Importance of performance status for treatment outcome in advanced pancreatic cancer.

abstract：AIM:To evaluate the effect of long-term treatment with leukocyte natural α-interferon (ln-α-IFN) plus ribavirin (RBV). METHODS:Forty-six patients with hepatitis C virus (HCV) recurrence received 3 MU three times a week of ln-α-IFN plus RBV for 1 mo; then, patients with good tolerability (n = 30) were switched to daily...

journal_title：World journal of gastroenterology

authors： Tamè M,Buonfiglioli F,Del Gaudio M,Lisotti A,Cecinato P,Colecchia A,Azzaroli F,D'Errico A,Arena R,Calvanese C,Quarneti C,Ballardini G,Pinna AD,Mazzella G

更新日期：2013-08-28 00:00:00

abstract：AIM:To investigate the anti-tumor effects of combined cytotoxic drug (gemcitabine) and photodynamic therapy (PDT) on human pancreatic cancer xenograft in nude mice. METHODS:Human pancreatic cancer cell line SW1990 was used in the investigation of the in vivo effect of combined gemcitabine and PDT on human pancreatic c...

journal_title：World journal of gastroenterology

authors： Xie Q,Jia L,Liu YH,Wei CG

更新日期：2009-02-14 00:00:00

abstract：:Endoscopic ultrasound (EUS)-guided biliary drainage is accepted as a less invasive, alternative treatment for patients in whom endoscopic retrograde cholangiopancreatography has failed. Most patients with malignant hilar obstruction undergo EUS-guided hepaticogastrostomy. The authors present the case of a 77-year-old ...

journal_title：World journal of gastroenterology

authors： Prachayakul V,Aswakul P

更新日期：2015-09-14 00:00:00

abstract：AIM:To study the association between hilar cholangiocarcinoma (HC) and pre-existing medical conditions. METHODS:Three hundred and thirteen HC patients admitted to the Eastern Hepatobiliary Surgery Hospital (Shanghai, China) in 2000-2005 and 608 healthy controls were enrolled in this study. Association between HC and p...

journal_title：World journal of gastroenterology

authors： Cai WK,Sima H,Chen BD,Yang GS

更新日期：2011-01-14 00:00:00

abstract：AIM:To establish a model for prognosis assessment of extranodal follicular dendritic cell (FDC) sarcoma. METHODS:Nine lesions were examined by routine and molecular approaches. Clinicopathological factors from the new cases and 97 reported cases were analyzed for their prognostic values. RESULTS:The current lesions w...

journal_title：World journal of gastroenterology

authors： Li L,Shi YH,Guo ZJ,Qiu T,Guo L,Yang HY,Zhang X,Zhao XM,Su Q

更新日期：2010-05-28 00:00:00

abstract：AIM:To evaluate attenuating properties of N-acetylcysteine (NAC) on oxidative stress and liver pathology in rats with non-alcoholic steatohepatitis (NASH). METHODS:Male Sprague-Dawley rats were randomly divided into three groups. Group 1 (control, n=8) was free accessed to regular dry rat chow (RC) for 6 wk. Group 2 (...

journal_title：World journal of gastroenterology

authors： Thong-Ngam D,Samuhasaneeto S,Kulaputana O,Klaikeaw N

更新日期：2007-10-14 00:00:00

abstract：AIM:To investigate the effects of guggulsterone on the proliferation and apoptosis of human hepatoma HepG2 cells in vitro and relevant mechanisms. METHODS:Human hepatocellular carcinoma HepG2 cells and normal human liver L-02 cells were treated with different concentrations of guggulsterone (5-100 μmol/L) for 24-72 h....

journal_title：World journal of gastroenterology

authors： Shi JJ,Jia XL,Li M,Yang N,Li YP,Zhang X,Gao N,Dang SS

更新日期：2015-12-21 00:00:00

abstract：AIM:To investigate the therapeutic efficacy and complications of splenectomy with endoscopic variceal ligation (EVL) and splenectomy with pericardial devascularization (i.e. Hassab's operation) in patients with portal hypertension. METHODS:A total of 103 patients with liver cirrhosis and portal hypertension were rando...

journal_title：World journal of gastroenterology

authors： Lin N,Liu B,Xu RY,Fang HP,Deng MH

更新日期：2006-12-07 00:00:00

abstract：AIM:To investigate the influence of remote ischemic preconditioning (RIPC) on anastomotic integrity. METHODS:Sixty male Wistar rats were randomized to six groups. The control group (n = 10) had an end-to-end ileal anastomosis without RIPC. The preconditioned groups (n = 34) varied in time of ischemia and time of reper...

journal_title：World journal of gastroenterology

authors： Holzner PA,Kulemann B,Kuesters S,Timme S,Hoeppner J,Hopt UT,Marjanovic G

更新日期：2011-03-14 00:00:00

abstract：AIM:To determine whether the expression profiles of EphB receptor and ephrin-B ligand can be used as markers for dysplastic/oncogenic transformation in gastric mucosa. METHODS:The protein expression and localization of EphB and ephrin-B in normal, ulcerated regenerating, and dysplastic gastric mucosa were examined in ...

