Pediatric nonalcoholic fatty liver disease: overview with emphasis on histology.

Abstract:

:Nonalcoholic fatty liver disease (NAFLD) is a disease in which excessive fat accumulates in the liver of a patient without a history of alcohol abuse. This disease includes simple steatosis and nonalcoholic steatohepatitis (NASH). NAFLD/NASH is recognized as a hepatic manifestation of metabolic syndrome. In recent years, pediatric NAFLD has increased in line with the increased prevalence of pediatric obesity. The estimated prevalence of pediatric NAFLD is 2.6%-9.6%, and it is associated with sex, age, and ethnicity. With regard to the pathogenesis of NAFLD, the "two-hit" hypothesis is widely accepted and oxidative stress is thought to play an important role in the second hit. Although clinical symptoms, laboratory data, and imaging findings are important, liver biopsy is regarded as the gold standard for the diagnosis of NAFLD/NASH. In addition, liver biopsy is essential for assessing the degree of necro-inflammatory change and fibrosis in NASH. Two different types of steatohepatitis (type 1 and type 2 NASH) have been reported, with type 2 NASH being present in as many as 51% of pediatric NAFLD patients. However, we and others have observed that type 1 and 2 patterns commonly overlap. Although pharmacotherapy has been studied in clinical trials, lifestyle modification by diet and exercise remains the mainstay of treatment for NAFLD/NASH.

journal_name

World J Gastroenterol

authors

Takahashi Y,Fukusato T

doi

10.3748/wjg.v16.i42.5280

subject

Has Abstract

pub_date

2010-11-14 00:00:00

pages

5280-5

issue

42

eissn

1007-9327

issn

2219-2840

journal_volume

16

pub_type

杂志文章
  • Adipokines and ghrelin in gastric cancer cachexia.

    abstract:AIM:To investigate the roles of the adipocytokines, ghrelin and leptin in gastric cancer cachexia. METHODS:Resistin, ghrelin, leptin, adiponectin, insulin and insulin-like growth factor (IGF-I), were measured in 30 healthy subjects, and 60 gastric cancer patients of which 30 suffered from cancer-induced cachexia and 3...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.3633

    authors: Kerem M,Ferahkose Z,Yilmaz UT,Pasaoglu H,Ofluoglu E,Bedirli A,Salman B,Sahin TT,Akin M

    更新日期:2008-06-21 00:00:00

  • Psychological controversies in gastroparesis: A systematic review.

    abstract:AIM:To systematically review literature addressing three key psychologically-oriented controversies associated with gastroparesis. METHODS:A comprehensive search of PubMed, CINAHL, and PsycINFO databases was performed to identify literature addressing the relationship between gastroparesis and psychological factors. T...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v23.i7.1298

    authors: Woodhouse S,Hebbard G,Knowles SR

    更新日期:2017-02-21 00:00:00

  • Multifocal gastrointestinal epithelioid angiosarcomas diagnosed by endoscopic mucosal resection: A case report.

    abstract:BACKGROUND:Epithelioid angiosarcoma is a vascular neoplasm that is among the most aggressive subtypes of sarcomas. Its involvement in the gastrointestinal tract is rare. We here report a case of multifocal gastrointestinal epithelioid angiosarcomas presenting with gastrointestinal bleeding. CASE SUMMARY:A 77-year-old ...

    journal_title:World journal of gastroenterology

    pub_type:

    doi:10.3748/wjg.v26.i29.4372

    authors: Chen YW,Dong J,Chen WY,Dai YN

    更新日期:2020-08-07 00:00:00

  • Role of inflammation and infection in the pathogenesis of human acute liver failure: Clinical implications for monitoring and therapy.

    abstract::Acute liver failure is a rare and devastating clinical condition. At present, emergency liver transplantation is the only life-saving therapy in advanced cases, yet the feasibility of transplantation is affected by the presence of systemic inflammation, infection and resultant multi-organ failure. The importance of im...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i26.5958

    authors: Donnelly MC,Hayes PC,Simpson KJ

    更新日期:2016-07-14 00:00:00

  • Drug therapy for ulcerative colitis.

    abstract::Ulcerative colitis (UC) is an inflammatory destructive disease of the large intestine occurred usually in the rectum and lower part of the colon as well as the entire colon. Drug therapy is not the only choice for UC treatment and medical management should be as a comprehensive whole. Azulfidine, Asacol, Pentasa, Dipe...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v10.i16.2311

    authors: Xu CT,Meng SY,Pan BR

    更新日期:2004-08-15 00:00:00

  • Associations between NOD2/CARD15 genotype and phenotype in Crohn's disease--Are we there yet?

