Association of NOD1 (CARD4) insertion/deletion polymorphism with susceptibility to IBD: a meta-analysis.

Abstract:

AIM:To find evidences about whether NOD1/CARD4 insertion/deletion polymorphism is associated with inflammatory bowel disease by meta-analysis. METHODS:We surveyed the studies on the association of NOD1/CARD4 insertion/deletion polymorphism with inflammatory bowel disease in PubMed. Meta-analysis was performed for genotypes GG/T vs T/T, GG/GG vs T/T, GG/T + GG/GG vs T/T, GG/GG vs T/T + GG/T, and GG allele vs T allele in a fixed/random effect model. RESULTS:We identified 8 studies (6439 cases and 4798 controls) in Caucasian populations using PubMed search. We found no association between NOD1/CARD4 insertion/deletion polymorphism and inflammatory bowel disease, Crohn's disease, and ulcerative colitis. Stratification of cases by age showed that NOD1/CARD4 insertion/deletion polymorphism was associated with inflammatory bowel disease in younger age group at onset (< 40 years) (GG vs T: OR = 0.68, 95% CI: 0.50-0.93, P = 0.02; GG/T + GG/GG vs T/T: OR = 0.71, 95% CI: 0.59-0.85, P = 0.0003). CONCLUSION:This meta-analysis demonstrates an association between NOD1/CARD4 insertion/deletion polymorphism and inflammatory bowel disease in the younger age group at onset (< 40 years) in Caucasian populations.

journal_name

World J Gastroenterol

authors

Lu WG,Zou YF,Feng XL,Yuan FL,Gu YL,Li X,Li CW,Jin C,Li JP

doi

10.3748/wjg.v16.i34.4348

subject

Has Abstract

pub_date

2010-09-14 00:00:00

pages

4348-56

issue

34

eissn

1007-9327

issn

2219-2840

journal_volume

16

pub_type

杂志文章,meta分析
  • New trends in colorectal surgery: single port and natural orifice techniques.

    abstract::Single-incision laparoscopic surgery (SILS) and natural orifice transluminal endoscopic surgery (NOTES) have rapidly gained pace worldwide, potentially replacing conventional laparoscopic surgery (CLS) as the preferred colorectal surgery technique. Currently available data mainly consist of retrospective series analyz...

    journal_title:World journal of gastroenterology

    pub_type: 历史文章,杂志文章,评审

    doi:10.3748/wjg.v20.i48.18104

    authors: Daher R,Chouillard E,Panis Y

    更新日期:2014-12-28 00:00:00

  • Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model.

    abstract:AIM:To investigate the expression and activity of leukotriene C4 (LTC4) synthesis enzymes and their underlying relationship with cysteinyl leukotriene (cys-LT) generation in a rat fulminant hepatic failure (FHF) model induced by D-galactosamine/lipopolysaccharide (D-GalN/ LPS). METHODS:Rats were treated with D-GalN (3...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.2748

    authors: Ma KF,Yang HY,Chen Z,Qi LY,Zhu DY,Lou YJ

    更新日期:2008-05-07 00:00:00

  • Prevalence and factors associated with irritable bowel syndrome among university students in Lebanon: findings from a cross-sectional study.

    abstract:AIM:To describe the bowel habits and the prevalence of irritable bowel syndrome (IBS) and to investigate the influence of health behavior and social factors on IBS prevalence in university students. METHODS:This cross-sectional study was conducted at five major universities in Greater Beirut and its suburbs, between F...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i12.3628

    authors: Costanian C,Tamim H,Assaad S

    更新日期:2015-03-28 00:00:00

  • Importance of performance status for treatment outcome in advanced pancreatic cancer.

    abstract::Despite progress in the treatment of advanced and metastatic pancreatic cancer (PC), the outcome of this disease remains dismal for the majority of patients. Given the moderate efficacy of treatment, prognostic factors may help to guide treatment decisions. Several trials identified baseline performance status as an i...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v13.i2.224

    authors: Boeck S,Hinke A,Wilkowski R,Heinemann V

    更新日期:2007-01-14 00:00:00

  • Impact of ribavirin dose on retreatment of chronic hepatitis C patients.

    abstract:AIM:To study the efficacy and factors associated with a sustained virological response (SVR) in chronic hepatitis C (CHC) relapsing patients. METHODS:Out of 1228 CHC patients treated with pegylated interferon (PEG-IFN) and ribavirin (RBV), 165 (13%) had a relapse. Among these, 62 patients were retreated with PEG-IFN-α...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i23.2966

    authors: Stern C,Martinot-Peignoux M,Ripault MP,Boyer N,Castelnau C,Valla D,Marcellin P

    更新日期:2012-06-21 00:00:00

  • Serum vitamin D and colonic vitamin D receptor in inflammatory bowel disease.

