Pathological and therapeutic interactions between bacteriophages, microbes and the host in inflammatory bowel disease.


:The intestinal microbiome is a dynamic system of interactions between the host and its microbes. Under physiological conditions, a fine balance and mutually beneficial relationship is present. Disruption of this balance is a hallmark of inflammatory bowel disease (IBD). Whether an altered microbiome is the consequence or the cause of IBD is currently not fully understood. The pathogenesis of IBD is believed to be a complex interaction between genetic predisposition, the immune system and environmental factors. In the recent years, metagenomic studies of the human microbiome have provided useful data that are helping to assemble the IBD puzzle. In this review, we summarize and discuss current knowledge on the composition of the intestinal microbiota in IBD, host-microbe interactions and therapeutic possibilities using bacteria in IBD. Moreover, an outlook on the possible contribution of bacteriophages in the pathogenesis and therapy of IBD is provided.


World J Gastroenterol


Babickova J,Gardlik R




Has Abstract


2015-10-28 00:00:00












  • Mesenteric vein thrombosis in a patient heterozygous for factor V Leiden and G20210A prothrombin genotypes.

    abstract::Mesenteric venous thrombosis (MVT) is a rare but life threatening form of bowel ischemia. It is implicated in 6%-9% of all cases of acute mesenteric ischemia. The proportion of patients with primary (or idiopathic) MVT varies from 0% to 49%, with a decrease in frequency secondary to more recent availability of newer i...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Karmacharya P,Aryal MR,Donato A

    更新日期:2013-11-21 00:00:00

  • Effect of DA-9701 on gastric emptying in a mouse model: assessment by ¹³C-octanoic acid breath test.

    abstract:AIM:To evaluate the effects of DA-9701 on the gastric emptying of a solid meal using the ¹³C-octanoic acid breath test in a mouse model. METHODS:Male C57BL/6 mice aged > 8 wk and with body weights of 20-25 g were used in this study. The solid test meal consisted of 200 mg of egg yolk labeled with 1.5 L/g ¹³C-octanoic ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Lim CH,Choi MG,Park H,Baeg MK,Park JM

    更新日期:2013-07-21 00:00:00

  • Microbial metabolites in non-alcoholic fatty liver disease.

    abstract::The prevalence of non-alcoholic fatty liver disease (NAFLD) is rising exponentially worldwide. The spectrum of NAFLD includes non-alcoholic fatty liver, non-alcoholic steatohepatitis, liver cirrhosis, and even hepatocellular carcinoma. Evidence shows that microbial metabolites play pivotal roles in the onset and progr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Zhou D,Fan JG

    更新日期:2019-05-07 00:00:00

  • Bronchial bleeding caused by recurrent pneumonia after radical esophagectomy for esophageal cancer.

    abstract::We herein report a case of bronchial bleeding after radical esophagectomy that was treated with lobectomy. A 65-year-old male who underwent subtotal esophagectomy with three-field lymph node dissection for esophageal carcinoma was referred to our hospital because of sudden hemoptysis. After the esophagectomy, bilatera...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Kitajima T,Momose K,Lee S,Haruta S,Ueno M,Shinohara H,Fujimori S,Fujii T,Takei R,Kohno T,Udagawa H

    更新日期:2015-03-21 00:00:00

  • Liver-directed therapies for liver metastases from neuroendocrine neoplasms: Can laser ablation play any role?

    abstract::Aggressive cytoreduction can prolong survival in patients with unresectable liver metastases (LM) from neuroendocrine neoplasms (NEN), and minimally invasive, liver-directed therapies are gaining increasing interest. Catheter-based treatments are used in disseminated disease, whereas ablation techniques are usually in...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Sartori S,Bianchi L,Di Vece F,Tombesi P

    更新日期:2020-06-21 00:00:00

  • Cytomegalovirus infection in liver transplant recipients: updates on clinical management.

    abstract::Cytomegalovirus (CMV) infection is a common complication after liver transplantation, and it is associated with multiple direct and indirect effects. Management of CMV infection and disease has evolved over the years, and clinical guidelines have been recently updated. Universal antiviral prophylaxis and a pre-emptive...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Marcelin JR,Beam E,Razonable RR

