    authors: Mendonça JA

    更新日期:2015-05-28 00:00:00

  • Ocular changes due to the treatment of juvenile systemic lupus erythematosus.

    abstract:OBJECTIVE:To assess retrospectively the ocular changes in children and adolescents with juvenile systemic lupus erythematosus (JSLE) in a tertiary pediatric rheumatology service. METHODS:This study assessed 117 JSLE patients (85.5% female, 60.7% non-Caucasian), who met at least four criteria of the 1997 SLE classifica...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:

    authors: Fraga MM,Len CA,dos Santos Finamor LP,Matos KT,Muccioli C,Hilário MO,Terreri MT

    更新日期:2011-12-01 00:00:00

  • Liver toxicity is rare in rheumatoid arthritis patients using combination therapy with leflunomide and methotrexate.

    abstract:OBJECTIVE:Some studies have reported that adding leflunomide (LEF) to the treatment of rheumatoid arthritis (RA) in patients who do not respond to methotrexate (MTX) improved efficacy but increased the risk of liver toxicity. This study aimed at assessing the incidence of liver toxicity in patients with active RA using...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:

    authors: Alves JA,Fialho SC,Morato EF,Castro GR,Zimmermann AF,Ribeiro GG,Neves FS,Pereira IA

    更新日期:2011-03-01 00:00:00

  • Juvenile systemic lupus erythematosus in a adolescent with acquired immunodeficiency syndrome.

    abstract::Systemic lupus erythematosus juvenile (SLEJ) is a multi-systemic, chronic inflammatory disease, and with autoimmune features. Some clinical manifestations of this disease are similar to those found in Acquired Immunodeficiency Syndrome (AIDS). Coexistence of AIDS with SLEJ is rare, especially in the pediatric populati...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:

    authors: Sacilotto Nde C,Yamashiro CY,Nishimoto TM

    更新日期:2010-07-01 00:00:00

  • [Translation and validation of the Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST 2.0) into Portuguese].

    abstract:OBJECTIVE:To translate and validate the Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST 2.0) into Brazilian Portuguese. METHODS:Certified translators translated and back-translated Quest. Content validity (CVI) was determined by 5 experts and, after the final version of B-Quest, a pre-test was ...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:10.1016/j.rbr.2014.04.003

    authors: de Carvalho KE,Gois Júnior MB,Sá KN

    更新日期:2014-07-01 00:00:00

  • Use of biological therapies in rheumatoid arthritis management: a comparison between the main worldwide and brazilian recommendations.

    abstract:INTRODUCTION:Rheumatoid arthritis (RA) is a chronic systemic and progressive inflammatory disorder of the joints, which can result in deformity and functional disability. The diagnosis, treatment, and follow-up of patients with RA vary worldwide. The major societies of rheumatology, as well as governmental agencies in ...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:

    authors: Fernandes V,de Assis TM,Queiroz CC,de Figueiredo PP,de Oliveira RU,da Silva NA

    更新日期:2011-05-01 00:00:00

  • Medication adherence in patients with juvenile idiopathic arthritis.

    abstract:OBJECTIVE:The aim of this study was to investigate pharmacological treatment adherence of patients with juvenile idiopathic arthritis, attended in an outpatient pharmacy at a tertiary hospital in northeastern Brazil. METHODS:The analysis of adherence was performed along with caregivers, through a structured questionna...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:10.1016/j.rbr.2015.11.004

    authors: Adriano LS,Fonteles MM,Azevedo MF,Beserra MP,Romero NR

    更新日期:2016-03-08 00:00:00

  • Description of a new method of ovariectomy in female rats.

    abstract::Rats are currently the most used laboratory animals to investigate osteoporosis. We report an efficient method of ovariectomy and compared this method with the two other operative methods of ovariectomy (i.e., midline dorsal skin incision and double dorsolateral approach, which are used commonly for inducing experimen...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:

    authors: Khajuria DK,Razdan R,Mahapatra DR

    更新日期:2012-05-01 00:00:00

  • Investigation of depression, anxiety and quality of life in patients with knee osteoarthritis: a comparative study.

