Guggulsterone induces apoptosis of human hepatocellular carcinoma cells through intrinsic mitochondrial pathway.

abstract：AIM:To investigate the relationship of changes in expression of marker genes in functional categories or molecular networks comprising one functional category or multiple categories in progression of hepatic fibrosis in hepatitis C (HCV) patients. METHODS:Marker genes were initially identified using DNA microarray dat...

journal_title：World journal of gastroenterology

authors： Takahara Y,Takahashi M,Zhang QW,Wagatsuma H,Mori M,Tamori A,Shiomi S,Nishiguchi S

更新日期：2008-04-07 00:00:00

abstract：AIM:To study the application of artificial neural network (ANN) in forecasting the incidence of hepatitis A, which had an autoregression phenomenon. METHODS:The data of the incidence of hepatitis A in Liaoning Province from 1981 to 2001 were obtained from Liaoning Disease Control and Prevention Center. We used the aut...

journal_title：World journal of gastroenterology

authors： Guan P,Huang DS,Zhou BS

更新日期：2004-12-15 00:00:00

abstract：AIM:To investigate the effects and mechanisms of melatonin on immunological liver injury in mice. METHODS:A model of liver injury was induced by tail vein injection of Bacillus Calmette Guerin (BCG) and lipopolysaccharide (LPS) in mice. Kupffer cells and hepatocytes were isolated and cultured according to a modified t...

journal_title：World journal of gastroenterology

authors： Wang H,Wei W,Shen YX,Dong C,Zhang LL,Wang NP,Yue L,Xu SY

更新日期：2004-09-15 00:00:00

abstract：:A 83-year-old woman was admitted to our hospital because of intermittent abdominal colicky pain and vomiting for 26 h. The pain localized over the periumbilical area with radiation along the medial side of the thigh. Computed tomography scan with three-dimensional reconstruction revealed a loop of small bowel protrudi...

journal_title：World journal of gastroenterology

authors： Zhang H,Cong JC,Chen CS

更新日期：2010-01-07 00:00:00

abstract：AIM:To examine the role of microRNA 1181 (miR-1181) in invasion and proliferation in pancreatic cancer. METHODS:We analyzed the expression of miR-1181 in several pancreatic cancer cell lines and generated stable MIA-PaCa-2 and PANC-1 cell lines with up-regulated miR-1181 expression using an adenovirus delivery system....

journal_title：World journal of gastroenterology

authors： Wang J,Guo XJ,Ding YM,Jiang JX

更新日期：2017-03-07 00:00:00

abstract：AIM:To find evidences about whether NOD1/CARD4 insertion/deletion polymorphism is associated with inflammatory bowel disease by meta-analysis. METHODS:We surveyed the studies on the association of NOD1/CARD4 insertion/deletion polymorphism with inflammatory bowel disease in PubMed. Meta-analysis was performed for geno...

journal_title：World journal of gastroenterology

authors： Lu WG,Zou YF,Feng XL,Yuan FL,Gu YL,Li X,Li CW,Jin C,Li JP

更新日期：2010-09-14 00:00:00

abstract：AIM:To clarify whether there is any difference in the symptom relief in patients with reflux esophagitis following the administration of four Proton pump inhibitors (PPIs). METHODS:Two hundred and seventy-four patients with erosive reflux esophagitis were randomized to receive 8 wk of 20 mg omeprazole (n = 68), 30 mg ...

journal_title：World journal of gastroenterology

authors： Zheng RN

更新日期：2009-02-28 00:00:00

abstract：AIM:To carry out a hospital-based case-control study to investigate risk factors for intrahepatic cholangiocarcinoma (ICC) in China. METHODS:A total of 312 ICC cases and 438 matched controls were included in the study. The presence of diabetes mellitus, hypertension, hepatolithiasis, primary sclerosing cholangitis, li...

journal_title：World journal of gastroenterology

authors： Zhou YM,Yin ZF,Yang JM,Li B,Shao WY,Xu F,Wang YL,Li DQ

更新日期：2008-01-28 00:00:00

abstract：:The clinical course of chronic liver diseases is significantly dependent on the progression rate and the extent of fibrosis, i.e. the non-structured replacement of necrotic parenchyma by extracellular matrix. Fibrogenesis, i.e. the development of fibrosis can be regarded as an unlimited wound healing process, which is...

journal_title：World journal of gastroenterology

authors： Gressner AM,Gao CF,Gressner OA

更新日期：2009-05-28 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors that arise from the gastrointestinal tract. In rare cases, these tumors are found in intra-abdominal sites unrelated to the gastrointestinal tract, such as the mesentery, omentum and retroperitoneum. However, pancreatic extra-gastrointestinal stromal tumor...

