New botanical drug, HL tablet, reduces hepatic fat as measured by magnetic resonance spectroscopy in patients with nonalcoholic fatty liver disease: A placebo-controlled, randomized, phase II trial.

abstract：AIM:To determine the association of circulating miR-125a/b expression with the risk and disease severity of Crohn's disease (CD), and with inflammatory cytokines. METHODS:Plasma samples were collected from patients with active CD (A-CD), or CD in remission (R-CD) and from healthy controls (HCs). The levels of the infl...

journal_title：World journal of gastroenterology

authors： Sun CM,Wu J,Zhang H,Shi G,Chen ZT

更新日期：2017-11-28 00:00:00

abstract：:Leptomeningeal carcinomatosis occurs very rarely in patients with pancreatic cancer. Leptomeningeal carcinomatosis is characterized by multifocal seeding of the leptomeninges by malignant cells that originate from a solid tumor. To the best of our knowledge, brain metastasis from pancreatic cancer is extremely rare. L...

journal_title：World journal of gastroenterology

authors： Yoo IK,Lee HS,Kim CD,Chun HJ,Jeen YT,Keum B,Kim ES,Choi HS,Lee JM,Kim SH,Nam SJ,Hyun JJ

更新日期：2015-01-21 00:00:00

abstract：AIM:To investigate whether octreotide can inhibit the growth of human gallbladder cancer cells in vitro and to elucidate the antineoplastic mechanism of octreotide in gallbladder cancer. METHODS:A human gallbladder cancer cell line, GBC-SD, was cultured in vitro. The antiproliferative effects of octreotide were examin...

journal_title：World journal of gastroenterology

authors： Wang JH,Xing QT,Yuan MB

更新日期：2004-04-01 00:00:00

abstract：:Despite major improvements concerning its diagnosis and treatment, pancreatic ductal adenocarcinoma (PDAC) remains an aggressive disease with an extremely poor prognosis. Pathology, as interface discipline between basic and clinical medicine, has substantially contributed to the recent developments and has laid the ba...

journal_title：World journal of gastroenterology

authors： Esposito I,Konukiewitz B,Schlitter AM,Klöppel G

更新日期：2014-10-14 00:00:00

abstract：AIM:To construct a noninvasive assessment model consisting of routine laboratory data to predict significant fibrosis and cirrhosis in patients with chronic hepatitis B (CHB). METHODS:A total of 137 consecutive patients with CHB who underwent percutaneous liver biopsy were retrospectively analyzed. These patients were...

journal_title：World journal of gastroenterology

authors： Zhang YX,Wu WJ,Zhang YZ,Feng YL,Zhou XX,Pan Q

更新日期：2008-12-14 00:00:00

abstract：AIM:A single-chain antibody fragment, ND-1scFv, against human colorectal carcinoma was constructed and expressed in E.coli, and its biodistribution and pharmacokinetic properties were studied in mice bearing tumor. METHODS:V(H) and V(L) genes were amplified from hybridoma cell IC-2, secreting monoclonal antibody ND-1,...

journal_title：World journal of gastroenterology

authors： Fang J,Jin HB,Song JD

更新日期：2003-04-01 00:00:00

abstract：AIM:To investigate and elucidate the molecular mechanism that regulates inducible expression of CD69 by Helicobacter pylori (H. pylori) infection. METHODS:The expression levels of CD69 in a T-cell line, Jurkat, primary human peripheral blood mononuclear cells (PBMCs), and CD4+ T cells, were assessed by immunohistochem...

journal_title：World journal of gastroenterology

authors： Mori N,Ishikawa C,Senba M

更新日期：2011-08-28 00:00:00

abstract：:Synchronous occurrence of epithelial neoplasia and gastrointestinal stromal tumor (GIST) in the stomach is uncommon. Only rare cases have been reported in the literature. We present here a 60-year-old female case of synchronous occurrence of gastric high-level intraepithelial neoplasia and GIST with the features of 22...

journal_title：World journal of gastroenterology

authors： Mou YP,Xu XW,Xie K,Zhou W,Zhou YC,Chen K

更新日期：2010-10-21 00:00:00

abstract：BACKGROUND:Neoadjuvant chemotherapy is currently recommended as preoperative treatment for locally advanced rectal cancer (LARC); however, evaluation of treatment response to neoadjuvant chemotherapy is still challenging. AIM:To create a multi-modal radiomics model to assess therapeutic response after neoadjuvant chem...

journal_title：World journal of gastroenterology

authors： Li ZY,Wang XD,Li M,Liu XJ,Ye Z,Song B,Yuan F,Yuan Y,Xia CC,Zhang X,Li Q

更新日期：2020-05-21 00:00:00

abstract：AIM:To investigate survival rate and incidence of hepatocellular carcinoma (HCC) in patients with decompensated cirrhosis in the antiviral era. METHODS:We used the Korean Health Insurance Review and Assessment. Korea's health insurance system is a public single-payer system. The study population consisted of 286871 pa...

