Abstract：
INTRODUCTION:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic joint inflammation that often leads to significant disability. Several effective anti-TNF agents have been used, but some patients have shown an inadequate response. Rituximab is a therapeutic monoclonal antibody indicated in such cases. METHODS:We conducted a systematic review to access efficacy and safety of rituximab in patients with active RA which have or have not been treated with anti-TNF agents before, and to relate outcome with RF and anti-CCP serology. We searched major electronics databases, grey literature and searched for references manually. We used Review Manager(r)5.1 for meta-analysis. RESULTS:We included six RCTs comparing rituximab 1000 mg with placebo. Methotrexate was used by both groups. Treatment with rituximab was more effective in naïve and in anti-TNF treatment failure patients - ACR20/50/70 and EULAR response. We observed lower changes in Total Genant-modified Sharp score, erosion score and joint narrowing scores in the rituximab group, and SF-36, FACIT-T and HAQ-DI scores were also better in this group. There were no differences between groups regarding safety outcomes, with exception of acute injection reactions, which were more common on rituximab group. More RF/anti-CCP seropositive patients achieved ACR20 than RF/anti-CP negative patients in rituximab group. CONCLUSION:Available data support the use of rituximab for the treatment of RA, as it is an effective and safe option for naïve and anti-TNF treatment failure patients. RF and anti-CCP seam to influence treatment results, but this inference needs further research.
journal_name
Rev Bras Reumatoljournal_title
Revista brasileira de reumatologiaauthors
de Lemos LL,Costa Jde O,Machado MA,Almeida AM,Barbosa MM,Kakehasi AM,de Araújo VE,Guerra Júnior AA,Acurcio Fde Asubject
Has Abstractpub_date
2014-05-01 00:00:00pages
220-30issue
3eissn
0482-5004issn
1809-4570pii
S2255-5021(14)00068-6journal_volume
54pub_type
杂志文章,评审abstract：OBJECTIVE:To translate and validate the Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST 2.0) into Brazilian Portuguese. METHODS:Certified translators translated and back-translated Quest. Content validity (CVI) was determined by 5 experts and, after the final version of B-Quest, a pre-test was ...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2014.04.003
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVES:To assess the association between hyperuricemia and different neuropsychiatric manifestations and stroke risk factors in systematic lupus erythematosus (SLE) patients. METHODS:This study was conducted on 204 SLE patients who were admitted to a tertiary referral center. A standardized questionnaire was compl...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2015.05.002
更新日期：2015-07-17 00:00:00
abstract：INTRODUCTION:Fibromyalgia (FM) is a chronic pain condition that causes impaired functional capacity, possibly through the adoption of sedentary behaviour. However, little is known regarding physical activity level and its relationship with physical performance in women with FM. OBJECTIVES:To compare physical activity ...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2013-05-01 00:00:00
abstract：:Anti-TNF-α agents have emerged as a potent treatment for patients with rheumatoid arthritis unresponsive to conventional disease-modifying antirheumatic drugs. Increased susceptibility to infections induced by these drugs is the main complication of their use. Reactivation of hepatitis B virus (HBV) is one of the most...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVE:To assess the quality of life, muscle strength and functional capacity in women with fibromyalgia (FM). PATIENTS AND METHODS:Cross-sectional study carried out with 31 female volunteers (age range, 35 to 60 years), paired in two groups (16 with FM, and 15 in the control group). Both groups underwent the follo...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2011-07-01 00:00:00
