Abstract：
:Rats are currently the most used laboratory animals to investigate osteoporosis. We report an efficient method of ovariectomy and compared this method with the two other operative methods of ovariectomy (i.e., midline dorsal skin incision and double dorsolateral approach, which are used commonly for inducing experimental osteoporosis. Female Wistar rats, 12 weeks old, were divided into three groups. Ovariectomy was preceded by a single midline dorsal skin incision, 3 cm long, in the group A; double dorsolateral incisions, approximately 1 cm long, in the group B; and a single ventral transverse incision of 0.4-0.6 cm at the middle abdominal region in the group C. Animals in groups A, B, and C had a mean weight of 258.12 ± 0.54 g, 255.78 ± 0.42 g, and 254.55 ± 1.69 g, respectively. There were significant differences in the duration (in minutes) of surgery in the groups B (9.65 ± 0.86) and C (7.55 ± 0.11, P < 0.001) when compared to the group A (15.52 ± 0.30) and in the group B (P < 0.01) when compared to the group C. Wound healing time (in days) for groups B (9.22 ± 0.67) and C (8.01 ± 0.93) was significantly shorter than that for group A (11.58 ± 1.2, P < 0.001), with the wound healing time for group C being slightly shorter than that for group B. The surgery, as conducted in the group C, was technically easier, less time consuming and showed less wound healing duration.
journal_name
Rev Bras Reumatoljournal_title
Revista brasileira de reumatologiaauthors
Khajuria DK,Razdan R,Mahapatra DRsubject
Has Abstractpub_date
2012-05-01 00:00:00pages
462-70issue
3eissn
0482-5004issn
1809-4570pii
S0482-50042012000300016journal_volume
52pub_type
杂志文章abstract：BACKGROUND:Lactic acid is a byproduct of both muscle metabolism and the central nervous system. Changes in metabolism are related to various physiological and pathological conditions. The aim of this study was to determine the relationship between migraine and fibromyalgia with the levels of lactic acid in the blood. ...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2015.02.002
更新日期：2015-11-01 00:00:00
abstract：INTRODUCTION:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic joint inflammation that often leads to significant disability. Several effective anti-TNF agents have been used, but some patients have shown an inadequate response. Rituximab is a therapeutic monoclonal antibody indicated ...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章,评审
doi：
更新日期：2014-05-01 00:00:00
abstract：OBJECTIVES:To determine the frequency of antibodies to chromatin components in juvenile systemic lupus erythematosus (JSLE), and to correlate the presence of these autoantibodies with clinical manifestations and disease activity. METHODS:Anti-chromatin (anti-CHR), anti-nucleosome core particle (anti-NCS) and anti-dsDN...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-10-01 00:00:00
abstract：INTRODUCTION:The Brazilian Unified Health Care System (SUS) offers treatment for patients with RA through federal funding (Ministry of Health) and state co-financing. The Clinical Protocol and Therapeutic Guidelines for the treatment of rheumatoid arthritis describe the therapeutic regimen for the disease, including th...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-03-01 00:00:00
abstract：INTRODUCTION:Osteoarthritis (OA) affects the articular cartilage and subchondral bone, compromising the joint as a whole. The knee joint is characterized as one of the main sites of involvement of OA and the most significant risk factors for developing the disease are aging, overweight and female gender. OA is consider...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2015.03.001
更新日期：2015-09-01 00:00:00
abstract：:Castleman's disease (CD) is a polyclonal lymphoproliferative disorder also known as giant nodular hyperplasia or angiofollicular lymph node hyperplasia. It is a rare disease often associated to human immunodeficiency virus (HIV) and human herpes virus 8 (HHV-8). Histopathological findings in Castleman's disease sugges...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2013.05.004
更新日期：2014-07-01 00:00:00
abstract：:Case report of a 38-year-old female patient with systemic lupus erythematosus (SLE) who presented an acute arterial thromboembolic event in the right lower limb. Investigation showed the presence of antiphospholipid antibodies and sterile vegetation in the mitral valve, Libman-Sacks endocarditis (LSE). Possible causes...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2010-11-01 00:00:00
abstract：INTRODUCTION:Very few studies carried out with Latin American populations on the demographic and clinical characteristics of patients diagnosed with early rheumatoid arthritis (RA) can be found in the literature. OBJECTIVE:To characterize a population of patients with early RA, prospectively followed, concerning demog...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVE:To assess the quality of life, muscle strength and functional capacity in women with fibromyalgia (FM). PATIENTS AND METHODS:Cross-sectional study carried out with 31 female volunteers (age range, 35 to 60 years), paired in two groups (16 with FM, and 15 in the control group). Both groups underwent the follo...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2011-07-01 00:00:00
abstract：:Machrophage activation syndrome (MAS) is a rare and potentially fatal disease, commonly associated with chronic rheumatic diseases, mainly juvenile idiopathic arthritis. It is included in the group of secondary forms of haemophagocytic syndrome, and other causes are lymphoproliferative diseases and infections. Its mos...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2014.02.007
更新日期：2015-01-01 00:00:00
abstract：INTRODUCTION:Fibromyalgia is a rheumatic syndrome characterized by diffuse and chronic pain associated with fatigue, sleep disorders, anxiety, depression, memory loss, and dizziness. Although the physiological mechanisms that control fibromyalgia have not been precisely established, neuroendocrine, genetic or molecular...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2010-03-01 00:00:00
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journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2014.08.014
更新日期：2015-03-01 00:00:00
abstract：:Psoriatic arthritis (PA) is an inflammatory seronegative arthritis of unknown origin. Classically, PA has five clinical forms, and asymmetric oligoarthritis is the most common type. We describe the case of a patient with PA refractory to disease-modifying drugs, who developed drug-induced hepatitis after chemoprophyla...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
abstract：:Ankylosing spondylitis (AS) is a chronic rheumatic disease of young men that affects mainly the axial skeleton and is associated with HLA-B27 in 90% of the cases. Incidence of cardiovascular involvement in AS ranges between 10%-30%; conduction disturbances have been described in 1%-9% of the patients with AS. The majo...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-10-01 00:00:00
abstract：UNLABELLED:While reaffirming that the clinical exam still is the best medical practice, the author has proposed a new maneuver (Cecin's sign or "X" sign) to help the diagnosis of herniated lumbar disk, describing its biomechanical bases. However, the diagnostic performance of this maneuver has not been formally tested....