journal_title：World journal of gastroenterology

authors： Ju YC,Jun DW,Choi J,Saeed WK,Lee HY,Oh HW

更新日期：2018-10-28 00:00:00

abstract：AIM:To assess intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) for monitoring early efficacy of chemotherapy in a human gastric cancer mouse model. METHODS:IVIM-DWI was performed with 12 b-values (0-800 s/mm(2)) in 25 human gastric cancer-bearing nude mice at baseline (day 0), and then they were rand...

journal_title：World journal of gastroenterology

authors： Song XL,Kang HK,Jeong GW,Ahn KY,Jeong YY,Kang YJ,Cho HJ,Moon CM

更新日期：2016-06-28 00:00:00

abstract：AIM:To investigate the effect of a fat rich diet on non-steroidal anti-inflammatory drug (NSAID)-induced mucosal damage in the murine small intestine. METHODS:C57BL6 mice were fed 4 types of diets with or without indomethacin. One group was fed standard laboratory chow. The other groups were fed a fat diet consisting ...

journal_title：World journal of gastroenterology

authors： Ueda T,Hokari R,Higashiyama M,Yasutake Y,Maruta K,Kurihara C,Tomita K,Komoto S,Okada Y,Watanabe C,Usui S,Nagao S,Miura S

更新日期：2015-01-07 00:00:00

abstract：AIM:To compare ghrelin levels in plasma and gastric mucosa before and after Helicobacter pylori (H. pylori) treatment in children with H. pylori-associated functional dyspepsia. METHODS:Children with H. pylori-associated functional dyspepsia were enrolled in this study. H. pylori infection was confirmed by positive ba...

journal_title：World journal of gastroenterology

authors： Deng ZH,Chu B,Xu YZ,Zhang B,Jiang LR

更新日期：2012-09-28 00:00:00

abstract：:Clostridium difficile (CD), specifically its toxins, have been implicated as a risk factor for exacerbation of the inflammatory process in up to 5% of patients with ulcerative colitis or Crohnos disease. Typical evidence of colonic changes with CD infection, including pseudomembranous exudate, are often not present; h...

journal_title：World journal of gastroenterology

authors： Freeman HJ

更新日期：2008-05-14 00:00:00

abstract：AIM:To investigate Fusobacterium nucleatum (F. nucleatum) abundance in colorectal cancer (CRC) tissues and its association with CRC invasiveness in Chinese patients. METHODS:The resected cancer and adjacent normal tissues (10 cm beyond cancer margins) from 101 consecutive patients with CRC were collected. Fluorescent ...

journal_title：World journal of gastroenterology

authors： Li YY,Ge QX,Cao J,Zhou YJ,Du YL,Shen B,Wan YJ,Nie YQ

更新日期：2016-03-21 00:00:00

abstract：AIM:To investigate the mechanism of chaperone-mediated autophagy (CMA)-induced resistance to irradiation-triggered apoptosis through regulation of the p53 protein in hepatocellular carcinoma (HCC). METHODS:Firstly, we detected expression of lysosome-associated membrane protein 2a (Lamp-2a), which is the key protein of...

journal_title：World journal of gastroenterology

authors： Wu JH,Guo JP,Shi J,Wang H,Li LL,Guo B,Liu DX,Cao Q,Yuan ZY

更新日期：2017-04-07 00:00:00

abstract：AIM:To establish cell line and patient-derived xenograft (PDX) models for neuroendocrine carcinomas (NEC) which is highly desirable for gaining insight into tumor development as well as preclinical research including biomarker testing and drug response prediction. METHODS:Cell line establishment was conducted from dir...

journal_title：World journal of gastroenterology

authors： Gock M,Mullins CS,Harnack C,Prall F,Ramer R,Göder A,Krämer OH,Klar E,Linnebacher M

更新日期：2018-09-07 00:00:00

abstract：AIM:To investigate the causes of missed diagnosis of early gastric cancer (EGC) or high-grade intraepithelial neoplasia (HGIN) in Chongqing, China. METHODS:The present study summarizes 103 cases of EGC/HGIN detected by esophagogastroduodenoscopy (EGD) and pathological analysis from January 2010 to December 2011. Dimet...

journal_title：World journal of gastroenterology

authors： Ren W,Yu J,Zhang ZM,Song YK,Li YH,Wang L

更新日期：2013-04-07 00:00:00

abstract：AIM:To determine the mechanical properties of anastomotic colonic tissue in experimental settings and therefore give a measure of wound healing. METHODS:Thirty-six male Wistar rats were used as experimental models of anastomotic tissue integrity. On the 5th post-operative day, the tensile strength was measured by appl...

journal_title：World journal of gastroenterology

authors： Ekmektzoglou KA,Zografos GC,Kourkoulis SK,Dontas IA,Giannopoulos PK,Marinou KA,Poulakou MV,Perrea DN

更新日期：2006-09-21 00:00:00

abstract：:Smoking of tobacco products continues to be a major cause of worldwide health problems. Epidemiological studies have shown that tobacco smoking is the greatest risk factor for the development of pancreatic cancer. Smokers who are able to quit smoking can reduce their risk of pancreatic cancer by nearly 50% within two ...

