Genetic alterations in benign lesions: chronic gastritis and gastric ulcer.

abstract：AIM:To elucidate the effect of p27(KIP1) on cell cycle and apoptosis regulation in gastric carcinoma cells. METHODS:The whole length of p27(KIP1) cDNA was transfected into human gastric cancer cell line SCG7901 by lipofectamine. Expression of p27(KIP1) protein or mRNA was analyzed by Western blot and RNA dot blotting,...

journal_title：World journal of gastroenterology

authors： Zheng JY,Wang WZ,Li KZ,Guan WX,Yan W

更新日期：2005-12-07 00:00:00

abstract：AIM:To investigate the clinical and pathologic findings, and to discuss the pathophysiology of hepatocellular carcinoma with cardiac metastasis. METHODS:Eight hepatoma patients with cardiac metastasis, who were treated by surgical excision from 1993 to 2006, were retrospectively studied. Detailed clinical parameters w...

journal_title：World journal of gastroenterology

authors： Lin YS,Jung SM,Tsai FC,Yeh CN,Shiu TF,Wu HH,Lin PJ,Chu PH

更新日期：2007-07-07 00:00:00

abstract：AIM:To investigate whether potent acid inhibition is effective in non-erosive reflux disease (NERD) refractory to standard rabeprazole (RPZ) treatment. METHODS:We treated 10 Japanese patients with NERD resistant to standard dosages of RPZ: 10 mg or 20 mg od, 20 mg bid, or 10 mg qid for 14 d. All patients completed a f...

journal_title：World journal of gastroenterology

authors： Sugimoto M,Nishino M,Kodaira C,Yamade M,Uotani T,Ikuma M,Umemura K,Furuta T

更新日期：2011-04-14 00:00:00

abstract：AIM:To investigate the effect of integrin-linked kinase (ILK) on proliferation, metastasis, and invasion of the colorectal cancer cell line SW480. METHODS:In this study, the colorectal cancer cell line SW480 was stably transfected with ILK plasmids, and small interfering RNA (siRNA) was used to knockdown expression of...

journal_title：World journal of gastroenterology

authors： Shen H,Ma JL,Zhang Y,Deng GL,Qu YL,Wu XL,He JX,Zhang S,Zeng S

更新日期：2016-04-21 00:00:00

abstract：AIM:To investigate the level of gastric ghrelin in stomach mucosa of dyspeptic patients in relation to Helicobacter pylori (H pylori) infection, bacterial cytotoxicity, topography and gender. METHODS:The study comprised 40 premenopausal women (19 H pylori positive) and 48 men (17 H pylori positive) with functional dys...

journal_title：World journal of gastroenterology

authors： Stec-Michalska K,Malicki S,Michalski B,Peczek L,Wisniewska-Jarosinska M,Nawrot B

更新日期：2009-11-21 00:00:00

abstract：:Ulcerative colitis (UC) is a chronic disease characterized by diffuse inflammation of the mucosa of the colon and rectum. The hallmark clinical symptom of UC is bloody diarrhea. The clinical course is marked by exacerbations and remissions, which may occur spontaneously or in response to treatment changes or intercurr...

journal_title：World journal of gastroenterology

authors： da Silva BC,Lyra AC,Rocha R,Santana GO

更新日期：2014-07-28 00:00:00

abstract：:The goal of therapy in chronic hepatitis C virus (HCV) infection is sustained virological response (SVR) which reflects HCV eradication. Treatment against HCV has dramatically improved with the recent availability of direct-acting antivirals (DAAs) including sofosbuvir, simeprevir, daclatasvir, ledipasvir/sofosbuvir, ...

journal_title：World journal of gastroenterology

authors： Cholongitas E,Pipili C,Papatheodoridis G

更新日期：2015-08-28 00:00:00

abstract：:An insufficient future liver remnant (FLR) is associated with post-hepatectomy liver failure. Associating liver partition and portal vein ligation for stage hepatectomy (ALPPS) has been shown to be effective for the induction of rapid FLR hypertrophy so as to improve the resectability in patients with insufficient FLR...

journal_title：World journal of gastroenterology

authors： Chan A,Chung PH,Poon RT

更新日期：2014-08-07 00:00:00

abstract：AIM:To investigate the effect of antiviral therapy with nucleoside analogs in hepatitis B virus (HBV)-related cirrhosis and esophageal varices. METHODS:Eligible patients with HBV-related cirrhosis and esophageal varices who consulted two tertiary hospitals in Beijing, China, the Chinese Second Artillery General Hospit...

journal_title：World journal of gastroenterology

authors： Li CZ,Cheng LF,Li QS,Wang ZQ,Yan JH

更新日期：2013-10-28 00:00:00

abstract：:Single-port laparoscopic surgery (SPLS) is proposed to be a step towards minimizing the invasiveness of surgery, and has since gained popularity in several surgical sub-specialties including hepatopancreatobiliary surgery. SPLS has since been applied to cholecystectomy, liver resection as well as pancreatectomy for a ...

