Abstract：
:A 67-year-old male underwent endoscopic submucosal dissection (ESD) to treat early gastric cancer (EGC) in 2001. The lesion (50 mm × 25 mm diameter) was histologically diagnosed as poorly differentiated adenocarcinoma, with an ulcer finding. Although the tumor was confined to the mucosa with no evidence of lymphovascular involvement, the ESD was regarded as a non-curative resection due to the histological type, tumor size, and existence of an ulcer finding (as indicated by the 2010 Japanese gastric cancer treatment guidelines, ver. 3). Despite strong recommendation for subsequent gastrectomy, the patient refused surgery. An alternative follow-up routine was designed, which included five years of biannual clinical examinations to detect and measure serum tumor markers and perform visual assessment of recurrence by endoscopy and computed tomography scan after which the examinations were performed annually. The patient's condition remained stable for eight years, until a complaint of back pain in 2010 prompted further clinical investigation. Bone scintigraphy indicated increased uptake. Histological examination of biopsy specimens taken from the lumbar spine revealed adenocarcinoma resembling the carcinoma cells from the EGC that had been treated previously by ESD, and which was consistent with immunohistochemical findings of gastrointestinal tract cancer. Thus, the diagnosis of bone metastasis from EGC was made. The reported rates of EGC recurrence in surgically resected cases range 1.4%-3.4%, but among these bone metastasis is very rare. To our knowledge, this is the first reported case of bone metastasis from EGC following a non-curative ESD and occurring after an eight-year disease-free interval.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Kawabata H,Oda I,Suzuki H,Nonaka S,Yoshinaga S,Katai H,Taniguchi H,Kushima R,Saito Ydoi
10.3748/wjg.v19.i30.5016subject
Has Abstractpub_date
2013-08-14 00:00:00pages
5016-20issue
30eissn
1007-9327issn
2219-2840journal_volume
19pub_type
杂志文章abstract：AIM:To determine whether bispectral index (BIS) monitoring is useful for propofol administration for deep sedation during endoscopic retrograde cholangiopancreatography (ERCP). METHODS:Fifty-nine consecutive patients with a variety of reasons for ERCP who underwent the procedure at least twice between 1 July 2010 and ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,随机对照试验
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journal_title：World journal of gastroenterology
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doi：10.3748/wjg.v23.i8.1338
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journal_title：World journal of gastroenterology
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doi：10.3748/wjg.v24.i16.1766
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.15.4156
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pub_type： 杂志文章,meta分析,评审
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journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
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更新日期：2015-04-14 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2016-08-21 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1999-04-01 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v22.i24.5616
更新日期：2016-06-28 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章,多中心研究
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更新日期：2014-09-14 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v20.i39.14329
更新日期：2014-10-21 00:00:00
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journal_title：World journal of gastroenterology
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journal_title：World journal of gastroenterology
pub_type： 杂志文章,随机对照试验
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journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
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更新日期：2015-01-28 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.14.1570
更新日期：2008-03-14 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v13.i19.2707
更新日期：2007-05-21 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v20.i39.14510
更新日期：2014-10-21 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
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更新日期：2002-02-01 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
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更新日期：2009-07-14 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
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journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
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更新日期：2016-06-07 00:00:00
