Predictive value of MTT assay as an in vitro chemosensitivity testing for gastric cancer: one institution's experience.

Abstract:

AIM:To investigate the predictive clinical value of in vitro 3-(4,5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay for directing chemosensitivity in patients with gastric cancer. METHODS:Results of a total of 353 consecutive patients with gastric cancer treated with MTT-directed chemotherapy or physician's empirical chemotherapy from July 1997 to April 2003 were reviewed and analyzed retrospectively. RESULTS:The overall 5-year survival rate of MTT-sensitive group (MSG) and control group (CG) was 47.5% and 45.1%, respectively. The results of subgroup analysis with Cox proportional-hazards model were favorable for the MSG-sensitive group. However, no statistically significant difference in survival rate was observed between the two groups. CONCLUSION:Individualized chemotherapy based on in vitro MTT assay is beneficial, but needs to be confirmed by further randomized controlled trials.

journal_name

World J Gastroenterol

authors

Wu B,Zhu JS,Zhang Y,Shen WM,Zhang Q

doi

10.3748/wjg.14.3064

subject

Has Abstract

pub_date

2008-05-21 00:00:00

pages

3064-8

issue

19

eissn

1007-9327

issn

2219-2840

journal_volume

14

pub_type

杂志文章
  • Case of pediatric traditional serrated adenoma resected via endoscopic submucosal dissection.

    abstract::Traditional serrated adenoma (TSA) is a type of serrated polyp of the colorectum and is thought to be a precancerous lesion. There are three types of serrated polyps, namely, hyperplastic polyps, sessile serrated adenomas/polyps, and TSAs. TSA is the least common of the three types and accounts for about 5% of serrate...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i24.4462

    authors: Kondo S,Mori H,Nishiyama N,Kondo T,Shimono R,Okada H,Kusaka T

    更新日期:2017-06-28 00:00:00

  • Expression and significance of heparanase and nm23-H1 in hepatocellular carcinoma.

    abstract:AIM:To explore the relation between heparanase (HPA) and nm23-H1 in hepatocellular carcinoma (HCC), and whether they could be used as valuable markers in predicting post-operative metastasis and recurrence of HCC. METHODS:Reverse transcription-polymerase chain reaction and immunohistochemistry (S-P method) were used t...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i9.1378

    authors: Liu YB,Gao SL,Chen XP,Peng SY,Fang HQ,Wu YL,Peng CH,Tang Z,Xu B,Wang JW,Deng GL,Li HJ,Feng XD,Qian HR

    更新日期:2005-03-07 00:00:00

  • Characteristics and long-term prognosis of patients with rectal neuroendocrine tumors.

    abstract:AIM:To analyze the clinicopathologic characteristics and prognostic factors of rectal neuroendocrine tumors. METHODS:The records of 48 patients with rectal neuroendocrine tumors who were treated at the Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, from March 2004 to September 2009 were r...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i43.16252

    authors: Chi Y,Du F,Zhao H,Wang JW,Cai JQ

    更新日期:2014-11-21 00:00:00

  • Multi-modal radiomics model to predict treatment response to neoadjuvant chemotherapy for locally advanced rectal cancer.

    abstract:BACKGROUND:Neoadjuvant chemotherapy is currently recommended as preoperative treatment for locally advanced rectal cancer (LARC); however, evaluation of treatment response to neoadjuvant chemotherapy is still challenging. AIM:To create a multi-modal radiomics model to assess therapeutic response after neoadjuvant chem...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i19.2388

    authors: Li ZY,Wang XD,Li M,Liu XJ,Ye Z,Song B,Yuan F,Yuan Y,Xia CC,Zhang X,Li Q

    更新日期:2020-05-21 00:00:00

  • Pathological and therapeutic interactions between bacteriophages, microbes and the host in inflammatory bowel disease.

    abstract::The intestinal microbiome is a dynamic system of interactions between the host and its microbes. Under physiological conditions, a fine balance and mutually beneficial relationship is present. Disruption of this balance is a hallmark of inflammatory bowel disease (IBD). Whether an altered microbiome is the consequence...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i40.11321

    authors: Babickova J,Gardlik R

    更新日期:2015-10-28 00:00:00

  • Role of ion channels in gastrointestinal cancer.

    abstract::In their seminal papers Hanahan and Weinberg described oncogenic processes a normal cell undergoes to be transformed into a cancer cell. The functions of ion channels in the gastrointestinal (GI) tract influence a variety of cellular processes, many of which overlap with these hallmarks of cancer. In this review we fo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v25.i38.5732

    authors: Anderson KJ,Cormier RT,Scott PM

    更新日期:2019-10-14 00:00:00

  • Superior mesenteric artery syndrome following scoliosis surgery: its risk indicators and treatment strategy.

