Study on the anticarcinogenic effect and acute toxicity of liver-targeting mitoxantrone nanoparticles.

abstract：AIM:To explore a safe and efficient strategy of tumor therapy using anti-angiogenetic agents. METHODS:Endostatin gene with a signal sequence of human IgGgamma chain was amplified by PCR and cloned into pVAX1 plasmid which was the only vector authorized by FDA in clinical trial to construct a recombinant plasmid named ...

journal_title：World journal of gastroenterology

authors： Ma CH,Zhang Y,Wang XY,Gao LF,Liu H,Guo C,Liu SX,Cao YL,Zhang LN,Sun WS

更新日期：2004-10-01 00:00:00

abstract：:Primary hepatic neuroendocrine tumor (PHNET) is an extremely rare liver tumor. Patients often have no clinical symptoms or have only non-specific symptoms, such as abdominal pain and abdominal mass. The clinical manifestations, disease development, treatment methods, and treatment outcomes of PHNET vary greatly among ...

journal_title：World journal of gastroenterology

authors： Meng XF,Pan YW,Wang ZB,Duan WD

更新日期：2018-06-28 00:00:00

abstract：AIM:To investigate the association of tumor necrosis factor alpha (TNFα) -G308A polymorphism with different liver pathological changes in treatment-naïve Egyptian patients infected with hepatitis C virus (HCV) genotype 4. METHODS:This study included 180 subjects, composed of 120 treatment-naïve chronic HCV patients wi...

journal_title：World journal of gastroenterology

authors： Bader El Din NG,Farouk S,El-Shenawy R,Ibrahim MK,Dawood RM,Elhady MM,Salem AM,Zayed N,Khairy A,El Awady MK

更新日期：2016-09-14 00:00:00

abstract：AIM:To investigate the effect of dermatan sulfate (DS) derivatives on platelet surface P-selectin expression and blood activated protein C (APC) activity in patients with inflammatory bowel disease (IBD), and to clarity the anti-inflammatory mechanism of DS derivatives. METHODS:Dermatan sulfate (DS) was sulfated with ...

journal_title：World journal of gastroenterology

authors： Ji SL,Du HY,Chi YQ,Cui HF,Cao JC,Geng MY,Guan HS

更新日期：2004-12-01 00:00:00

abstract：AIM:To investigate the effects of sodium alginate (AL-Na) on indomethacin-induced small intestinal lesions in rats. METHODS:Gastric injury was assessed by measuring ulcerated legions 4 h after indomethacin (25 mg/kg) administration. Small intestinal injury was assessed by measuring ulcerated legions 24 h after indomet...

journal_title：World journal of gastroenterology

authors： Yamamoto A,Itoh T,Nasu R,Nishida R

更新日期：2014-03-14 00:00:00

abstract：AIM:To objectively evaluate the effect of TJ-68 on colonic spasms during colonoscopy. METHODS:One hundred and one patients subjected to screening colonoscopy were randomly assigned to two groups: TJ-68 in 51 subjects and saline as the control in 50. The endoscope was inserted into the sigmoid colon, then a spastic reg...

journal_title：World journal of gastroenterology

authors： Ai M,Yamaguchi T,Odaka T,Mitsuhashi K,Shishido T,Yan J,Seza A,Saisho H

更新日期：2006-02-07 00:00:00

abstract：AIM:To retrospectively evaluate the vaccination-induced anti-HBs seroconversion rates in treatment-naive and treatment-experienced chronic hepatitis C (CHC) patients. Also to prospectively evaluate the seroconversion rates in CHC patients during pegylated interferon (PEG) plus ribavirin (RIB) treatment. METHODS:Sevent...

journal_title：World journal of gastroenterology

authors： Elefsiniotis IS,Vezali E,Kamposioras K,Pantazis KD,Tontorova R,Ketikoglou I,Moulakakis A,Saroglou G

