Hedgehog signaling pathway as a new therapeutic target in pancreatic cancer.

abstract：:We report the case of a 57-year-old man who was diagnosed with a large unresectable cholangiocarcinoma associated with 2 satellite nodules and without clear margins with the right hepatic vein. Despite 4 cycles of GEMOX (stopped due to a hypertransaminasemia believed to be due to gemcitabine) and 4 cycles of FOLFIRINO...

journal_title：World journal of gastroenterology

authors： Servajean C,Gilabert M,Piana G,Monges G,Delpero JR,Brenot I,Raoul JL

更新日期：2014-05-07 00:00:00

abstract：:A 83-year-old woman was admitted to our hospital because of intermittent abdominal colicky pain and vomiting for 26 h. The pain localized over the periumbilical area with radiation along the medial side of the thigh. Computed tomography scan with three-dimensional reconstruction revealed a loop of small bowel protrudi...

journal_title：World journal of gastroenterology

authors： Zhang H,Cong JC,Chen CS

更新日期：2010-01-07 00:00:00

abstract：AIM:To study the pattern of cancer incidence and determine the incidence rates in Eastern Libya (for the first time in a decade). METHODS:A hospital-based registry of cancer patients was formed using records from the primary oncology center in eastern Libya - focusing on those diagnosed in the year 2012. RESULTS:The ...

journal_title：World journal of gastroenterology

authors： Bodalal Z,Azzuz R,Bendardaf R

更新日期：2014-05-28 00:00:00

abstract：AIM:To investigate whether the apoptotic activities of 8-bromo-7-methoxychrysin (BrMC) involve reactive oxygen species (ROS) generation and c-Jun N-terminal kinase (JNK) activation in human hepatocellular carcinoma cells (HCC). METHODS:HepG2, Bel-7402 and L-02 cell lines were cultured in vitro and the apoptotic effect...

journal_title：World journal of gastroenterology

authors： Yang XH,Zheng X,Cao JG,Xiang HL,Liu F,Lv Y

更新日期：2010-07-21 00:00:00

abstract：AIM:To characterize AXL receptor tyrosine kinase (AXL) expression in relationship to tumor protein P53 (TP53 gene, p53 protein) and its role in tumor invasion and response to therapy. METHODS:We used 14 cell lines, including 3 isogenic pairs carrying mutant/knockout p53, to gain insight into the relationship between A...

journal_title：World journal of gastroenterology

authors： Abdel-Rahman WM,Al-Khayyal NA,Nair VA,Aravind SR,Saber-Ayad M

更新日期：2017-05-21 00:00:00

abstract：:Hepatitis B virus (HBV) and hepatitis C virus (HCV) share common mode of transmission and both are able to induce a chronic infection. Dual HBV/HCV chronic coinfection is a fairly frequent occurrence, especially in high endemic areas and among individuals at high risk of parenterally transmitted infections. The intrac...

journal_title：World journal of gastroenterology

authors： Caccamo G,Saffioti F,Raimondo G

更新日期：2014-10-28 00:00:00

abstract：AIM:To confirm if p53 mutation could be a routine predictive marker for the prognosis of hepatocellular carcinoma (HCC) patients. METHODS:Two hundreds and forty-four formalin-fixed paraffin-embedded tumor samples of the patients with HCC receiving liver resection were detected for nuclear accumulation of p53. The perc...

journal_title：World journal of gastroenterology

authors： Qin LX,Tang ZY,Ma ZC,Wu ZQ,Zhou XD,Ye QH,Ji Y,Huang LW,Jia HL,Sun HC,Wang L

更新日期：2002-06-01 00:00:00

abstract：AIM:To investigate the hotspots, direction, and the time course of evolution of hepatitis A virus in the process of consecutive cell culture passage in human KMB17 diploid cells. METHODS:Wild type hepatitis A virus H2w was serially propagated in KMB17 cells until passage 30, and the full-length genomes of H2w and its ...

journal_title：World journal of gastroenterology

authors： Tang CH,Mao JS,Chai SA,Chen Y,Zhuang FC

更新日期：2007-09-14 00:00:00

abstract：AIM:To assess the outcome of patients, who underwent transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) and subsequently liver transplantation (OLT) irrespective of tumor size when no tumor progression was observed. METHODS:Records, imaging studies and pathology of 84 patients with HCC were revi...

journal_title：World journal of gastroenterology

authors： Obed A,Beham A,Püllmann K,Becker H,Schlitt HJ,Lorf T

更新日期：2007-02-07 00:00:00

abstract：:The scientific framework concerning estrogen effects on different tissues has expanded enormously during the last decades, when estrogen receptor (ER) subtypes were identified. Estrogens are not only essential for the female reproductive system, but they also control fundamental functions in other tissues including th...

