Construction, expression and tumor targeting of a single-chain Fv against human colorectal carcinoma.

abstract：AIM:To investigate the effect of activation of canonical Wnt signaling pathway on the proliferation and differentiation of hepatic oval cells in vitro. METHODS:WB-F344 cells were treated with recombinant Wnt3a (20, 40, 80, 160, 200 ng/mL) in serum-free medium for 24 h. Cell proliferation was measured by Brdu incorpora...

journal_title：World journal of gastroenterology

authors： Zhang Y,Li XM,Zhang FK,Wang BE

更新日期：2008-11-21 00:00:00

abstract：:P21-activated kinases (PAKs) are central players in various oncogenic signaling pathways. The six PAK family members are classified into group I (PAK1-3) and group II (PAK4-6). Focus is currently shifting from group I PAKs to group II PAKs. Group II PAKs play important roles in many fundamental cellular processes, som...

journal_title：World journal of gastroenterology

authors： Shao YG,Ning K,Li F

更新日期：2016-01-21 00:00:00

abstract：AIM:To understand the role of toll-like receptor 4 (TLR4) signaling in the regulation of iron-regulatory hormone, hepcidin by chronic alcohol consumption. METHODS:For chronic alcohol intake studies, TLR4 mutant mice on C3H/HeJ background and wildtype counterpart on C3H/HeOuJ background were pair-fed with regular (cont...

journal_title：World journal of gastroenterology

authors： Zmijewski E,Lu S,Harrison-Findik DD

更新日期：2014-09-14 00:00:00

abstract：AIM:Inducible nitric oxide synthase (iNOS) plays a central role in the pathway of reactive oxygen and nitrogen species metabolism when Helicobacter pylori (H pylori) infection occurs in humans. iNOS Ser(608)Leu allele, a novel genetic polymorphism (C/T) occurring within exon 16 of the iNOS reductase domain, may have a ...

journal_title：World journal of gastroenterology

authors： Shen J,Wang RT,Wang LW,Xu YC,Wang XR

更新日期：2004-11-15 00:00:00

abstract：AIM:CMU-1 is a new preservation solution with a low potassium concentration as well as low viscosity that is highly effective in reducing preservation injury. The purpose of this experiment is to compare the protective effect of CMU-1 solution with that of UW during cold preservation and normothermic reperfusion. METH...

journal_title：World journal of gastroenterology

authors： Cheng Y,Liu YF,Cheng DH,Li BF,Zhao N

更新日期：2005-04-28 00:00:00

abstract：AIM:To assess the clinicopathological and biological significance of cripto in human colorectal cancer. METHODS:Real-time reverse-transcription polymerase chain reaction (PCR) was used to examine cripto mRNA levels in primary colon cancer and normal colon tissues as well as normal and metastatic lymph nodes from colon...

journal_title：World journal of gastroenterology

authors： Jiang PC,Zhu L,Fan Y,Zhao HL

更新日期：2013-12-14 00:00:00

abstract：AIM:To investigate whether potent acid inhibition is effective in non-erosive reflux disease (NERD) refractory to standard rabeprazole (RPZ) treatment. METHODS:We treated 10 Japanese patients with NERD resistant to standard dosages of RPZ: 10 mg or 20 mg od, 20 mg bid, or 10 mg qid for 14 d. All patients completed a f...

journal_title：World journal of gastroenterology

authors： Sugimoto M,Nishino M,Kodaira C,Yamade M,Uotani T,Ikuma M,Umemura K,Furuta T

更新日期：2011-04-14 00:00:00

abstract：AIM:To evaluate whether FDG-positron emission tomography (PET)/computed tomography (CT) may be an accurate technique in the assessment of the T stage in patients with colorectal cancer. METHODS:Thirty four consecutive patients (20 men and 14 women; mean age: 63 years) with a histologically proven diagnosis of colorect...