    abstract:AIM:To investigate the risk indicators, pattern of clinical presentation and treatment strategy of superior mesenteric artery syndrome (SMAS) after scoliosis surgery. METHODS:From July 1997 to October 2003, 640 patients with adolescent scoliosis who had undergone surgical treatment were evaluated prospectively, and am...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i21.3307

    authors: Zhu ZZ,Qiu Y

    更新日期:2005-06-07 00:00:00

  • Vanishing bile duct syndrome in Hodgkin's lymphoma: A case report and literature review.

    abstract::Vanishing bile duct syndrome (VBDS) has been described in different pathologic conditions including infection, ischemia, adverse drug reactions, autoimmune diseases, allograft rejection, and humoral factors associated with malignancy. It is an acquired condition characterized by progressive destruction and loss of the...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v23.i2.366

    authors: Bakhit M,McCarty TR,Park S,Njei B,Cho M,Karagozian R,Liapakis A

    更新日期:2017-01-14 00:00:00

  • Possible contribution of artificial neural networks and linear discriminant analysis in recognition of patients with suspected atrophic body gastritis.

    abstract:AIM:To investigate whether ANNs and LDA could recognize patients with ABG in a database, containing only clinical and biochemical variables, of a pool of patients with and without ABG, by selecting the most predictive variables and by reducing input data to the minimum. METHODS:Data was collected from 350 consecutive ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i37.5867

    authors: Lahner E,Grossi E,Intraligi M,Buscema M,Corleto VD,Delle Fave G,Annibale B

    更新日期:2005-10-07 00:00:00

  • Gastroesophageal reflux: the features in elderly patients.

    abstract::AIM:To compare the features of gastroesophageal reflux disease between elderly and younger patients.METHODS:Twenty-four hour pH-monitoring and endoscopy were performed for the 66 elderly patients with typical gastroesophageal reflux symptoms, and the results were compared with 112 symptomatic younger patients.RESULTS:...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v5.i5.421

    authors: Huang X,Zhu HM,Deng CZ,Porro GB,Sangaletti O,Pace F

    更新日期:1999-10-01 00:00:00

  • Sub-classification of intermediate-stage (Barcelona Clinic Liver Cancer stage-B) hepatocellular carcinomas.

    abstract::Hepatocellular carcinoma (HCC), the fifth most common cancer in the world, shows increasing incidence worldwide. Curative treatments such as hepatectomy, liver transplantation, and radiofrequency ablation are applied in only 30%-60% of cases. Most remaining patients receive transarterial chemoembolization (TACE). Pati...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i37.10604

    authors: Yamakado K,Hirota S

    更新日期:2015-10-07 00:00:00

  • Increased risk of second malignancy in pancreatic intraductal papillary mucinous tumors: Review of the literature.

    abstract:AIM:To analyze the available evidence about the risk of extrapancreatic malignancies and pancreatic ductal adenocarcinoma associated to pancreatic intraductal papillary mucinous tumors (IPMNs). METHODS:A systematic search of literature was undertaken using MEDLINE, EMBASE, Cochrane and Web-of-Science libraries. No lim...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i23.7313

    authors: Baiocchi GL,Molfino S,Frittoli B,Pigozzi G,Gheza F,Gaverini G,Tarasconi A,Ricci C,Bertagna F,Grazioli L,Tiberio GA,Portolani N

    更新日期:2015-06-21 00:00:00

  • Comparison of protocatechuic aldchyde in Radix Salvia miltiorrhiza and corresponding pharmacological sera from normal and fibrotic rats by high performance liquid chromatography.

    abstract:AIM:To observe the effect of protocatechuic aldchyde on the proliferation of hepatic stellate cells (HSCs). METHODS:Liver fibrosis was induced in rats by carbon tetrachloride (CCl4). Then normal and fibrotic drug sera were extracted from rats. The effects of protocatechuic aldchyde, raw Radix Salvia miltiorrhiza and d...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i14.2195

    authors: Lv T,Yao XX

    更新日期:2006-04-14 00:00:00

  • Specific activation of 2'-5'oligoadenylate synthetase gene promoter by hepatitis C virus-core protein: a potential for developing hepatitis C virus targeting gene therapy.

    abstract:AIM:To examine whether 2'-5'oligoadenylate synthetase (OAS) gene promoter can be specifically activated by hepatitis C virus (HCV)-core protein. METHODS:Human embryo hepatic cell line L02 was transfected with pcDNA3.1-core plasmid and selected by G418. Expression of HCV-core was detected by reverse transcription polym...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.3178

    authors: Wang Y,Mao SS,He QQ,Zi Y,Wen JF,Feng DY

    更新日期:2009-07-07 00:00:00

  • Relationship and significance between anti-beta2-glycoprotein I antibodies and platelet activation state in patients with ulcerative colitis.

