Abstract：
UNLABELLED:While reaffirming that the clinical exam still is the best medical practice, the author has proposed a new maneuver (Cecin's sign or "X" sign) to help the diagnosis of herniated lumbar disk, describing its biomechanical bases. However, the diagnostic performance of this maneuver has not been formally tested. PATIENTS AND METHODS:The maneuver, which consists on the flexion of the lumbar spine while simultaneously performing the Valsalva maneuver, was tested in 45 patients with typical sciatic pain and herniated lumbar disk confirmed by magnetic resonance imaging (MRI), and in 21 patients with simple mechanical back pain with normal MRI. Lasègue's sign was investigated concomitantly and the concordance with the "X" sign was assessed. RESULTS:Concordance between the two tests was very low (Kappa = 0.17, Kappa <0.4) and discordance was statically significant (P <0.001). The "X" sign had a sensitivity of 73.3%, specificity of 95.2%, positive predictive level of 97.1%, and negative predictive level of 62.5% in the diagnosis of herniated lumbar disk by MRI, while Lasègue's sign showed sensitivity of 22.2%, specificity of 95.2% (P <0.001), positive predictive value of 90.9%, and negative predictive value of 36.4% (P = 0.153). CONCLUSION:Cecin's sign had higher sensitivity, positive predictive value, and negative predictive value than Lasègue's sign in the diagnosis of symptomatic herniated lumbar disk.
journal_name
Rev Bras Reumatoljournal_title
Revista brasileira de reumatologiaauthors
Cecin HAsubject
Has Abstractpub_date
2010-01-01 00:00:00pages
44-55issue
1eissn
0482-5004issn
1809-4570pii
S0482-50042010000100005journal_volume
50pub_type
杂志文章abstract：INTRODUCTION:TCF7L2 is a transcription factor involved in Wnt/beta-catenin signaling and which has a variant known to be consistently associated with type 2 diabetes risk and some studies have also indicated its association with risk of certain types of cancer. OBJECTIVE:Since this pathway may be involved in the patho...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVE:To analyze the frequency of psychiatric comorbidities in patients with systemic lupus erythematosus (SLE) using the systematic review method. METHODS:A systematic literature search was performed between April and July 2011 in the following databases: BIREME, PubMed and CAPES thesis database. This search prio...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章,评审
doi：
更新日期：2013-09-01 00:00:00
abstract：PURPOSE:The aim of the present study was to investigate the HLA phenotype in Dupuytren's contracture (DC) patients in order to verify the correlation of these alleles with risk factors for development of DC in the Brazilian population. METHODS:This was a case-controlled study of 25 DC patients and 443 healthy individu...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:Osteoporosis is considered a common metabolic bone disease and its prevalence is increasing worldwide. In this context, physical activity has been used as a non-pharmacological tool for prevention and auxiliary treatment of this disease. The aim of this systematic review was to evaluate the effects of cycling and swim...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2015.09.010
更新日期：2016-02-17 00:00:00
abstract：INTRODUCTION:Osteoarthritis (OA) affects the articular cartilage and subchondral bone, compromising the joint as a whole. The knee joint is characterized as one of the main sites of involvement of OA and the most significant risk factors for developing the disease are aging, overweight and female gender. OA is consider...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2015.03.001
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVE:To translate and validate the Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST 2.0) into Brazilian Portuguese. METHODS:Certified translators translated and back-translated Quest. Content validity (CVI) was determined by 5 experts and, after the final version of B-Quest, a pre-test was ...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2014.04.003
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVES:To assess the association between hyperuricemia and different neuropsychiatric manifestations and stroke risk factors in systematic lupus erythematosus (SLE) patients. METHODS:This study was conducted on 204 SLE patients who were admitted to a tertiary referral center. A standardized questionnaire was compl...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2015.05.002
更新日期：2015-07-17 00:00:00
abstract：OBJECTIVE:To evaluate the serum levels of leptin and adiponectin in patients with systemic lupus erythematosus (SLE) and correlate their levels with disease activity, presence of autoantibodies and clinical manifestations. METHODS:52 women with SLE and 33 healthy women were evaluated. The patients were divided into tw...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2014.08.014
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVE:To investigate the feasibility of bone turnover markers (BTMs) for the assessment of bone metabolism in patients with systemic lupus erythematosus (SLE), according to the guidelines of the International Osteoporosis Foundation and the International Federation of Clinical Chemistry and Laboratory Medicine. ME...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2014.10.004
更新日期：2015-03-01 00:00:00
abstract：INTRODUCTION:Fibromyalgia (FM) is a chronic pain condition that causes impaired functional capacity, possibly through the adoption of sedentary behaviour. However, little is known regarding physical activity level and its relationship with physical performance in women with FM. OBJECTIVES:To compare physical activity ...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2013-05-01 00:00:00
abstract：OBJECTIVE:To assess retrospectively the ocular changes in children and adolescents with juvenile systemic lupus erythematosus (JSLE) in a tertiary pediatric rheumatology service. METHODS:This study assessed 117 JSLE patients (85.5% female, 60.7% non-Caucasian), who met at least four criteria of the 1997 SLE classifica...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
