Is concomitant radiotherapy necessary with gemcitabine-based chemotherapy in pancreatic cancer?

abstract：AIM:Various side effects have been reported in patients infected with hepatitis C virus (HCV) who were treated with interferon-alpha (IFN-alpha), including the appearance or exacerbation of underlying autoimmune diseases and the development of a variety of organ and non-organ specific autoantibodies (NOSA). However, ve...

journal_title：World journal of gastroenterology

authors： Gatselis NK,Georgiadou SP,Tassopoulos N,Zachou K,Liaskos C,Hatzakis A,Dalekos GN

更新日期：2005-01-28 00:00:00

abstract：AIM:To investigate the prevalence of gastroesophageal reflux disease (GERD) in patients with a laryngoscopic diagnosis of laryngopharyngeal reflux (LPR). METHODS:Between May 2011 and October 2011, 41 consecutive patients with laryngopharyngeal symptoms (LPS) and laryngoscopic diagnosis of LPR were empirically treated ...

journal_title：World journal of gastroenterology

authors： de Bortoli N,Nacci A,Savarino E,Martinucci I,Bellini M,Fattori B,Ceccarelli L,Costa F,Mumolo MG,Ricchiuti A,Savarino V,Berrettini S,Marchi S

更新日期：2012-08-28 00:00:00

abstract：AIM:To investigate the effect of regulatory peptides bombesin (BBS) and neurotensin (NT) on intestinal barrier function in partially hepatectomized rats. METHODS:Ninety male Wistar rats were randomly divided into five groups: I (n=0): controls, II (n= 20): sham operated, III (n=20): partial hepatectomy 70% (PHx), IV (...

journal_title：World journal of gastroenterology

authors： Assimakopoulos SF,Alexandris IH,Scopa CD,Mylonas PG,Thomopoulos KC,Georgiou CD,Nikolopoulou VN,Vagianos CE

更新日期：2005-11-21 00:00:00

abstract：AIM:To evaluate the prognostic power of different molecular data in liver cancer. METHODS:Cox regression screen and least absolute shrinkage and selection operator were performed to select significant prognostic variables. Then the concordance index was calculated to evaluate the prognostic power. For the combination ...

journal_title：World journal of gastroenterology

authors： Song YZ,Li X,Li W,Wang Z,Li K,Xie FL,Zhang F

更新日期：2018-07-28 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the 10 most common cancers worldwide. There is no ideal treatment for HCC yet and many researchers are trying to improve the effects of treatment by changing therapeutic strategies. As the majority of human cancers seem to exhibit either abnormal p53 gene or disrupted p53 gene ...

journal_title：World journal of gastroenterology

authors： Guan YS,La Z,Yang L,He Q,Li P

更新日期：2007-02-21 00:00:00

abstract：AIM:To determine whether efflux systems contribute to multidrug resistance of H pylori. METHODS:A chloramphenicol-induced multidrug resistance model of six susceptible H pylori strains (5 isolates and H pylori NCTC11637) was developed. Multidrug-resistant (MDR) strains were selected and the minimal inhibitory concentr...

journal_title：World journal of gastroenterology

authors： Liu ZQ,Zheng PY,Yang PC

更新日期：2008-09-07 00:00:00

abstract：AIM:To describe a three-dimensional model (3DM) to accurately reconstruct anatomic relationships of centrally located hepatocellular carcinomas (HCCs). METHODS:From March 2013 to July 2014, reconstructions and visual simulations of centrally located HCCs were performed in 39 patients using a 3D subject-based computed ...

journal_title：World journal of gastroenterology

authors： Tian F,Wu JX,Rong WQ,Wang LM,Wu F,Yu WB,An SL,Liu FQ,Feng L,Bi C,Liu YH

更新日期：2015-04-21 00:00:00

abstract：:In 2004, an association of genetic variation in the discs large homolog 5 (DLG5) gene with inflammatory bowel disease (IBD) was described in two large European study samples. The initial report of DLG5 as a novel IBD susceptibility gene sparked a multitude of studies investigating its effect on CD and IBD, respectivel...

journal_title：World journal of gastroenterology

authors： Friedrichs F,Stoll M

更新日期：2006-06-21 00:00:00

abstract：AIM:To search the pathophysiological mechanism of diarrhea based on daily stool weights, fecal electrolytes, osmotic gap and pH. METHODS:Seventy-six patients were included: 51 with microscopic colitis (MC) (40 with lymphocytic colitis (LC); 11 with collagenous colitis (CC)); 7 with MC without diarrhea and 18 as a cont...

journal_title：World journal of gastroenterology

authors： Protic M,Jojic N,Bojic D,Milutinovic S,Necic D,Bojic B,Svorcan P,Krstic M,Popovic O

更新日期：2005-09-21 00:00:00

abstract：AIM:To investigate mucin expression profiles in colorectal carcinoma (CRC) histological subtypes with regard to clinicopathologic variables and prognosis. METHODS:Mucin (MUC)2 and MUC5AC expressions were assessed by immunohistochemistry for a total of 250 CRC cases that underwent surgical resection. CRCs included 63 w...

