Poorly differentiated endocrine carcinoma of the pancreas responded to gemcitabine: Case report.

Abstract:

:Poorly differentiated endocrine carcinoma (PDEC) of the pancreas is a rare and aggressive tumor. First-line treatment is commonly a combination of etoposide and cisplatin, but there is no consensus regarding further treatment recommendations. In this report, we describe a case of pancreatic PDEC treated with gemcitabine as third-line chemotherapy. A 62-year-old man with pancreatic PDEC was administered etoposide plus cisplatin as first-line treatment; he then received irinotecan for tumor relapse. However, because irinotecan induced ileus in this patient, we chose gemcitabine as third-line chemotherapy. After two cycles of gemcitabine (1000 mg/m(2) on days 1, 8 and 15 every 4 wk), a partial tumor response was noted by computed tomography (approximately 68% reduction in tumor size). Our patient survived for 15 mo after diagnosis. This is a rare case of unresectable pancreatic PDEC, which showed a partial response to gemcitabine after the failure of two other regimens. Gemcitabine could be an effective treatment option for pancreatic PDEC that is resistant to other treatments.

journal_name

World J Gastroenterol

authors

Nakazuru S,Yoshio T,Suemura S,Itoh M,Araki M,Yoshioka C,Ohta M,Sueyoshi Y,Ohta T,Hasegawa H,Morita K,Toyama T,Kuzushita N,Kodama Y,Mano M,Mita E

doi

10.3748/wjg.v16.i30.3853

subject

Has Abstract

pub_date

2010-08-14 00:00:00

pages

3853-6

issue

30

eissn

1007-9327

issn

2219-2840

journal_volume

16

pub_type

杂志文章
  • The spirit of Henry Norman Bethune and gastroenterology.

    abstract::Henry Norman Bethune was a physician and surgeon from Canada. He had a highly impressive medical career in Montreal but did his most important work in China where he cared for soldiers on the battlefield. He died in 1939 and was recognized as a hero, but only much later received recognition in Canada. He was a skilled...

    journal_title:World journal of gastroenterology

    pub_type: 传,历史文章,杂志文章

    doi:10.3748/wjg.14.174

    authors: Freeman HJ

    更新日期:2008-01-14 00:00:00

  • Pathological and therapeutic interactions between bacteriophages, microbes and the host in inflammatory bowel disease.

    abstract::The intestinal microbiome is a dynamic system of interactions between the host and its microbes. Under physiological conditions, a fine balance and mutually beneficial relationship is present. Disruption of this balance is a hallmark of inflammatory bowel disease (IBD). Whether an altered microbiome is the consequence...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i40.11321

    authors: Babickova J,Gardlik R

    更新日期:2015-10-28 00:00:00

  • Tumor growth inhibition effect of hIL-6 on colon cancer cells transfected with the target gene by retroviral vector.

    abstract::AIM:To observe the tumor inhibitory effects by transfecting IL-6 cDNA into colon cancer cell line HT-29 with retroviral vector pZIP cDNA.METHODS:Human IL-6 gene was reconstructed in retrovirus vector and transfected into incasing cells PA317 by lipofectamine mediated method, the clones of the cells transferred with hI...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v6.i1.89

    authors: Xiao B,Jing B,Zhang YL,Zhou DY,Zhang WD

    更新日期:2000-02-01 00:00:00

  • Primary hepatic choriocarcinoma in a 49-year-old man: report of a case.

    abstract::We report a case of hepatic choriocarcinoma in a man diagnosed at autopsy after a rapid downhill clinical course. The patient was a 49-year-old man who presented with acute right-sided abdominal pain. There were no masses palpable on physical examination. Radiographic findings showed large multi-nodular tumors mainly ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i48.9485

    authors: Sekine R,Hyodo M,Kojima M,Meguro Y,Suzuki A,Yokoyama T,Lefor AT,Hirota N

    更新日期:2013-12-28 00:00:00

  • Hepatitis elimination by 2030: Progress and challenges.

    abstract::Globally, over 300 million people are living with viral hepatitis with approximately 1.3 million deaths per year. In 2016, World Health Assembly adopted the Global Health Sector Strategy on viral hepatitis to eliminate hepatitis by 2030. Different World Health Organization member countries are working on hepatitis con...

    journal_title:World journal of gastroenterology

    pub_type: 社论

    doi:10.3748/wjg.v24.i44.4959

    authors: Waheed Y,Siddiq M,Jamil Z,Najmi MH

    更新日期:2018-11-28 00:00:00

  • Bronchial bleeding caused by recurrent pneumonia after radical esophagectomy for esophageal cancer.

