Management of hepatocellular carcinoma with portal vein thrombosis.

Abstract:

:Management of hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT) is complex and requires an understanding of multiple therapeutic options. PVT is present in 10%-40% of HCC at the time of diagnosis, and is an adverse prognostic factor. Management options are limited, as transplantation is generally contraindicated, and surgical resection is only rarely performed in select centers. Systemic medical therapy with sorafenib has been shown to modestly prolong survival. Transarterial chemoembolization has been performed in select cases but has shown a high incidence of complications. Emerging data on treatment of PVT with Y-90 radioembolization suggest that this modality is well-tolerated and associated with favorable overall survival. Current society guidelines do not yet specifically recommend radioembolization for patients with PVT, but this may change with the development of newer staging systems and treatment algorithms. In this comprehensive literature review, we present current and available management options with the relative advantages, disadvantages and contraindications of these treatment options with summarized data on overall survival.

journal_name

World J Gastroenterol

authors

Quirk M,Kim YH,Saab S,Lee EW

doi

10.3748/wjg.v21.i12.3462

subject

Has Abstract

pub_date

2015-03-28 00:00:00

pages

3462-71

issue

12

eissn

1007-9327

issn

2219-2840

journal_volume

21

pub_type

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