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVE:To analyze the frequency of psychiatric comorbidities in patients with systemic lupus erythematosus (SLE) using the systematic review method. METHODS:A systematic literature search was performed between April and July 2011 in the following databases: BIREME, PubMed and CAPES thesis database. This search prio...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章,评审
doi：
更新日期：2013-09-01 00:00:00
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journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1590/s0482-50042010000500007
更新日期：2010-09-01 00:00:00
abstract：:The aim of this study was to determine the prevalence of osteopenia and osteoporosis in a female population, that had bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) in a specialized clinic in the south of Brazil. We conducted a cross-sectional study including 1,871 women that performed s...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2014.08.012
更新日期：2015-05-01 00:00:00
abstract：:Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, and its excess can lead to severe consequences. Those effects are known to be antagonized by TNF-alpha inhibitors. Etanercept is a fusion protein that inhibits TNF-alpha action. As TNF-alpha regulation is related to cellular differentiation of vari...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章,评审
doi：
更新日期：2012-01-01 00:00:00
abstract：:Systemic lupus erythematosus juvenile (SLEJ) is a multi-systemic, chronic inflammatory disease, and with autoimmune features. Some clinical manifestations of this disease are similar to those found in Acquired Immunodeficiency Syndrome (AIDS). Coexistence of AIDS with SLEJ is rare, especially in the pediatric populati...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
abstract：PURPOSE:The aim of the present study was to investigate the HLA phenotype in Dupuytren's contracture (DC) patients in order to verify the correlation of these alleles with risk factors for development of DC in the Brazilian population. METHODS:This was a case-controlled study of 25 DC patients and 443 healthy individu...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:To study the association of anti-nucleosome (anti-NCS) antibodies in primary antiphospholipid syndrome (APS) and the development of systemic lupus erythematosus (SLE) during follow-up. MATERIALS AND METHODS:Thirty-six women with primary APS were evaluated prospectively for clinical features of systemic autoi...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-05-01 00:00:00
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journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章,评审
doi：10.1016/j.rbr.2013.01.001
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVES:To assess the association between hyperuricemia and different neuropsychiatric manifestations and stroke risk factors in systematic lupus erythematosus (SLE) patients. METHODS:This study was conducted on 204 SLE patients who were admitted to a tertiary referral center. A standardized questionnaire was compl...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2015.05.002
更新日期：2015-07-17 00:00:00
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journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章,评审
doi：10.1016/s2255-5021(13)70010-5
更新日期：2013-02-01 00:00:00
abstract：INTRODUCTION:Rheumatoid arthritis (RA) is a chronic systemic and progressive inflammatory disorder of the joints, which can result in deformity and functional disability. The diagnosis, treatment, and follow-up of patients with RA vary worldwide. The major societies of rheumatology, as well as governmental agencies in ...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2011-05-01 00:00:00
abstract：OBJECTIVE:Some studies have reported that adding leflunomide (LEF) to the treatment of rheumatoid arthritis (RA) in patients who do not respond to methotrexate (MTX) improved efficacy but increased the risk of liver toxicity. This study aimed at assessing the incidence of liver toxicity in patients with active RA using...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2011-03-01 00:00:00
abstract：OBJECTIVE:To report the results of a retrospective cohort involving 139 patients with dermatomyositis, conducted from 1991 to 2011. METHODS:All patients met at least four of the five Bohan and Peter criteria (1975). RESULTS:The patients' mean age at disease onset was 41.7 ± 14.1 years, and mean disease duration was 7...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVE:We aimed to determine the value of ultrasonography (US) in the diagnosis of carpal tunnel syndrome (CTS). METHODS:Two hundred patients (400 hands) were submitted to wrist US to measure median nerve area (MNA), questioning on paresthesia and pain in the median nerve territory, Tinel and Phalen maneuvers. An M...
journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2014.12.002
更新日期：2015-07-01 00:00:00
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journal_title：Revista brasileira de reumatologia
pub_type： 杂志文章
doi：10.1016/j.rbr.2015.11.004
更新日期：2016-03-08 00:00:00
