Abstract:
AIM:To evaluate whether alcohol dehydrogenase-1B (ADH1B) His47Arg and aldehyde dehydrogenase-2 (ALDH2) Glu487Lys polymorphism is involved in the esophageal squamous cell carcinoma (ESCC) risk in Chinese Han population. METHODS:Seven studies of ADH1B and ALDH2 genotypes in Chinese Han population in 1450 cases and 2459 controls were included for meta-analysis. Stratified analyses were carried out to determine the gene-alcohol and gene-gene interaction with ESCC risk. Potential sources of heterogeneity between studies were explored, and publication bias was also evaluated. RESULTS:Individuals with ADH1B arginine (Arg)/Arg genotype showed 3.95-fold increased ESCC risk in the recessive genetic model [Arg/Arg vs Arg/histidine (His) + His/His: odds ratio (OR) = 3.95, 95% confidence interval (CI): 2.76-5.67]. Significant association was found in the dominant model for ALDH2 lysine (Lys) allele [glutamate (Glu)/Lys + Lys/Lys vs Glu/Glu: OR = 2.00, 95% CI: 1.54-2.61]. Compared with the non-alcoholics, Arg/Arg (OR = 25.20, 95% CI: 10.87-53.44) and Glu/Lys + Lys/Lys (OR = 21.47, 95% CI: 6.44-71.59) were found to interact with alcohol drinking to increase the ESCC risk. ADH1B Arg+ and ALDH2 Lys+ had a higher risk for ESCC (OR = 7.09, 95% CI: 2.16-23.33). CONCLUSION:The genetic variations of ADH1B His47Arg and ALDH2 Glu487Lys are susceptible loci for ESCC in Chinese Han population and interact substantially with alcohol consumption. The individuals carrying both risky genotypes have a higher baseline risk of ESCC.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Zhang GH,Mai RQ,Huang Bdoi
10.3748/wjg.v16.i47.6020subject
Has Abstractpub_date
2010-12-21 00:00:00pages
6020-5issue
47eissn
1007-9327issn
2219-2840journal_volume
16pub_type
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journal_title:World journal of gastroenterology
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pub_type: 杂志文章
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更新日期:2005-12-14 00:00:00
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pub_type: 杂志文章
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journal_title:World journal of gastroenterology
pub_type: 社论,评审
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更新日期:2006-09-21 00:00:00
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pub_type: 杂志文章
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更新日期:2017-03-07 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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更新日期:2020-04-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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更新日期:2003-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-09-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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更新日期:2004-12-01 00:00:00