    abstract:AIM:To determine serum vitamin D levels and colonic vitamin D receptor (VDR) expression in inflammatory bowel disease (IBD) and non-IBD patients and correlate these with histopathology. METHODS:Puerto Rican IBD (n = 10) and non-IBD (n = 10) patients ≥ 21 years old scheduled for colonoscopy were recruited. Each patient...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i13.3581

    authors: Abreu-Delgado Y,Isidro RA,Torres EA,González A,Cruz ML,Isidro AA,González-Keelan CI,Medero P,Appleyard CB

    更新日期:2016-04-07 00:00:00

  • Extrahepatic collaterals and liver damage in embolotherapy for ruptured hepatic artery pseudoaneurysm following hepatobiliary pancreatic surgery.

    abstract:AIM:To evaluate the effects of extrahepatic collaterals to the liver on liver damage and patient outcome after embolotherapy for the ruptured hepatic artery pseudoaneurysm following hepatobiliary pancreatic surgery. METHODS:We reviewed 9 patients who underwent transcatheter arterial embolization (TAE) for the ruptured...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i3.408

    authors: Tajima Y,Kuroki T,Tsutsumi R,Sakamoto I,Uetani M,Kanematsu T

    更新日期:2007-01-21 00:00:00

  • Poorly differentiated endocrine carcinoma of the pancreas responded to gemcitabine: Case report.

    abstract::Poorly differentiated endocrine carcinoma (PDEC) of the pancreas is a rare and aggressive tumor. First-line treatment is commonly a combination of etoposide and cisplatin, but there is no consensus regarding further treatment recommendations. In this report, we describe a case of pancreatic PDEC treated with gemcitabi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i30.3853

    authors: Nakazuru S,Yoshio T,Suemura S,Itoh M,Araki M,Yoshioka C,Ohta M,Sueyoshi Y,Ohta T,Hasegawa H,Morita K,Toyama T,Kuzushita N,Kodama Y,Mano M,Mita E

    更新日期:2010-08-14 00:00:00

  • Cyclooxygenase 2 in liver dysfunction and carcinogenesis: Facts and perspectives.

    abstract::The biosynthesis of prostaglandins and thromboxanes has been a focus of interest in the management of many liver diseases. Cyclooxygenases are the enzymes involved in the first step of the biosynthesis of these lipid mediators and selective inhibitors for these isoenzymes as well as pharmacological analogues of prosta...

    journal_title:World journal of gastroenterology

    pub_type: 社论

    doi:10.3748/wjg.v23.i20.3572

    authors: Martín-Sanz P,Casado M,Boscá L

    更新日期:2017-05-28 00:00:00

  • Clinicopathological evaluation of duodenal well-differentiated endocrine tumors.

    abstract:AIM:To assess the clinicopathological characteristics of duodenal well-differentiated endocrine tumors. METHODS:We examined clinicopathological characteristics in 11 consecutive patients with duodenal well-differentiated endocrine tumors treated by endoscopic therapy or surgery in our hospital from 1992 through 2007. ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i36.4583

    authors: Ishido K,Tanabe S,Higuchi K,Sasaki T,Katada C,Azuma M,Naruke A,Koizumi W,Mikami T

    更新日期:2010-09-28 00:00:00

  • Diagnosis and treatment of iron-deficiency anemia in gastrointestinal bleeding: A systematic review.

    abstract:BACKGROUND:Anemia is considered a public health issue and is often caused by iron deficiency. Iron-deficiency anemia (IDA) often originates from blood loss from lesions in the gastrointestinal tract in men and postmenopausal women, and its prevalence among patients with gastrointestinal bleeding has been estimated to b...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i45.7242

    authors: Cotter J,Baldaia C,Ferreira M,Macedo G,Pedroto I

    更新日期:2020-12-07 00:00:00

  • Endoscopy is of low yield in the identification of gastrointestinal neoplasia in patients with dermatomyositis: A cross-sectional study.

    abstract:AIM:To determine the prevalence of gastrointestinal neoplasia among dermatomyositis patients who underwent an esophagogastroduodenoscopy and/or colonoscopy. METHODS:A cross-sectional study examining the results of upper endoscopy and colonoscopy in adults with dermatomyositis at an urban, university hospital over a te...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i26.4788

    authors: Kidambi TD,Schmajuk G,Gross AJ,Ostroff JW,Terdiman JP,Lee JK

    更新日期:2017-07-14 00:00:00

  • Combined treatment of oxaliplatin and capecitabine in patients with metastatic esophageal squamous cell cancer.