journal_title：World journal of gastroenterology

authors： Uchiyama S,Saeki N,Ogawa K

更新日期：2015-01-14 00:00:00

abstract：AIM:To construct pcDNA3.1-Egr.1p-p16 recombinant plasmid and investigate the expression of p16 in pancreatic cancer JF305 cells induced by radiation and the feasibility of gene radiotherapy for pancreatic carcinoma. METHODS:Human p16 cDNA was ligated to the downstream of Egr-1 promotor to construct pcDNA3.1-Egr.1p-p16...

journal_title：World journal of gastroenterology

authors： Ma HB,Wang XJ,Di ZL,Xia H,Li Z,Liu J,Ma J,Kang HF,Wu CM,Bai MH

更新日期：2007-08-21 00:00:00

abstract：:Hepatitis B virus (HBV) and hepatitis C virus (HCV) share common mode of transmission and both are able to induce a chronic infection. Dual HBV/HCV chronic coinfection is a fairly frequent occurrence, especially in high endemic areas and among individuals at high risk of parenterally transmitted infections. The intrac...

journal_title：World journal of gastroenterology

authors： Caccamo G,Saffioti F,Raimondo G

更新日期：2014-10-28 00:00:00

abstract：AIM:To characterize the expression and dynamic changes of bone morphogenetic protein (BMP)-2 in hepatocytes in the regenerating liver in rats after partial hepatectomy (PH), and examine the effects of BMP-2 on proliferation of human Huh7 hepatoma cells. METHODS:Fifty-four adult male Wistar rats were randomly divided i...

journal_title：World journal of gastroenterology

authors： Xu CP,Ji WM,van den Brink GR,Peppelenbosch MP

更新日期：2006-12-21 00:00:00

abstract：:Neurofibromas of the large bowel are very rare and usually are part of the colonic involvement in neurofibromatosis type 1 (Nf1, von Recklinghausen's disease). Solitary neurofibromas of the colon are extremely rare. We describe a case of an isolated neurofibroma that was found in the large bowel of a patient who suffe...

journal_title：World journal of gastroenterology

authors： Panteris V,Vassilakaki T,Vaitsis N,Elemenoglou I,Mylonakou I,Karamanolis DG

更新日期：2005-09-21 00:00:00

abstract：AIM:To assess the usefulness of contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) for lymph node metastasis in pancreatobiliary carcinoma. METHODS:All patients suspected of pancreatobiliary carcinoma with visible lymph nodes after standard EUS between June, 2009 and January, 2012 were enrolled. In the pri...

journal_title：World journal of gastroenterology

authors： Miyata T,Kitano M,Omoto S,Kadosaka K,Kamata K,Imai H,Sakamoto H,Nisida N,Harwani Y,Murakami T,Takeyama Y,Chiba Y,Kudo M

更新日期：2016-03-28 00:00:00

abstract：AIM:To better understand the clinical significance of hepatitis B serologic markers in babies born to hepatitis B surface antigen (HBsAg) positive mothers, the incidence of maternal serologic markers of hepatitis B via placenta and its transformation in these babies were investigated. METHODS:Mothers with positive HBs...

journal_title：World journal of gastroenterology

authors： Wang JS,Chen H,Zhu QR

更新日期：2005-06-21 00:00:00

abstract：AIM:To assess the etiology of chronic liver diseases (CLD) from 1998 to 2014 at the outpatient clinic of Gastroenterology of the main hospital in Northwest of Italy among those dedicated to hepatology. METHODS:A random sample of charts of patients referred to for increased liver enzymes between January 1998 and Decemb...

journal_title：World journal of gastroenterology

authors： Saracco GM,Evangelista A,Fagoonee S,Ciccone G,Bugianesi E,Caviglia GP,Abate ML,Rizzetto M,Pellicano R,Smedile A

更新日期：2016-09-28 00:00:00

abstract：AIM:To investigate Fusobacterium nucleatum (F. nucleatum) abundance in colorectal cancer (CRC) tissues and its association with CRC invasiveness in Chinese patients. METHODS:The resected cancer and adjacent normal tissues (10 cm beyond cancer margins) from 101 consecutive patients with CRC were collected. Fluorescent ...

journal_title：World journal of gastroenterology

authors： Li YY,Ge QX,Cao J,Zhou YJ,Du YL,Shen B,Wan YJ,Nie YQ

更新日期：2016-03-21 00:00:00

abstract：AIM:To elucidate high mobility group-box 3 (HMGB3) protein expression in gastric adenocarcinoma, its potential prognostic relevance, and possible mechanism of action. METHODS:Ninety-two patients with gastric adenocarcinomas surgically removed entered the study. HMGB3 expression was determined by immunohistochemistry t...

journal_title：World journal of gastroenterology

authors： Tang HR,Luo XQ,Xu G,Wang Y,Feng ZJ,Xu H,Shi YW,Zhang Q,Wu LG,Xue CQ,Wang CW,Wu CY

更新日期：2012-12-28 00:00:00

abstract：:The liver is one of the most important organs in the body, performing a fundamental role in the regulation of diverse processes, among which the metabolism, secretion, storage, and detoxification of endogenous and exogenous substances are prominent. Due to these functions, hepatic diseases continue to be among the mai...

