Abstract:
AIM:To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn's disease (CD) and ulcerative colitis (UC). METHODS:The data from 41 patients with CD and 22 patients with UC were assessed. Twenty-four CD patients received infliximab, and 17 received adalimumab. The endoscopic severity of CD was quantified with the simplified endoscopic activity score for Crohn's disease in CD and with the Mayo endoscopic subscore in UC. RESULTS:Mucosal healing was achieved in 23 CD and 7 UC patients. Biological therapy had to be restarted in 78% of patients achieving complete mucosal healing with CD and in 100% of patients with UC. Neither clinical remission nor mucosal healing was associated with the time to restarting the biological therapy in either CD or UC. CONCLUSION:Mucosal healing did not predict sustained clinical remission in patients in whom the biological therapies had been stopped.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Farkas K,Lakatos PL,Szűcs M,Pallagi-Kunstár É,Bálint A,Nagy F,Szepes Z,Vass N,Kiss LS,Wittmann T,Molnár Tdoi
10.3748/wjg.v20.i11.2995subject
Has Abstractpub_date
2014-03-21 00:00:00pages
2995-3001issue
11eissn
1007-9327issn
2219-2840journal_volume
20pub_type
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