journal_title：World journal of gastroenterology

authors： Mainenti PP,Iodice D,Segreto S,Storto G,Magliulo M,De Palma GD,Salvatore M,Pace L

更新日期：2011-03-21 00:00:00

abstract：AIM:To explore the significance of corticotropin-releasing hormone (CRH)-receptor (R)2 in mucosal healing of dextran sulfate sodium (DSS)-induced colitis and the effect of Tong-Xie-Yao-Fang (TXYF) on CRH-R2 expression and regulation. METHODS:Ulcerative colitis was induced in mice by administration of 3% (w/v) DSS for ...

journal_title：World journal of gastroenterology

authors： Gong SS,Fan YH,Wang SY,Han QQ,Lv B,Xu Y,Chen X,He YE

更新日期：2018-04-28 00:00:00

abstract：AIM:To investigate the characteristic radiologic findings of cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) which can be differentiated from other similar bowel disease and to assess their clinical behavior. METHODS:Twenty pathologically and clinically confirmed CMUSE patients (males:females = 8:12; mean ...

journal_title：World journal of gastroenterology

authors： Hwang J,Kim JS,Kim AY,Lim JS,Kim SH,Kim MJ,Kim MS,Song KD,Woo JY

更新日期：2017-07-07 00:00:00

abstract：AIM:To determine the efficacy of Mac-2 binding protein (Mac-2bp) for diagnosis of chronic pancreatitis. METHODS:Fifty-nine healthy volunteers (HV), 162 patients with chronic pancreatitis (CP), and 94 patients with pancreatic ductal adenocarcinoma (PDAC) were enrolled in this study. We measured serum Mac-2bp using our ...

journal_title：World journal of gastroenterology

authors： Maekawa T,Kamada Y,Ebisutani Y,Ueda M,Hata T,Kawamoto K,Takamatsu S,Mizutani K,Shimomura M,Sobajima T,Fujii H,Nakayama K,Nishino K,Yamada M,Kumada T,Ito T,Eguchi H,Nagano H,Miyoshi E

更新日期：2016-05-07 00:00:00

abstract：AIM:To study the association between exposure to Salmonella enterica (SE) and Crohn's disease (CD) and its clinical implications in Chilean patients. METHODS:Ninety-four unrelated Chilean CD patients from CAREI (Active Cohort Registry of Inflammatory Bowel Disease) presenting to a single inflammatory bowel disease (IB...

journal_title：World journal of gastroenterology

authors： Alvarez-Lobos M,Pizarro DP,Palavecino CE,Espinoza A,Sebastián VP,Alvarado JC,Ibañez P,Quintana C,Díaz O,Kalergis AM,Bueno SM

更新日期：2013-09-21 00:00:00

abstract：AIM:To investigate the risk association and compare the onset age of hepatocellular carcinoma (HCC) patients in Taiwan with different genotypes of MDM2-SNP309. METHODS:We analyzed MDM2-SNP309 genotypes from 58 patients with HCC and 138 cancer-free healthy controls consecutively. Genotyping of MDM2-SNP309 was conducted...

journal_title：World journal of gastroenterology

authors： Leu JD,Lin IF,Sun YF,Chen SM,Liu CC,Lee YJ

更新日期：2009-11-28 00:00:00

abstract：AIM:To investigate the relationship between exercise-provoked esophageal motility disorders and the prognosis for patients with chest pain. METHODS:The study involved 63 subjects with recurrent angina-like chest pain non-responsive to empirical therapy with proton pump inhibitor (PPI). In all, a coronary artery angiog...

journal_title：World journal of gastroenterology

authors： Budzyński J

更新日期：2010-09-21 00:00:00

abstract：:Recent advances in diagnostic techniques have allowed the diagnosis of gastric cancer (GC) at an early stage. Due to the low incidence of lymph node metastasis and favorable prognosis in early GC, function-preserving surgery which improves postoperative quality of life may be possible. Pylorus-preserving gastrectomy (...

