Cancer risk in primary sclerosing cholangitis: Epidemiology, prevention, and surveillance strategies.

abstract：AIM:To explore the mechanism for interactions of leptin with ghrelin and orexin in the arcuate nucleus (ARC) activating neuropeptide Y (NPY) neurons during physiological regulation of feeding. METHODS:Single neurons from ARC of adult rats with matured feeding function were isolated. [Ca2+]i was measured to monitor the...

journal_title：World journal of gastroenterology

authors： Kohno D,Suyama S,Yada T

更新日期：2008-11-07 00:00:00

abstract：BACKGROUND:Liver resection is an effective treatment for benign and malignant liver tumors. However, a method for preoperative evaluation of hepatic reserve has not yet been established. Previously reported assessments of preoperative hepatic reserve focused only on liver failure in the early postoperative period and d...

journal_title：World journal of gastroenterology

authors： Ishii M,Itano O,Shinoda M,Kitago M,Abe Y,Hibi T,Yagi H,Takeuchi A,Tsujikawa H,Abe T,Kitagawa Y

更新日期：2020-02-21 00:00:00

abstract：BACKGROUND:People with achalasia typically have a thick lower esophageal muscularis propria (LEMP), and peroral endoscopic myotomy (POEM) has been effective in treating most patients. LEMP thickness may be associated with the outcomes and prognosis after POEM. However, more evidence is needed regarding the relationship...

journal_title：World journal of gastroenterology

authors： Liao Y,Xiao TY,Wu YF,Zhang JJ,Zhang BZ,Wang YD,Wang S,Liu X,Sun SY,Guo JT

更新日期：2020-10-14 00:00:00

abstract：:Solitary fibrous tumors are predominantly benign and are most commonly found in the thoracic cavity and pleura; while reports exist in the literature of malignant solitary fibrous tumors and those located in extrathoracic organs, these cases are considered extremely rare. Herein, a case is reported of a malignant soli...

journal_title：World journal of gastroenterology

authors： Jakob M,Schneider M,Hoeller I,Laffer U,Kaderli R

更新日期：2013-06-07 00:00:00

abstract：AIM:To investigate the correlation between ezrin expression and invasive phenotype formation in malignantly transformed esophageal epithelial cells. METHODS:The experimental cell line employed in the present study was originated form the progressive induction of a human embryonic esophageal epithelial cell line (SHEE)...

journal_title：World journal of gastroenterology

authors： Shen ZY,Xu LY,Chen MH,Li EM,Li JT,Wu XY,Zeng Y

更新日期：2003-06-01 00:00:00

abstract：AIM:To retrospectively analyze factors affecting the long-term survival of patients with pancreatic cancer who underwent pancreatic resection. METHODS:From January 2000 to December 2011, 195 patients underwent pancreatic resection in our hospital. The prognostic factors after pancreatic resection were analyzed in all ...

journal_title：World journal of gastroenterology

authors： Yamamoto T,Yagi S,Kinoshita H,Sakamoto Y,Okada K,Uryuhara K,Morimoto T,Kaihara S,Hosotani R

更新日期：2015-01-07 00:00:00

abstract：AIM:To investigate the effects of herbal compound 861 (Cpd 861) on cell proliferation in human hepatic stellate cells (LX-2) and human hepatocellular liver carcinoma cells (HepG2), and expression of alpha-smooth muscle actin (alpha-SMA) in LX-2 cells. METHODS:LX-2 and HepG2 cells were incubated with various concentrat...

journal_title：World journal of gastroenterology

authors： Wang L,Wang J,Wang BE,Xiao PG,Qiao YJ,Tan XH

更新日期：2004-10-01 00:00:00

abstract：AIM:To investigate the role of pre-core and basal core promoter (BCP) mutations before and after hepatitis B e antigen (HBeAg) seroconversion. METHODS:The proportion of pre-core (G1896A) and basal core promoter (A1762T and G1764A) mutant viruses and serum levels of hepatitis B virus (HBV) DNA, hepatitis B surface anti...