更新日期：2006-07-21 00:00:00

abstract：AIM:To investigate the prevalence of celiac disease (CD) in adult patients referred to an open access gastroenterology clinic in the south of Italy and submitted to esophago-gastro-duodenoscopy (EGD) for evaluation of refractory functional dyspepsia. METHODS:Seven hundred and twenty six consecutive dyspeptic patients ...

journal_title：World journal of gastroenterology

authors： Giangreco E,D'agate C,Barbera C,Puzzo L,Aprile G,Naso P,Bonanno G,Russo FP,Nicoletti A,Incarbone S,Trama G,Russo A

更新日期：2008-12-07 00:00:00

abstract：AIM:To investigate the effectiveness of antioxidant compounds in modulating mitochondrial oxidative alterations and lipids accumulation in fatty hepatocytes. METHODS:Silybin-phospholipid complex containing vitamin E (Realsil(®)) was daily administered by gavage (one pouch diluted in 3 mL of water and containing 15 mg ...

journal_title：World journal of gastroenterology

authors： Grattagliano I,Diogo CV,Mastrodonato M,de Bari O,Persichella M,Wang DQ,Liquori A,Ferri D,Carratù MR,Oliveira PJ,Portincasa P

更新日期：2013-05-28 00:00:00

abstract：AIM:To investigate the association between adiponectin levels and risk of colorectal adenoma and cancer (early and advanced). METHODS:A cross-sectional study in a cohort of hospital-based patients was conducted between January 2004 and March 2006 at Yamagata University Hospital. Male subjects, who had colorectal tumor...

journal_title：World journal of gastroenterology

authors： Otake S,Takeda H,Fujishima S,Fukui T,Orii T,Sato T,Sasaki Y,Nishise S,Kawata S

更新日期：2010-03-14 00:00:00

abstract：AIM:To assess CT, MR manifestations and their diagnostic value in hepatic tuberculosis. METHODS:CT findings in 12 cases and MR findings in 4 cases of hepatic tuberculosis proved by surgery or biopsy were retrospectively analyzed. RESULTS:(1) CT findings: One case of serohepatic type of hepatic tuberculosis had multip...

journal_title：World journal of gastroenterology

authors： Yu RS,Zhang SZ,Wu JJ,Li RF

更新日期：2004-06-01 00:00:00

abstract：:Non celiac gluten sensitivity (NCGS) is a syndrome characterized by a cohort of symptoms related to the ingestion of gluten-containing food in subjects who are not affected by celiac disease (CD) or wheat allergy. The possibility of systemic manifestations in this condition has been suggested by some reports. In most ...

journal_title：World journal of gastroenterology

authors： Losurdo G,Principi M,Iannone A,Amoruso A,Ierardi E,Di Leo A,Barone M

更新日期：2018-04-14 00:00:00

abstract：AIM:To investigate the relationship between sense of coherence, psychological distress and health related quality of life in inflammatory bowel disease (IBD). METHODS:This cross-sectional study enrolled a consecutive sample of 147 IBD (aged 45.1 ± 14.1 years; 57.1% female) patients recruited from a tertiary gastroente...

journal_title：World journal of gastroenterology

authors： Freitas TH,Andreoulakis E,Alves GS,Miranda HL,Braga LL,Hyphantis T,Carvalho AF

更新日期：2015-06-07 00:00:00

abstract：AIM:To examine whether 2'-5'oligoadenylate synthetase (OAS) gene promoter can be specifically activated by hepatitis C virus (HCV)-core protein. METHODS:Human embryo hepatic cell line L02 was transfected with pcDNA3.1-core plasmid and selected by G418. Expression of HCV-core was detected by reverse transcription polym...

journal_title：World journal of gastroenterology

authors： Wang Y,Mao SS,He QQ,Zi Y,Wen JF,Feng DY

更新日期：2009-07-07 00:00:00

abstract：AIM:To investigate the proportion of patients with moderate-severe erosive esophagitis (EE) who will have Barrett's esophagus (BE) after healing of inflammation. METHODS:Patients with EE of Los Angeles (LA) class B, C and D who underwent follow-up endoscopy documenting complete mucosal healing. RESULTS:A total of 86/...