journal_title：World journal of gastroenterology

authors： Saito T,Kurokawa Y,Takiguchi S,Mori M,Doki Y

更新日期：2014-12-14 00:00:00

abstract：AIM:To compare the prevalence of Helicobacter pylori (H pylori) IgG and IgA antibodies between adult subjects, with defined gastric diseases, non-defined gastric disorders and those representing the population. METHODS:Data on H pylori IgG and IgA antibodies, determined by enzyme immunoassay, were analyzed in 3,252 su...

journal_title：World journal of gastroenterology

authors： Kosunen TU,Seppala K,Sarna S,Aromaa A,Knekt P,Virtamo J,Salomaa-Rasanen A,Rautelin H

更新日期：2005-11-21 00:00:00

abstract：BACKGROUND:Increasing levels of antibiotic resistance have reduced the Helicobacter pylori (H. pylori) eradication rates afforded by the standard triple therapy. Thus, 2-wk first-line four-drug regimens must be considered. AIM:To analyze the eradication rates of modified bismuth-containing quadruple therapy (mBCQT) an...

journal_title：World journal of gastroenterology

authors： Kim SJ,Chung JW,Woo HS,Kim SY,Kim JH,Kim YJ,Kim KO,Kwon KA,Park DK

更新日期：2019-12-14 00:00:00

abstract：AIM:To examine the association between parity and gastric cancer (the cases are almost all premenopausal women) risk in a cohort of young parous women. METHODS:The study cohort consisted of all women with a record of a first and singleton childbirth in the Birth Register between 1978 and 1987. We tracked each woman fr...

journal_title：World journal of gastroenterology

authors： Chang CC,Chen CC,Chiu HF,Yang CY

更新日期：2011-02-14 00:00:00

abstract：BACKGROUND:Early diagnosis of hepatocellular carcinoma may help to ensure that patients have a chance for long-term survival; however, currently available biomarkers lack sensitivity and specificity. AIM:To characterize the serum metabolome of hepatocellular carcinoma in order to develop a new metabolomics diagnostic ...

journal_title：World journal of gastroenterology

authors： Zhou PC,Sun LQ,Shao L,Yi LZ,Li N,Fan XG

更新日期：2020-08-21 00:00:00

abstract：AIM:To examine the epidemiology of hepatitis B virus carrier status (HBVC) and sonographic fatty liver (SFL) in Taiwanese adults, and to evaluate their possible interaction in inducing liver damage (LD). >From an epidemiological viewpoint, we analyzed previous studies which indicated that fatty liver sensitizes host im...

journal_title：World journal of gastroenterology

authors： Lin YC,Hsiao ST,Chen JD

更新日期：2007-03-28 00:00:00

abstract：:A primary clear cell adenocarcinoma of the colon is a rare oncologic entity. We herein report a case of such a tumor of the sigmoid colon in a 71-year-old woman who was successfully treated by an endoscopic polypectomy in our hospital. We also reviewed the published reports regarding cases of primary clear cell tumors...

journal_title：World journal of gastroenterology

authors： Soga K,Konishi H,Tatsumi N,Konishi C,Nakano K,Wakabayashi N,Mitsufuji S,Kataoka K,Okanoue T,Mukaisho K,Hattori T

更新日期：2008-02-21 00:00:00

abstract：:Long-term outcome data in pancreatic adenocarcinoma are predominantly based on surgical series, as resection is currently considered essential for long-term survival. In contrast, five-year survival in non-resected patients has rarely been reported. In this report, we examined the incidence and natural history of ≥ 5-...

journal_title：World journal of gastroenterology

authors： Oh SY,Edwards A,Mandelson MT,Lin B,Dorer R,Helton WS,Kozarek RA,Picozzi VJ

更新日期：2015-12-28 00:00:00

abstract：:An inefficient cellular immune response likely leads to chronic hepatitis C virus (HCV) infection. Resolution of chronic HCV infection in the absence of treatment is a rare occurrence. We report the case of a 39-year old white male with a 17-year history of chronic HCV infection, who eradicated HCV following a serious...

