Left ventricular assist device hemolysis leading to dysphagia.

Abstract:

:A 41-year-old man with a continuous-flow left ventricular assist device presented for evaluation of dysphagia and dark urine. He was found to have a significantly elevated L-lactate dehydrogenase and an elevated plasma free hemoglobin consistent with intravascular hemolysis. After the hemolysis ceased, both the black urine and dysphagia resolved spontaneously. Transient esophageal dysfunction, as a manifestation of gastrointestinal dysmotility, is known to occur in the setting of hemolysis. Paroxysmal nocturnal hemoglobinuria is another recognized cause of massive hemolysis with gastrointestinal dysmotility occurring in 25%-35% of patients during a paroxysm. Intravascular hemolysis increases plasma free hemoglobin, which scavenges nitric oxide (NO), an important second messenger for smooth muscle cell relaxation. The decrease in NO can lead to esophageal spasm and resultant dysphagia. In our patient the resolution of hemolysis resulted in resolution of dysphagia.

journal_name

World J Gastroenterol

authors

Wuschek A,Iqbal S,Estep J,Quigley E,Richards D

doi

10.3748/wjg.v21.i18.5735

subject

Has Abstract

pub_date

2015-05-14 00:00:00

pages

5735-8

issue

18

eissn

1007-9327

issn

2219-2840

journal_volume

21

pub_type

杂志文章
  • Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-kappaB activation.

    abstract:AIM:Different strains of bifidobacteria were analysed for their effects on HT-29 intestinal epithelial cells (IECs) in in vitro models both of the non-inflamed and inflamed intestinal epithelium. METHODS:A reporter gene system in HT-29 cells was used to measure levels of NF-kappaB activation after challenge with bifid...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i23.3729

    authors: Riedel CU,Foata F,Philippe D,Adolfsson O,Eikmanns BJ,Blum S

    更新日期:2006-06-21 00:00:00

  • Constant serum levels of secreted asialoglycoprotein receptor sH2a and decrease with cirrhosis.

    abstract:AIM:To investigate the existence and levels of sH2a, a soluble secreted form of the asialoglycoprotein receptor in human serum. METHODS:Production of recombinant sH2a and development of a monoclonal antibody and an enzyme-linked immunosorbent assay (ELISA). This assay was used to determine the presence and concentrati...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i48.5305

    authors: Benyair R,Kondratyev M,Veselkin E,Tolchinsky S,Shenkman M,Lurie Y,Lederkremer GZ

    更新日期:2011-12-28 00:00:00

  • Molecular mechanisms of liver preconditioning.

    abstract::Ischemia/reperfusion (I/R) injury still represents an important cause of morbidity following hepatic surgery and limits the use of marginal livers in hepatic transplantation. Transient blood flow interruption followed by reperfusion protects tissues against damage induced by subsequent I/R. This process known as ische...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v16.i48.6058

    authors: Alchera E,Dal Ponte C,Imarisio C,Albano E,Carini R

    更新日期:2010-12-28 00:00:00

  • Changes in lipid metabolism in chronic hepatitis C.

    abstract:AIM:To investigate the relationship between certain biochemical parameters of lipid metabolism in the serum and steatosis in the liver. METHODS:The grade of steatosis (0-3) and histological activity index (HAI, 0-18) in liver biopsy specimens were correlated with serum alanine aminotransferase (ALT), total cholesterol...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i41.6422

    authors: Jármay K,Karácsony G,Nagy A,Schaff Z

    更新日期:2005-11-07 00:00:00

  • Role of autophagy in the pathogenesis of inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD) results from a complex series of interactions between susceptibility genes, the environment, and the immune system. Recently, some studies provided strong evidence that the process of autophagy affects several aspects of mucosal immune responses. Autophagy is a cellular stress response...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v23.i11.1944

    authors: Iida T,Onodera K,Nakase H

    更新日期:2017-03-21 00:00:00

  • XRCC1 genetic polymorphism Arg399Gln and gastric cancer risk: A meta-analysis.

    abstract:AIM:To evaluate the association between X-ray cross-complementing gene 1 (XRCC1) genetic polymorphism Arg399Gln and gastric cancer risk by means of meta-analysis. METHODS:We searched PubMed and NCBI up to June 1, 2008. A total of 16 clinical trials and reports were identified, but only 8 trials qualified under our sel...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.14.6733

    authors: Geng J,Zhang YW,Huang GC,Chen LB

    更新日期:2008-11-21 00:00:00

  • Colorectal cancer and immunity: what we know and perspectives.

