Abstract:
OBJECTIVE:To evaluate the serum levels of leptin and adiponectin in patients with systemic lupus erythematosus (SLE) and correlate their levels with disease activity, presence of autoantibodies and clinical manifestations. METHODS:52 women with SLE and 33 healthy women were evaluated. The patients were divided into two groups, the first with active SLE and the second with inactive SLE. Patients with SLEDAI ≥3 were considered active. Serum levels of leptin (ng/ml) and adiponectin (μg/ml) were measured by enzyme immunoassay. RESULTS:There was a significant difference in leptin levels between SLE and controls (20.7 ± 17.1 vs. 8.0 ± 5.0 ng/mL, P <0.001), but no significant difference in adiponectin levels (87.5 ± 69.7 vs. 118.1 ± 70.6 pg/ml, P = 0.053). No significant difference in levels of leptin and adiponectin was noted between inactive and active SLE groups. There was a significant association between low levels of leptin and positivity for anticardiolipin (aCL) (P = 0.025) and lupus anticoagulant (LA) (p = 0.003) and a significant association between high levels of leptin and the presence of renal disease (p <0.001). However, there was no association between adiponectin levels with autoantibodies and clinical features in SLE patients. CONCLUSION:Patients with SLE had elevated leptin levels, with association with renal involvement. Leptin and adiponectin were not correlated with disease activity. Low levels of leptin have been associated with the presence of LA and aCL.
journal_name
Rev Bras Reumatoljournal_title
Revista brasileira de reumatologiaauthors
Barbosa Vde S,Francescantônio PL,Silva NAdoi
10.1016/j.rbr.2014.08.014subject
Has Abstractpub_date
2015-03-01 00:00:00pages
140-5issue
2eissn
0482-5004issn
1809-4570pii
S0482-5004(14)00212-5journal_volume
55pub_type
杂志文章abstract::Castleman's disease (CD) is a polyclonal lymphoproliferative disorder also known as giant nodular hyperplasia or angiofollicular lymph node hyperplasia. It is a rare disease often associated to human immunodeficiency virus (HIV) and human herpes virus 8 (HHV-8). Histopathological findings in Castleman's disease sugges...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2013.05.004
更新日期:2014-07-01 00:00:00
abstract:INTRODUCTION:Very few studies carried out with Latin American populations on the demographic and clinical characteristics of patients diagnosed with early rheumatoid arthritis (RA) can be found in the literature. OBJECTIVE:To characterize a population of patients with early RA, prospectively followed, concerning demog...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2010-05-01 00:00:00
abstract:INTRODUCTION:The Brazilian Unified Health Care System (SUS) offers treatment for patients with RA through federal funding (Ministry of Health) and state co-financing. The Clinical Protocol and Therapeutic Guidelines for the treatment of rheumatoid arthritis describe the therapeutic regimen for the disease, including th...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2012-03-01 00:00:00
abstract:UNLABELLED:While reaffirming that the clinical exam still is the best medical practice, the author has proposed a new maneuver (Cecin's sign or "X" sign) to help the diagnosis of herniated lumbar disk, describing its biomechanical bases. However, the diagnostic performance of this maneuver has not been formally tested....
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, and its excess can lead to severe consequences. Those effects are known to be antagonized by TNF-alpha inhibitors. Etanercept is a fusion protein that inhibits TNF-alpha action. As TNF-alpha regulation is related to cellular differentiation of vari...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章,评审
doi:
更新日期:2012-01-01 00:00:00
abstract::Camptocormia is a postural affliction characterised by abnormal flexion of the thoracolumbar spine, which appears upon standing, increases with walking, and disappears in the supine position. Only five cases of camptocormia secondary to idiopathic inflammatory myopathies have been described in the literature. In this ...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1590/s0482-50042013000400010
更新日期:2013-08-01 00:00:00
abstract::Machrophage activation syndrome (MAS) is a rare and potentially fatal disease, commonly associated with chronic rheumatic diseases, mainly juvenile idiopathic arthritis. It is included in the group of secondary forms of haemophagocytic syndrome, and other causes are lymphoproliferative diseases and infections. Its mos...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2014.02.007
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To assess retrospectively the ocular changes in children and adolescents with juvenile systemic lupus erythematosus (JSLE) in a tertiary pediatric rheumatology service. METHODS:This study assessed 117 JSLE patients (85.5% female, 60.7% non-Caucasian), who met at least four criteria of the 1997 SLE classifica...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:To translate and validate the Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST 2.0) into Brazilian Portuguese. METHODS:Certified translators translated and back-translated Quest. Content validity (CVI) was determined by 5 experts and, after the final version of B-Quest, a pre-test was ...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2014.04.003
更新日期:2014-07-01 00:00:00
abstract::Over the past decades, the role of exercise training in rheumatic diseases has been largely explored. Currently, physical activity is well known to benefit patients with osteoporosis, osteoarthritis, systemic lupus erythematosus, systemic sclerosis, idiopathic inflammatory myopathy, fibromyalgia and rheumatoid arthrit...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章,评审
doi:
更新日期:2011-09-01 00:00:00
abstract::Idiopathic inflammatory myopathies (IIM), which include dermatomyositis (DM) and polymyositis (PM), are chronic systemic diseases associated with high morbidity and functional disability. Current treatment is based on the use of glucocorticoids and immunosuppressive drugs, but a considerable number of patients is refr...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章,评审
doi:10.1016/s2255-5021(13)70010-5
更新日期:2013-02-01 00:00:00
abstract::Rats are currently the most used laboratory animals to investigate osteoporosis. We report an efficient method of ovariectomy and compared this method with the two other operative methods of ovariectomy (i.e., midline dorsal skin incision and double dorsolateral approach, which are used commonly for inducing experimen...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2012-05-01 00:00:00
abstract::This is a case report of juvenile idiopathic arthritis (JIA) in two pairs of brothers followed in the department of pediatric rheumatology, Universidade Federal da Bahia. Genetic involvement in JIA pathogenesis is clear and the risk of recurrence among siblings supports this contribution. An important landmark of this...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2013.05.006