journal_title：World journal of gastroenterology

authors： Madrigal-Santillán E,Madrigal-Bujaidar E,Álvarez-González I,Sumaya-Martínez MT,Gutiérrez-Salinas J,Bautista M,Morales-González Á,García-Luna y González-Rubio M,Aguilar-Faisal JL,Morales-González JA

更新日期：2014-10-28 00:00:00

abstract：:Hepatic sinusoidal obstruction syndrome (HSOS) can be caused by the intake of pyrrolizidine alkaloids (PAs). To date, PAs-induced HSOS has not been extensively studied. In view of the difference in etiology of HSOS between the West and China, clinical profiles, imaging findings, treatment, and outcomes of HSOS associa...

journal_title：World journal of gastroenterology

authors： Yang XQ,Ye J,Li X,Li Q,Song YH

更新日期：2019-07-28 00:00:00

abstract：:Patients with inflammatory bowel disease are known to have a high demand of recurrent evaluation for therapy and disease activity. Further, the risk of developing cancer during the disease progression is increasing from year to year. New, mostly non-radiant, quick to perform and quantitative methods are challenging, c...

journal_title：World journal of gastroenterology

authors： Knieling F,Waldner MJ

更新日期：2016-07-07 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDA) is one of the major causes for cancer death worldwide. Treatment of metastatic disease remains challenging as only certain patients benefit from advances made with the intensified chemotherapy regimen folinic acid, irinotecan and oxaliplatin, the epidermal growth factor receptor ...

journal_title：World journal of gastroenterology

authors： Kruger S,Haas M,Ormanns S,Bächmann S,Siveke JT,Kirchner T,Heinemann V,Boeck S

更新日期：2014-08-21 00:00:00

abstract：:The discovery of induced pluripotent stem cells (iPSCs) unraveled a mystery in stem cell research, after identification of four re-programming factors for generating pluripotent stem cells without the need of embryos. This breakthrough in generating iPSCs from somatic cells has overcome the ethical issues and immune r...

journal_title：World journal of gastroenterology

authors： Subba Rao M,Sasikala M,Nageshwar Reddy D

更新日期：2013-06-14 00:00:00

abstract：AIM:H101, an E1B 55 kD gene deleted adenovirus, has been shown to possess oncolysis activity experimentally and proved to be safe in preliminary phase I study. The current study was designed to evaluate its anti-tumor activity and toxicity in combination with chemotherapy in patients with late stage cancers. METHODS:H...

journal_title：World journal of gastroenterology

authors： Lu W,Zheng S,Li XF,Huang JJ,Zheng X,Li Z

更新日期：2004-12-15 00:00:00

abstract：AIM:To evaluate the effect of preoperative transcatheter arterial chemoembolization (TACE) on proliferation of hepatocellular carcinoma (HCC) cells. METHODS:A total of 136 patients with HCC underwent liver resection. Of 136 patients, 79 patients received 1 to 5 courses of TACE prior to liver resection (TACE group), wh...

journal_title：World journal of gastroenterology

authors： Xiao EH,Li JQ,Huang JF

更新日期：2007-09-07 00:00:00

abstract：AIM:To describe a method for the transjugular intrahepatic portal systemic shunt (TIPS) placement performed with the aid of contrast-enhanced computed tomography (CECT) and three-dimensional reconstructed vascular images (3D RVIs), and to assess its safety and effectiveness. METHODS:Four hundred and ninety patients we...

journal_title：World journal of gastroenterology

authors： Qin JP,Tang SH,Jiang MD,He QW,Chen HB,Yao X,Zeng WZ,Gu M

更新日期：2015-08-28 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the second most common cause of cancer death worldwide. It is broadly described that cyclooxygenase-2 (COX-2) is mainly overexpressed in CRC but less is known regarding post-translational modifications of this enzyme that may regulate its activity, intracellular localization and st...

journal_title：World journal of gastroenterology

authors： Prieto P,Jaén RI,Calle D,Gómez-Serrano M,Núñez E,Fernández-Velasco M,Martín-Sanz P,Alonso S,Vázquez J,Cerdán S,Peinado MÁ,Boscá L

更新日期：2019-01-28 00:00:00

abstract：:Irritable bowel syndrome (IBS) is a chronic condition affecting 3%-25% of the general population. As no curative treatment is available, therapy is aimed at reducing symptoms, often with little success. Because alteration of the normal intestinal microflora has been observed in IBS, probiotics (beneficial microbes tak...

journal_title：World journal of gastroenterology

authors： McFarland LV,Dublin S

更新日期：2008-05-07 00:00:00

abstract：AIM:To investigate the effect of synbiotics, i.e. probiotics and prebiotics mixture, on the gut microbial ecology and digestive enzyme activities in rats. METHODS:Forty-eight SD rats weighing about 280 g were used in this study. Rats were divided into three groups according to the contents of probiotics and prebiotics...

journal_title：World journal of gastroenterology

authors： Yang SC,Chen JY,Shang HF,Cheng TY,Tsou SC,Chen JR

更新日期：2005-12-21 00:00:00