    abstract::Strong evidence supports the concept of immunosurveillance and immunoediting in colorectal cancer. In particular, the density of T CD8⁺ and CD45⁺ lymphocyte infiltration was recently shown to have a better prognostic value than the classic tumor node metastasis classification factor. Other immune subsets, as macrophag...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i14.3738

    authors: Pernot S,Terme M,Voron T,Colussi O,Marcheteau E,Tartour E,Taieb J

    更新日期:2014-04-14 00:00:00

  • Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension.

    abstract:AIM:To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension. METHODS:Neuronal nitric oxide synthase (nNOS) and HSP-90 were analyzed by immunofluorescence, western blotting and co-immunoprecipitation in the mesenteric ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i15.1837

    authors: Moleda L,Jurzik L,Froh M,Gäbele E,Hellerbrand C,Straub RH,Schölmerich J,Wiest R

    更新日期:2010-04-21 00:00:00

  • Dominating expression of negative regulatory factors downmodulates major histocompatibility complex Class-II expression on dendritic cells in chronic hepatitis C infection.

    abstract:AIM:To elucidate the molecular mechanisms leading to development of functionally impaired dendritic cells (DCs) in chronic hepatitis C (CHC) patients infected with genotype 3 virus. METHODS:This prospective study was conducted on the cohorts of CHC individuals identified as responders or non-responders to antiviral th...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i22.5173

    authors: Tomer S,Chawla YK,Duseja A,Arora SK

    更新日期:2016-06-14 00:00:00

  • Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells.

    abstract:AIM:To investigate the impact of arachidonic acid (AA) and docosahexaenoic acid (DHA) and their combination on colon cancer cell growth. METHODS:The LS-174T colon cancer cell line was used to study the role of the prostaglandin precursor AA and the omega-3 polyunsaturated fatty acid DHA on cell growth. Cell viability ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.1079

    authors: Habbel P,Weylandt KH,Lichopoj K,Nowak J,Purschke M,Wang JD,He CW,Baumgart DC,Kang JX

    更新日期:2009-03-07 00:00:00

  • Microarray analysis of Escherichia coli O157:H7.

    abstract:AIM:To establish the rapid, specific, and sensitive method for detecting O157:H7 with DNA microchips. METHODS:Specific oligonucleotide probes (26-28 nt) of bacterial antigenic and virulent genes of E. coli O157:H7 and other related pathogen genes were pre-synthesized and immobilized on a solid support to make microchi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i37.5811

    authors: Jin HY,Tao KH,Li YX,Li FQ,Li SQ

    更新日期:2005-10-07 00:00:00

  • Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese.

    abstract:AIM:Single nucleotide polymorphisms (SNPs) of uridine-diphosphoglucuro-nosyltransferase 1A7 (UGT1A7) gene are associated with the development of orolaryngeal cancer, hepatocellular carcinoma, and colorectal cancer. We performed this research to establish the techniques for determining UGT1A7 gene and basic data of this...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i6.797

    authors: Huang MJ,Yang SS,Lin MS,Huang CS

    更新日期:2005-02-14 00:00:00

  • Effect of alcohol consumption on liver stiffness measured by transient elastography.

    abstract:AIM:To determine the evolution of transient elastography (TE) in patients with alcoholic liver disease according to alcohol cessation or continuation. METHODS:We retrospectively selected in our local database all patients who had two TE between June 2005 and November 2010 with chronic alcohol excessive consumption and...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i4.516

    authors: Bardou-Jacquet E,Legros L,Soro D,Latournerie M,Guillygomarc'h A,Le Lan C,Brissot P,Guyader D,Moirand R

    更新日期:2013-01-28 00:00:00

  • Induction of clinical response and remission of inflammatory bowel disease by use of herbal medicines: a meta-analysis.

    abstract:AIM:To evaluate the efficacy and tolerability of herbal medicines in inflammatory bowel disease (IBD) by conducting a meta-analysis. METHODS:Electronic databases were searched for studies investigating efficacy and/or tolerability of herbal medicines in the management of different types of IBD. The search terms were: ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.3748/wjg.v19.i34.5738

    authors: Rahimi R,Nikfar S,Abdollahi M

    更新日期:2013-09-14 00:00:00

  • Characteristics of upper digestive tract diseases in Bohai Bay fishermen.

    abstract:AIM:To study the characteristics of upper digestive tract diseases (UDTDs) in fishermen who live in Bohai Bay. METHODS:An investigation was carried out in 1488 fishermen with symptoms of UDTDs (aside from liver, biliary and pancreatic diseases) during the time period between December 1991 and February 1995. This inves...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v3.i3.171

    authors: Wang YB,Wang YP,Zou J,Bai BJ,Ren GC,Cai BQ

    更新日期:1997-09-15 00:00:00

  • miR-30b inhibits autophagy to alleviate hepatic ischemia-reperfusion injury via decreasing the Atg12-Atg5 conjugate.

