Herbal hepatotoxicity: challenges and pitfalls of causality assessment methods.

abstract：AIM:To investigate the efficacy and safety of stellate ganglion block for the treatment of patients with chronic ulcerative colitis. METHODS:A total of 120 randomly selected patients with chronic ulcerative colitis treated in Cangzhou Central Hospital from January 2014 to January 2016 were included in this study. Thes...

journal_title：World journal of gastroenterology

authors： Zhao HY,Yang GT,Sun NN,Kong Y,Liu YF

更新日期：2017-01-21 00:00:00

abstract：AIM:To investigate the efficacy and safety of gemcitabine (Gem)-based combination chemotherapies for the treatment of advanced biliary tract cancer. METHODS:Clinical trials were identified by searching scientific literature databases (PubMed, EMBASE and the Cochrane Library) for studies published between 1975 and 2013...

journal_title：World journal of gastroenterology

authors： Liu H,Zhang QD,Li ZH,Zhang QQ,Lu LG

更新日期：2014-12-21 00:00:00

abstract：AIM:To detect linc00675 expression in pancreatic ductal adenocarcinoma (PDAC), to analyze the relationship between the expression level of linc00675 and the clinical pathological characteristics, to explore the biological functions of linc00675, and to determine whether linc00675 has independent prognostic value in PDA...

journal_title：World journal of gastroenterology

authors： Li DD,Fu ZQ,Lin Q,Zhou Y,Zhou QB,Li ZH,Tan LP,Chen RF,Liu YM

更新日期：2015-08-21 00:00:00

abstract：:Hepatitis B virus (HBV) infection is still the most common cause of hepatocellular carcinoma and liver cirrhosis world wide. Recently, however, there has been quite dramatic improvement in the understanding of HBV associated liver disease and its treatment. It has become clear that high viral replication is a major ri...

journal_title：World journal of gastroenterology

authors： Tillmann HL

更新日期：2007-01-07 00:00:00

abstract：AIM:To explore the contribution of AXIN1, AXIN2 and beta-catenin, components of Wnt signaling pathway, to the carcinogenesis of gastric cancer (GC), we examined AXIN1, AXIN2 exon7 and CTNNB1 (encoding beta-catenin) exon3 mutations in 70 GCs. METHODS:The presence of mutations was identified by polymerase chain reaction...

journal_title：World journal of gastroenterology

authors： Pan KF,Liu WG,Zhang L,You WC,Lu YY

更新日期：2008-03-14 00:00:00

abstract：AIM:To conduct a prospective assessment of anti-hepatitis E virus (HEV) IgG seroprevalence in the Western Cape Province of South Africa in conjunction with evaluating risk factors for exposure. METHODS:Consenting participants attending clinics and wards of Groote Schuur, Red Cross Children's Hospital and their affilia...

journal_title：World journal of gastroenterology

authors： Madden RG,Wallace S,Sonderup M,Korsman S,Chivese T,Gavine B,Edem A,Govender R,English N,Kaiyamo C,Lutchman O,van der Eijk AA,Pas SD,Webb GW,Palmer J,Goddard E,Wasserman S,Dalton HR,Spearman CW

更新日期：2016-11-28 00:00:00

abstract：:Despite substantial efforts at early diagnosis, accurate staging and advanced treatments, esophageal cancer (EC) continues to be an ominous disease worldwide. Risk factors for esophageal carcinomas include obesity, gastroesophageal reflux disease, hard-alcohol use and tobacco smoking. Five-year survival rates have imp...

journal_title：World journal of gastroenterology

authors： DaVee T,Ajani JA,Lee JH

更新日期：2017-02-07 00:00:00

abstract：AIM:To demonstrate the possible associations between genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2) and esophageal squamous cell dysplasia (ESCD). METHODS:All participants came from an area of high incidence of esophageal cancer and underwent an endoscopic staining examination; biopsies were taken from a no...

journal_title：World journal of gastroenterology

authors： Zhou YZ,Diao YT,Li H,Li HQ,Ma Q,Cui J

更新日期：2010-07-21 00:00:00

abstract：:Pancreatic cancer is associated with a poor prognosis, and surgical resection remains the only chance for curative therapy. In the absence of metastatic disease, which would preclude resection, assessment of vascular invasion is an important parameter for determining resectability of pancreatic cancer. A frequent erro...

journal_title：World journal of gastroenterology

authors： Buchs NC,Chilcott M,Poletti PA,Buhler LH,Morel P

更新日期：2010-02-21 00:00:00

abstract：:We herein report a case of bronchial bleeding after radical esophagectomy that was treated with lobectomy. A 65-year-old male who underwent subtotal esophagectomy with three-field lymph node dissection for esophageal carcinoma was referred to our hospital because of sudden hemoptysis. After the esophagectomy, bilatera...

journal_title：World journal of gastroenterology

authors： Kitajima T,Momose K,Lee S,Haruta S,Ueno M,Shinohara H,Fujimori S,Fujii T,Takei R,Kohno T,Udagawa H