journal_title：World journal of gastroenterology

authors： Kamijo N,Matsumoto A,Umemura T,Shibata S,Ichikawa Y,Kimura T,Komatsu M,Tanaka E

更新日期：2015-01-14 00:00:00

abstract：:Colorectal cancer (CRC) is fourth most common cancer in men and third in women worldwide. Developing a diagnostic panel of sensitive and specific biomarkers for the early detection of CRC is recognised as to be crucial for early initial diagnosis, which in turn leads to better long term survival. Most of the research ...

journal_title：World journal of gastroenterology

authors： Kadiyska T,Nossikoff A

更新日期：2015-09-21 00:00:00

abstract：:Recent advances in diagnostic techniques have allowed the diagnosis of gastric cancer (GC) at an early stage. Due to the low incidence of lymph node metastasis and favorable prognosis in early GC, function-preserving surgery which improves postoperative quality of life may be possible. Pylorus-preserving gastrectomy (...

journal_title：World journal of gastroenterology

authors： Saito T,Kurokawa Y,Takiguchi S,Mori M,Doki Y

更新日期：2014-12-14 00:00:00

abstract：BACKGROUND:Systemic inflammation and nutrition status play an important role in cancer metastasis. The combined index of hemoglobin, albumin, lymphocyte, and platelet (HALP), consisting of haemoglobin, albumin, lymphocytes, and platelets, is considered as a novel marker to reflect both systemic inflammation and nutriti...

journal_title：World journal of gastroenterology

authors： Xu SS,Li S,Xu HX,Li H,Wu CT,Wang WQ,Gao HL,Jiang W,Zhang WH,Li TJ,Ni QX,Liu L,Yu XJ

更新日期：2020-02-28 00:00:00

abstract：AIM:To investigate the relationship between glucose metabolism and glypican-3 (GPC3) expression in hepatocellular carcinoma (HCC). METHODS:Immunohistochemical staining of pathological samples for GPC3 and glucose transporter 1 (GLUT1), and whole-body 18F-FDG PET/CT for measuring tumour glucose uptake were performed in...

journal_title：World journal of gastroenterology

authors： Li YC,Yang CS,Zhou WL,Li HS,Han YJ,Wang QS,Wu HB

更新日期：2018-01-28 00:00:00

abstract：AIM:To investigate the underlying molecular mechanisms of miR-451 to inhibit proliferation of esophageal carcinoma cell line EC9706. METHODS:Assays for cell growth, apoptosis and invasion were used to evaluate the effects of miR-451 expression on EC cells. Luciferase reporter and Western blot assays were used to test ...

journal_title：World journal of gastroenterology

authors： Zang WQ,Yang X,Wang T,Wang YY,Du YW,Chen XN,Li M,Zhao GQ

更新日期：2015-05-21 00:00:00

abstract：:Liver regeneration after major surgery may activate occult micrometastases and facilitate tumor growth, leading to liver tumor recurrence. Molecular changes during liver regeneration can provide a microenvironment that stimulates intrahepatic tumor propagation through alterations in cellular signaling pathways, where ...

journal_title：World journal of gastroenterology

authors： Shi JH,Line PD

更新日期：2014-11-21 00:00:00

abstract：AIM:To explore the relationship of clinicopathological features and the distribution of neutrophils in the tumor microenvironment with the prognosis of cholangiocarcinoma. METHODS:Two hundred and fifty-four formalin-fixed and paraffin embedded tissue blocks were analyzed, including tissues from cholangiocarcinoma (n =...

journal_title：World journal of gastroenterology

authors： Mao ZY,Zhu GQ,Xiong M,Ren L,Bai L

更新日期：2015-04-28 00:00:00

abstract：:Cystic formations within the liver are a frequent finding among populations. Besides the common cystic lesions, like simple liver cysts, rare cystic liver lesions like cystadenocarcinoma should also be considered in the differential diagnosis. Thorough knowledge of each entity's nature and course are key elements to s...