abstract：INTRODUCTION:Fibromyalgia is a rheumatic syndrome characterized by diffuse and chronic pain associated with fatigue, sleep disorders, anxiety, depression, memory loss, and dizziness. Although the physiological mechanisms that control fibromyalgia have not been precisely established, neuroendocrine, genetic or molecular...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2010-03-01 00:00:00
abstract：:Case report of a 38-year-old female patient with systemic lupus erythematosus (SLE) who presented an acute arterial thromboembolic event in the right lower limb. Investigation showed the presence of antiphospholipid antibodies and sterile vegetation in the mitral valve, Libman-Sacks endocarditis (LSE). Possible causes...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2010-11-01 00:00:00
abstract：INTRODUCTION:Osteoarthritis (OA) affects the articular cartilage and subchondral bone, compromising the joint as a whole. The knee joint is characterized as one of the main sites of involvement of OA and the most significant risk factors for developing the disease are aging, overweight and female gender. OA is consider...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2015.03.001
更新日期：2015-09-01 00:00:00
abstract：INTRODUCTION:Rheumatoid arthritis (RA) is a chronic systemic and progressive inflammatory disorder of the joints, which can result in deformity and functional disability. The diagnosis, treatment, and follow-up of patients with RA vary worldwide. The major societies of rheumatology, as well as governmental agencies in ...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2011-05-01 00:00:00
abstract：:Camptocormia is a postural affliction characterised by abnormal flexion of the thoracolumbar spine, which appears upon standing, increases with walking, and disappears in the supine position. Only five cases of camptocormia secondary to idiopathic inflammatory myopathies have been described in the literature. In this ...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1590/s0482-50042013000400010
更新日期：2013-08-01 00:00:00
abstract：:Castleman's disease (CD) is a polyclonal lymphoproliferative disorder also known as giant nodular hyperplasia or angiofollicular lymph node hyperplasia. It is a rare disease often associated to human immunodeficiency virus (HIV) and human herpes virus 8 (HHV-8). Histopathological findings in Castleman's disease sugges...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2013.05.004
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVE:To evaluate the serum levels of leptin and adiponectin in patients with systemic lupus erythematosus (SLE) and correlate their levels with disease activity, presence of autoantibodies and clinical manifestations. METHODS:52 women with SLE and 33 healthy women were evaluated. The patients were divided into tw...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2014.08.014
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVE:Some studies have reported that adding leflunomide (LEF) to the treatment of rheumatoid arthritis (RA) in patients who do not respond to methotrexate (MTX) improved efficacy but increased the risk of liver toxicity. This study aimed at assessing the incidence of liver toxicity in patients with active RA using...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2011-03-01 00:00:00
abstract：OBJECTIVE:We aimed to determine the value of ultrasonography (US) in the diagnosis of carpal tunnel syndrome (CTS). METHODS:Two hundred patients (400 hands) were submitted to wrist US to measure median nerve area (MNA), questioning on paresthesia and pain in the median nerve territory, Tinel and Phalen maneuvers. An M...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2014.12.002
更新日期：2015-07-01 00:00:00
abstract：UNLABELLED:While reaffirming that the clinical exam still is the best medical practice, the author has proposed a new maneuver (Cecin's sign or "X" sign) to help the diagnosis of herniated lumbar disk, describing its biomechanical bases. However, the diagnostic performance of this maneuver has not been formally tested....