更新日期：2015-03-21 00:00:00

abstract：:AIM:To study the anticarcinogenic effect and acute toxicity of liver targeting mitoxantrone nanospheres.METHODS:The anticarcinogenic effect of mitoxan-trone polybutylcyanoacrylate nanoparticles (DHAQ-PBCA-NP) was investigated by using heterotopic and orthotopic transplantation models of human hepatocellular carcinoma ...

journal_title：World journal of gastroenterology

authors： Zhang ZR,He Q,Liao GT,Bai SH

更新日期：1999-12-01 00:00:00

abstract：:The incidence of adenocarcinoma of the esophago-gastric junction is constantly increasing. Curative treatment is no longer possible at the time of diagnosis in more than 50% of patients with esophageal carcinoma, and palliative treatment focusing on eliminating dysphagia is required. Endoscopic therapy with stent impl...

journal_title：World journal of gastroenterology

authors： Aymaz S,Dormann AJ

更新日期：2008-06-28 00:00:00

abstract：:Ischemia/reperfusion (I/R) injury still represents an important cause of morbidity following hepatic surgery and limits the use of marginal livers in hepatic transplantation. Transient blood flow interruption followed by reperfusion protects tissues against damage induced by subsequent I/R. This process known as ische...

journal_title：World journal of gastroenterology

authors： Alchera E,Dal Ponte C,Imarisio C,Albano E,Carini R

更新日期：2010-12-28 00:00:00

abstract：:Tumor immunity proceeds through multiple processes, which consist of antigen presentation by antigen presenting cells (APCs) to educate effector cells and destruction by the effector cytotoxic cells. However, tumor immunity is frequently repressed at tumor sites. Malignantly transformed cells rarely survive the attack...

journal_title：World journal of gastroenterology

authors： Mukaida N,Nakamoto Y

更新日期：2018-05-07 00:00:00

abstract：:Hepatic encephalopathy (HE) is a neuropsychiatric complication of cirrhosis or acute liver failure. Currently, HE is regarded as a continuous cognitive impairment ranging from the mildest stage, minimal HE to overt HE. Hyperammonaemia and neuroinflammation are two main underlying factors which contribute to the neurol...

journal_title：World journal of gastroenterology

authors： Zhang XD,Zhang LJ,Wu SY,Lu GM

更新日期：2014-08-28 00:00:00

abstract：AIM:To discuss the rationality of extended radical resection (ERR) and to guide the surgical treatment of rectal cancer. METHODS:Total 211 patients who underwent ERR from 1981 to 1987 (follow-up rate of 94.8 %) were selected to study the patterns of lymphatic metastasis and therapeutic effect. The control group was ma...

journal_title：World journal of gastroenterology

authors： Dong XS,Xu HT,Yu ZW,Liu M,Cu BB,Zhao P,Wang XS

更新日期：2003-05-01 00:00:00

abstract：:A primary clear cell adenocarcinoma of the colon is a rare oncologic entity. We herein report a case of such a tumor of the sigmoid colon in a 71-year-old woman who was successfully treated by an endoscopic polypectomy in our hospital. We also reviewed the published reports regarding cases of primary clear cell tumors...

journal_title：World journal of gastroenterology

authors： Soga K,Konishi H,Tatsumi N,Konishi C,Nakano K,Wakabayashi N,Mitsufuji S,Kataoka K,Okanoue T,Mukaisho K,Hattori T

更新日期：2008-02-21 00:00:00

abstract：:Chronic radiation proctopathy occurs in 5%-20% of patients following pelvic radiotherapy. Although many cases resolve spontaneously, some lead to chronic symptoms including diarrhea, tenesmus, urgency and persistent rectal bleeding with iron deficiency anemia requiring blood transfusions. Treatments for chronic radiat...

journal_title：World journal of gastroenterology

authors： Rustagi T,Mashimo H

更新日期：2011-11-07 00:00:00

abstract：AIM:To examine the association between parity and gastric cancer (the cases are almost all premenopausal women) risk in a cohort of young parous women. METHODS:The study cohort consisted of all women with a record of a first and singleton childbirth in the Birth Register between 1978 and 1987. We tracked each woman fr...

journal_title：World journal of gastroenterology

authors： Chang CC,Chen CC,Chiu HF,Yang CY

更新日期：2011-02-14 00:00:00

abstract：AIM:To investigate the association between babA2 gene and peptic ulcer disease (PUD) and gastric cancer (GC) in Helicobacter pylori-infected populations. METHODS:We evaluated the relationship between babA2 and clinical outcomes (PUD and GC) using a meta-analysis. A literature search was performed using the PubMed and ...

