Abstract:
:The annual incidence of adenocarcinoma arising from Barrett's esophagus (BE) is approximately 0.5%. Through a process of gradual transformation from low-grade dysplasia to high-grade dysplasia (HGD), adenocarcinoma can develop in the setting of BE. The clinical importance of appropriate identification and treatment of BE in its various stages, from intestinal metaplasia to intramucosal carcinoma (IMC) hinges on the dramatically different prognostic status between early neoplasia and more advanced stages. Once a patient has symptoms of adenocarcinoma, there is usually locally advanced disease with an approximate 5-year survival rate of about 20%. Esophagectomy has been the gold standard treatment for BE with HGD, due to the suspected risk of harboring occult invasive carcinoma, which was traditionally estimated to be as high as 40%. In recent years, the paradigm of BE early neoplasia management has recently evolved, and endoscopic therapies (endoscopic mucosal resection, radiofrequency ablation, and cryotherapy) have entered the clinical forefront as acceptable non-surgical alternatives for HGD and IMC. The goal of endoscopic therapy for HGD or IMC is to ablate all BE epithelium (both dysplastic and non-dysplastic) due to risk of synchronous/metachronous lesion development in the remaining BE segment.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Chennat J,Waxman Idoi
10.3748/wjg.v16.i30.3780subject
Has Abstractpub_date
2010-08-14 00:00:00pages
3780-5issue
30eissn
1007-9327issn
2219-2840journal_volume
16pub_type
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pub_type: 杂志文章
doi:10.3748/wjg.v19.i18.2818
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pub_type: 杂志文章
doi:10.3748/wjg.15.373
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pub_type: 杂志文章,随机对照试验
doi:10.3748/wjg.v16.i1.63
更新日期:2010-01-07 00:00:00
abstract:AIM:To establish the rapid, specific, and sensitive method for detecting O157:H7 with DNA microchips. METHODS:Specific oligonucleotide probes (26-28 nt) of bacterial antigenic and virulent genes of E. coli O157:H7 and other related pathogen genes were pre-synthesized and immobilized on a solid support to make microchi...
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.3748/wjg.v11.i21.3307
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2014-10-28 00:00:00
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pub_type: 评论,信件
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更新日期:2008-04-28 00:00:00
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pub_type: 杂志文章
doi:10.3748/wjg.v11.i3.426
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pub_type: 杂志文章
doi:10.3748/wjg.v23.i31.5746
更新日期:2017-08-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v23.i36.6650
更新日期:2017-09-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v16.i26.3249
更新日期:2010-07-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v13.i47.6446
更新日期:2007-12-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.3748/wjg.v10.i1.12
更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-10-28 00:00:00
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pub_type: 杂志文章
doi:10.3748/wjg.v17.i37.4191
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pub_type: 杂志文章,评审
doi:10.3748/wjg.v19.i14.2144
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更新日期:2010-04-14 00:00:00
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pub_type: 杂志文章,随机对照试验
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journal_title:World journal of gastroenterology
pub_type: 社论
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更新日期:2009-05-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,随机对照试验
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更新日期:2019-12-14 00:00:00
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pub_type: 杂志文章
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更新日期:2003-06-01 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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更新日期:2006-02-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2008-09-07 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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更新日期:2008-03-28 00:00:00