    abstract::There have been multiple NOD2/CARD15 genotype-phenotype analyses undertaken in patients with Crohn's disease since the gene's discovery in 2001. This review focuses on the major published series based upon their size and on the presence of specific clinical and genetic information provided in the published material fr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v12.i44.7097

    authors: Radford-Smith G,Pandeya N

    更新日期:2006-11-28 00:00:00

  • Choroidal and cutaneous metastasis from gastric adenocarcinoma.

    abstract::Choroidal or cutaneous metastasis of gastric cancer is rare. Gastrointestinal cancer was found in only 4% in patients with uveal metastasis. Choroidal metastasis from gastric cancer was reported in two cases in earlier literature. The frequency of gastric cancer as a primary lesion was 6% in cutaneous metastasis of me...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i9.1485

    authors: Kawai S,Nishida T,Hayashi Y,Ezaki H,Yamada T,Shinzaki S,Miyazaki M,Nakai K,Yakushijin T,Watabe K,Iijima H,Tsujii M,Nishida K,Takehara T

    更新日期:2013-03-07 00:00:00

  • Liver fat deposition and mitochondrial dysfunction in morbid obesity: An approach combining metabolomics with liver imaging and histology.

    abstract:AIM:To explore the usefulness of magnetic resonance imaging (MRI) and spectroscopy (MRS) for assessment of non-alcoholic fat liver disease (NAFLD) as compared with liver histological and metabolomics findings. METHODS:Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectom...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i24.7529

    authors: Calvo N,Beltrán-Debón R,Rodríguez-Gallego E,Hernández-Aguilera A,Guirro M,Mariné-Casadó R,Millá L,Alegret JM,Sabench F,del Castillo D,Vinaixa M,Rodríguez MÀ,Correig X,García-Álvarez R,Menendez JA,Camps J,Joven J

    更新日期:2015-06-28 00:00:00

  • Patient education improves adherence to peg-interferon and ribavirin in chronic genotype 2 or 3 hepatitis C virus infection: a prospective, real-life, observational study.

    abstract:AIM:To evaluate the impact of therapeutic education on adherence to antiviral treatment and sustained virological response (SVR) in a real-life setting in genotype 2/3 hepatitis C, as there are few adherence data in genotype 2/3 infection, even from randomized trials. METHODS:This prospective survey included genotype ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3748/wjg.14.6195

    authors: Cacoub P,Ouzan D,Melin P,Lang JP,Rotily M,Fontanges T,Varastet M,Chousterman M,Marcellin P

    更新日期:2008-10-28 00:00:00

  • Hepatitis C virus: virology, diagnosis and management of antiviral therapy.

    abstract::Hepatitis C virus (HCV) infects approximately 170 million individuals worldwide. Prevention of HCV infection complications is based on antiviral therapy with the combination of pegylated interferon alfa and ribavirin. The use of serological and virological tests has become essential in the management of HCV infection ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v13.i17.2461

    authors: Chevaliez S,Pawlotsky JM

    更新日期:2007-05-07 00:00:00

  • Transhepatic catheter-directed thrombolysis for portal vein thrombosis after partial splenic embolization in combination with balloon-occluded retrograde transvenous obliteration of splenorenal shunt.

    abstract::A 66-year-old woman underwent partial splenic embolization (PSE) for hypersplenism with idiopathic portal hypertension (IPH). One week later, contrast-enhanced CT revealed extensive portal vein thrombosis (PVT) and dilated portosystemic shunts. The PVT was not dissolved by the intravenous administration of urokinase. ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i31.5071

    authors: Nakai M,Sato M,Sahara S,Kawai N,Kimura M,Maeda Y,Ibata Y,Higashi K

    更新日期:2006-08-21 00:00:00

  • Identification of antigens by monoclonal antibody PD4 and its expression in Escherichia coli.

    abstract:AIM:To clone and express the antigen of monoclonal antibody (MAb) PD4 for further investigation of its function. METHODS:MGC803 cDNA expression library was constructed and screened with PD4 as probes to clone the antigen. After failed in the library screening, immunoprecipitation and SDS-polyacrylamide gel electrophor...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i10.2164

    authors: Ning JY,Sun GX,Huang S,Ma H,An P,Meng L,Song SM,Wu J,Shou CC

    更新日期:2003-10-01 00:00:00

  • Altered distribution of regulatory lymphocytes by oral administration of soy-extracts exerts a hepatoprotective effect alleviating immune mediated liver injury, non-alcoholic steatohepatitis and insulin resistance.

    abstract:AIM:To determine the immune-modulatory and the hepatoprotective effects of oral administration of two soy extracts in immune mediated liver injury and non-alcoholic steatohepatitis (NASH). METHODS:Two soy extracts, M1 and OS, were orally administered to mice with concanavalin A (ConA) immune-mediated hepatitis, to hig...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i24.7443

    authors: Khoury T,Ben Ya'acov A,Shabat Y,Zolotarovya L,Snir R,Ilan Y

    更新日期:2015-06-28 00:00:00

  • Campylobacter concisus and inflammatory bowel disease.