    更新日期:2014-08-21 00:00:00

  • Clinical and therapeutic considerations of rectal lymphoma: a case report and literature review.

    abstract::Primary rectal lymphoma is a rare presentation of gastrointestinal lymphomas. Its clinical presentation is indistinguishable from that of rectal carcinoma. Although surgical resection is often technically feasible, optimal therapy for colorectal lymphoma has not yet been identified. We report a case of primary rectal ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Bilsel Y,Balik E,Yamaner S,Bugra D

    更新日期:2005-01-21 00:00:00

  • Value of mink vomit model in study of anti-emetic drugs.

    abstract:AIM:To establish a new, reliable vomit model of minks. METHODS:Adult male minks were randomly divided into 8 groups (n=6): cisplatin (7.5 mg/kg) intraperitoneal injection (i.p.) group, copper sulfate (40 mg/kg) intragastric injection (i.g.) group, apomorphine (1.6 mg/kg) subcutaneous injection (s.c.) group, and 18 Gy ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Zhang F,Wang L,Yang ZH,Liu ZT,Yue W

    更新日期:2006-02-28 00:00:00

  • Stretta: a valuable endoscopic treatment modality for gastroesophageal reflux disease.

    abstract::One potential option for the management of refractory gastro-esophageal reflux disease (GERD) is the delivery of radiofrequency energy to the gastro-esophageal junction (Stretta). This endoscopic therapy is safe, effective, durable, and repeatable if necessary and serves an unmet need for many GERD sufferers. Stretta ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Triadafilopoulos G

    更新日期:2014-06-28 00:00:00

  • The spirit of Henry Norman Bethune and gastroenterology.

    abstract::Henry Norman Bethune was a physician and surgeon from Canada. He had a highly impressive medical career in Montreal but did his most important work in China where he cared for soldiers on the battlefield. He died in 1939 and was recognized as a hero, but only much later received recognition in Canada. He was a skilled...

    journal_title:World journal of gastroenterology

    pub_type: 传,历史文章,杂志文章


    authors: Freeman HJ

    更新日期:2008-01-14 00:00:00

  • Overexpression of insulin-like growth factor-I receptor as a pertinent biomarker for hepatocytes malignant transformation.

    abstract:AIM:To investigate the dynamic features of insulin-like growth factor-I receptor (IGF-IR) expression in rat hepatocarcinogenesis, and the relationship between IGF-IR and hepatocytes malignant transformation at mRNA or protein level. METHODS:Hepatoma models were made by inducing with 2-fluorenylacetamide (2-FAA) on mal...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Yan XD,Yao M,Wang L,Zhang HJ,Yan MJ,Gu X,Shi Y,Chen J,Dong ZZ,Yao DF

    更新日期:2013-09-28 00:00:00

  • Effect of discounting on estimation of benefits determined by hepatitis C treatment.

    abstract::The combination of either boceprevir or telaprevir with ribavirin and interferon (triple therapy) has been shown to be more effective than ribavirin+interferon (dual therapy) for the treatment of genotype 1 hepatitis C. Since the benefit of these treatments takes place after years, simulation models are needed to pred...

    journal_title:World journal of gastroenterology

    pub_type: 信件


    authors: Messori A,Fadda V,Maratea D,Trippoli S

    更新日期:2012-06-21 00:00:00

  • Construction, expression and tumor targeting of a single-chain Fv against human colorectal carcinoma.

    abstract:AIM:A single-chain antibody fragment, ND-1scFv, against human colorectal carcinoma was constructed and expressed in E.coli, and its biodistribution and pharmacokinetic properties were studied in mice bearing tumor. METHODS:V(H) and V(L) genes were amplified from hybridoma cell IC-2, secreting monoclonal antibody ND-1,...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Fang J,Jin HB,Song JD

    更新日期:2003-04-01 00:00:00

  • Intestinal perforation after combined liver-kidney transplantation for a case of congenital polycystic disease.

    abstract:AIM:To highlight the intestinal perforation (IP), an uncommon and catastrophic complication after combined liver-kidney transplantation. METHODS:Combined liver-kidney transplantation (LKTx) with left kidney excision and a cyst fenestration procedure on the right kidney were performed on a case of 46-year-old female wi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Peng T,Peng MH,Li LQ,Deng YL,Yang DH,Lu BY,Chen XG,Guo Y,Xiao KY,Chen B,Zhong Q,Wei MY