    abstract:INTRODUCTION:Osteoarthritis (OA) affects the articular cartilage and subchondral bone, compromising the joint as a whole. The knee joint is characterized as one of the main sites of involvement of OA and the most significant risk factors for developing the disease are aging, overweight and female gender. OA is consider...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:10.1016/j.rbr.2015.03.001

    authors: Ferreira AH,Godoy PB,Oliveira NR,Diniz RA,Diniz RE,Padovani Rda C,Silva RC

    更新日期:2015-09-01 00:00:00

  • [Multicentric Castleman disease not associated with HHV-8 and HIV viruses].

    abstract::Castleman's disease (CD) is a polyclonal lymphoproliferative disorder also known as giant nodular hyperplasia or angiofollicular lymph node hyperplasia. It is a rare disease often associated to human immunodeficiency virus (HIV) and human herpes virus 8 (HHV-8). Histopathological findings in Castleman's disease sugges...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:10.1016/j.rbr.2013.05.004

    authors: Forteski Dde F,Netto FC,Lomonte AB,dos Anjos BC,Zerbini MC,Zerbini CA

    更新日期:2014-07-01 00:00:00

  • Feasibility of measurement of bone turnover markers in female patients with systemic lupus erythematosus.

    abstract:OBJECTIVE:To investigate the feasibility of bone turnover markers (BTMs) for the assessment of bone metabolism in patients with systemic lupus erythematosus (SLE), according to the guidelines of the International Osteoporosis Foundation and the International Federation of Clinical Chemistry and Laboratory Medicine. ME...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:10.1016/j.rbr.2014.10.004

    authors: Bogaczewicz J,Karczmarewicz E,Pludowski P,Zabek J,Kowalski J,Lukaszkiewicz J,Wozniacka A

    更新日期:2015-03-01 00:00:00

  • Therapeutic effects of exercise training in patients with pediatric rheumatic diseases.

    abstract::Over the past decades, the role of exercise training in rheumatic diseases has been largely explored. Currently, physical activity is well known to benefit patients with osteoporosis, osteoarthritis, systemic lupus erythematosus, systemic sclerosis, idiopathic inflammatory myopathy, fibromyalgia and rheumatoid arthrit...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章,评审

    doi:

    authors: Gualano B,Pinto AL,Perondi MB,Roschel H,Sallum AM,Hayashi AP,Solis MY,Silva CA

    更新日期:2011-09-01 00:00:00

  • Antinucleosome antibodies and primary antiphospholipid syndrome: an observational study.

    abstract:OBJECTIVE:To study the association of anti-nucleosome (anti-NCS) antibodies in primary antiphospholipid syndrome (APS) and the development of systemic lupus erythematosus (SLE) during follow-up. MATERIALS AND METHODS:Thirty-six women with primary APS were evaluated prospectively for clinical features of systemic autoi...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:

    authors: de Souza AW,Keusseyan SP,da Silva NP,Sato EI,Andrade LE

    更新日期:2012-05-01 00:00:00

  • Swimming and cycling do not cause positive effects on bone mineral density: a systematic review.

    abstract::Osteoporosis is considered a common metabolic bone disease and its prevalence is increasing worldwide. In this context, physical activity has been used as a non-pharmacological tool for prevention and auxiliary treatment of this disease. The aim of this systematic review was to evaluate the effects of cycling and swim...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:10.1016/j.rbr.2015.09.010

    authors: Abrahin O,Rodrigues RP,Marçal AC,Alves EA,Figueiredo RC,Sousa EC

    更新日期:2016-02-17 00:00:00

  • [Ultrasonography as a tool in diagnosis of carpal tunnel syndrome].