    abstract::Investigation of the possible role of Campylobacter concisus (C. concisus) in inflammatory bowel disease (IBD) is an emerging research area. Despite the association found between C. concisus and IBD, it has been difficult to explain how C. concisus, a bacterium that is commonly present in the human oral cavity, may co...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i5.1259

    authors: Zhang L,Lee H,Grimm MC,Riordan SM,Day AS,Lemberg DA

    更新日期:2014-02-07 00:00:00

  • Upper gastrointestinal bleeding in Scotland 2000-2010: Improved outcomes but a significant weekend effect.

    abstract:AIM:To assess numbers and case fatality of patients with upper gastrointestinal bleeding (UGIB), effects of deprivation and whether weekend presentation affected outcomes. METHODS:Data was obtained from Information Services Division (ISD) Scotland and National Records of Scotland (NRS) death records for a ten year per...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i38.10890

    authors: Ahmed A,Armstrong M,Robertson I,Morris AJ,Blatchford O,Stanley AJ

    更新日期:2015-10-14 00:00:00

  • Targeted medical therapy of biliary tract cancer: recent advances and future perspectives.

    abstract::The limited efficacy of cytotoxic therapy for advanced biliary tract and gallbladder cancers emphasizes the need for novel and more effective medical treatment options. A better understanding of the specific biological features of these neoplasms led to the development of new targeted therapies, which take the abundan...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审

    doi:10.3748/wjg.14.7021

    authors: Hopfner M,Schuppan D,Scherubl H

    更新日期:2008-12-14 00:00:00

  • Distribution of solitary lymph nodes in primary gastric cancer: a retrospective study and clinical implications.

    abstract:AIM:To investigate the distribution pathway of metastatic lymph nodes in gastric carcinoma as a foundation for rational lymphadenectomy. METHODS:We investigated 173 cases with solitary or single station metastatic lymph nodes (LN) from among 2476 gastric carcinoma patients. The location of metastatic LN, histological ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i35.4776

    authors: Liu CG,Lu P,Lu Y,Jin F,Xu HM,Wang SB,Chen JQ

    更新日期:2007-09-21 00:00:00

  • Variations of very low-density lipoprotein receptor subtype expression in gastrointestinal adenocarcinoma cells with various differentiations.

    abstract:AIM:This study is aimed at investigating the expression and possible significances of very low-density lipoprotein receptor (VLDLR) subtypes in gastroenteric adenocarcinoma tissues and cells with various differentiations. METHODS:Thirty-one cases of gastroenteric carcinoma/adjacent normal tissues were enrolled in the ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i18.2817

    authors: Chen T,Wu F,Chen FM,Tian J,Qu S

    更新日期:2005-05-14 00:00:00

  • Profiling of differentially expressed genes in human gastric carcinoma by cDNA expression array.

    abstract:AIM:To investigate the expression of cancer related genes in gastric carcinoma (GC) through the use of Atlas Human Cancer Array membranes with 588 well-characterized human genes related to cancer and tumor biology. METHODS:Hybridization of cDNA blotting membrane was performed with (32)P-labeled cDNA probes synthesized...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v8.i4.580

    authors: Liu LX,Liu ZH,Jiang HC,Qu X,Zhang WH,Wu LF,Zhu AL,Wang XQ,Wu M

    更新日期:2002-08-01 00:00:00

  • Frequency and prognostic role of mucosal healing in patients with Crohn's disease and ulcerative colitis after one-year of biological therapy.

    abstract:AIM:To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn's disease (CD) and ulcerative colitis (UC). METHODS:The data from 41 patients with CD and 22 patients w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3748/wjg.v20.i11.2995

    authors: Farkas K,Lakatos PL,Szűcs M,Pallagi-Kunstár É,Bálint A,Nagy F,Szepes Z,Vass N,Kiss LS,Wittmann T,Molnár T

    更新日期:2014-03-21 00:00:00

  • Occupational exposure to vinyl chloride and liver diseases.

    abstract::Portal hypertension, liver fibrosis, and angiosarcoma of the liver (ASL) have been reported among workers exposed to vinyl chloride monomer (VCM) since the 1970s. In 2007, the International Agency for Research on Cancer established the association of VCM with hepatocellular carcinoma (HCC), though only on the basis of...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v25.i33.4885

    authors: Fedeli U,Girardi P,Mastrangelo G

    更新日期:2019-09-07 00:00:00

  • Pathological and therapeutic interactions between bacteriophages, microbes and the host in inflammatory bowel disease.