journal_title：World journal of gastroenterology

authors： Imai Y,Yamagishi H,Fukuda K,Ono Y,Inoue T,Ueda Y

更新日期：2013-07-07 00:00:00

abstract：AIM:To improve the technique of tissue microarray (tissue chip). METHODS:A new tissue microarraying method was invented with a common microscope installed with a special holing needle, a sampling needle, and a special box fixing paraffin blocks on the microscope slide carrier. With the movement of microscope tube and ...

journal_title：World journal of gastroenterology

authors： Dan HL,Zhang YL,Zhang Y,Wang YD,Lai ZS,Yang YJ,Cui HH,Jian YT,Geng J,Ding YQ,Guo CH,Zhou DY

更新日期：2004-02-15 00:00:00

abstract：AIM:To investigate the effects of entero-hepatic bile acid circulation on the inter-digestive migrating myoelectrical complex (MMC) in rats. METHODS:Thirty-two rats were divided into four groups. Three pairs of bipolar silver electrodes were chronically implanted in the antrum, duodenum and jejunum. Three groups of th...

journal_title：World journal of gastroenterology

authors： Fang P,Dong L,Zhang WJ,Luo JY

更新日期：2005-09-14 00:00:00

abstract：:The chronic inflammatory process underlying inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, derives from the interplay of several components in a genetically susceptible host. These components include environmental elements and gut microbiota a dysbiosis. For decades, immune abnorm...

journal_title：World journal of gastroenterology

authors： Nanini HF,Bernardazzi C,Castro F,de Souza HSP

更新日期：2018-11-07 00:00:00

abstract：:The use of non-steroidal anti-inflammatory drugs (NSAIDs) is widespread worldwide thanks to their analgesic, anti-inflammatory and antipyretic effects. However, even more attention is placed upon the recurrence of digestive system complications in the course of their use. Recent data suggests that the complications of...

journal_title：World journal of gastroenterology

authors： Utzeri E,Usai P

更新日期：2017-06-14 00:00:00

abstract：:Colorectal adenocarcinoma (CRC) is the third most common type of cancer and the fourth most frequent cause of death due to cancer worldwide. Given the natural history of CRC, early diagnosis appears to be the most appropriate tool to reduce disease-related mortality. A field of recent interest is clinical proteomics, ...

journal_title：World journal of gastroenterology

authors： de Noo ME,Tollenaar RA,Deelder AM,Bouwman LH

更新日期：2006-11-07 00:00:00

abstract：:It is common practice to follow patients with colorectal cancer for some years after resection and/or adjuvant treatment. Data are lacking about how often patients should be seen, what tests should be performed, and what surveillance strategy has a significant impact on patient outcome. Seven randomized trials have ad...

journal_title：World journal of gastroenterology

authors： Rosati G

更新日期：2010-03-28 00:00:00

abstract：AIM:To evaluate virological response to adefovir (ADV) monotherapy and emergence of ADV-resistant mutations in lamivudine (LAM)-resistant chronic hepatitis B patients. METHODS:Seventy-seven patients with documented LAM resistance who were treated with 10 mg/d ADV for > 96 wk were analyzed for ADV resistance. RESULTS:...

journal_title：World journal of gastroenterology

authors： Sinn DH,Lee HIe,Gwak GY,Choi MS,Koh KC,Paik SW,Yoo BC,Lee JH

更新日期：2011-08-14 00:00:00

abstract：AIM:To investigate the biological effects of internal irradiation, and the therapeutic effectiveness was assessed of (131)I-labeled anti-epidermal growth factor receptor (EGFR) liposomes, derived from cetuximab, when used as a tumor-targeting carrier in a colorectal cancer mouse model. METHODS:We described the liposom...

journal_title：World journal of gastroenterology

authors： Li W,Ji YH,Li CX,Liu ZY,Li N,Fang L,Chang J,Tan J

更新日期：2016-04-14 00:00:00

abstract：AIM:To analyze the Hepatitis C virus (HCV) genotype distribution and transmission risk factors in a population of unselected patients in Luxembourg. METHODS:Epidemiological information (gender, age and transmission risks) were collected from 802 patients newly diagnosed for hepatitis C and living in Luxembourg, among ...

journal_title：World journal of gastroenterology

authors： Roman F,Hawotte K,Struck D,Ternes AM,Servais JY,Arendt V,Hoffman P,Hemmer R,Staub T,Seguin-Devaux C,Schmit JC

更新日期：2008-02-28 00:00:00

abstract：AIM:To evaluate whether alcohol dehydrogenase-1B (ADH1B) His47Arg and aldehyde dehydrogenase-2 (ALDH2) Glu487Lys polymorphism is involved in the esophageal squamous cell carcinoma (ESCC) risk in Chinese Han population. METHODS:Seven studies of ADH1B and ALDH2 genotypes in Chinese Han population in 1450 cases and 2459 ...

