Effect of liver regeneration on malignant hepatic tumors.

Abstract:

:Liver regeneration after major surgery may activate occult micrometastases and facilitate tumor growth, leading to liver tumor recurrence. Molecular changes during liver regeneration can provide a microenvironment that stimulates intrahepatic tumor propagation through alterations in cellular signaling pathways, where activation and proliferation of mature hepatocytes, hepatic progenitor cells, non-parenchymal liver cells might favor both liver regeneration and tumor growth. This review highlights recent advances of tumor growth and development in the regenerating liver, possible mechanisms and clinical implications.

journal_name

World J Gastroenterol

authors

Shi JH,Line PD

doi

10.3748/wjg.v20.i43.16167

subject

Has Abstract

pub_date

2014-11-21 00:00:00

pages

16167-77

issue

43

eissn

1007-9327

issn

2219-2840

journal_volume

20

pub_type

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