    abstract::We herein report a case of bronchial bleeding after radical esophagectomy that was treated with lobectomy. A 65-year-old male who underwent subtotal esophagectomy with three-field lymph node dissection for esophageal carcinoma was referred to our hospital because of sudden hemoptysis. After the esophagectomy, bilatera...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i11.3394

    authors: Kitajima T,Momose K,Lee S,Haruta S,Ueno M,Shinohara H,Fujimori S,Fujii T,Takei R,Kohno T,Udagawa H

    更新日期:2015-03-21 00:00:00

  • Penicillium marneffei chylous ascites in acquired immune deficiency syndrome: a case report.

    abstract::Penicillium marneffei (P. marneffei) infection usually occurs with skin, bone marrow, lung or hepatic involvement. However, no cases of P. marneffei infection with chylous ascites have been reported thus far. In this report, we describe the first case of acquired immune deficiency syndrome (AIDS) which has been compli...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i37.5312

    authors: Shen YZ,Wang ZY,Lu HZ

    更新日期:2012-10-07 00:00:00

  • HBx activates FasL and mediates HepG2 cell apoptosis through MLK3-MKK7-JNKs signal module.

    abstract:AIM:To investigate the possible mechanism by which hepatitis B virus X protein (HBx) mediates apoptosis of HepG2 cells. METHODS:HBx expression vector pcDNA3.1-X was transfected into HepG2 cells to establish an HBx high-expression cellular model as pcDNA3.1-X transfected group. The pcDNA3.1-X and pSilencer3.1-shHBX (HB...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i13.1485

    authors: Tang RX,Kong FY,Fan BF,Liu XM,You HJ,Zhang P,Zheng KY

    更新日期:2012-04-07 00:00:00

  • Safety of Curcuma aromatica oil gelatin microspheres administered via hepatic artery.

    abstract:AIM:To evaluate the safety of Curcuma aromatica oil gelatin microspheres (CAO-GMS) infused via hepatic artery against primary liver cancer. METHODS:The safety of CAO-GMS was evaluated in view of its acute toxicity in rats, long-term toxicity in Beagle dogs and general pharmacology in rats and mongrel dogs. RESULTS:Th...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i18.2637

    authors: Deng SG,Wu ZF,Li WY,Yang ZG,Chang G,Meng FZ,Mo LL

    更新日期:2004-09-15 00:00:00

  • Incidence and predictors of upper gastrointestinal bleeding in patients receiving low-dose aspirin for secondary prevention of cardiovascular events in patients with coronary artery disease.

    abstract:AIM:The use of low-dose aspirin to prevent cardiovascular disease events is well established. However, the incidence and predictors of upper gastrointestinal bleeding (UGIB) with its use are unknown. We studied prospectively the incidence and outcome of peptic ulceration in low-dose aspirin users. METHODS:A total of 9...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i18.2923

    authors: Ng W,Wong WM,Chen WH,Tse HF,Lee PY,Lai KC,Li SW,Ng M,Lam KF,Cheng X,Lau CP

    更新日期:2006-05-14 00:00:00

  • Rockall score in predicting outcomes of elderly patients with acute upper gastrointestinal bleeding.

    abstract:AIM:To validate the clinical Rockall score in predicting outcomes (rebleeding, surgery and mortality) in elderly patients with acute upper gastrointestinal bleeding (AUGIB). METHODS:A retrospective analysis was undertaken in 341 patients admitted to the emergency room and Intensive Care Unit of Xuanwu Hospital of Capi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i22.3466

    authors: Wang CY,Qin J,Wang J,Sun CY,Cao T,Zhu DD

    更新日期:2013-06-14 00:00:00

  • Role of stress-activated MAP kinase P38 in cisplatin- and DTT-induced apoptosis of the esophageal carcinoma cell line Eca109.

    abstract:AIM:To study the role of P38 kinase in esophageal cancer cell apoptosis induced by genotoxin, cisplatin and the unfolded protein response (UPR) inducer, dithiothreitol (DTT). METHODS:Esophageal carcinoma cell line Eca109 was cultured in RPMI 1640 medium to 70% confluency and treated with either cisplatin, DTT, or cisp...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i29.4451

    authors: Zhang QX,Feng R,Zhang W,Ding Y,Yang JY,Liu GH

    更新日期:2005-08-07 00:00:00

  • Non-invasive biomarkers for monitoring the fibrogenic process in liver: a short survey.

    abstract::The clinical course of chronic liver diseases is significantly dependent on the progression rate and the extent of fibrosis, i.e. the non-structured replacement of necrotic parenchyma by extracellular matrix. Fibrogenesis, i.e. the development of fibrosis can be regarded as an unlimited wound healing process, which is...

    journal_title:World journal of gastroenterology

    pub_type: 社论

    doi:10.3748/wjg.15.2433

    authors: Gressner AM,Gao CF,Gressner OA

    更新日期:2009-05-28 00:00:00

  • Prevalence and characteristics of dyspepsia among college students in Zhejiang Province.