    abstract:AIM:To study the relationship between anti-beta2-glycoprotein I (abeta2GPI) antibodies and platelet activation state in patients with ulcerative colitis (UC) and its significance. METHODS:Peripheral blood samples were collected from 56 UC patients (34 males and 22 females, aged 43.5 years, range 21-66 years), includin...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.771

    authors: Gao YH,Gao PJ,Wang CG,Wang XC,Piao YF

    更新日期:2008-02-07 00:00:00

  • Escherichia coli-host macrophage interactions in the pathogenesis of inflammatory bowel disease.

    abstract::Multiple studies have demonstrated alterations in the intestinal microbial community (termed the microbiome) in Crohn's disease (CD) and several lines of evidence suggest these changes may have a significant role in disease pathogenesis. In active and quiescent disease, both the faecal and mucosa-associated microbiome...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i27.8751

    authors: Tawfik A,Flanagan PK,Campbell BJ

    更新日期:2014-07-21 00:00:00

  • On-treatment monitoring of liver fibrosis with serum hepatitis B core-related antigen in chronic hepatitis B.

    abstract:BACKGROUND:Non-invasive evaluation for liver fibrosis is clinically important, especially in patients with undetectable hepatitis B virus (HBV) DNA treated with nucleoside analogs. AIM:To clarify the monitoring power of hepatitis B core-related antigen (HBcrAg) for hepatic histologic changes in patients with chronic h...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.3748/wjg.v25.i32.4764

    authors: Chang XJ,Sun C,Chen Y,Li XD,Yu ZJ,Dong Z,Bai WL,Wang XD,Li ZQ,Chen D,Du WJ,Liao H,Jiang QY,Sun LJ,Li YY,Zhang CH,Xu DP,Chen YP,Li Q,Yang YP

    更新日期:2019-08-28 00:00:00

  • Helicobacter pylori eradication therapy for functional dyspepsia: Systematic review and meta-analysis.

    abstract:AIM:To evaluate whether Helicobacter pylori (H. pylori) eradication therapy benefits patients with functional dyspepsia (FD). METHODS:Randomized controlled trials (RCTs) investigating the efficacy and safety of H. pylori eradication therapy for patients with functional dyspepsia published in English (up to May 2015) w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v22.i12.3486

    authors: Du LJ,Chen BR,Kim JJ,Kim S,Shen JH,Dai N

    更新日期:2016-03-28 00:00:00

  • Pseudo-Meigs' syndrome secondary to metachronous ovarian metastases from transverse colon cancer.

    abstract::Pseudo-Meigs' syndrome associated with colorectal cancer is extremely rare. We report here a case of pseudo-Meigs' syndrome secondary to metachronous ovarian metastases from colon cancer. A 65-year-old female with a history of surgery for transverse colon cancer and peritoneal dissemination suffered from metachronous ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i18.4604

    authors: Kyo K,Maema A,Shirakawa M,Nakamura T,Koda K,Yokoyama H

    更新日期:2016-05-14 00:00:00

  • Is alcoholic pancreatitis associated with enteroviral infection?

    abstract:AIM:To investigate whether enteroviral infection might trigger acute pancreatitis in patients made susceptible due to high alcohol consumption. METHODS:Patients with alcohol-induced acute pancreatitis were analyzed for signs of simultaneous or preceding enteroviral infection. We studied the serum samples of 40 patient...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i24.3819

    authors: Khan J,Nordback I,Seppänen H,Lappalainen-Lehto R,Järvinen S,Oikarinen S,Tauriainen S,Räty S,Hyöty H,Sand J

    更新日期:2013-06-28 00:00:00

  • Cysteamine increases expression and activity of H+-K+-ATPase of gastric mucosal cells in weaning piglets.

    abstract:AIM:To determine the in vivo and in vivo effects of cysteamine (CS) on expression and activity of H(+)-K(+)-ATPase of gastric mucosal cells in weaning piglets. METHODS:Eighteen litters of newborn Xinhuai piglets were employed in the in vivo experiment and allocated to control and treatment groups. From 12 d of age (D1...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i42.6707

    authors: Shi ZM,Du GM,Wei XH,Zhang L,Chen J,Zhao RQ

    更新日期:2005-11-14 00:00:00

  • Accuracy of combined PET/CT in image-guided interventions of liver lesions: an ex-vivo study.