journal_title：World journal of gastroenterology

authors： Alvaro D,Mancino MG,Onori P,Franchitto A,Alpini G,Francis H,Glaser S,Gaudio E

更新日期：2006-06-14 00:00:00

abstract：AIM:To investigate the clinical efficacy and toxic effects of neoadjuvant chemotherapy using docetaxel combined with oxaliplatin and fluorouracil for treating stage III/IV gastric cancer. METHODS:A total of 53 stage III/IV gastric cancer patients were enrolled into the study and treated with neoadjuvant chemotherapy. ...

journal_title：World journal of gastroenterology

authors： Yu YJ,Sun WJ,Lu MD,Wang FH,Qi DS,Zhang Y,Li PH,Huang H,You T,Zheng ZQ

更新日期：2014-12-28 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the fourth cause of cancer related mortality, and its incidence is rapidly increasing. Viral hepatitis, alcohol abuse, and exposure to hepatotoxins are major risk factors, but nonalcoholic fatty liver disease (NAFLD) associated with obesity, insulin resistance, and type 2 diabetes, is...

journal_title：World journal of gastroenterology

authors： Dongiovanni P,Romeo S,Valenti L

更新日期：2014-09-28 00:00:00

abstract：:Treatment of chronic pancreatitis has been exclusively surgical for a long time. Recently, endoscopic therapy has become widely used as a primary therapeutic option. Initially performed for drainage of pancreatic cysts and pseudocysts, endoscopic treatments were adapted to biliary and pancreatic ducts stenosis. Pancre...

journal_title：World journal of gastroenterology

authors： Heyries L,Sahel J

更新日期：2007-12-14 00:00:00

abstract：AIM:To examine the epidemiology of hepatitis B virus carrier status (HBVC) and sonographic fatty liver (SFL) in Taiwanese adults, and to evaluate their possible interaction in inducing liver damage (LD). >From an epidemiological viewpoint, we analyzed previous studies which indicated that fatty liver sensitizes host im...

journal_title：World journal of gastroenterology

authors： Lin YC,Hsiao ST,Chen JD

更新日期：2007-03-28 00:00:00

abstract：AIM:To investigate the prognostic value of the expression of connexin (Cx) 26, 32 and 43 messenger RNA (mRNA) in hepatocellular carcinoma (HCC) tissues. METHODS:Using a reverse-transcriptase polymerase chain reaction (RT-PCR), Cx 26, Cx 32 and Cx 43 mRNAs were determined in the liver tissues of 15 controls and in HCC ...

journal_title：World journal of gastroenterology

authors： Sheen IS,Jeng KS,Wang PC,Shih SC,Chang WH,Wang HY,Chen CC,Shyung LR

更新日期：2004-10-01 00:00:00

abstract：:Pancreatic fluid collections (PFCs) are seen in up to 50% of cases of acute pancreatitis. The Revised Atlanta classification categorized these collections on the basis of duration of disease and contents, whether liquid alone or a mixture of fluid and necrotic debris. Management of these different types of collections...

journal_title：World journal of gastroenterology

authors： Dhaka N,Samanta J,Kochhar S,Kalra N,Appasani S,Manrai M,Kochhar R

更新日期：2015-12-28 00:00:00

abstract：:Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (OGCs) is very rare, less than 1% of all pancreatic malignancies, and shows worse prognosis than that of invasive ductal adenocarcinoma of the pancreas. We present a case of en bloc resection for a huge undifferentiated carcinoma with OGCs tha...

journal_title：World journal of gastroenterology

authors： Jo S

更新日期：2014-03-14 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease that might affect up to one-third of the adult population in industrialised countries. NAFLD incorporates histologically and clinically different non-alcoholic entities; fatty liver (NAFL, steatosis hepatis) and steatohepatitis (NASH-characterised by...

journal_title：World journal of gastroenterology

authors： Firneisz G

更新日期：2014-07-21 00:00:00

abstract：AIM:To describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous therapy. METHODS:A retrospective study of records of 63 PLA patients presenting between 1998 and 2008 to Australian tertiary referral centre, were rev...

journal_title：World journal of gastroenterology

authors： Pang TC,Fung T,Samra J,Hugh TJ,Smith RC

更新日期：2011-03-28 00:00:00

abstract：:Hepatitis C virus (HCV) infection disrupts the normal metabolism processes, but is also influenced by several of the host's metabolic factors. An obvious and significantly detrimental pathophysiological feature of HCV infection is insulin resistance in hepatic and peripheral tissues. Substantial research efforts have ...

