Abstract:
OBJECTIVE:To assess retrospectively the ocular changes in children and adolescents with juvenile systemic lupus erythematosus (JSLE) in a tertiary pediatric rheumatology service. METHODS:This study assessed 117 JSLE patients (85.5% female, 60.7% non-Caucasian), who met at least four criteria of the 1997 SLE classification of the American College of Rheumatology. Their mean age was 10.4 years, and their mean time of disease progression was 5.4 years. A protocol containing clinical and demographic data, ophthalmologic complaints and changes, age of onset, duration of medication use, and cumulative medication dose was applied. RESULTS:Of the 117 patients, 24 (20.5%) had ocular changes. Sixteen of them had abnormal fundoscopy associated with systemic hypertension and/or use of chloroquine; four had cataract; two had glaucoma; and two had cataract and glaucoma. The mean age of ocular change onset was 14.1 years. Patients with ocular changes received statistically higher and longer doses of glucocorticoid pulse therapy as compared with patients without ocular changes [1.5 (0.4 to 1.6) versus 1 (0.2 to 1.6) mg/kg, P = 0.003; 25.7 (2-99) versus 17.8 (1-114) months, P = 0.0001, respectively]. CONCLUSION:A high prevalence of ocular changes relating mainly to the treatment of JSLE was observed. This demonstrates the need for regular ophthalmologic examinations even in asymptomatic patients, aiming at the early diagnosis and intervention, and at decreasing the ocular morbidity related to that disease.
journal_name
Rev Bras Reumatoljournal_title
Revista brasileira de reumatologiaauthors
Fraga MM,Len CA,dos Santos Finamor LP,Matos KT,Muccioli C,Hilário MO,Terreri MTsubject
Has Abstractpub_date
2011-12-01 00:00:00pages
554-7issue
6eissn
0482-5004issn
1809-4570pii
S0482-50042011000600003journal_volume
51pub_type
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journal_title:Revista brasileira de reumatologia
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更新日期:2010-07-01 00:00:00
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更新日期:2011-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:2010-05-01 00:00:00
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更新日期:2013-04-01 00:00:00
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更新日期:2012-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-11-01 00:00:00
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更新日期:2010-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-09-01 00:00:00
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journal_title:Revista brasileira de reumatologia
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更新日期:2010-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-05-01 00:00:00
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更新日期:2015-05-28 00:00:00
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