    abstract:OBJECTIVE:We aimed to determine the value of ultrasonography (US) in the diagnosis of carpal tunnel syndrome (CTS). METHODS:Two hundred patients (400 hands) were submitted to wrist US to measure median nerve area (MNA), questioning on paresthesia and pain in the median nerve territory, Tinel and Phalen maneuvers. An M...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:10.1016/j.rbr.2014.12.002

    authors: do Amaral e Castro A,Skare TL,Sakuma AK,Barros WH

    更新日期:2015-07-01 00:00:00

  • [Colonic perforation due to invasive amebic colitis during anti-TNF therapy for spondyloarthritis].

    abstract::TNF blockade has been successful in the treatment of some rheumatic diseases such as spondyloarthritis. Many infectious complications have been reported with anti-TNF therapy, mainly bacterial, mycobacterial, viral and fungal infections. Entamoeba histolytica is an extracellular protozoan parasite that mainly causes c...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:10.1016/j.rbr.2013.09.004

    authors: Restrepo JP,Molina Mdel P

    更新日期:2014-11-01 00:00:00

  • Serotonin receptor (5-HT 2A) and catechol-O-methyltransferase (COMT) gene polymorphisms: triggers of fibromyalgia?

    abstract:INTRODUCTION:Fibromyalgia is a rheumatic syndrome characterized by diffuse and chronic pain associated with fatigue, sleep disorders, anxiety, depression, memory loss, and dizziness. Although the physiological mechanisms that control fibromyalgia have not been precisely established, neuroendocrine, genetic or molecular...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:

    authors: Matsuda JB,Barbosa FR,Morel LJ,França Sde C,Zingaretti SM,da Silva LM,Pereira AM,Marins M,Fachin AL

    更新日期:2010-03-01 00:00:00

  • Chondrolysis of the hip in an adolescent: clinical and radiological outcomes.

    abstract::Idiopathic chondrolysis of the hip is a rare condition of unknown etiology characterized by progressive destruction of the hyaline cartilage that covers the femoral head and acetabulum. Idiopathic chondrolysis of the hip has an insidious beginning and affects more often female adolescents. Patients report severe hip p...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:

    authors: Sakamoto AP,Ramos LL,Fernandes Ada R,Terreri MT

    更新日期:2013-04-01 00:00:00

  • Incidence of neoplasms in the most prevalent autoimmune rheumatic diseases: a systematic review.

    abstract::This article is a systematic review of the literature about the coexistence of cancer and autoimmune rheumatic diseases, their main associations, cancers and possible risk factors associated, with emphasis on existing population-based studies, besides checking the relation of this occur with the use of the drugs used ...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章,评审

    doi:

    authors: Machado RI,Braz Ade S,Freire EA

    更新日期:2014-03-01 00:00:00

  • Dermatomyositis and polymyositis: from immunopathology to immunotherapy (immunobiologics).

    abstract::Idiopathic inflammatory myopathies (IIM), which include dermatomyositis (DM) and polymyositis (PM), are chronic systemic diseases associated with high morbidity and functional disability. Current treatment is based on the use of glucocorticoids and immunosuppressive drugs, but a considerable number of patients is refr...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章,评审

    doi:10.1016/s2255-5021(13)70010-5

    authors: Shinjo SK,de Souza FH,de Moraes JC

    更新日期:2013-02-01 00:00:00

  • The contribution of HLA molecules to Dupuytren's contracture in a Southeast Brazilian population.

    abstract:PURPOSE:The aim of the present study was to investigate the HLA phenotype in Dupuytren's contracture (DC) patients in order to verify the correlation of these alleles with risk factors for development of DC in the Brazilian population. METHODS:This was a case-controlled study of 25 DC patients and 443 healthy individu...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:

    authors: Usó SM,Sanson AC,Covolo-Santana Fde S,Marcos EV,Marques T,Cury Filho M,Ura S

