Leukopenia and thrombocytopenia induced by etanercept: two case reports and literature review.

Abstract:

:Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, and its excess can lead to severe consequences. Those effects are known to be antagonized by TNF-alpha inhibitors. Etanercept is a fusion protein that inhibits TNF-alpha action. As TNF-alpha regulation is related to cellular differentiation of various cellular types involved in immune response through expression of several other cytokines, it is possible that the use of its inhibitors may cause cytopenia. We report two cases of bicytopenia induced by etanercept. Both cases recovered after drug withdrawal. We discuss the need of introduction of routine laboratorial tests in patients using anti-TNF therapy, in order to identify possible hematological changes.

journal_name

Rev Bras Reumatol

authors

Azevedo VF,Silva MB,Marinello DK,Santos FD,Silva GB

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

110-2

issue

1

eissn

0482-5004

issn

1809-4570

pii

S0482-50042012000100011

journal_volume

52

pub_type

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