journal_title：World journal of gastroenterology

authors： Tian YT,Liu H,Shi SS,Xie YB,Xu Q,Zhang JW,Zhao DB,Wang CF,Chen YT

更新日期：2014-01-21 00:00:00

abstract：:Cancer patients have unique problems associated with hepatitis C virus (HCV) infection and treatment not seen in the general population. HCV infection poses additional challenges and considerations for the management of cancer, and vice versa. HCV infection also can lead to the development of cancer, particularly hepa...

journal_title：World journal of gastroenterology

authors： Borchardt RA,Torres HA

更新日期：2014-03-21 00:00:00

abstract：AIM:Complete resection of the bile duct carcinoma is sometimes difficult by subepithelial spread in the duct wall or direct invasion of adjacent blood vessels. Nonresected extrahepatic bile duct carcinoma has a dismal prognosis, with a life expectancy of about 6 mo to 1 year. To improve the treatment results of locally...

journal_title：World journal of gastroenterology

authors： Kamisawa T,Tu Y,Egawa N,Karasawa K,Matsuda T,Tsuruta K,Okamoto A

更新日期：2005-07-21 00:00:00

abstract：:More than five years ago, the treatment of hepatitis C virus infection was revolutionized with the introduction of all-oral direct-acting antiviral (DAA) drugs. They proved highly efficient in curing patients with chronic hepatitis C (CHC), including patients with cirrhosis. The new DAA treatments were alleged to indu...

journal_title：World journal of gastroenterology

authors： Laursen TL,Sandahl TD,Kazankov K,George J,Grønbæk H

更新日期：2020-06-14 00:00:00

abstract：AIM:To clarify the association of glypican-3 (GPC3) expression with Wnt and other growth signaling molecules in hepatocellular carcinoma (HCC). METHODS:Expression of GPC3, Wnt, matrix metalloproteinases (MMPs), sulfatase (SULF)1, SULF2, and other growth signaling molecules was analyzed in HCC cell lines and tissue sam...

journal_title：World journal of gastroenterology

authors： Akutsu N,Yamamoto H,Sasaki S,Taniguchi H,Arimura Y,Imai K,Shinomura Y

更新日期：2010-07-28 00:00:00

abstract：AIM:To evaluate the possible influences of HCV infection and relative antiviral treatment on seminal parameters and reproductive hormonal serum levels. METHODS:Ten male patients with HCV-related chronic hepatitis and 16 healthy male volunteers were studied. In all subjects seminal parameters (nemaspermic concentration...

journal_title：World journal of gastroenterology

authors： Durazzo M,Premoli A,Di Bisceglie C,Bertagna A,Faga E,Biroli G,Manieri C,Bo S,Pagano G

更新日期：2006-05-21 00:00:00

abstract：AIM:To assess the outcome of patients, who underwent transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) and subsequently liver transplantation (OLT) irrespective of tumor size when no tumor progression was observed. METHODS:Records, imaging studies and pathology of 84 patients with HCC were revi...

journal_title：World journal of gastroenterology

authors： Obed A,Beham A,Püllmann K,Becker H,Schlitt HJ,Lorf T

更新日期：2007-02-07 00:00:00

abstract：AIM:To investigate the seroprevalence and molecular characteristics of hepatitis E virus (HEV) in the illegal blood donors (IBDs) of central China in the early 1990s. METHODS:A total of 546 blood samples were collected from the IBDs in Maanshan city, a questionnaire was completed by each subject, detailing the age, se...

journal_title：World journal of gastroenterology

authors： Cheng XF,Wen YF,Zhu M,Zhan SW,Zheng JX,Dong C,Xiang KX,Xia XB,Wang G,Han LF

更新日期：2012-03-07 00:00:00

abstract：AIM:To compare molecular profiles of proximal colon, distal colon and rectum in large adenomas, early and late carcinomas. To assess feasibility of testing directed at molecular markers from this study in routine clinical practice. METHODS:A prospective 3-year study has resulted in the acquisition of samples from 159 ...

journal_title：World journal of gastroenterology

authors： Minarikova P,Benesova L,Halkova T,Belsanova B,Suchanek S,Cyrany J,Tuckova I,Bures J,Zavoral M,Minarik M

更新日期：2016-05-28 00:00:00

abstract：:Although recent diagnostic and therapeutic advances have substantially improved the survival of patients with gastric cancer (GC), the overall prognosis is still poor. Surgery is the only curative treatment and should be performed in experienced centers. Due to high relapse following surgery, complementary and systemi...

journal_title：World journal of gastroenterology

authors： Cravo M,Fidalgo C,Garrido R,Rodrigues T,Luz G,Palmela C,Santos M,Lopes F,Maio R

更新日期：2015-11-07 00:00:00

abstract：AIM:To study the epidemiology of gastric malignancies in Jordan as a model for Middle East countries where such data is scarce. METHODS:Pertinent epidemiological and clinicopathological data for 201 patients with gastric malignancy in north of Jordan between 1991 and 2001 were analyzed. RESULTS:Male: female ratio was...