    更新日期:2014-01-01 00:00:00

  • Profile of users of anticytokines offered by the health care system in the state of Paraná for the treatment of rheumatoid arthritis.

    abstract:INTRODUCTION:The Brazilian Unified Health Care System (SUS) offers treatment for patients with RA through federal funding (Ministry of Health) and state co-financing. The Clinical Protocol and Therapeutic Guidelines for the treatment of rheumatoid arthritis describe the therapeutic regimen for the disease, including th...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:

    authors: Wiens A,Grochocki MC,Pontarolli DR,Venson R,Correr CJ,Pontarolo R

    更新日期:2012-03-01 00:00:00

  • [Hyperuricemia in systemic lupus erythematosus: is it associated with the neuropsychiatric manifestations of the disease?]

    abstract:OBJECTIVES:To assess the association between hyperuricemia and different neuropsychiatric manifestations and stroke risk factors in systematic lupus erythematosus (SLE) patients. METHODS:This study was conducted on 204 SLE patients who were admitted to a tertiary referral center. A standardized questionnaire was compl...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:10.1016/j.rbr.2015.05.002

    authors: Sheikh M,Movassaghi S,Khaledi M,Moghaddassi M

    更新日期:2015-07-17 00:00:00

  • The importance of lactic acid in migraines and fibromyalgia.

    abstract:BACKGROUND:Lactic acid is a byproduct of both muscle metabolism and the central nervous system. Changes in metabolism are related to various physiological and pathological conditions. The aim of this study was to determine the relationship between migraine and fibromyalgia with the levels of lactic acid in the blood. ...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:10.1016/j.rbr.2015.02.002

    authors: de Sá Ribeiro GA,Scola RH,Piovesan EJ,Wollmann Junior DR,Paiva Edos S,da Cunha CL,Werneck LC

    更新日期:2015-11-01 00:00:00

  • [Two pairs of brothers with juvenile idiopathic arthritis (JIA): case reports].

    abstract::This is a case report of juvenile idiopathic arthritis (JIA) in two pairs of brothers followed in the department of pediatric rheumatology, Universidade Federal da Bahia. Genetic involvement in JIA pathogenesis is clear and the risk of recurrence among siblings supports this contribution. An important landmark of this...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:10.1016/j.rbr.2013.05.006

    authors: Robazzi TC,Rios G,Castro C

    更新日期:2015-01-01 00:00:00

  • Lack of association between the CC genotype of the rs7903146 polymorphism in the TCF7L2 gene and rheumatoid arthritis.

    abstract:INTRODUCTION:TCF7L2 is a transcription factor involved in Wnt/beta-catenin signaling and which has a variant known to be consistently associated with type 2 diabetes risk and some studies have also indicated its association with risk of certain types of cancer. OBJECTIVE:Since this pathway may be involved in the patho...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:

    authors: Mota LM,Rabelo Fde S,Lima FA,Lima RA,Carvalho JF,Barra GB,Amato AA

    更新日期:2012-08-01 00:00:00

  • Demographic and clinical characteristics of a cohort of patients with early rheumatoid arthritis.

    abstract:INTRODUCTION:Very few studies carried out with Latin American populations on the demographic and clinical characteristics of patients diagnosed with early rheumatoid arthritis (RA) can be found in the literature. OBJECTIVE:To characterize a population of patients with early RA, prospectively followed, concerning demog...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:

    authors: da Mota LM,Laurindo IM,dos Santos Neto LL

    更新日期:2010-05-01 00:00:00

  • IgA nephropathy in spondyloarthritis.

    abstract::Spondyloarthritis patients can be more frequently affected by IgA nephropathy than the general population, and a common etiopathogenic mechanism can be involved. We report four cases that may exemplify that association. ...

    journal_title:Revista brasileira de reumatologia

    pub_type: 杂志文章

    doi:

    authors: Azevedo DC,Ferreira GA,Carvalho MA

    更新日期:2011-01-01 00:00:00