journal_title：World journal of gastroenterology

authors： Gilani N,Gerkin RD,Ramirez FC,Hakim S,Randolph AC

更新日期：2008-06-14 00:00:00

abstract：:Understanding the occurrence, development, and treatment of liver diseases is the main goal of hepatopathology research. Liver diseases are not only diverse but also highly heterogeneous among individuals. At present, research on liver diseases is conducted mainly through cell culture, animal models, pathological spec...

journal_title：World journal of gastroenterology

authors： Wu LJ,Chen ZY,Wang Y,Zhao JG,Xie XZ,Chen G

更新日期：2019-04-28 00:00:00

abstract：AIM:To evaluate the efficacy and safety of gemcitabine (GEM) plus radiotherapy compared with GEM alone for pancreatic cancer (PC). METHODS:A systematic search for eligible studies comparing gemcitabine plus radiotherapy with gemcitabine alone for PC was performed using MEDLINE, EMBASE, and the Cochrane Library. A qual...

journal_title：World journal of gastroenterology

authors： Zhang X,Huang HJ,Feng D,Yang DJ,Wang CM,Cai QP

更新日期：2014-12-14 00:00:00

abstract：AIM:To further investigate the role of human B7 homolog 1 (B7-H1) in the mechanism of persistent hepatitis B virus (HBV) infection. METHODS:Peripheral and intra-hepatic B7-H1 expression were compared by flow cytometry and immunochemical staining between two 2 distinct groups, one being chronic HBV tolerance patients (C...

journal_title：World journal of gastroenterology

authors： Zhang WJ,Xie HY,Duan X,Wan YL,Peng CH,Shi SH,Su R,Zheng ZH,Pan LL,Zhou L,Zheng SS

更新日期：2012-07-28 00:00:00

abstract：AIM:To investigate the non-Helicobacter pylori (H. pylori) bacterial flora concurrent with H. pylori infection. METHODS:A total of 103 gastric biopsy specimens from H. pylori positive patients were selected for bacterial culture. All the non-H. pylori bacterial isolates were identified by matrix-assisted laser desorpt...

journal_title：World journal of gastroenterology

authors： Hu Y,He LH,Xiao D,Liu GD,Gu YX,Tao XX,Zhang JZ

更新日期：2012-03-21 00:00:00

abstract：AIM:To evaluate the safety of lamivudine (LAM) treatment for chronic hepatitis B in early pregnancy. METHODS:A total of 92 pregnant women who received LAM treatment either before pregnancy or in early pregnancy were enrolled in this study. All of the pregnant women volunteered to take lamivudine during pregnancy and w...

journal_title：World journal of gastroenterology

authors： Yi W,Liu M,Cai HD

更新日期：2012-12-07 00:00:00

abstract：AIM:To identify factors associated with the age at onset of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). METHODS:Five hundred and fifty-six consecutive patients positive for HCV antibody and treatment-naïve HCC diagnosed between 1995 and 2004 were analyzed. Patients were classified into three groups...

journal_title：World journal of gastroenterology

authors： Akiyama T,Mizuta T,Kawazoe S,Eguchi Y,Kawaguchi Y,Takahashi H,Ozaki I,Fujimoto K

更新日期：2011-02-21 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common cancer worldwide and, despite improved treatments, is still an important cause of cancer-related deaths. CRC encompasses a complex of diseases arising from a multi-step process of genetic and epigenetic events. Besides heterogeneity in the molecular and biological featu...

journal_title：World journal of gastroenterology

authors： Bertorelle R,Rampazzo E,Pucciarelli S,Nitti D,De Rossi A

更新日期：2014-02-28 00:00:00

abstract：AIM:To review the cases reported in the literature, examined their clinicopathological features, and evaluated the efficacy of different therapeutic modalities for this rare condition. METHODS:A search of the MEDLINE database revealed 16 cases of pericarditis carcinomatosa (PC) originating from GC reported in the lite...