journal_title：World journal of gastroenterology

authors： Bani-Hani KE,Yaghan RJ,Heis HA,Shatnawi NJ,Matalka II,Bani-Hani AM,Gharaibeh KA

更新日期：2004-08-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and leading cause of death among patients with cirrhosis. Treatment guidelines are based according to the Barcelona Clinic Liver Cancer staging system. The choice among therapeutic options that include liver resection, liver transplantation, loco...

journal_title：World journal of gastroenterology

authors： Tabrizian P,Roayaie S,Schwartz ME

更新日期：2014-08-14 00:00:00

abstract：:Two major types of cancer occur in the esophagus: squamous cell carcinoma, which is associated with chronic smoking and alcohol consumption, and adenocarcinoma, which typically arises in gastric reflux-associated Barrett's esophagus. Although there is increasing incidence of esophageal adenocarcinoma in Western counti...

journal_title：World journal of gastroenterology

authors： Sasaki Y,Tamura M,Koyama R,Nakagaki T,Adachi Y,Tokino T

更新日期：2016-02-21 00:00:00

abstract：:Autoimmune hepatitis (AIH) is an unresolving progressive liver disease of unknown etiology characterized by hypergammaglobulinemia, autoantibodies detection and interface hepatitis. Due to the absence of specific diagnostic markers and the large heterogeneity of its clinical, laboratory and histological features, AIH ...

journal_title：World journal of gastroenterology

authors： Gatselis NK,Zachou K,Koukoulis GK,Dalekos GN

更新日期：2015-01-07 00:00:00

abstract：AIM:To elucidate the expression of the apoptosis-associated molecules in human primary hepatocellular carcinoma (HCC) cells, and prepare the monoclonal antibodies (mAb) against the apoptosis-associated antigens of HCC cells. METHODS:Human HCC cell line HCC-9204 cells were induced apoptosis with 60 mL x L(-1) ethanol f...

journal_title：World journal of gastroenterology

authors： Yang LJ,Wang WL

更新日期：2002-10-01 00:00:00

abstract：AIM:To investigate the effects of Terminalia arjuna (T. arjuna) extract on human hepatoma cell line (HepG2) and its possible role in induction of apoptosis. METHODS:Human hepatoma cells were treated with different concentrations of ethanolic extract of T. arjuna and its cytotoxicity effect was measured by trypan blue ...

journal_title：World journal of gastroenterology

authors： Sivalokanathan S,Vijayababu MR,Balasubramanian MP

更新日期：2006-02-21 00:00:00

abstract：:Inflammatory bowel disease (IBD) is associated with increased risk of colorectal cancer (CRC). The risk is known to increase with longer duration of the disease, family history of CRC, and history of primary sclerosing cholangitis. The diagnosis of the neoplastic changes associated with IBD is difficult owing to the h...

journal_title：World journal of gastroenterology

authors： Althumairi AA,Lazarev MG,Gearhart SL

更新日期：2016-01-21 00:00:00

abstract：AIM:To investigate the changes that occur in E-cadherin expression during the process of metastasis in colorectal cancer. METHODS:E-cadherin expression was detected by immunohistochemistry and two indices of expression were calculated which reflected the level of expression and the locations (membrane and cytoplasm). ...

journal_title：World journal of gastroenterology

authors： Elzagheid A,Algars A,Bendardaf R,Lamlum H,Ristamaki R,Collan Y,Syrjanen K,Pyrhonen S

更新日期：2006-07-21 00:00:00

abstract：:We herein report a case of bronchial bleeding after radical esophagectomy that was treated with lobectomy. A 65-year-old male who underwent subtotal esophagectomy with three-field lymph node dissection for esophageal carcinoma was referred to our hospital because of sudden hemoptysis. After the esophagectomy, bilatera...

journal_title：World journal of gastroenterology

authors： Kitajima T,Momose K,Lee S,Haruta S,Ueno M,Shinohara H,Fujimori S,Fujii T,Takei R,Kohno T,Udagawa H

更新日期：2015-03-21 00:00:00

abstract：:Pancreatic cystic lesions (PCLs) are increasingly being identified because of the widespread use of high-resolution abdominal imaging. These cysts encompass a spectrum from malignant disease to benign lesions, and therefore, accurate diagnosis is crucial to determine the best management strategy, either surgical resec...

journal_title：World journal of gastroenterology

authors： Alvarez-Sánchez MV,Napoléon B

更新日期：2018-07-14 00:00:00

abstract：AIM:To evaluate the efficacy and safety of a hybrid bioartificial liver (HBAL) system in the treatment of acute liver failure. METHODS:Canine models with acute liver failure were introduced with intravenous administration of D-galactosamine. The animals were divided into: the HBAL treatment group (n = 8), in which the...

journal_title：World journal of gastroenterology

authors： Shi XL,Zhang Y,Chu XH,Han B,Gu JY,Xiao JQ,Tan JJ,Gu ZZ,Ren HZ,Yuan XW,Ding YT

更新日期：2012-07-28 00:00:00