Recent developments on the role of Clostridium difficile in inflammatory bowel disease.

Abstract:

:Clostridium difficile (CD), specifically its toxins, have been implicated as a risk factor for exacerbation of the inflammatory process in up to 5% of patients with ulcerative colitis or Crohnos disease. Typical evidence of colonic changes with CD infection, including pseudomembranous exudate, are often not present; however, a severe clinical course may result, including precipitation of toxic colitis and toxic megacolon. Recently, hypervirulent CD strains have been reported raising concern for a more severe disease process in patients with underlying inflammatory bowel disease. Moreover, small bowel involvement or CD enteritis has been increasingly described, usually in those with a history of a prior colectomy or total proctocolectomy for prior severe and extensive inflammatory bowel disease. Finally, refractory or treatment-resistant pouchitis may occur with CD infection.

journal_name

World J Gastroenterol

authors

Freeman HJ

doi

10.3748/wjg.14.2794

subject

Has Abstract

pub_date

2008-05-14 00:00:00

pages

2794-6

issue

18

eissn

1007-9327

issn

2219-2840

journal_volume

14

pub_type

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