journal_title：World journal of gastroenterology

authors： Chen MY,He CY,Meng X,Yuan Y

更新日期：2013-07-14 00:00:00

abstract：AIM:To assess the outcomes of ampulla dilation with different sized balloons to remove common bile duct (CBD) stones. METHODS:Patients (n = 208) were divided into five groups based on the largest CBD stone size of < 5, 6-8, 8-12, 12-14, and > 14 mm. Patients underwent limited endoscopic sphincterotomy (EST) alone or l...

journal_title：World journal of gastroenterology

authors： Li NP,Liu JQ,Zhou ZQ,Ji TY,Cai XY,Zhu QY

更新日期：2013-02-14 00:00:00

abstract：AIM:Several neural and hormonal factors are known to affect motility of sphincter of Oddi (SO). The major roles of SO are to regulate the flow of bile and pancreatic juice into the duodenum and to prevent the reflux of duodenal contents into the biliary and pancreatic duct. After pancreas transplantation, graft SO was ...

journal_title：World journal of gastroenterology

authors： Li GC,Yuan CH,Cheng Y,Liu YF

更新日期：2003-12-01 00:00:00

abstract：:Anorectal melanoma is a very rare tumor with poor prognosis. Rectal bleeding is the most frequent symptom and surgical treatment ranges from local excision to radical abdominoperineal resection. We report a case of a 75-years-old male patient who presented with a history of recurrent rectal bleeding, and whose histopa...

journal_title：World journal of gastroenterology

authors： Balicevic D,Tomic K,Bekavac-Beslin M,Kovacevic I,Mijic A,Belicza M,Kruslin B

更新日期：2006-06-07 00:00:00

abstract：AIM:To investigate the relationship between the polymorphism of class II transactivator (CIITA) gene promoters and chronic hepatitis B (CHB). METHODS:Genomic DNA was prepared from peripheral blood leukocytes. Promoters I, III and IV of gene were analyzed respectively with polymerase chain reaction single strand confor...

journal_title：World journal of gastroenterology

authors： Zhao YR,Gong L,He YL,Liu F,Lu C

更新日期：2005-02-14 00:00:00

abstract：AIM:To elucidate the relationship between apoptotic protease activating factor-1 (Apaf-1) gene and gastric cancer. METHODS:Thirty-five postoperative cancer and adjacent normal tissue samples were collected in the present study. Expression of the Apaf-1 gene in these samples was analyzed by semi-quantitative RT-PCR. Lo...

journal_title：World journal of gastroenterology

authors： Wang HL,Bai H,Li Y,Sun J,Wang XQ

更新日期：2007-10-14 00:00:00

abstract：AIM:To investigate control of two different types of massive presacral bleeding according to the anatomy of the presacral venous system. METHODS:A retrospective review was performed in 1628 patients with middle or low rectal carcinoma who were treated surgically in the Department of Colorectal Surgery, Changhai Hospit...

journal_title：World journal of gastroenterology

authors： Lou Z,Zhang W,Meng RG,Fu CG

更新日期：2013-07-07 00:00:00

abstract：AIM:To investigate the effect of epidural anaesthesia (EA) on pancreatic microcirculation during acute pancreatitis (AP). METHODS:AP was induced by injection of sodium taurocholate into the pancreatic duct of Sprague-Dawley rats. To realize EA, a catheter was introduced into the epidural space between T7 and T9 and bu...

journal_title：World journal of gastroenterology

authors： Demirag A,Pastor CM,Morel P,Jean-Christophe C,Sielenkämper AW,Güvener N,Mai G,Berney T,Frossard JL,Bühler LH

更新日期：2006-02-14 00:00:00

abstract：AIM:To evaluate the effects of ginger on gastric motility and emptying, abdominal symptoms, and hormones that influence motility in dyspepsia. METHODS:Eleven patients with functional dyspepsia were studied twice in a randomized double-blind manner. After an 8-h fast, the patients ingested three capsules that contained...

journal_title：World journal of gastroenterology

authors： Hu ML,Rayner CK,Wu KL,Chuah SK,Tai WC,Chou YP,Chiu YC,Chiu KW,Hu TH

更新日期：2011-01-07 00:00:00

abstract：AIM:To identify the incidence and etiology of anemia after gastrectomy in patients with long-term follow-up after gastrectomy for early gastric cancer. METHODS:The medical records of those patients with early gastric adenocarcinoma who underwent curative gastrectomy between January 2006 and October 2007 were reviewed....

journal_title：World journal of gastroenterology

authors： Lim CH,Kim SW,Kim WC,Kim JS,Cho YK,Park JM,Lee IS,Choi MG,Song KY,Jeon HM,Park CH

更新日期：2012-11-14 00:00:00

abstract：:Irritable bowel syndrome (IBS) is a chronic condition affecting 3%-25% of the general population. As no curative treatment is available, therapy is aimed at reducing symptoms, often with little success. Because alteration of the normal intestinal microflora has been observed in IBS, probiotics (beneficial microbes tak...

journal_title：World journal of gastroenterology

authors： McFarland LV,Dublin S

更新日期：2008-05-07 00:00:00