    abstract:AIM:To investigate the efficacy and side effects of the combined therapy of oxaliplatin and capecitabine in patients with metastatic esophageal squamous cell cancer (ESCC) and the survival of the patients. METHODS:Sixty-four patients (median age of 63 years) with histological or cytological confirmation of ESCC receiv...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.871

    authors: Qin TJ,An GL,Zhao XH,Tian F,Li XH,Lian JW,Pan BR,Gu SZ

    更新日期:2009-02-21 00:00:00

  • Randomized study of lafutidine vs lansoprazole in patients with mild gastroesophageal reflux disease.

    abstract:AIM:To compare the clinical efficacy of the second-generation H2RA lafutidine with that of lansoprazole in Japanese patients with mild gastroesophageal reflux disease (GERD). METHODS:Patients with symptoms of GERD and a diagnosis of grade A reflux esophagitis (according to the Los Angeles classification) were randomiz...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.3748/wjg.v22.i23.5430

    authors: Takenaka R,Okada H,Kawano S,Komazawa Y,Yoshinaga F,Nagata S,Inoue M,Komatsu H,Onogawa S,Kushiyama Y,Mukai S,Todo H,Okanobu H,Manabe N,Tanaka S,Haruma K,Kinoshita Y

    更新日期:2016-06-21 00:00:00

  • Treatment of cholecystitis with Chinese herbal medicines: a systematic review of the literature.

    abstract:AIM:To analyze the literature on the use of Chinese herbal medicines for the treatment of cholecystitis. METHODS:The literature on treatment of cholecystitis with traditional Chinese medicines (TCM) was analyzed based on the principles and methods described by evidence-based medicine (EBM). Eight databases including M...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v18.i14.1689

    authors: Dong ZY,Wang GL,Liu X,Liu J,Zhu DZ,Ling CQ

    更新日期:2012-04-14 00:00:00

  • Massive gastrointestinal tuberculosis in a young patient without immunosuppression.

    abstract::Although the lung is the major site for Mycobacterium tuberculosis infection, gastrointestinal involvement can be present as part of multiorgan disease process or, less commonly, can be seen as primary gastrointestinal tuberculosis. In the cases where the culture is negative, it can be difficult to differentiate tuber...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i10.2382

    authors: Settbas Y,Alper M,Akcan Y,Gurbuz Y,Oksuz S

    更新日期:2003-10-01 00:00:00

  • Modulation of tryptase secretion from human colon mast cells by histamine.

    abstract:AIM:To investigate the ability of histamine to modulate tryptase release from human colon mast cells and the potential mechanisms. METHODS:Enzymatically dispersed cells from human colons were challenged with histamine, anti-IgE or calcium ionophore A23187 (CI), and the cell supernatants after challenge were collected....

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i3.323

    authors: He SH,Xie H

    更新日期:2004-02-01 00:00:00

  • Safety and efficacy of oral HD-03/ES given for six months in patients with chronic hepatitis B virus infection.

    abstract:AIM:To investigate the safety and efficacy of the formulation HD-03/ES capsules in the management of patients with chronic hepatitis B infection. METHODS:A total of 25 patients were recruited to the study and were given HD-03/ES, two capsules twice daily for six months. Clinical assessment of symptoms and signs were d...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i30.4103

    authors: Rajkumar JS,Sekar MG,Mitra SK

    更新日期:2007-08-14 00:00:00

  • Upregulated expression of Ezrin and invasive phenotype in malignantly transformed esophageal epithelial cells.

    abstract:AIM:To investigate the correlation between ezrin expression and invasive phenotype formation in malignantly transformed esophageal epithelial cells. METHODS:The experimental cell line employed in the present study was originated form the progressive induction of a human embryonic esophageal epithelial cell line (SHEE)...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i6.1182

    authors: Shen ZY,Xu LY,Chen MH,Li EM,Li JT,Wu XY,Zeng Y

    更新日期:2003-06-01 00:00:00

  • Computed tomography vs liver stiffness measurement and magnetic resonance imaging in evaluating esophageal varices in cirrhotic patients: A systematic review and meta-analysis.

    abstract:BACKGROUND:Computed tomography (CT), liver stiffness measurement (LSM), and magnetic resonance imaging (MRI) are non-invasive diagnostic methods for esophageal varices (EV) and for the prediction of high-bleeding-risk EV (HREV) in cirrhotic patients. However, the clinical use of these methods is controversial. AIM:To ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i18.2247

    authors: Li Y,Li L,Weng HL,Liebe R,Ding HG

    更新日期:2020-05-14 00:00:00

  • Sclerosing encapsulating peritonitis in a liver transplant patient: a case report.

    abstract::We report a patient with HBV-related hepatocellular carcinoma (HCC) and refractory ascites who had received a peritoneal-venous shunt (PVS) 1 year before liver transplantation. Urgent surgical intervention following bowel obstruction and failure of immunosuppression therapy. No intestinal obstruction was found during ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i34.5412

    authors: Lin CH,Yu JC,Chen TW,Chan DC,Chen CJ,Hsieh CB

    更新日期:2005-09-14 00:00:00

  • "Rescue" regimens after Helicobacter pylori treatment failure.