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Recent studies show an association between autoimmune thyroiditis and systemic sclerosis (SSc) and suggest that this condition may interfere with the ES phenotype. However these studies evaluate the autoimmune thyroiditis as a whole and none of them specifically addresses Hashimoto's thyroiditis (HT) in SS...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2014.04.001
更新日期:2014-09-01 00:00:00
abstract:INTRODUCTION:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic joint inflammation that often leads to significant disability. Several effective anti-TNF agents have been used, but some patients have shown an inadequate response. Rituximab is a therapeutic monoclonal antibody indicated ...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章,评审
doi:
更新日期:2014-05-01 00:00:00
abstract::Spondyloarthritis patients can be more frequently affected by IgA nephropathy than the general population, and a common etiopathogenic mechanism can be involved. We report four cases that may exemplify that association. ...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the use of the spectral Doppler (SDoppler) to quantify inflammatory activity and to detect nail echotextural differences in patients with psoriatic arthritis and onychomycosis. METHODS:Two patients, one with psoriatic arthritis but with no joint pain nor nail clinical change and the other with on...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2014.03.029
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:To assess the quality of life, muscle strength and functional capacity in women with fibromyalgia (FM). PATIENTS AND METHODS:Cross-sectional study carried out with 31 female volunteers (age range, 35 to 60 years), paired in two groups (16 with FM, and 15 in the control group). Both groups underwent the follo...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2011-07-01 00:00:00
abstract::This article is a systematic review of the literature about the coexistence of cancer and autoimmune rheumatic diseases, their main associations, cancers and possible risk factors associated, with emphasis on existing population-based studies, besides checking the relation of this occur with the use of the drugs used ...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章,评审
doi:
更新日期:2014-03-01 00:00:00
abstract::Systemic Sclerosis (SSc) is an autoimmune disease of multifactorial etiology, triggered by a combination of genetic and environmental factors. Its varied clinical expression results from the complex physiopathogenic interaction of three main elements: proliferative vasculopathy, immune dysregulation and abnormal depos...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章,评审
doi:10.1016/j.rbr.2013.01.001
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVES:To assess the association between hyperuricemia and different neuropsychiatric manifestations and stroke risk factors in systematic lupus erythematosus (SLE) patients. METHODS:This study was conducted on 204 SLE patients who were admitted to a tertiary referral center. A standardized questionnaire was compl...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2015.05.002
更新日期:2015-07-17 00:00:00
abstract::Systemic lupus erythematosus juvenile (SLEJ) is a multi-systemic, chronic inflammatory disease, and with autoimmune features. Some clinical manifestations of this disease are similar to those found in Acquired Immunodeficiency Syndrome (AIDS). Coexistence of AIDS with SLEJ is rare, especially in the pediatric populati...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2010-07-01 00:00:00
abstract::The aim of this study was to determine the prevalence of osteopenia and osteoporosis in a female population, that had bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) in a specialized clinic in the south of Brazil. We conducted a cross-sectional study including 1,871 women that performed s...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2014.08.012
更新日期:2015-05-01 00:00:00
abstract::TNF blockade has been successful in the treatment of some rheumatic diseases such as spondyloarthritis. Many infectious complications have been reported with anti-TNF therapy, mainly bacterial, mycobacterial, viral and fungal infections. Entamoeba histolytica is an extracellular protozoan parasite that mainly causes c...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2013.09.004
更新日期:2014-11-01 00:00:00
abstract::Osteoporosis is considered a common metabolic bone disease and its prevalence is increasing worldwide. In this context, physical activity has been used as a non-pharmacological tool for prevention and auxiliary treatment of this disease. The aim of this systematic review was to evaluate the effects of cycling and swim...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2015.09.010
更新日期:2016-02-17 00:00:00
abstract::Psoriatic arthritis (PA) is an inflammatory seronegative arthritis of unknown origin. Classically, PA has five clinical forms, and asymmetric oligoarthritis is the most common type. We describe the case of a patient with PA refractory to disease-modifying drugs, who developed drug-induced hepatitis after chemoprophyla...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2010-05-01 00:00:00
abstract:INTRODUCTION:Osteoarthritis (OA) affects the articular cartilage and subchondral bone, compromising the joint as a whole. The knee joint is characterized as one of the main sites of involvement of OA and the most significant risk factors for developing the disease are aging, overweight and female gender. OA is consider...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2015.03.001
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVES:To determine the frequency of antibodies to chromatin components in juvenile systemic lupus erythematosus (JSLE), and to correlate the presence of these autoantibodies with clinical manifestations and disease activity. METHODS:Anti-chromatin (anti-CHR), anti-nucleosome core particle (anti-NCS) and anti-dsDN...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:Some studies have reported that adding leflunomide (LEF) to the treatment of rheumatoid arthritis (RA) in patients who do not respond to methotrexate (MTX) improved efficacy but increased the risk of liver toxicity. This study aimed at assessing the incidence of liver toxicity in patients with active RA using...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2011-03-01 00:00:00
abstract::Idiopathic chondrolysis of the hip is a rare condition of unknown etiology characterized by progressive destruction of the hyaline cartilage that covers the femoral head and acetabulum. Idiopathic chondrolysis of the hip has an insidious beginning and affects more often female adolescents. Patients report severe hip p...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2013-04-01 00:00:00