journal_title：World journal of gastroenterology

authors： Kobayashi M,Okabayashi T,Okamoto K,Namikawa T,Araki K

更新日期：2005-11-28 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) represents the fourth cause of death in cancer and has a 5-year survival of < 5%. Only about 15% of the patients present with a resectable PDAC with potential to undergo "curative" surgery. After surgery, local and systemic recurrence, is though very common. The median survival ...

journal_title：World journal of gastroenterology

authors： Ansari D,Gustafsson A,Andersson R

更新日期：2015-03-21 00:00:00

abstract：AIM:To detect significant clusters of co-expressed genes associated with tumorigenesis that might help to predict stomach adenocarcinoma (SA) prognosis. METHODS:The Cancer Genome Atlas database was used to obtain RNA sequences as well as complete clinical data of SA and adjacent normal tissues from patients. Weighted ...

journal_title：World journal of gastroenterology

authors： Zhang J,Wu Y,Jin HY,Guo S,Dong Z,Zheng ZC,Wang Y,Zhao Y

更新日期：2018-11-21 00:00:00

abstract：AIM:To analyze the association between Helicobacter spp. and some common gut bacteria in patients with cholecystitis. METHODS:A nested-polymerase chain reaction (PCR), specific to 16S rRNA of Helicobacter spp. was performed on paraffin-embedded gallbladder samples of 100 cholecystitis and 102 control cases. The sample...

journal_title：World journal of gastroenterology

authors： Karagin PH,Stenram U,Wadström T,Ljungh A

更新日期：2010-10-14 00:00:00

abstract：AIM:To investigate the relationship between pathological oropharyngeal (OP) acid exposure and esophageal motility in patients with extra-esophageal syndromes. METHODS:In this prospective study we enrolled consecutive outpatients with extra-esophageal symptoms suspected to be related to gastroesophageal reflux disease ...

journal_title：World journal of gastroenterology

authors： Passaretti S,Mazzoleni G,Vailati C,Testoni PA

更新日期：2016-10-28 00:00:00

abstract：AIM:To investigate the expression profiles of hsa-miR-29c and hsa-miR-135b in gastric mucosal samples and their values as gastric carcinogenesis biomarkers. METHODS:The expression levels of hsa-miR-29c and hsa-miR-135b in normal gastric mucosa, non-atrophic chronic gastritis, intestinal metaplasia and intestinal-type ...

journal_title：World journal of gastroenterology

authors： Vidal AF,Cruz AM,Magalhães L,Pereira AL,Anaissi AK,Alves NC,Albuquerque PJ,Burbano RM,Demachki S,Ribeiro-dos-Santos Â

更新日期：2016-02-14 00:00:00

abstract：AIM:To retrospectively analyze factors affecting the long-term survival of patients with pancreatic cancer who underwent pancreatic resection. METHODS:From January 2000 to December 2011, 195 patients underwent pancreatic resection in our hospital. The prognostic factors after pancreatic resection were analyzed in all ...

journal_title：World journal of gastroenterology

authors： Yamamoto T,Yagi S,Kinoshita H,Sakamoto Y,Okada K,Uryuhara K,Morimoto T,Kaihara S,Hosotani R

更新日期：2015-01-07 00:00:00

abstract：:According to the main international clinical guidelines, the recommended treatment for locally-advanced rectal cancer is neoadjuvant chemoradiotherapy followed by surgery. However, doubts have been raised about the appropriate definition of clinical complete response (cCR) after neoadjuvant therapy and the role of sur...

journal_title：World journal of gastroenterology

authors： López-Campos F,Martín-Martín M,Fornell-Pérez R,García-Pérez JC,Die-Trill J,Fuentes-Mateos R,López-Durán S,Domínguez-Rullán J,Ferreiro R,Riquelme-Oliveira A,Hervás-Morón A,Couñago F

更新日期：2020-08-07 00:00:00