Abstract:
:AIM:To explore the expression and changes of hepatoma specific alkaline phospatase (ALP) in rats during canceration.METHODS:The ALPs and isoenzymes of rat livers and sera were investigated in SD hepatomas induced with 0.05% 2-fluoenylacetamide (2-FAA).RESULTS: By pathological examination and biochemical analysis. ALPs were overexpressed in rat livers during canceration and then were secreted into blood. Serum total ALP activities, liver ALP specific activities (U/g) including soluble and membrane-combined ALP activities of each group were all significantly higher (P < 0.01)than those of control group. The average ratios of soluble ALP to membrane-combined ALP were increased significantly after 6 weeks. ALP isoenzymes of rat sera and livers showed 5 bands on PAGE:ALP-I and ALP-II were specific for normal liver and rat hepatoma tissues, the ALP-II appeared in rat liver after 6 weeks and in sera after 8 weeks.CONCLUSION:ALP with carcino-embryonic protein was overexpressed in hepatoma tissues; the abnormal ALP-II of ALP isoenzymes in sera and liver of rats can be used as a tumor marker for early diagnosis of rat hepatoma.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Xiao MB,Yao DF,Zhang H,Qiang H,Huang JF,Wei Q,Jiang Fdoi
10.3748/wjg.v4.i4.323keywords:
subject
Has Abstractpub_date
1998-08-01 00:00:00pages
323-325issue
4eissn
1007-9327issn
2219-2840journal_volume
4pub_type
杂志文章abstract:AIM:A single-chain antibody fragment, ND-1scFv, against human colorectal carcinoma was constructed and expressed in E.coli, and its biodistribution and pharmacokinetic properties were studied in mice bearing tumor. METHODS:V(H) and V(L) genes were amplified from hybridoma cell IC-2, secreting monoclonal antibody ND-1,...
journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v9.i4.726
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.14.1293
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pub_type: 杂志文章
doi:10.3748/wjg.v22.i8.2524
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pub_type: 杂志文章,meta分析
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更新日期:2019-09-21 00:00:00
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pub_type: 杂志文章
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更新日期:2012-03-07 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v11.i26.4108
更新日期:2005-07-14 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-01-07 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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更新日期:2009-07-07 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2014-05-14 00:00:00
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pub_type: 杂志文章,评审
doi:10.3748/wjg.v17.i20.2456
更新日期:2011-05-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.3748/wjg.v20.i17.4892
更新日期:2014-05-07 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.15.3440
更新日期:2009-07-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v19.i39.6689
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v13.i34.4586
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pub_type: 杂志文章,已发布勘误
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更新日期:2018-10-21 00:00:00
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pub_type: 杂志文章,评审
doi:10.3748/wjg.v21.i20.6146
更新日期:2015-05-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
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更新日期:2015-07-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
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更新日期:2014-06-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v11.i42.6656
更新日期:2005-11-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v11.i11.1634
更新日期:2005-03-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.3748/wjg.v16.i30.3780
更新日期:2010-08-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 社论
doi:10.3748/wjg.v19.i34.5593
更新日期:2013-09-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v19.i20.3165
更新日期:2013-05-28 00:00:00
abstract:AIM:To identify predictors for synchronous liver metastasis from resectable pancreatic ductal adenocarcinoma (PDAC) and assess unresectability of synchronous liver metastasis. METHODS:Retrospective records of PDAC patients with synchronous liver metastasis who underwent simultaneous resections of primary PDAC and sync...
journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v22.i45.10024
更新日期:2016-12-07 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.14.1836
更新日期:2008-03-28 00:00:00