Pathological and therapeutic interactions between bacteriophages, microbes and the host in inflammatory bowel disease.

Abstract:

:The intestinal microbiome is a dynamic system of interactions between the host and its microbes. Under physiological conditions, a fine balance and mutually beneficial relationship is present. Disruption of this balance is a hallmark of inflammatory bowel disease (IBD). Whether an altered microbiome is the consequence or the cause of IBD is currently not fully understood. The pathogenesis of IBD is believed to be a complex interaction between genetic predisposition, the immune system and environmental factors. In the recent years, metagenomic studies of the human microbiome have provided useful data that are helping to assemble the IBD puzzle. In this review, we summarize and discuss current knowledge on the composition of the intestinal microbiota in IBD, host-microbe interactions and therapeutic possibilities using bacteria in IBD. Moreover, an outlook on the possible contribution of bacteriophages in the pathogenesis and therapy of IBD is provided.

journal_name

World J Gastroenterol

authors

Babickova J,Gardlik R

doi

10.3748/wjg.v21.i40.11321

subject

Has Abstract

pub_date

2015-10-28 00:00:00

pages

11321-30

issue

40

eissn

1007-9327

issn

2219-2840

journal_volume

21

pub_type

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