    更新日期:2004-09-15 00:00:00

  • Evaluation of esophageal function in patients with esophageal motor abnormalities using multichannel intraluminal impedance esophageal manometry.

    abstract:AIM:To evaluate the functional aspect of esophageal motility in healthy subjects and in patients who were referred for esophageal function testing using multichannel intraluminal impedance-esophageal manometry (MII-EM), and to assess the clinical utility of MII-EM. METHODS:From September 2003 to January 2004, we perfo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Cho YK,Choi MG,Park JM,Oh JH,Paik CN,Lee JW,Lee IS,Kim SW,Chung IS

    更新日期:2006-10-21 00:00:00

  • Role of three-dimensional endoanal ultrasound in assessing the anal sphincter morphology of female patients with chronic proctalgia.

    abstract:AIM:To assess the role of three-dimensional endoanal ultrasound (3D-EAUS) for morphological assessment of the anal sphincter of female patients with chronic proctalgia (CP). METHODS:In this unmatched case control study, 30 consecutive female patients with CP and 25 normal women (control group) were enrolled. 3D-EAUS w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Xue YH,Ding SQ,Ding YJ,Pan LQ

    更新日期:2017-06-07 00:00:00

  • Gut perforation after orthotopic liver transplantation in adults.

    abstract:AIM:To describe cases of gut perforation after orthotopic liver transplantation. METHODS:Data were collected from our center database and medical records. Six of 187 patients (3.2%) who underwent orthotopic liver transplantation from January to December 2005 developed gut perforation. All patients were male with an av...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Xiong J,You S,He XS

    更新日期:2007-04-14 00:00:00

  • Effectiveness and safety of continuous wound infiltration for postoperative pain management after open gastrectomy.

    abstract:AIM:To prospectively evaluate the effectiveness and safety of continuous wound infiltration (CWI) for pain management after open gastrectomy. METHODS:Seventy-five adult patients with American Society of Anesthesiologists (ASA) Physical Status Classification System (ASA) grade 1-3 undergoing open gastrectomy were rando...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验


    authors: Zheng X,Feng X,Cai XJ

    更新日期:2016-02-07 00:00:00

  • Differences in endoscopic classification of early colorectal carcinoma between China and Japan: a comparative study.

    abstract:AIM:To compare the differences in the endoscopic classification of early colorectal carcinoma (CRC) between Japan and China. METHODS:Ten cases of early CRC were included in the study. After reviewing the color pictures of these cases, 5 Japanese endoscopists and 5 Chinese endoscopists made their classificatory diagnos...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Zhu RM,Wang FY,Hirata I,Katsu K,Xiao SD,Yu ZL,Zhang ZH,Xu ZM

    更新日期:2003-09-01 00:00:00

  • Oncogenic ADAM28 induces gemcitabine resistance and predicts a poor prognosis in pancreatic cancer.

    abstract:BACKGROUND:Pancreatic cancer is a major cause of cancer-related death, with a 5-year overall survival rate being below 5%. The main causes of poor prognosis in pancreatic cancer include easy metastasis, high recurrence rate, and robust drug resistance. Gemcitabine is a first-line drug for patients with unresectable pan...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Wei L,Wen JY,Chen J,Ma XK,Wu DH,Chen ZH,Huang JL

    更新日期:2019-10-07 00:00:00

  • Assessment of the hepatic microvascular changes in liver cirrhosis by perfusion computed tomography.

    abstract:AIM:To assess the hepatic microvascular parameters in patients with liver cirrhosis by perfusion computed tomography (CT). METHODS:Perfusion CT was performed in 29 patients without liver disease (control subjects) and 39 patients with liver cirrhosis, including 22 patients with compensated cirrhosis and 17 patients wi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Chen ML,Zeng QY,Huo JW,Yin XM,Li BP,Liu JX

    更新日期:2009-07-28 00:00:00

  • Isolated intrapancreatic IgG4-related sclerosing cholangitis.