    abstract::The intestinal microbiome is a dynamic system of interactions between the host and its microbes. Under physiological conditions, a fine balance and mutually beneficial relationship is present. Disruption of this balance is a hallmark of inflammatory bowel disease (IBD). Whether an altered microbiome is the consequence...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i40.11321

    authors: Babickova J,Gardlik R

    更新日期:2015-10-28 00:00:00

  • Primary biliary cirrhosis-associated hepatocellular carcinoma in Chinese patients: incidence and risk factors.

    abstract:AIM:To investigate the incidence, characteristics, and risk factors for hepatocellular carcinoma (HCC) in Chinese patients with primary biliary cirrhosis (PBC). METHODS:We reviewed the data of 52 PBC-associated HCC patients treated at Beijing 302 Hospital from January 2002 to December 2013 and analyzed its incidence a...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i12.3554

    authors: Zhang XX,Wang LF,Jin L,Li YY,Hao SL,Shi YC,Zeng QL,Li ZW,Zhang Z,Lau GK,Wang FS

    更新日期:2015-03-28 00:00:00

  • Clinical application of microRNA in gastric cancer in Eastern Asian area.

    abstract::Recent research has shown that microRNA (miRNA), which is involved in almost every step of gastric carcinogenesis, has broad prospective application in diagnosis and therapy of gastric carcinoma. Eastern Asia (South Korea, Japan and China) has the highest incidence of gastric cancer in the world. There were 988,000 ne...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v19.i13.2019

    authors: Gao M,Yin H,Fei ZW

    更新日期:2013-04-07 00:00:00

  • Immunosuppressive therapies for inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD) is comprised of Crohn's disease and ulcerative colitis, both chronic inflammatory intestinal disorders of unknown etiology characterized by a waxing and waning clinical course. For many years, the drug therapy was limited to sulfasalazine and related aminosalicylates, corticosteroids a...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i12.3146

    authors: Zenlea T,Peppercorn MA

    更新日期:2014-03-28 00:00:00

  • Increased activity of Pgp multidrug transporter in patients with Helicobacter pylori infection.

    abstract:AIM:To determine whether local antibiotic resistance involves P-glycoprotein (Pgp)-mediated active drug out-pumping during Helicobacter pylori (H pylori) infection treatment with classic antibiotic therapy. METHODS:Pgp activity was determined in gastric mucosa biopsy specimens obtained from 53 patients with pathohisto...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i18.2720

    authors: Babic Z,Svoboda-Beusan I,Kucisec-Tepes N,Dekaris D,Troskot R

    更新日期:2005-05-14 00:00:00

  • Interaction or relationship between Helicobacter pylori and non-steroidal anti-inflammatory drugs in upper gastrointestinal diseases.

    abstract::According to a meta-analysis, H pylori and non-steroidal anti-inflammatory drugs (NSAID) independently and significantly increase the risk of gastroduodenal ulcer and ulcer bleeding. Their coincidence is frequent, demonstration of a possible relationship and consequent attitude is of important implications. But unfort...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v12.i24.3789

    authors: Ji KY,Hu FL

    更新日期:2006-06-28 00:00:00

  • Role of mitochondria in cell apoptosis during hepatic ischemia-reperfusion injury and protective effect of ischemic postconditioning.

    abstract:AIM:To investigate the role of mitochondria in cell apoptosis during hepatic ischemia-reperfusion injury and protective effect of ischemic postconditioning (IPC). METHODS:A rat model of acute hepatic ischemia-reperfusion was established, 24 healthy male Wistar rats were randomly divided into sham-operated group, ische...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i13.1934

    authors: Sun K,Liu ZS,Sun Q

    更新日期:2004-07-01 00:00:00

  • Intrabiliary rupture: an algorithm in the treatment of controversial complication of hepatic hydatidosis.

    abstract:AIM:Intrabiliary rupture (IBR) is a common and serious complication of hepatic hydatid cyst. The incidence varies from 1% to 25%. The treatment of IBR is still controversial. We aimed to design an algorithm for the treatment of hepatic hydatidosis with IBR by reviewing our cases. METHODS:Eight cases of IBR were analyz...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i16.2472

    authors: Erzurumlu K,Dervisoglu A,Polat C,Senyurek G,Yetim I,Hokelek M

    更新日期:2005-04-28 00:00:00

  • JNKs, insulin resistance and inflammation: A possible link between NAFLD and coronary artery disease.

    abstract::The incidence of obesity has dramatically increased in recent years. Consequently, obesity and associated disorders such as nonalcoholic fatty liver disease constitute a serious problem. Therefore, the contribution of adipose tissue to metabolic homeostasis has become a focus of interest. In this review, we discuss th...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v17.i33.3785

    authors: Tarantino G,Caputi A

    更新日期:2011-09-07 00:00:00