journal_title：World journal of gastroenterology

authors： Byrnes V,Chopra S,Koziel MJ

更新日期：2007-08-21 00:00:00

abstract：AIM:To investigate the anti-diabetogenic mechanism of Nardostachys jatamansi extract (NJE). METHODS:Mice were injected with streptozotocin via a tail vein to induce diabetes. Rat insulinoma RINm5F cells and isolated rat islets were treated with interleukin-1beta and interferon-gamma to induce cytotoxicity. RESULTS:Tr...

journal_title：World journal of gastroenterology

authors： Song MY,Bae UJ,Lee BH,Kwon KB,Seo EA,Park SJ,Kim MS,Song HJ,Kwon KS,Park JW,Ryu DG,Park BH

更新日期：2010-07-14 00:00:00

abstract：AIM:To clone and express the antigen of monoclonal antibody (MAb) PD4 for further investigation of its function. METHODS:MGC803 cDNA expression library was constructed and screened with PD4 as probes to clone the antigen. After failed in the library screening, immunoprecipitation and SDS-polyacrylamide gel electrophor...

journal_title：World journal of gastroenterology

authors： Ning JY,Sun GX,Huang S,Ma H,An P,Meng L,Song SM,Wu J,Shou CC

更新日期：2003-10-01 00:00:00

abstract：AIM:To investigate protective effects and molecular mechanisms of green tea polyphenols (GTP) on non-alcoholic fatty liver disease (NAFLD) in Zucker fatty (ZF) rats. METHODS:Male ZF rats were fed a high-fat diet (HFD) for 2 wk then treated with GTP (200 mg/kg) or saline (5 mL/kg) for 8 wk, with Zucker lean rat as thei...

journal_title：World journal of gastroenterology

authors： Tan Y,Kim J,Cheng J,Ong M,Lao WG,Jin XL,Lin YG,Xiao L,Zhu XQ,Qu XQ

更新日期：2017-06-07 00:00:00

abstract：AIM:To investigate Helicobacter pylori (H. pylori) eradication rates using second-line bismuth-containing quadruple therapy and to identify predictors of eradication failure. METHODS:This study included 636 patients who failed first-line triple therapy and received 7 d of bismuth-containing quadruple therapy between J...

journal_title：World journal of gastroenterology

authors： Kim SE,Park MI,Park SJ,Moon W,Kim JH,Jung K,Kim HK,Lee YD

更新日期：2017-02-14 00:00:00

abstract：AIM:The purpose of the present study is to compare the optical properties of normal human colon mucosa/submucosa and muscle layer/chorion, and adenomatous human colon mucosa/submucosa and muscle layer/chorion in vitro at 476.5, 488, 496.5, 514.5 and 532 nm. We believe these differences in optical properties should help...

journal_title：World journal of gastroenterology

authors： Wei HJ,Xing D,Lu JJ,Gu HM,Wu GY,Jin Y

更新日期：2005-04-28 00:00:00

abstract：AIM:To investigate the effects of Terminalia arjuna (T. arjuna) extract on human hepatoma cell line (HepG2) and its possible role in induction of apoptosis. METHODS:Human hepatoma cells were treated with different concentrations of ethanolic extract of T. arjuna and its cytotoxicity effect was measured by trypan blue ...

journal_title：World journal of gastroenterology

authors： Sivalokanathan S,Vijayababu MR,Balasubramanian MP

更新日期：2006-02-21 00:00:00

abstract：AIM:To study immune response induced by foreign plasmid DNA after oral administration in mice. METHODS:Mice were orally administered with 200 mug of plasmid pcDNA3 once and spleen was isolated 4 h and 18 h after administration. Total RNA was extracted from spleen and gene expression profile of BALB/c mice spleen was a...

journal_title：World journal of gastroenterology

authors： Liu JW,Cheng J

更新日期：2007-07-28 00:00:00