    abstract:AIM:Positioning of interventional devices in liver lesions is a challenging task if only CT is available. We investigated the potential benefit of combined PET/CT images for localization of interventional devices in interventional liver studies. METHODS:Thirty lesions each of hyperdense, isodense and hypodense attenua...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i15.2388

    authors: Veit P,Kuehle C,Beyer T,Kuehl H,Bockisch A,Antoch G

    更新日期:2006-04-21 00:00:00

  • Is endoscopic ultrasonography essential for endoscopic resection of small rectal neuroendocrine tumors?

    abstract:AIM:To evaluate the importance of endoscopic ultrasonography (EUS) for small (≤ 10 mm) rectal neuroendocrine tumor (NET) treatment. METHODS:Patients in whom rectal NETs were diagnosed by endoscopic resection (ER) at the Pusan National University Yangsan Hospital between 2008 and 2014 were included in this study. A tot...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i11.2037

    authors: Park SB,Kim DJ,Kim HW,Choi CW,Kang DH,Kim SJ,Nam HS

    更新日期:2017-03-21 00:00:00

  • Metabolomics of gastric cancer metastasis detected by gas chromatography and mass spectrometry.

    abstract:AIM:To elucidate the underlying mechanisms of metastasis and to identify the metabolomic markers of gastric cancer metastasis. METHODS:Gastric tumors from metastatic and non-metastatic groups were used in this study. Metabolites and different metabolic patterns were analyzed by gas chromatography, mass spectrometry an...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i46.5874

    authors: Chen JL,Tang HQ,Hu JD,Fan J,Hong J,Gu JZ

    更新日期:2010-12-14 00:00:00

  • Relationship between bilirubin free radical and formation of pigment gallstone.

    abstract::In this paper, we summarize the main progresses made in our group in the field of the mechanism of pigment gallstone formation. It was found that after treatment with free radicals, bilirubin (BR) was changed into free radical itself, and a semiquinone free radical and a superoxide free radical bound with metal were r...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v8.i3.413

    authors: Liu XT,Hu J

    更新日期:2002-06-01 00:00:00

  • Role of bacteria in the etiopathogenesis of inflammatory bowel disease.

    abstract::Increased numbers of mucosa-associated Escherichia coli are observed in both of the major inflammatory bowel diseases, Crohn d' disease (CD) and ulcerative colitis (UC). A potential pathophysiological link between the presence of pathogenic invasive bacteria and genetic host susceptibility of patients with ileal CD is...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v13.i42.5571

    authors: Barnich N,Darfeuille-Michaud A

    更新日期:2007-11-14 00:00:00

  • Cystic dystrophy of the duodenal wall is not always associated with chronic pancreatitis.

    abstract::Cystic dystrophy of the duodenal wall is a rare form of the disease which was described in 1970 by French authors who reported the presence of focal pancreatic disease localized in an area comprising the C-loop of the duodenum and the head of the pancreas. German authors have defined this area as a "groove". We report...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审

    doi:10.3748/wjg.v17.i39.4349

    authors: Pezzilli R,Santini D,Calculli L,Casadei R,Morselli-Labate AM,Imbrogno A,Fabbri D,Taffurelli G,Ricci C,Corinaldesi R

    更新日期:2011-10-21 00:00:00

  • Sickle cell cholangiopathy: an endoscopic retrograde cholangiopancreatography evaluation.

    abstract:AIM:To evaluate the role of endoscopic retrograde cholangiopancreatography (ERCP) in patients with sickle cell disease (SCD). METHODS:Two hundred and twenty four SCD patients with cholestatic jaundice (CJ) had ERCP. The indications for ERCP were based on clinical and biochemical evidence of CJ and ultrasound findings....

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.5316

    authors: Issa H,Al-Haddad A,Al-Salem A

    更新日期:2009-11-14 00:00:00

  • Effect of Helicobacter pylori infection on gastric mucosal pathologic change and level of nitric oxide and nitric oxide synthase.

    abstract:AIM:To investigate the level of nitric oxide (NO) and nitrous oxide synthase (NOS) enzyme and its effect on gastric mucosal pathologic change in patients infected with Helicobacter pylori (H pylori), and to study the pathogenic mechanism of H pylori. METHODS:The mucosal tissues of gastric antrum were taken by endoscop...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i32.5029

    authors: Wang YF,Guo CL,Zhao LZ,Yang GA,Chen P,Wang HK

    更新日期:2005-08-28 00:00:00

  • Strangulated diaphragmatic hernia presenting clinically as pericarditis.

    abstract::A case of strangulation of the transverse colon in a traumatic left diaphragmatic hernia manifesting as pericarditis is reported. This is unusual because pericardial signs in traumatic diaphragmatic hernia have been previously described in association with direct pericardial injury. This is the only such case where el...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i9.1449

    authors: Makhija R,Akoh JA

    更新日期:2007-03-07 00:00:00