    abstract:AIM:To investigate the prevalence and characteristics of uninvestigated dyspepsia among college students in Zhejiang Province. METHODS:Young adult students attending undergraduate (within the 4-year program) and graduate (only first-year students) colleges in Zhejiang Province were recruited between November 2010 and ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i13.3649

    authors: Li M,Lu B,Chu L,Zhou H,Chen MY

    更新日期:2014-04-07 00:00:00

  • Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis.

    abstract:AIM:To investigate the diagnostic accuracy of acoustic radiation force impulse (ARFI) imaging as a noninvasive method for the assessment of liver fibrosis in chronic hepatitis C (CHC) patients. METHODS:We performed a prospective blind comparison of ARFI elastography, APRI index and FibroMax in a consecutive series of ...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.15.5525

    authors: Fierbinteanu-Braticevici C,Andronescu D,Usvat R,Cretoiu D,Baicus C,Marinoschi G

    更新日期:2009-11-28 00:00:00

  • Coexistence of Helicobacter pylori spiral and coccoid forms in experimental mice.

    abstract::AIM:To infect mice with Helicobacter pylori and detect immune response against two form of H. pylori.METHODS:An isolate of H. pylori obtained from a patient with gastric cancer was used to infect mice. Fifty mice were divided into eight groups. Two groups served as negative control without any inoculation and internal...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v4.i6.485

    authors: Hua JS,Bow H,Zheng PY,Yeoh GK,Ng CH,Lim GS

    更新日期:1998-12-01 00:00:00

  • Dihydromyricetin-mediated inhibition of the Notch1 pathway induces apoptosis in QGY7701 and HepG2 hepatoma cells.

    abstract:AIM:To investigate whether Dihydromyricetin (DHM) inhibits cell proliferation and promotes apoptosis by downregulating Notch1 expression. METHODS:The correlation between Notch1 and Hes1 (a Notch1 target molecule) expression in hepatoma samples was confirmed by qRT-PCR. In addition, MTT assays, flow cytometry and TUNEL...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i34.6242

    authors: Lu CJ,He YF,Yuan WZ,Xiang LJ,Zhang J,Liang YR,Duan J,He YH,Li MY

    更新日期:2017-09-14 00:00:00

  • Investigation of HGV and TTV infection in sera and saliva from non-hepatitis patients with oral diseases.

    abstract:AIM:To determine the frequencies of HGV and TTV infections in serum and saliva samples of non-hepatitis patients with oral diseases in Hangzhou area, and to understand the correlation between detected results of HGV RNA and/or TTV DNA in sera and in saliva from the same patients. METHODS:RT-nested PCR for HGV RNA dete...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v8.i5.857

    authors: Yan J,Chen LL,Lou YL,Zhong XZ

    更新日期:2002-10-01 00:00:00

  • Vascular tumors and malformations of the colon.

    abstract::The term "hemangioma" refers to the common tumor of infancy that exhibits rapid postnatal growth and slow regression during childhood. It may cause confusion with venous malformations that are often incorrectly called "cavernous hemangioma". Venous malformations comprise abnormally formed channels that are lined by qu...

    journal_title:World journal of gastroenterology

    pub_type: 评论,信件

    doi:10.3748/wjg.15.5242

    authors: Fernandez-Pineda I

    更新日期:2009-11-07 00:00:00

  • TIP30 regulates apoptosis-related genes in its apoptotic signal transduction pathway.

    abstract:AIM:To investigate the role of TIP30 in apoptotic signal pathway in hepatoblastoma cells and to provide a basis for TIP30 as a gene therapy candidate in the regression of hepatoblastoma cells. METHODS:Apoptosis of human hepatoblastoma cell lines HepG2 (p53 wild), Hep3B (p53 null) and PLC/RPF/5 (p53 mutant) infected wi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i2.221

    authors: Shi M,Zhang X,Wang P,Zhang HW,Zhang BH,Wu MC

    更新日期:2005-01-14 00:00:00

  • Efficacy, effectiveness, immunogenicity--are not the same in vaccinology.

    abstract::Manuscript of Carrera et al is devoted to immunization in inflammatory bowel disease (IBD) that is very important issue in gastroenterology. However, some specific definitions used in the article need clarification. Efficacy of vaccine is measured in a randomised, placebo-controlled studies, that are expensive and dif...

    journal_title:World journal of gastroenterology

    pub_type: 评论,信件

    doi:10.3748/wjg.v19.i41.7217

    authors: Banaszkiewicz A,Radzikowski A

    更新日期:2013-11-07 00:00:00

  • Endoscopic management of intragastric penetrated adjustable gastric band for morbid obesity.