journal_title：World journal of gastroenterology

authors： Kawaguchi Y,Mizuta T

更新日期：2014-03-21 00:00:00

abstract：:Alcohol-related cirrhosis is a consequence of heavy and prolonged drinking. Similarly to patients with cirrhosis of other etiologies, patients with alcoholic cirrhosis develop portal hypertension and the hepatic, splanchnic and systemic hemodynamic alterations that follow. However, in alcoholic cirrhosis, some specifi...

journal_title：World journal of gastroenterology

authors： Bolognesi M,Verardo A,Di Pascoli M

更新日期：2014-07-07 00:00:00

abstract：AIM:To investigate the effects of guggulsterone on the proliferation and apoptosis of human hepatoma HepG2 cells in vitro and relevant mechanisms. METHODS:Human hepatocellular carcinoma HepG2 cells and normal human liver L-02 cells were treated with different concentrations of guggulsterone (5-100 μmol/L) for 24-72 h....

journal_title：World journal of gastroenterology

authors： Shi JJ,Jia XL,Li M,Yang N,Li YP,Zhang X,Gao N,Dang SS

更新日期：2015-12-21 00:00:00

abstract：AIM:To investigate the long-term outcomes of endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS) with a fully covered self-expandable metallic stent (FCSEMS). METHODS:From April 2009 to August 2010, 15 patients with distal malignant biliary obstructions who were candidates for alternative techniques for bili...

journal_title：World journal of gastroenterology

authors： Song TJ,Hyun YS,Lee SS,Park DH,Seo DW,Lee SK,Kim MH

更新日期：2012-08-28 00:00:00

abstract：:A 46-year-old female patient with terminal ileum Crohn's disease and ankylosing spondylitis presented with recurrent angioedema and urticaria. Investigations ruled out hereditary angioedema, and environmental or food allergen triggers. She was diagnosed with chronic idiopathic urticaria with angioedema, and was treate...

journal_title：World journal of gastroenterology

authors： Habal F,Huang V

更新日期：2012-09-14 00:00:00

abstract：:Since the development of uncovered self-expanding metal stents (SEMS) in the 1990s, endoscopic stents have evolved dramatically. Application of new materials and new designs has expanded the indications for enteral SEMS. At present, enteral stents are considered the first-line modality for palliative care, and numerou...

journal_title：World journal of gastroenterology

authors： Kim EJ,Kim YJ

更新日期：2016-01-14 00:00:00

abstract：AIM:To evaluate the factors involved in the impairment of health-related quality of life (HRQOL) in patients with celiac disease. METHODS:A multicenter, cross-sectional prospective study was performed in patients with celiac disease who completed two HRQOL questionnaires: the gastrointestinal quality of life index (GI...

journal_title：World journal of gastroenterology

authors： Casellas F,Rodrigo L,Vivancos JL,Riestra S,Pantiga C,Baudet JS,Junquera F,Diví VP,Abadia C,Papo M,Gelabert J,Malagelada JR

更新日期：2008-01-07 00:00:00

abstract：AIM:To evaluate the effects of betaine on the ethanol-induced secretion of IGF-I and IGFBP-1 using radioimmunoassay and Western blotting, respectively, in primary cultured rat hepatocytes. METHODS:Hepatocytes isolated from male Sprague-Dawley rats were incubated with various concentrations of ethanol and PD98059 proce...

journal_title：World journal of gastroenterology

authors： Lee MS,Kim MS,Park SY,Kang CW

更新日期：2006-03-21 00:00:00

abstract：AIM:To explore the mechanism for interactions of leptin with ghrelin and orexin in the arcuate nucleus (ARC) activating neuropeptide Y (NPY) neurons during physiological regulation of feeding. METHODS:Single neurons from ARC of adult rats with matured feeding function were isolated. [Ca2+]i was measured to monitor the...

journal_title：World journal of gastroenterology

authors： Kohno D,Suyama S,Yada T

更新日期：2008-11-07 00:00:00

abstract：AIM:To investigate functional change of dendritic cells (DCs) derived from allogeneic partial liver graft undergoing acute rejection in rats. METHODS:Allogeneic (SD rat to LEW rat) whole and 50 % partial liver transplantation were performed. DCs from liver grafts 0 hr and 4 days after transplantation were isolated and...

journal_title：World journal of gastroenterology

authors： Xu MQ,Yao ZX

更新日期：2003-01-01 00:00:00

abstract：AIM:To investigate if transnasal endoscopic retrograde cholangiopancreatography (n-ERCP) using an ultrathin forward-viewing scope may overcome the disadvantages of conventional oral ERCP (o-ERCP) related to the large-caliber side-viewing duodenoscope. METHODS:The study involved 50 patients in whom 25 cases each were a...

journal_title：World journal of gastroenterology

authors： Mori A,Ohashi N,Maruyama T,Tatebe H,Sakai K,Shibuya T,Inoue H,Takegoshi S,Okuno M

更新日期：2008-03-14 00:00:00