    abstract:AIM:To explore the role and potential mechanism of miR-30b regulation of autophagy in hepatic ischemia-reperfusion injury (IRI). METHODS:An animal model of hepatic IRI was generated in C57BL/6 mice. For in vitro studies, AML12 cells were immersed in mineral oil for 1 h and then cultured in complete Dulbecco's Modified...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i18.4501

    authors: Li SP,He JD,Wang Z,Yu Y,Fu SY,Zhang HM,Zhang JJ,Shen ZY

    更新日期:2016-05-14 00:00:00

  • Hepatoid adenocarcinoma of the stomach: a report of three cases.

    abstract::Hepatoid adenocarcinoma of the stomach (HAS) is a rare form of gastric cancer that has unique clinicopathological features and an extremely poor prognosis. Here, we report on three patients with suspected gastric cancer who were referred to our hospital. Gastrointestinal fiberscopy on the three patients revealed two l...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i27.4437

    authors: Ye MF,Tao F,Liu F,Sun AJ

    更新日期:2013-07-21 00:00:00

  • Liuweiwuling tablets attenuate acetaminophen-induced acute liver injury and promote liver regeneration in mice.

    abstract:AIM:To explore the mechanism of protection against acetaminophen-induced acute liver injury by Liuweiwuling tablets. METHODS:Intraperitoneal injections of acetaminophen (250 mg/kg) were used to induce acute liver injury in male C57BL/6 mice. A total of 24 healthy mice were randomly assigned to two groups: an acute liv...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i26.8089

    authors: Lei YC,Li W,Luo P

    更新日期:2015-07-14 00:00:00

  • Comparison of two types of colectomy in treating slow transit constipation with or without melanosis coli.

    abstract:AIM:To compare the follow-up outcomes of ileosigmoidal anastomosis (ISA) and caecorectal anastomosis (CRA) in patients with slow transit constipation (STC) with or without melanosis coli (MC). METHODS:We collected the clinical data of 48 STC patients with or without MC from May 2002 to May 2007. Twenty-six patients un...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i33.9736

    authors: Sun JW,Gu JN,Du P,Chen W

    更新日期:2015-09-07 00:00:00

  • Caffeic acid phenethyl ester up-regulates antioxidant levels in hepatic stellate cell line T6 via an Nrf2-mediated mitogen activated protein kinases pathway.

    abstract:AIM:To investigate the antioxidant effect of caffeic acid phenethyl ester (CAPE) in hepatic stellate cell-T6 (HSC-T6) cells cultured in vitro and the potential mechanisms. METHODS:HSC-T6 cells were cultured in vitro and treated with various concentrations of CAPE for 24, 48 and 72 h, respectively. Cell proliferation w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i7.1203

    authors: Yang N,Shi JJ,Wu FP,Li M,Zhang X,Li YP,Zhai S,Jia XL,Dang SS

    更新日期:2017-02-21 00:00:00

  • High-flow nasal oxygen availability for sedation decreases the use of general anesthesia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasound.

    abstract:AIM:To examine whether high-flow nasal oxygen (HFNO) availability influences the use of general anesthesia (GA) in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound (EUS) and associated outcomes. METHODS:In this retrospective study, patients were stratified into 3 eras...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i47.10398

    authors: Schumann R,Natov NS,Rocuts-Martinez KA,Finkelman MD,Phan TV,Hegde SR,Knapp RM

    更新日期:2016-12-21 00:00:00

  • Adverse events with bismuth salts for Helicobacter pylori eradication: systematic review and meta-analysis.

    abstract:AIM:To assess the safety of bismuth used in Helicobacter pylori (H pylori) eradication therapy regimens. METHODS:We conducted a systematic review and meta-analysis. MEDLINE and EMBASE were searched (up to October 2007) to identify randomised controlled trials comparing bismuth with placebo or no treatment, or bismuth ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.14.7361

    authors: Ford AC,Malfertheiner P,Giguere M,Santana J,Khan M,Moayyedi P

    更新日期:2008-12-28 00:00:00

  • Pre-treatment urea breath test results predict the efficacy of Helicobacter pylori eradication therapy in patients with active duodenal ulcers.

