Autoantibodies in primary sclerosing cholangitis.

Abstract:

:The aetiology of primary sclerosing cholangitis (PSC) is not known and controversy exists as to whether PSC should be denominated an autoimmune disease. A large number of autoantibodies have been detected in PSC patients, but the specificity of these antibodies is generally low, and the frequencies vary largely between different studies. The presence of autoantibodies in PSC may be the result of a nonspecific dysregulation of the immune system, but the literature in PSC points to the possible presence of specific antibody targets in the biliary epithelium and in neutrophil granulocytes. The present review aims to give an overview of the studies of autoantibodies in PSC, with a particular emphasis on the prevalence, clinical relevance and possible pathogenetic importance of each individual marker.

journal_name

World J Gastroenterol

authors

Hov JR,Boberg KM,Karlsen TH

doi

10.3748/wjg.14.3781

subject

Has Abstract

pub_date

2008-06-28 00:00:00

pages

3781-91

issue

24

eissn

1007-9327

issn

2219-2840

journal_volume

14

pub_type

社论,评审
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