journal_title：World journal of gastroenterology

authors： MacLeod SL,Chowdhury P

更新日期：2006-12-14 00:00:00

abstract：:Metastatic breast cancer involving the hepatobiliary tract or ascites secondary to peritoneal carcinomatosis has been well described. Luminal gastrointestinal tract involvement is less common and recognition of the range of possible presentations is important for early and accurate diagnosis and treatment. We report 6...

journal_title：World journal of gastroenterology

authors： Nazareno J,Taves D,Preiksaitis HG

更新日期：2006-10-14 00:00:00

abstract：:Dilatation of the colon and the rectum, which is not attributable to aganglionosis, is a rare finding and can be the result of intractable chronic constipation. We report a rare case of a 29-year-old male patient with impressive megacolon, in whom Hirschsprung's or Chagas disease was ruled out. In the present case, di...

journal_title：World journal of gastroenterology

authors： Mecklenburg I,Leibig M,Weber C,Schmidbauer S,Folwaczny C

更新日期：2005-12-28 00:00:00

abstract：AIM:To evaluate the clinic features of eosinophilic gastroenteritis and to examine the diagnosis, treatment, long-term outcome of this disease. METHODS:Charts with a diagnosis of eosinophilic gastroenteritis from 1984 to 2002 at Mackay Memorial Hospital were reviewed retrospectively. There were 15 patients diagnosed w...

journal_title：World journal of gastroenterology

authors： Chen MJ,Chu CH,Lin SC,Shih SC,Wang TE

更新日期：2003-12-01 00:00:00

abstract：AIM:To examine the effects of aspirin and enoxaparin on liver function, coagulation index and histopathology in a rat model of liver fibrosis. METHODS Forty-five male Sprague-Dawley rats were randomly divided into the control group (n = 5) and model group (n = 40). Thioacetamide (TAA) was used to induce liver fibrosis ...

journal_title：World journal of gastroenterology

authors： Li CJ,Yang ZH,Shi XL,Liu DL

更新日期：2017-09-21 00:00:00

abstract：:Acute hepatic failure due to hepatitis B virus (HBV) can occur both during primary infection as well as after reactivation of chronic infection. Guidelines recommend considering antiviral therapy in both situations, although evidence supporting this recommendation is weak. Since HBV is not directly cytopathic, the mec...

journal_title：World journal of gastroenterology

authors： Bockmann JH,Dandri M,Lüth S,Pannicke N,Lohse AW

更新日期：2015-02-21 00:00:00

abstract：AIM:To determine the prevalence, characteristics and clinical course of pancreatic cystic neoplasms (PCNs) in liver transplantation (LT) recipients. METHODS:We retrospectively studied consecutive patients who underwent LT between January 1998 to April 2016. Clinical and laboratory data were obtained from patient medic...

journal_title：World journal of gastroenterology

authors： Liu K,Joshi V,van Camp L,Yang QW,Baars JE,Strasser SI,McCaughan GW,Majumdar A,Saxena P,Kaffes AJ

更新日期：2017-12-28 00:00:00

abstract：BACKGROUND:The Korea National Cancer Screening Program currently provides screening for colorectal cancer (CRC) for adults older than 50 years with no upper age limit. In general, people are likely to only pay attention to the benefits of cancer screening and to neglect its risks. Most consider the benefits of cancer s...

journal_title：World journal of gastroenterology

authors： Luu XQ,Lee K,Lee YY,Suh M,Kim Y,Choi KS

更新日期：2020-07-21 00:00:00

abstract：AIM:To study the effect of progesterone on contractile activity of isolated gastric strips in rats. METHODS:Wistar rats were sacrificed to remove whole stomach. Then, the stomach was opened and the mucosal layer was removed. Parallel to either the circular or the longitudinal fibers, muscle strips were cut from fundus...

journal_title：World journal of gastroenterology

authors： Wang F,Zheng TZ,Li W,Qu SY,He DY

更新日期：2003-04-01 00:00:00

abstract：:Over the last 15 years, there have been major advances in the multimodal treatment of gastric cancer, in large part due to several phase III studies showing the treatment benefits of neoadjuvant and adjuvant chemotherapy and chemoradiation protocols. The objective of this editorial is to review the current high-level ...

journal_title：World journal of gastroenterology

authors： Choi AH,Kim J,Chao J

更新日期：2015-06-28 00:00:00

abstract：AIM:To investigate the existence and levels of sH2a, a soluble secreted form of the asialoglycoprotein receptor in human serum. METHODS:Production of recombinant sH2a and development of a monoclonal antibody and an enzyme-linked immunosorbent assay (ELISA). This assay was used to determine the presence and concentrati...

journal_title：World journal of gastroenterology

authors： Benyair R,Kondratyev M,Veselkin E,Tolchinsky S,Shenkman M,Lurie Y,Lederkremer GZ

更新日期：2011-12-28 00:00:00