[Multicentric Castleman disease not associated with HHV-8 and HIV viruses].

Abstract:

:Castleman's disease (CD) is a polyclonal lymphoproliferative disorder also known as giant nodular hyperplasia or angiofollicular lymph node hyperplasia. It is a rare disease often associated to human immunodeficiency virus (HIV) and human herpes virus 8 (HHV-8). Histopathological findings in Castleman's disease suggest an exaggerated response to antigenic stimuli seen in other diseases associated with immune activation, such as rheumatoid arthritis. An important aspect of its pathogenesis is the autonomous production of interleukin-6 (IL-6). In this disease, the clinical manifestations are associated to IL-6 serum levels, and surgical removal of the compromised lymph nodes or use of anti-IL-6 antibodies can slow down the symptoms. We describe a multicentric Castleman's disease in a young woman not associated to HHV-8 virus infection or immunosuppression. A short review of the literature follows the description of this clinical case.

journal_name

Rev Bras Reumatol

authors

Forteski Dde F,Netto FC,Lomonte AB,dos Anjos BC,Zerbini MC,Zerbini CA

doi

10.1016/j.rbr.2013.05.004

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

326-9

issue

4

eissn

0482-5004

issn

1809-4570

pii

S0482-5004(14)00127-2

journal_volume

54

pub_type

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