Abstract:
AIM:To explore the contribution of AXIN1, AXIN2 and beta-catenin, components of Wnt signaling pathway, to the carcinogenesis of gastric cancer (GC), we examined AXIN1, AXIN2 exon7 and CTNNB1 (encoding beta-catenin) exon3 mutations in 70 GCs. METHODS:The presence of mutations was identified by polymerase chain reaction (PCR)-based denaturing high-performance liquid chromatography and direct DNA sequencing. Beta-catenin expression was detected by immunohistochemical analysis. RESULTS:Among the 70 GCs, 5 (7.1%) had mutations in one or two of these three components. A frameshift mutation (1 bp deletion) in exon7 of AXIN2 was found in one case. Four cases, including the case with a mutation in AXIN2, had frameshift mutations and missense mutations in AXIN1. Five single nucleotide polymorphisms (SNPs), 334 C>T, 874 C>T, 1396 G>A, 1690 C>T and 1942 T>G, were identified in AXIN1. A frameshift mutation (27 bp deletion) spanning exon3 of CTNNB1 was observed in one case. All four cases with mutations in AXIN1 and AXIN2 showed nuclear beta-catenin expression. CONCLUSION:These data indicate that the mutations in AXIN1 and AXIN2 may contribute to gastric carcino-genesis.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Pan KF,Liu WG,Zhang L,You WC,Lu YYdoi
10.3748/wjg.14.1570subject
Has Abstractpub_date
2008-03-14 00:00:00pages
1570-4issue
10eissn
1007-9327issn
2219-2840journal_volume
14pub_type
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:World journal of gastroenterology
pub_type: 评论,信件
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pub_type: 临床试验,杂志文章
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v12.i30.4908
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1999-08-01 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
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更新日期:2016-12-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v11.i1.22
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pub_type: 社论,评审
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pub_type: 杂志文章
doi:10.3748/wjg.15.5960
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v9.i11.2574
更新日期:2003-11-01 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v11.i35.5480
更新日期:2005-09-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.14.960
更新日期:2008-02-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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更新日期:2005-04-14 00:00:00