    abstract::This report describes a case of successful endoscopic management of intragastric penetrated adjustable gastric band in a patient with morbid obesity. The favorable course of the case described here demonstrates that adjustable gastric bands in the process of migration need not be removed surgically in patients who are...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i25.4098

    authors: De Palma GD,Formato A,Pilone V,Rega M,Giuliano ME,Simeoli I,Forestieri P

    更新日期:2006-07-07 00:00:00

  • Decreased expression of miR-133a correlates with poor prognosis in colorectal cancer patients.

    abstract:AIM:To investigate microRNA-133a (miR-133a) expression in colorectal cancer (CRC) and its relationship with tumorigenesis and disease prognosis. METHODS:Quantitative real-time polymerase chain reaction was used to measure levels of miR-133a in tumor samples and adjacent non-cancerous tissues from 169 patients undergoi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i32.11340

    authors: Wang LL,Du LT,Li J,Liu YM,Qu AL,Yang YM,Zhang X,Zheng GX,Wang CX

    更新日期:2014-08-28 00:00:00

  • Probiotic monotherapy and Helicobacter pylori eradication: A systematic review with pooled-data analysis.

    abstract:AIM:To define probiotic monotherapy effect on Helicobacter pylori (H. pylori) status by performing a systematic review. METHODS:Methods of analysis and inclusion criteria were based on PRISMA recommendations. Relevant publications were identified by searching PubMed, MEDLINE, Science Direct, and EMBASE. The end-point ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v24.i1.139

    authors: Losurdo G,Cubisino R,Barone M,Principi M,Leandro G,Ierardi E,Di Leo A

    更新日期:2018-01-07 00:00:00

  • Lack of correlation between Treg quantification assays in inflammatory bowel disease patients.

    abstract:AIM:To compare the number of regulatory T-cells (Tregs) measured by flow cytometry with those obtained using a real-time quantitative PCR (qPCR) method in patients suffering from inflammatory bowel disease (IBD). METHODS:Tregs percentages obtained by both flow cytometry and qPCR methods in 35 adult IBD patients, 18 ou...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i11.3325

    authors: Brandhorst G,Petrova DT,Weigand S,Eberle C,von Ahsen N,Schmitz J,Schultze FC,Raddatz D,Karaus M,Oellerich M,Walson PD

    更新日期:2015-03-21 00:00:00

  • Diet and microbiota in inflammatory bowel disease: The gut in disharmony.

    abstract::Bacterial colonization of the gut shapes both the local and the systemic immune response and is implicated in the modulation of immunity in both healthy and disease states. Recently, quantitative and qualitative changes in the composition of the gut microbiota have been detected in Crohn's disease and ulcerative colit...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v23.i12.2124

    authors: Rapozo DC,Bernardazzi C,de Souza HS

    更新日期:2017-03-28 00:00:00

  • Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?

    abstract::Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma (HCC) since 2007 and numerous studies have investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v24.i36.4152

    authors: Marisi G,Cucchetti A,Ulivi P,Canale M,Cabibbo G,Solaini L,Foschi FG,De Matteis S,Ercolani G,Valgiusti M,Frassineti GL,Scartozzi M,Casadei Gardini A

    更新日期:2018-09-28 00:00:00

  • Split-dose bowel preparation improves adequacy of bowel preparation and gastroenterologists' adherence to National Colorectal Cancer Screening and Surveillance Guidelines.

    abstract:AIM:To quantify the impact of split-dose regimen on endoscopists' compliance with guideline recommendations for timing of repeat colonoscopy in patients with normal colonoscopy or 1-2 small polyps (< 10 mm). METHODS:A retrospective chart review of all endoscopy reports was undertaken in average-risk individuals > 50 y...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v24.i6.716

    authors: Menees SB,Kim HM,Schoenfeld P

    更新日期:2018-02-14 00:00:00

  • Xenobiotics and loss of tolerance in primary biliary cholangitis.

    abstract::Data from genome wide association studies and geoepidemiological studies established that a combination of genetic predisposition and environmental stimulation is required for the loss of tolerance in primary biliary cholangitis (PBC). The serologic hallmark of PBC are the presence of high titer anti-mitochondrial aut...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i1.338

    authors: Wang J,Yang G,Dubrovsky AM,Choi J,Leung PS

    更新日期:2016-01-07 00:00:00

  • Association of erectile dysfunction with depression in patients with chronic viral hepatitis.

    abstract:AIM:To investigate the prevalence of erectile dysfunction (ED) and its association with depression in patients with chronic viral hepatitis. METHODS:This single center cross-sectional study was conducted from August 2013 through January 2014. All outpatients with chronic viral hepatitis in our liver clinic between 18 ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i18.5641

    authors: Ma BO,Shim SG,Yang HJ

    更新日期:2015-05-14 00:00:00