journal_title：World journal of gastroenterology

authors： Bakoyiannis A,Delis S,Triantopoulou C,Dervenis C

更新日期：2013-11-21 00:00:00

abstract：:Long-term outcome data in pancreatic adenocarcinoma are predominantly based on surgical series, as resection is currently considered essential for long-term survival. In contrast, five-year survival in non-resected patients has rarely been reported. In this report, we examined the incidence and natural history of ≥ 5-...

journal_title：World journal of gastroenterology

authors： Oh SY,Edwards A,Mandelson MT,Lin B,Dorer R,Helton WS,Kozarek RA,Picozzi VJ

更新日期：2015-12-28 00:00:00

abstract：AIM:To determine the expression of c-fos in gastric myenteric plexus and spinal cord of rats with cervical spondylosis and its clinical significance. METHODS:A cervical spondylosis model was established in rats by destroying the stability of cervical posterior column, and the cord segments C(4-6) and gastric antrum we...

journal_title：World journal of gastroenterology

authors： Song PS,Kong KM,Niu CY,Qi WL,Wu LF,Wang XJ,Han W,Huang K,Chen ZF

更新日期：2005-01-28 00:00:00

abstract：AIM:To evaluate the role of preoperative angiography in the diagnosis and treatment of colorectal cancer. METHODS:The authors performed selective arterial cannulation by Seldinger's method in 47 patients to locate the primary cancer and to diagnose metastasis to the liver. Each patient was then given intra-arterial re...

journal_title：World journal of gastroenterology

authors： Gu J,Ma ZL,Li Y,Li M,Xu GW

更新日期：2003-02-01 00:00:00

abstract：AIM:To develop a novel Helicobacter pylori (H. pylori) CagA antibody enzyme-linked immunosorbent assay (ELISA) suitable for detecting serum anti-CagA antibodies with high sensitivity. METHODS:Recombinant East Asian-type CagA protein was purified and immobilized for ELISA. Serum samples from 217 Vietnamese individuals ...

journal_title：World journal of gastroenterology

authors： Matsuo Y,Kido Y,Akada J,Shiota S,Binh TT,Trang TT,Dung HD,Tung PH,Tri TD,Thuan NP,Tam LQ,Nam BC,Khien VV,Yamaoka Y

更新日期：2017-01-07 00:00:00

abstract：AIM:To detect significant clusters of co-expressed genes associated with tumorigenesis that might help to predict stomach adenocarcinoma (SA) prognosis. METHODS:The Cancer Genome Atlas database was used to obtain RNA sequences as well as complete clinical data of SA and adjacent normal tissues from patients. Weighted ...

journal_title：World journal of gastroenterology

authors： Zhang J,Wu Y,Jin HY,Guo S,Dong Z,Zheng ZC,Wang Y,Zhao Y

更新日期：2018-11-21 00:00:00

abstract：AIM:To evaluate the optimal intervention point of a selective cyclooxygenase-2 (COX-2) inhibitor, celecoxib, for inhibiting Helicobacter pylori (H. pylori)-associated gastric carcinogenesis in Mongolian gerbils (MGs). METHODS:One hundred and twelve MGs were divided into six groups (A-F). One hundred gerbils were inocu...

journal_title：World journal of gastroenterology

authors： Kuo CH,Hu HM,Tsai PY,Wu IC,Yang SF,Chang LL,Wang JY,Jan CM,Wang WM,Wu DC

更新日期：2009-10-21 00:00:00

abstract：AIM:To clarify the role of neoadjuvant concurrent chemoradiotherapy (NACCRT) followed by surgical resection for localized or locally advanced perihilar cholangiocarcinoma (CCA). METHODS:We retrospectively reviewed 57 patients who underwent surgical resection with or without NACCRT for perihilar CCA; 12 patients receiv...

