Abstract:
OBJECTIVE:Some studies have reported that adding leflunomide (LEF) to the treatment of rheumatoid arthritis (RA) in patients who do not respond to methotrexate (MTX) improved efficacy but increased the risk of liver toxicity. This study aimed at assessing the incidence of liver toxicity in patients with active RA using the LEF and MTX combination therapy in comparison with that of patients on MTX monotherapy. METHODS:Between February and September 2009, 97 consecutive patients followed up at the University Hospital of the Universidade Federal de Santa Catarina, Brazil, were enrolled. RA patients on MTX alone or using the LEF and MTX combination had their medical records systematically reviewed. The alanine/aspartate aminotransferase enzymes were retrospectively analyzed since the beginning of treatment with MTX or MTX plus LEF. Hepatotoxicity was defined as an increase of at least two-fold the upper limits of normal of the liver enzymes. RESULTS:71 RA patients were included in the study: 36.6% were using 20-25 mg/week of MTX alone and 63.4% were using 20-25 mg/week of MTX plus 20 mg/day of LEF. Of the patients on the combination therapy, 11.1% had abnormal levels of liver enzymes versus 11.5% of the patients on monotherapy (P = 1.0). Abnormal aminotransferase levels have been seen with both MTX and LEF monotherapies in patients with RA. In our study, no difference was found between the percentages of aminotransferase elevations of patients being treated with MTX alone or in combination with LEF. CONCLUSION:The combination of MTX and LEF in RA patients is generally safe and well tolerated.
journal_name
Rev Bras Reumatoljournal_title
Revista brasileira de reumatologiaauthors
Alves JA,Fialho SC,Morato EF,Castro GR,Zimmermann AF,Ribeiro GG,Neves FS,Pereira IAsubject
Has Abstractpub_date
2011-03-01 00:00:00pages
141-4issue
2eissn
0482-5004issn
1809-4570pii
S0482-50042011000200004journal_volume
51pub_type
杂志文章abstract:INTRODUCTION:Premature development of atherosclerosis in systemic lupus erythematosus has been widely reported. Anti-lipoprotein lipase antibody may be one cause contributing to this disorder. OBJECTIVE:To assess the extent of coronary risk due to autoimmune antibodies in terms of carotid plaque in lupus patients. PA...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
abstract::Idiopathic inflammatory myopathies (IIM), which include dermatomyositis (DM) and polymyositis (PM), are chronic systemic diseases associated with high morbidity and functional disability. Current treatment is based on the use of glucocorticoids and immunosuppressive drugs, but a considerable number of patients is refr...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章,评审
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journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
abstract:OBJECTIVES:To assess the association between hyperuricemia and different neuropsychiatric manifestations and stroke risk factors in systematic lupus erythematosus (SLE) patients. METHODS:This study was conducted on 204 SLE patients who were admitted to a tertiary referral center. A standardized questionnaire was compl...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2015.05.002
更新日期:2015-07-17 00:00:00
abstract:OBJECTIVE:To assess retrospectively the ocular changes in children and adolescents with juvenile systemic lupus erythematosus (JSLE) in a tertiary pediatric rheumatology service. METHODS:This study assessed 117 JSLE patients (85.5% female, 60.7% non-Caucasian), who met at least four criteria of the 1997 SLE classifica...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2011-12-01 00:00:00
abstract::Ankylosing spondylitis (AS) is a chronic rheumatic disease of young men that affects mainly the axial skeleton and is associated with HLA-B27 in 90% of the cases. Incidence of cardiovascular involvement in AS ranges between 10%-30%; conduction disturbances have been described in 1%-9% of the patients with AS. The majo...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2012-10-01 00:00:00
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journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2015.02.002
更新日期:2015-11-01 00:00:00
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journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2012-05-01 00:00:00
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journal_title:Revista brasileira de reumatologia
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doi:
更新日期:2011-01-01 00:00:00
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journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章,评审
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更新日期:2013-09-01 00:00:00
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journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1590/s0482-50042013000400010
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journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2012-12-01 00:00:00
abstract::Systemic Sclerosis (SSc) is an autoimmune disease of multifactorial etiology, triggered by a combination of genetic and environmental factors. Its varied clinical expression results from the complex physiopathogenic interaction of three main elements: proliferative vasculopathy, immune dysregulation and abnormal depos...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章,评审
doi:10.1016/j.rbr.2013.01.001
更新日期:2013-11-01 00:00:00
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journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2013-04-01 00:00:00
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journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2014.04.003
更新日期:2014-07-01 00:00:00
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journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2012-10-01 00:00:00
abstract:INTRODUCTION:The Brazilian Unified Health Care System (SUS) offers treatment for patients with RA through federal funding (Ministry of Health) and state co-financing. The Clinical Protocol and Therapeutic Guidelines for the treatment of rheumatoid arthritis describe the therapeutic regimen for the disease, including th...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2012-03-01 00:00:00
abstract::This is a case report of juvenile idiopathic arthritis (JIA) in two pairs of brothers followed in the department of pediatric rheumatology, Universidade Federal da Bahia. Genetic involvement in JIA pathogenesis is clear and the risk of recurrence among siblings supports this contribution. An important landmark of this...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2013.05.006
更新日期:2015-01-01 00:00:00
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journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2015.11.004
更新日期:2016-03-08 00:00:00
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journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章,评审
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更新日期:2014-05-01 00:00:00
abstract::Case report of a 38-year-old female patient with systemic lupus erythematosus (SLE) who presented an acute arterial thromboembolic event in the right lower limb. Investigation showed the presence of antiphospholipid antibodies and sterile vegetation in the mitral valve, Libman-Sacks endocarditis (LSE). Possible causes...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2010-11-01 00:00:00
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journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2014.12.016
更新日期:2015-05-28 00:00:00
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journal_title:Revista brasileira de reumatologia
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doi:
更新日期:2012-05-01 00:00:00
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doi:
更新日期:2012-08-01 00:00:00
abstract::Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, and its excess can lead to severe consequences. Those effects are known to be antagonized by TNF-alpha inhibitors. Etanercept is a fusion protein that inhibits TNF-alpha action. As TNF-alpha regulation is related to cellular differentiation of vari...
journal_title:Revista brasileira de reumatologia
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更新日期:2012-01-01 00:00:00
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journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:10.1016/j.rbr.2014.12.002
更新日期:2015-07-01 00:00:00
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journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2010-07-01 00:00:00
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journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2011-07-01 00:00:00
abstract::Psoriatic arthritis (PA) is an inflammatory seronegative arthritis of unknown origin. Classically, PA has five clinical forms, and asymmetric oligoarthritis is the most common type. We describe the case of a patient with PA refractory to disease-modifying drugs, who developed drug-induced hepatitis after chemoprophyla...
journal_title:Revista brasileira de reumatologia
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doi:
更新日期:2010-05-01 00:00:00
abstract:INTRODUCTION:Rheumatoid arthritis (RA) is a chronic systemic and progressive inflammatory disorder of the joints, which can result in deformity and functional disability. The diagnosis, treatment, and follow-up of patients with RA vary worldwide. The major societies of rheumatology, as well as governmental agencies in ...
journal_title:Revista brasileira de reumatologia
pub_type: 杂志文章
doi:
更新日期:2011-05-01 00:00:00