    abstract::Helicobacter pylori (H pylori) infection is the main cause of gastritis, gastroduodenal ulcer disease, and gastric cancer. After more than 20 years of experience in H pylori treatment, in my opinion, the ideal regimen to treat this infection is still to be found. Currently, apart from having to know first-line eradica...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.5385

    authors: Gisbert JP

    更新日期:2008-09-21 00:00:00

  • New approach to anal cancer: individualized therapy based on sentinel lymph node biopsy.

    abstract::Oncological treatment is currently directed toward a tailored therapy concept. Squamous cell carcinoma of the anal canal could be considered a suitable platform to test new therapeutic strategies to minimize treatment morbidity. Standard of care for patients with anal canal cancer consists of a combination of radiothe...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审

    doi:10.3748/wjg.v18.i44.6349

    authors: De Nardi P,Carvello M,Staudacher C

    更新日期:2012-11-28 00:00:00

  • Green tea and the risk of gastric cancer: epidemiological evidence.

    abstract::Gastric cancer (GC) is one of the leading causes of cancer death in the world. Numerous efforts are being made to find chemoprotective agents able to reduce its risk. Amongst these, green tea has been reported to have a protective effect against stomach cancer. This article aims to critically evaluate all epidemiologi...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审

    doi:10.3748/wjg.v19.i24.3713

    authors: Hou IC,Amarnani S,Chong MT,Bishayee A

    更新日期:2013-06-28 00:00:00

  • Coexistence of esophageal superficial carcinoma and multiple leiomyomas: A case report.

    abstract::Leiomyomas are the most common benign tumors of the esophagus. They usually occur as a single lesion or as two or three nodules. Only two cases of esophageal multiple leiomyomas comprising more than 10 nodules have been reported previously. Moreover, there have been few reports of esophageal squamous cell carcinoma ov...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v12.i28.4588

    authors: Iwaya T,Maesawa C,Uesugi N,Kimura T,Ikeda K,Kimura Y,Mitomo S,Ishida K,Sato N,Wakabayashi G

    更新日期:2006-07-28 00:00:00

  • Left ventricular assist device hemolysis leading to dysphagia.

    abstract::A 41-year-old man with a continuous-flow left ventricular assist device presented for evaluation of dysphagia and dark urine. He was found to have a significantly elevated L-lactate dehydrogenase and an elevated plasma free hemoglobin consistent with intravascular hemolysis. After the hemolysis ceased, both the black ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i18.5735

    authors: Wuschek A,Iqbal S,Estep J,Quigley E,Richards D

    更新日期:2015-05-14 00:00:00

  • Treatment and survival in a population-based sample of patients diagnosed with gastroesophageal adenocarcinoma.

    abstract:AIM:To examine the extent of use of specific therapies in clinical practice, and their relationship to therapies validated in clinical trials. METHODS:The US National Cancer Institutes' Patterns of Care study was used to examine therapies and survival of patients diagnosed in 2001 with histologically-confirmed gastroe...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.3165

    authors: Cronin-Fenton DP,Mooney MM,Clegg LX,Harlan LC

    更新日期:2008-05-28 00:00:00

  • Breastfeeding and chronic HBV infection: clinical and social implications.

    abstract::Mother-to-child transmission of hepatitis B virus (HBV) is among the most important causes of chronic HBV infection and is the commonest mode of transmission worldwide. Currently, the presence of HBsAg, HBeAg and HBV DNA in breast milk is confirmed. Several studies have reported that breastfeeding carries no additiona...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v16.i40.5042

    authors: Petrova M,Kamburov V

    更新日期:2010-10-28 00:00:00

  • Herbal hepatotoxicity: challenges and pitfalls of causality assessment methods.

    abstract::The diagnosis of herbal hepatotoxicity or herb induced liver injury (HILI) represents a particular clinical and regulatory challenge with major pitfalls for the causality evaluation. At the day HILI is suspected in a patient, physicians should start assessing the quality of the used herbal product, optimizing the clin...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v19.i19.2864

    authors: Teschke R,Frenzel C,Schulze J,Eickhoff A

    更新日期:2013-05-21 00:00:00

  • Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension.

    abstract:AIM:To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension. METHODS:Neuronal nitric oxide synthase (nNOS) and HSP-90 were analyzed by immunofluorescence, western blotting and co-immunoprecipitation in the mesenteric ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i15.1837

    authors: Moleda L,Jurzik L,Froh M,Gäbele E,Hellerbrand C,Straub RH,Schölmerich J,Wiest R

    更新日期:2010-04-21 00:00:00