Abstract:
AIM:To analyze RASSF6 expression in pancreatic ductal adenocarcinoma (PDAC) and to determine whether RASSF6 has an independent prognostic value in PDAC. METHODS:We studied RASSF6 expression in 96 histologically confirmed PDAC samples and 20 chronic pancreatitis specimens using immunohistochemistry and real-time quantitative reverse transcription-PCR. PDAC issues were then classified as RASSF6 strongly positive, weakly positive or negative. RASSF6 mRNA and protein expression in PDAC samples with strong positive staining was further evaluated using real-time PCR and Western blot analysis. Lastly, correlations between RASSF6 staining and patients' clinicopathological variables and outcomes were assessed. RESULTS:RASSF6 was negatively expressed in 51 (53.1%) PDAC samples, weakly positively expressed in 29 (30.2%) and strongly positively expressed in 16 (16.7%), while its expression was much higher in para-tumor tissues and chronic pancreatitis tissues. Positive relationships between RASSF6 expression and T-stage (P = 0.047) and perineural invasion (P = 0.026) were observed. The median survival time of strongly and weakly positive and negative RASSF6 staining groups was 33 mo, 15 mo and 11 mo, respectively. Cox multivariate analysis indicated that RASSF6 was an independent prognostic indicator of overall survival in patients with PDAC. A survival curve analysis revealed that increased RASSF6 expression was correlated with better overall survival (P = 0.009). CONCLUSION:RASSF6 expression is an independent biomarker of an unfavorable prognosis in patients with PDAC.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Ye HL,Li DD,Lin Q,Zhou Y,Zhou QB,Zeng B,Fu ZQ,Gao WC,Liu YM,Chen RW,Li ZH,Chen RFdoi
10.3748/wjg.v21.i21.6621subject
Has Abstractpub_date
2015-06-07 00:00:00pages
6621-30issue
21eissn
1007-9327issn
2219-2840journal_volume
21pub_type
杂志文章abstract:AIM:To investigate the impact of chronic fatigue on disease-related worries in inflammatory bowel disease (IBD) and the potential multicolinearity between subjective questionnaires. METHODS:Patients in remission or with mild-to-moderate disease activity completed the fatigue questionnaire (FQ), the rating form of IBD ...
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pub_type: 杂志文章,评审
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journal_title:World journal of gastroenterology
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pub_type: 临床试验,杂志文章
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更新日期:2004-03-15 00:00:00
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更新日期:2014-08-14 00:00:00