journal_title：World journal of gastroenterology

authors： Chang SK,Lee KY

更新日期：2014-10-21 00:00:00

abstract：AIM:To investigate the role of heme oxygenase-1 (HO-1) in pathogenesis of experimental hepatorenal syndrome (HRS). METHODS:Rats were divided into liver cirrhotic group, zinc protoporphyrin IX (ZnPP) treatment group, cobalt protoporphyrin (CoPP) treatment group and sham group. Biliary cirrhosis was established by bile ...

journal_title：World journal of gastroenterology

authors： Guo SB,Duan ZJ,Li Q,Sun XY

更新日期：2011-01-21 00:00:00

abstract：:We report a 31-year-old woman with Crohn's disease complicated by multiple stenoses and internal fistulas clinically misdiagnosed as small bowel endometriosis, due to the patient's perimenstrual symptoms of mechanical subileus for 3 years; at first monthly, but later continuous, and gradually increasing in severity. W...

journal_title：World journal of gastroenterology

authors： Teke Z,Aytekin FO,Atalay AO,Demirkan NC

更新日期：2008-01-07 00:00:00

abstract：AIM:To assess the practice of caring for acute liver failure (ALF) patients in varying geographic locations and medical centers. METHODS:Members of the European Acute Liver Failure Consortium completed an 88-item questionnaire detailing management of ALF. Responses from 22 transplantation centers in 11 countries were ...

journal_title：World journal of gastroenterology

authors： Rabinowich L,Wendon J,Bernal W,Shibolet O

更新日期：2016-09-07 00:00:00

abstract：AIM:To assess the practically usefulness and diagnostic yield of this new method in a group of patients with suspected small bowel lesions. METHODS:Capsule endoscopic (CE) examination by using M2A capsule endoscope TM (Given Imaging, Yoqneam, Israel) was performed in thirty nine patients (26 males, 13 females) with su...

journal_title：World journal of gastroenterology

authors： Ersoy O,Sivri B,Arslan S,Batman F,Bayraktar Y

更新日期：2006-06-28 00:00:00

abstract：AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated (polyethylene glycol) interferon (IFN)-alpha-2a (Reiferon Retard) plus ribavirin customized regimen in treatment-naïve and previously treated (non-responders and relapsers) Egyptian children with chronic hepatitis C infection. METHODS:Forty-si...

journal_title：World journal of gastroenterology

authors： El Naghi S,Abdel-Ghaffar TY,El-Karaksy H,Abdel-Aty EF,El-Raziky MS,Allam AA,Helmy H,El-Araby HA,Behairy BE,El-Guindi MA,El-Sebaie H,Abdel-Ghaffar AY,Ehsan NA,El-Hennawy AM,Sira MM

更新日期：2014-04-28 00:00:00

abstract：AIM:To investigate the effects of sodium alginate (AL-Na) on indomethacin-induced small intestinal lesions in rats. METHODS:Gastric injury was assessed by measuring ulcerated legions 4 h after indomethacin (25 mg/kg) administration. Small intestinal injury was assessed by measuring ulcerated legions 24 h after indomet...

journal_title：World journal of gastroenterology

authors： Yamamoto A,Itoh T,Nasu R,Nishida R

更新日期：2014-03-14 00:00:00

abstract：:Liver cancers are the second most frequent cause of global cancer-related mortality of which 90% are attributable to hepatocellular carcinoma (HCC). Despite the advent of screening programmes for patients with known risk factors, a substantial number of patients are ineligible for curative surgery at presentation with...

journal_title：World journal of gastroenterology

authors： Inchingolo R,Posa A,Mariappan M,Spiliopoulos S

更新日期：2019-08-28 00:00:00

abstract：AIM:To offer an up-to-date review of all available treatment strategies for patients with synchronous colorectal liver metastases (CLM). METHODS:A comprehensive literature search was performed to identify articles related to the management of patients with synchronous CLM. A search of the electronic databases PubMed, ...

journal_title：World journal of gastroenterology

authors： Ihnát P,Vávra P,Zonča P

更新日期：2015-06-14 00:00:00

abstract：AIM:To evaluate the usefulness of contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) in differentiating between pancreatic adenocarcinomas and other pancreatic disease. METHODS:This retrospective cohort study evaluated 90 patients who were seen between November 2010 and May 2013. All these patients had solid pa...

journal_title：World journal of gastroenterology

authors： Park JS,Kim HK,Bang BW,Kim SG,Jeong S,Lee DH

更新日期：2014-01-14 00:00:00

abstract：:Transplantation is the optimal treatment for end-stage organ failure, and modern immunosuppression has allowed important progress in short-term outcomes. However, immunosuppression poorly influences chronic rejection and elicits chronic toxicity in current clinical practice. Thus, a major goal in transplantation is to...

