Importance of investigating high-risk human papillomavirus in lymph node metastasis of esophageal adenocarcinoma.

Abstract:

:High-risk human papillomavirus has been suggested as a risk factor for esophageal adenocarcinoma. Tumor human papillomavirus status has been reported to confer a favorable prognosis in esophageal adenocarcinoma. The size of the primary tumor and degree of lymphatic spread determines the prognosis of esophageal carcinomas. Lymph node status has been found to be a predictor of recurrent disease as well as 5-year survival in esophageal malignancies. In human papillomavirus driven cancers, e.g. cervical, anogenital, head and neck cancers, associated lymph nodes with a high viral load suggest metastatic lymph node involvement. Thus, human papillomavirus could potentially be useful as a marker of micro-metastases. To date, there have been no reported studies regarding human papillomavirus involvement in lymph nodes of metastatic esophageal adenocarcinoma. This review highlights the importance of investigating human papillomavirus in lymph node metastasis of esophageal adenocarcinoma based on data derived from other human papillomavirus driven cancers.

journal_name

World J Gastroenterol

authors

Sharma P,Gautam SD,Rajendra S

doi

10.3748/wjg.v26.i21.2729

subject

Has Abstract

pub_date

2020-06-07 00:00:00

pages

2729-2739

issue

21

eissn

1007-9327

issn

2219-2840

journal_volume

26

pub_type

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