    abstract::Immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) is frequently associated with type 1 autoimmune pancreatitis (AIP). Association with AIP can be utilized in the diagnosis of IgG4-SC. However, some cases of IgG4-SC are isolated from AIP, which complicates the diagnosis. Most of the reported cases of isolated ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Nakazawa T,Ikeda Y,Kawaguchi Y,Kitagawa H,Takada H,Takeda Y,Makino I,Makino N,Naitoh I,Tanaka A

    更新日期:2015-01-28 00:00:00

  • Comparison of four models for end-stage liver disease in evaluating the prognosis of cirrhosis.

    abstract:AIM:To investigate the prognostic value of the model for end-stage liver disease (MELD) and three new MELD-based models combination with serum sodium in decompensated cirrhosis patients-the MELD with the incorporation of serum sodium (MELD-Na), the integrated MELD (iMELD), and the MELD to sodium (MESO) index. METHODS:...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Jiang M,Liu F,Xiong WJ,Zhong L,Chen XM

    更新日期:2008-11-14 00:00:00

  • Micronucleus analysis in patients with colorectal adenocarcinoma and colorectal polyps.

    abstract:AIM:To determine, by counting micronucleus (MN) frequencies, whether chromosomal or DNA damage have an effect on the pathogenesis of early colorectal adenocarcinoma (CRC). METHODS:We analyzed MN frequencies in 21 patients with CRC, 24 patients with colon polyps [10 neoplastic polyps (NP) and 14 non-neoplastic polyps (...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Karaman A,Binici DN,Kabalar ME,Calikuşu Z

    更新日期:2008-11-28 00:00:00

  • New perspectives of studying gastrointestinal muscle function.

    abstract::The motor function of the gastrointestinal tract has primarily been studied using manometry and radiography, though more indirect tests have also been applied. Manometry and radiography do not provide detailed information about the muscle properties as can be assessed from studies of muscle properties in muscle strips...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Gregersen H,Liao D

    更新日期:2006-05-14 00:00:00

  • Effect of liver regeneration on malignant hepatic tumors.

    abstract::Liver regeneration after major surgery may activate occult micrometastases and facilitate tumor growth, leading to liver tumor recurrence. Molecular changes during liver regeneration can provide a microenvironment that stimulates intrahepatic tumor propagation through alterations in cellular signaling pathways, where ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Shi JH,Line PD

    更新日期:2014-11-21 00:00:00

  • Perivascular epithelioid cell tumour of the liver.

    abstract::Perivascular epithelioid cell tumour is not uncommon in the liver but seldom malignant. ...

    journal_title:World journal of gastroenterology

    pub_type: 评论,信件


    authors: Stenram U

    更新日期:2008-05-21 00:00:00

  • Management of patients with sphincter of Oddi dysfunction based on a new classification.

    abstract:AIM:To propose a new classification system for sphincter of Oddi dysfunction (SOD) based on clinical data of patients. METHODS:The clinical data of 305 SOD patients documented over the past decade at our center were analyzed retrospectively, and typical cases were reported. RESULTS:The new classification with two mor...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Gong JQ,Ren JD,Tian FZ,Jiang R,Tang LJ,Pang Y

    更新日期:2011-01-21 00:00:00

  • Inhibition of gastric perception of mild distention by omeprazole in volunteers.

    abstract:AIM:To evaluate the effects of omeprazole on gastric mechanosensitivity in humans. METHODS:A double lumen polyvinyl tube with a plastic bag was introduced into the stomach of healthy volunteers under fluorography and connected to a barostat device. Subjects were then positioned so they were sitting comfortably, and th...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Iida A,Kaneko H,Konagaya T,Funaki Y,Tokudome K,Izawa S,Tamura Y,Mizuno M,Ogasawara N,Sasaki M,Kasugai K

    更新日期:2012-10-21 00:00:00

  • Urotensin II-induced insulin resistance is mediated by NADPH oxidase-derived reactive oxygen species in HepG2 cells.

    abstract:AIM:To investigated the effects of urotensin II (UII) on hepatic insulin resistance in HepG2 cells and the potential mechanisms involved. METHODS:Human hepatoma HepG2 cells were cultured with or without exogenous UII for 24 h, in the presence or absence of 100 nmol/L insulin for the last 30 min. Glucose levels were de...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Li YY,Shi ZM,Yu XY,Feng P,Wang XJ

    更新日期:2016-07-07 00:00:00