Abstract:
AIM:To investigate the risk association and compare the onset age of hepatocellular carcinoma (HCC) patients in Taiwan with different genotypes of MDM2-SNP309. METHODS:We analyzed MDM2-SNP309 genotypes from 58 patients with HCC and 138 cancer-free healthy controls consecutively. Genotyping of MDM2-SNP309 was conducted by restriction fragment length polymorphism assay. RESULTS:The proportion of homozygous MDM2-SNP309 genotype (G/G) in cases and cancer-free healthy controls was similar (17.2% vs 16.7%). Multivariate analysis showed that the risk of G/G genotype of MDM2-SNP309 vs wild-type T/T genotype in patients with HCC was not significant (OR = 1.265, 95% CI = 0.074-21.77) after adjustment for sex, hepatitis B or C virus infection, age, and cardiovascular disease/diabetes. Nevertheless, there was a trend that GG genotype of MDM2-SNP309 might increase the risk in HCC patients infected with hepatitis virus (OR = 2.568, 95% CI = 0.054-121.69). Besides, the homozygous MDM2-SNP309 genotype did not exhibit a significantly earlier age of onset for HCC. CONCLUSION:Current data suggest that the association between MDM2-SNP309 GG genotype and HCC is not significant, while the risk may be enhanced in patients infected by hepatitis virus in Taiwan.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Leu JD,Lin IF,Sun YF,Chen SM,Liu CC,Lee YJdoi
10.3748/wjg.15.5592subject
Has Abstractpub_date
2009-11-28 00:00:00pages
5592-7issue
44eissn
1007-9327issn
2219-2840journal_volume
15pub_type
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pub_type: 杂志文章
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doi:10.3748/wjg.v22.i25.5769
更新日期:2016-07-07 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2014-08-14 00:00:00
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pub_type: 杂志文章,随机对照试验
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