    abstract:AIM:To evaluate the association of pre-treatment (13)C-urea breath test (UBT) results with H pylori density and efficacy of eradication therapy in patients with active duodenal ulcers. METHODS:One hundred and seventeen consecutive outpatients with active duodenal ulcer and H pylori infection were recruited. H pylori d...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v10.i7.991

    authors: Lai YC,Yang JC,Huang SH

    更新日期:2004-04-01 00:00:00

  • Anemia and long-term outcome in adjuvant and neoadjuvant radiochemotherapy of stage II and III rectal adenocarcinoma: the Freiburg experience (1989-2002).

    abstract:AIM:To evaluate the long-term outcome of standard 5-FU based adjuvant or neoadjuvant radiochemotherapy and to identify the predictive factors, especially anemia before and after radiotherapy as well as hemoglobin increase or decrease during radiotherapy. METHODS:Two hundred and eighty-six patients with Union Internati...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i12.1849

    authors: Weissenberger C,Geissler M,Otto F,Barke A,Henne K,von Plehn G,Rein A,Muller C,Bartelt S,Henke M

    更新日期:2006-03-28 00:00:00

  • Glycyrrhizic acid inhibits apoptosis and fibrosis in carbon-tetrachloride-induced rat liver injury.

    abstract:AIM:To investigate anti-apoptotic effects of glycyrrhizic acid (GA) against fibrosis in carbon tetrachloride (CCl4)-induced liver injury and its contributing factors. METHODS:Liver fibrosis was induced by administration of CCl4 for 8 wk. Pathological changes in the liver of rats were examined by hematoxylin-eosin stai...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i17.5271

    authors: Liang B,Guo XL,Jin J,Ma YC,Feng ZQ

    更新日期:2015-05-07 00:00:00

  • Impaired contractility and remodeling of the upper gastrointestinal tract in diabetes mellitus type-1.

    abstract:AIM:To investigate that both the neuronal function of the contractile system and structural apparatus of the gastrointestinal tract are affected in patients with longstanding diabetes and auto mic neuropathy. METHODS:The evoked esophageal and duodenal contractile activity to standardized bag distension was assessed us...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i36.4881

    authors: Frokjaer JB,Andersen SD,Ejskjaer N,Funch-Jensen P,Drewes AM,Gregersen H

    更新日期:2007-09-28 00:00:00

  • Interferon-free regimens for the treatment of hepatitis C virus in liver transplant candidates or recipients.

    abstract::The goal of therapy in chronic hepatitis C virus (HCV) infection is sustained virological response (SVR) which reflects HCV eradication. Treatment against HCV has dramatically improved with the recent availability of direct-acting antivirals (DAAs) including sofosbuvir, simeprevir, daclatasvir, ledipasvir/sofosbuvir, ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i32.9526

    authors: Cholongitas E,Pipili C,Papatheodoridis G

    更新日期:2015-08-28 00:00:00

  • Effect of b value on monitoring therapeutic response by diffusion-weighted imaging.

    abstract:AIM:To explore the diffusion gradient b-factor that optimizes both apparent diffusion coefficient (ADC) measurement and contrast-to-noise (CNR) for assessing tumor response to transarterial chemoembolization (TACE) in a rabbit model. METHODS:Twelve New Zealand white rabbits bearing VX2 tumors in the liver were treated...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.5893

    authors: Jiang ZX,Peng WJ,Li WT,Tang F,Liu SY,Qu XD,Wang JH,Lu HF

    更新日期:2008-10-14 00:00:00

  • Expression of macrophage inflammatory protein-1alpha in Kupffer cells following liver ischemia or reperfusion injury in rats.

    abstract:AIM:To explore the expression of macrophage inflammatory protein-1alpha (MIP-1alpha) in Kupffer cells (KCs) following liver ischemia/reperfusion injury IRI in rats. METHODS:Forty male SD rats were divided randomly into five groups. A model of partial warm ischemia/reperfusion injury in the rat liver was established. K...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i24.3854

    authors: Ma W,Wang ZR,Shi L,Yuan Y

    更新日期:2006-06-28 00:00:00

  • Clinical usefulness of adherence to gastro-esophageal reflux disease guideline by Spanish gastroenterologists.

    abstract:AIM:To investigate usefulness of adherence to gastro-esophageal reflux disease (GERD) guideline established by the Spanish Association of Gastroenterology. METHODS:Prospective, observational and multicentre study of 301 patients with typical symptoms of GERD who should be managed in accordance with guidelines and were...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3748/wjg.v18.i35.4885

    authors: Mearin F,Ponce J,Ponce M,Balboa A,González MA,Zapardiel J

    更新日期:2012-09-21 00:00:00