journal_title：World journal of gastroenterology

authors： Zhang GH,Mai RQ,Huang B

更新日期：2010-12-21 00:00:00

abstract：AIM:To examine whether 2'-5'oligoadenylate synthetase (OAS) gene promoter can be specifically activated by hepatitis C virus (HCV)-core protein. METHODS:Human embryo hepatic cell line L02 was transfected with pcDNA3.1-core plasmid and selected by G418. Expression of HCV-core was detected by reverse transcription polym...

journal_title：World journal of gastroenterology

authors： Wang Y,Mao SS,He QQ,Zi Y,Wen JF,Feng DY

更新日期：2009-07-07 00:00:00

abstract：:Dilatation of the colon and the rectum, which is not attributable to aganglionosis, is a rare finding and can be the result of intractable chronic constipation. We report a rare case of a 29-year-old male patient with impressive megacolon, in whom Hirschsprung's or Chagas disease was ruled out. In the present case, di...

journal_title：World journal of gastroenterology

authors： Mecklenburg I,Leibig M,Weber C,Schmidbauer S,Folwaczny C

更新日期：2005-12-28 00:00:00

abstract：:Exocrine pancreatic insufficiency caused by chronic pancreatitis results from various factors which regulate digestion and absorption of nutrients. Pancreatic function has been extensively studied over the last 40 years, even if some aspects of secretion and gastrointestinal adaptation are not completely understood. T...

journal_title：World journal of gastroenterology

authors： Pezzilli R

更新日期：2009-04-14 00:00:00

abstract：AIM:To investigate the effect of APOBEC3G mediated antiviral activity against hepatitis B virus (HBV) in cell cultures and replication competent HBV vector-based mouse model. METHODS:The mammalian hepatoma cells Huh7 and HepG2 were cotransfected with various amounts of CMV-driven expression vector encoding APOBEC3G an...

journal_title：World journal of gastroenterology

authors： Lei YC,Hao YH,Zhang ZM,Tian YJ,Wang BJ,Yang Y,Zhao XP,Lu MJ,Gong FL,Yang DL

更新日期：2006-07-28 00:00:00

abstract：AIM:To investigate the expression and clinical relevance of inhibitor of differentiation (ID) proteins in biliary tract cancer. METHODS:ID protein expression was analyzed in 129 samples from patients with advanced biliary tract cancer (BTC) (45 extrahepatic, 50 intrahepatic, and 34 gallbladder cancers), compared to no...

journal_title：World journal of gastroenterology

authors： Harder J,Müller MJ,Fuchs M,Gumpp V,Schmitt-Graeff A,Fischer R,Frank M,Opitz O,Hasskarl J

更新日期：2013-12-28 00:00:00

abstract：:Point-of-care (POC) tests enable rapid results and are well established in medical practice. Recent advances in analytical techniques have led to a new generation of POC devices that will alter gastrointestinal diagnostic pathways. This review aims to identify current and new technologies for the POC diagnosis of gast...

journal_title：World journal of gastroenterology

authors： Huddy JR,Ni MZ,Markar SR,Hanna GB

更新日期：2015-04-14 00:00:00

abstract：AIM:H101, an E1B 55 kD gene deleted adenovirus, has been shown to possess oncolysis activity experimentally and proved to be safe in preliminary phase I study. The current study was designed to evaluate its anti-tumor activity and toxicity in combination with chemotherapy in patients with late stage cancers. METHODS:H...

journal_title：World journal of gastroenterology

authors： Lu W,Zheng S,Li XF,Huang JJ,Zheng X,Li Z

更新日期：2004-12-15 00:00:00

abstract：:Foreign body ingestion is a common clinical problem in early childhood. However, it may occur even in adults, unknowingly. Most ingested foreign bodies entering the stomach pass through the gastrointestinal tract uneventfully. Here we report on a 13-year-old boy who presented with chronic abdominal pain, weight loss a...

journal_title：World journal of gastroenterology

authors： Müller KE,Arató A,Lakatos PL,Papp M,Veres G

更新日期：2013-06-28 00:00:00

abstract：:Many epidemiological reports indicate that Helicobacter pylori (H pylori) infection plays an important role in gastric carcinogenesis. Several genetic and epigenetic alterations contribute to the initiation, promotion, and progression of the cancer cells in a multi-step manner. H pylori is known to induce chronic infl...

journal_title：World journal of gastroenterology

authors： Ito M,Tanaka S,Kamada T,Haruma K,Chayama K

更新日期：2006-01-07 00:00:00

abstract：AIM:To evaluate the influence of multiple samplings during esophagogastroduodenoscopy (EGD) on the accuracy of the rapid urease test, and the validity of newly developed rapid urease tests, HelicotecUT plus test and HelicotecUT test, CLO test and ProntoDry test. METHODS:A total of 355 patients undergoing EGD for dyspe...

journal_title：World journal of gastroenterology

authors： Hsu WH,Wang SS,Kuo CH,Chen CY,Chang CW,Hu HM,Wang JY,Yang YC,Lin YC,Wang WM,Wu DC,Wu MT,Kuo FC

更新日期：2010-06-21 00:00:00