journal_title：World journal of gastroenterology

authors： Jung JH,Lee HJ,Lee HS,Jo JH,Cho IR,Chung MJ,Park JY,Park SW,Song SY,Bang S

更新日期：2017-05-14 00:00:00

abstract：AIM:To evaluate when Helicobacter pylori (H. pylori) eradication therapy (ET) should be started in patients with peptic ulcer bleeding (PUB). METHODS:Clinical data concerning adults hospitalized with PUB were retrospectively collected and analyzed. Age, sex, type and stage of peptic ulcer, whether endoscopic therapy w...

journal_title：World journal of gastroenterology

authors： Yoon H,Lee DH,Jang ES,Kim J,Shin CM,Park YS,Hwang JH,Kim JW,Jeong SH,Kim N

更新日期：2015-02-28 00:00:00

abstract：AIM:To compare the clinical outcomes between jejunal interposition reconstruction and Roux-en-Y anastomosis after total gastrostomy in patients with gastric cancer. METHODS:A systematic literature search was conducted by two independent researchers on PubMed, EMBASE, the Cochrane Library, Google Scholar, and other Eng...

journal_title：World journal of gastroenterology

authors： Fan KX,Xu ZF,Wang MR,Li DT,Yang XS,Guo J

更新日期：2015-03-14 00:00:00

abstract：:A clinical trial of radiotherapy with modified simultaneous integrated boost (SIB) technique against huge tumors was conducted. A 58-year-old male patient who had a huge pelvic tumor diagnosed as a rectal adenocarcinoma due to familial adenomatous polyposis was enrolled in this trial. The total dose of 77 Gy (equivale...

journal_title：World journal of gastroenterology

authors： Nomiya T,Akamatsu H,Harada M,Ota I,Hagiwara Y,Ichikawa M,Miwa M,Kawashiro S,Hagiwara M,Chin M,Hashizume E,Nemoto K

更新日期：2014-12-28 00:00:00

abstract：AIM:To determine if exacerbation of pre-existing chronic colitis in Winnie (Muc2 mutant) mice induces colonic dysplasia. METHODS:Winnie mice and C57BL6 as a genotype control, were administered 1% w/v dextran sulphate sodium (DSS) orally, followed by drinking water alone in week-long cycles for a total of three cycles....

journal_title：World journal of gastroenterology

authors： Randall-Demllo S,Fernando R,Brain T,Sohal SS,Cook AL,Guven N,Kunde D,Spring K,Eri R

更新日期：2016-10-07 00:00:00

abstract：AIM:To evaluate the efficacy and safety of HL tablet extracted from magnolia officinalis for treating patients with nonalcoholic fatty liver disease (NAFLD). METHODS:Seventy-four patients with NAFLD diagnosed by ultrasonography were randomly assigned to 3 groups given high dose (400 mg) HL tablet, low dose (133.4 mg) ...

journal_title：World journal of gastroenterology

authors： Jeong JY,Sohn JH,Baek YH,Cho YK,Kim Y,Kim H

更新日期：2017-08-28 00:00:00

abstract：AIM:To examine the expressions of matrix metalloproteinases-2 (MMP-2) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in rat fibrotic liver and in normal rat hepatic stellate cells, and to investigate the changes in their expressions in response to treatment with interleukin-10 (IL-10) and platelet-derived growth...

journal_title：World journal of gastroenterology

authors： Zhang LJ,Chen YX,Chen ZX,Huang YH,Yu JP,Wang XZ

更新日期：2004-09-01 00:00:00

abstract：AIM:To investigate the effect of transfected survivin antisense oligonucleotide (ASODN) on proliferation and apoptosis of gastric cancer cells. METHODS:The authors designed ASODNs targeting different regions of survivin mRNA, including surviving ASODN1, ASODN2 and ASODN3. ASODNs were transfected into gastric cancer ce...

journal_title：World journal of gastroenterology

authors： Yang JH,Zhang YC,Qian HQ

更新日期：2004-04-15 00:00:00