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:Idiopathic inflammatory myopathies (IIM), which include dermatomyositis (DM) and polymyositis (PM), are chronic systemic diseases associated with high morbidity and functional disability. Current treatment is based on the use of glucocorticoids and immunosuppressive drugs, but a considerable number of patients is refr...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章,评审
doi：10.1016/s2255-5021(13)70010-5
更新日期：2013-02-01 00:00:00
abstract：OBJECTIVE:To assess retrospectively the ocular changes in children and adolescents with juvenile systemic lupus erythematosus (JSLE) in a tertiary pediatric rheumatology service. METHODS:This study assessed 117 JSLE patients (85.5% female, 60.7% non-Caucasian), who met at least four criteria of the 1997 SLE classifica...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
abstract：:Spondyloarthritis patients can be more frequently affected by IgA nephropathy than the general population, and a common etiopathogenic mechanism can be involved. We report four cases that may exemplify that association. ...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVE:To report the results of a retrospective cohort involving 139 patients with dermatomyositis, conducted from 1991 to 2011. METHODS:All patients met at least four of the five Bohan and Peter criteria (1975). RESULTS:The patients' mean age at disease onset was 41.7 ± 14.1 years, and mean disease duration was 7...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-12-01 00:00:00
abstract：:Idiopathic chondrolysis of the hip is a rare condition of unknown etiology characterized by progressive destruction of the hyaline cartilage that covers the femoral head and acetabulum. Idiopathic chondrolysis of the hip has an insidious beginning and affects more often female adolescents. Patients report severe hip p...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2013-04-01 00:00:00
abstract：:The aim of this study was to determine the prevalence of osteopenia and osteoporosis in a female population, that had bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) in a specialized clinic in the south of Brazil. We conducted a cross-sectional study including 1,871 women that performed s...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2014.08.012
更新日期：2015-05-01 00:00:00
abstract：:Ankylosing spondylitis (AS) is a chronic rheumatic disease of young men that affects mainly the axial skeleton and is associated with HLA-B27 in 90% of the cases. Incidence of cardiovascular involvement in AS ranges between 10%-30%; conduction disturbances have been described in 1%-9% of the patients with AS. The majo...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-10-01 00:00:00
abstract：:Systemic lupus erythematosus juvenile (SLEJ) is a multi-systemic, chronic inflammatory disease, and with autoimmune features. Some clinical manifestations of this disease are similar to those found in Acquired Immunodeficiency Syndrome (AIDS). Coexistence of AIDS with SLEJ is rare, especially in the pediatric populati...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
abstract：:Systemic Sclerosis (SSc) is an autoimmune disease of multifactorial etiology, triggered by a combination of genetic and environmental factors. Its varied clinical expression results from the complex physiopathogenic interaction of three main elements: proliferative vasculopathy, immune dysregulation and abnormal depos...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章,评审
doi：10.1016/j.rbr.2013.01.001
更新日期：2013-11-01 00:00:00
abstract：:Psoriatic arthritis (PA) is an inflammatory seronegative arthritis of unknown origin. Classically, PA has five clinical forms, and asymmetric oligoarthritis is the most common type. We describe the case of a patient with PA refractory to disease-modifying drugs, who developed drug-induced hepatitis after chemoprophyla...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
abstract：:Machrophage activation syndrome (MAS) is a rare and potentially fatal disease, commonly associated with chronic rheumatic diseases, mainly juvenile idiopathic arthritis. It is included in the group of secondary forms of haemophagocytic syndrome, and other causes are lymphoproliferative diseases and infections. Its mos...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2014.02.007
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVE:To analyze the frequency of psychiatric comorbidities in patients with systemic lupus erythematosus (SLE) using the systematic review method. METHODS:A systematic literature search was performed between April and July 2011 in the following databases: BIREME, PubMed and CAPES thesis database. This search prio...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章,评审
doi：
更新日期：2013-09-01 00:00:00
abstract：:This is a case report of juvenile idiopathic arthritis (JIA) in two pairs of brothers followed in the department of pediatric rheumatology, Universidade Federal da Bahia. Genetic involvement in JIA pathogenesis is clear and the risk of recurrence among siblings supports this contribution. An important landmark of this...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2013.05.006
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVE:To study the association of anti-nucleosome (anti-NCS) antibodies in primary antiphospholipid syndrome (APS) and the development of systemic lupus erythematosus (SLE) during follow-up. MATERIALS AND METHODS:Thirty-six women with primary APS were evaluated prospectively for clinical features of systemic autoi...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-05-01 00:00:00
abstract：PURPOSE:The aim of the present study was to investigate the HLA phenotype in Dupuytren's contracture (DC) patients in order to verify the correlation of these alleles with risk factors for development of DC in the Brazilian population. METHODS:This was a case-controlled study of 25 DC patients and 443 healthy individu...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
