Role of inflammation and infection in the pathogenesis of human acute liver failure: Clinical implications for monitoring and therapy.

Abstract:

:Acute liver failure is a rare and devastating clinical condition. At present, emergency liver transplantation is the only life-saving therapy in advanced cases, yet the feasibility of transplantation is affected by the presence of systemic inflammation, infection and resultant multi-organ failure. The importance of immune dysregulation and acquisition of infection in the pathogenesis of acute liver failure and its associated complications is now recognised. In this review we discuss current thinking regarding the role of infection and inflammation in the pathogenesis of and outcome in human acute liver failure, the implications for the management of such patients and suggest directions for future research.

journal_name

World J Gastroenterol

authors

Donnelly MC,Hayes PC,Simpson KJ

doi

10.3748/wjg.v22.i26.5958

subject

Has Abstract

pub_date

2016-07-14 00:00:00

pages

5958-70

issue

26

eissn

1007-9327

issn

2219-2840

journal_volume

22

pub_type

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