abstract：:Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, and its excess can lead to severe consequences. Those effects are known to be antagonized by TNF-alpha inhibitors. Etanercept is a fusion protein that inhibits TNF-alpha action. As TNF-alpha regulation is related to cellular differentiation of vari...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章,评审
doi：
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Lactic acid is a byproduct of both muscle metabolism and the central nervous system. Changes in metabolism are related to various physiological and pathological conditions. The aim of this study was to determine the relationship between migraine and fibromyalgia with the levels of lactic acid in the blood. ...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2015.02.002
更新日期：2015-11-01 00:00:00
abstract：INTRODUCTION:Premature development of atherosclerosis in systemic lupus erythematosus has been widely reported. Anti-lipoprotein lipase antibody may be one cause contributing to this disorder. OBJECTIVE:To assess the extent of coronary risk due to autoimmune antibodies in terms of carotid plaque in lupus patients. PA...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1590/s0482-50042010000500007
更新日期：2010-09-01 00:00:00
abstract：:Rats are currently the most used laboratory animals to investigate osteoporosis. We report an efficient method of ovariectomy and compared this method with the two other operative methods of ovariectomy (i.e., midline dorsal skin incision and double dorsolateral approach, which are used commonly for inducing experimen...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-05-01 00:00:00
abstract：:Anti-TNF-α agents have emerged as a potent treatment for patients with rheumatoid arthritis unresponsive to conventional disease-modifying antirheumatic drugs. Increased susceptibility to infections induced by these drugs is the main complication of their use. Reactivation of hepatitis B virus (HBV) is one of the most...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVES:To determine the frequency of antibodies to chromatin components in juvenile systemic lupus erythematosus (JSLE), and to correlate the presence of these autoantibodies with clinical manifestations and disease activity. METHODS:Anti-chromatin (anti-CHR), anti-nucleosome core particle (anti-NCS) and anti-dsDN...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:Some studies have reported that adding leflunomide (LEF) to the treatment of rheumatoid arthritis (RA) in patients who do not respond to methotrexate (MTX) improved efficacy but increased the risk of liver toxicity. This study aimed at assessing the incidence of liver toxicity in patients with active RA using...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2011-03-01 00:00:00
abstract：:Case report of a 38-year-old female patient with systemic lupus erythematosus (SLE) who presented an acute arterial thromboembolic event in the right lower limb. Investigation showed the presence of antiphospholipid antibodies and sterile vegetation in the mitral valve, Libman-Sacks endocarditis (LSE). Possible causes...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2010-11-01 00:00:00
abstract：:Idiopathic inflammatory myopathies (IIM), which include dermatomyositis (DM) and polymyositis (PM), are chronic systemic diseases associated with high morbidity and functional disability. Current treatment is based on the use of glucocorticoids and immunosuppressive drugs, but a considerable number of patients is refr...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章,评审
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journal_title：Revista brasileira de reumatologia
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doi：10.1016/j.rbr.2015.11.004
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journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2014.12.002
更新日期：2015-07-01 00:00:00
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journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章,评审
doi：10.1016/j.rbr.2013.01.001
更新日期：2013-11-01 00:00:00
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journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-05-01 00:00:00
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journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章,评审
doi：
更新日期：2011-09-01 00:00:00
abstract：INTRODUCTION:Fibromyalgia is a rheumatic syndrome characterized by diffuse and chronic pain associated with fatigue, sleep disorders, anxiety, depression, memory loss, and dizziness. Although the physiological mechanisms that control fibromyalgia have not been precisely established, neuroendocrine, genetic or molecular...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2010-03-01 00:00:00
abstract：INTRODUCTION:The Brazilian Unified Health Care System (SUS) offers treatment for patients with RA through federal funding (Ministry of Health) and state co-financing. The Clinical Protocol and Therapeutic Guidelines for the treatment of rheumatoid arthritis describe the therapeutic regimen for the disease, including th...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-03-01 00:00:00
abstract：:Idiopathic chondrolysis of the hip is a rare condition of unknown etiology characterized by progressive destruction of the hyaline cartilage that covers the femoral head and acetabulum. Idiopathic chondrolysis of the hip has an insidious beginning and affects more often female adolescents. Patients report severe hip p...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2013-04-01 00:00:00
abstract：:Systemic lupus erythematosus juvenile (SLEJ) is a multi-systemic, chronic inflammatory disease, and with autoimmune features. Some clinical manifestations of this disease are similar to those found in Acquired Immunodeficiency Syndrome (AIDS). Coexistence of AIDS with SLEJ is rare, especially in the pediatric populati...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
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journal_title：Revista brasileira de reumatologia
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doi：10.1016/j.rbr.2014.08.012
更新日期：2015-05-01 00:00:00