journal_title：World journal of gastroenterology

authors： Baroja-Mazo A,Revilla-Nuin B,Parrilla P,Martínez-Alarcón L,Ramírez P,Pons JA

更新日期：2016-09-14 00:00:00

abstract：AIM:To evaluate virological response to adefovir (ADV) monotherapy and emergence of ADV-resistant mutations in lamivudine (LAM)-resistant chronic hepatitis B patients. METHODS:Seventy-seven patients with documented LAM resistance who were treated with 10 mg/d ADV for > 96 wk were analyzed for ADV resistance. RESULTS:...

journal_title：World journal of gastroenterology

authors： Sinn DH,Lee HIe,Gwak GY,Choi MS,Koh KC,Paik SW,Yoo BC,Lee JH

更新日期：2011-08-14 00:00:00

abstract：:Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma (HCC) since 2007 and numerous studies have investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years ...

journal_title：World journal of gastroenterology

authors： Marisi G,Cucchetti A,Ulivi P,Canale M,Cabibbo G,Solaini L,Foschi FG,De Matteis S,Ercolani G,Valgiusti M,Frassineti GL,Scartozzi M,Casadei Gardini A

更新日期：2018-09-28 00:00:00

abstract：:Hepatitis C virus (HCV) infection disrupts the normal metabolism processes, but is also influenced by several of the host's metabolic factors. An obvious and significantly detrimental pathophysiological feature of HCV infection is insulin resistance in hepatic and peripheral tissues. Substantial research efforts have ...

journal_title：World journal of gastroenterology

authors： Kawaguchi Y,Mizuta T

更新日期：2014-03-21 00:00:00

abstract：AIM:To identify the scFv antibody fragments specific for hepatocellular carcinoma by biopanning from a large human naive scFv phage display library. METHODS:A large human naive scFv phage library was used to search for the specific targets by biopanning with the hepatocellular carcinoma cell line HepG2 for the positiv...

journal_title：World journal of gastroenterology

authors： Yu B,Ni M,Li WH,Lei P,Xing W,Xiao DW,Huang Y,Tang ZJ,Zhu HF,Shen GX

更新日期：2005-07-14 00:00:00

abstract：AIM:This study is aimed at investigating the expression and possible significances of very low-density lipoprotein receptor (VLDLR) subtypes in gastroenteric adenocarcinoma tissues and cells with various differentiations. METHODS:Thirty-one cases of gastroenteric carcinoma/adjacent normal tissues were enrolled in the ...

journal_title：World journal of gastroenterology

authors： Chen T,Wu F,Chen FM,Tian J,Qu S

更新日期：2005-05-14 00:00:00

abstract：AIM:To transfer hepatitis E virus (HEV) ORF2 partial gene to tomato plants, to investigate its expression in transformants and the immunoactivity of expression products, and to explore the feasibility of developing a new type of plant-derived HEV oral vaccine. METHODS:Plant binary expression vector p1301E2, carrying a...

journal_title：World journal of gastroenterology

authors： Ma Y,Lin SQ,Gao Y,Li M,Luo WX,Zhang J,Xia NS

更新日期：2003-10-01 00:00:00

abstract：AIM:To compare the hemostatic efficacy and safety of two mechanical endoscopic methods: endoscopic band ligation (EBL) and endoscopic hemoclip placement (EHP) in patients with actively bleeding Mallory-Weiss syndrome (MWS). METHODS:A prospective randomized study to compare the efficacy and safety of EHP with EBL was p...

journal_title：World journal of gastroenterology

authors： Cho YS,Chae HS,Kim HK,Kim JS,Kim BW,Kim SS,Han SW,Choi KY

更新日期：2008-04-07 00:00:00

abstract：AIM:To compare the prevalence of Helicobacter pylori (H pylori) IgG and IgA antibodies between adult subjects, with defined gastric diseases, non-defined gastric disorders and those representing the population. METHODS:Data on H pylori IgG and IgA antibodies, determined by enzyme immunoassay, were analyzed in 3,252 su...

journal_title：World journal of gastroenterology

authors： Kosunen TU,Seppala K,Sarna S,Aromaa A,Knekt P,Virtamo J,Salomaa-Rasanen A,Rautelin H

更新日期：2005-11-21 00:00:00

abstract：:Pancreatic fluid collections (PFCs) are seen in up to 50% of cases of acute pancreatitis. The Revised Atlanta classification categorized these collections on the basis of duration of disease and contents, whether liquid alone or a mixture of fluid and necrotic debris. Management of these different types of collections...

journal_title：World journal of gastroenterology

authors： Dhaka N,Samanta J,Kochhar S,Kalra N,Appasani S,Manrai M,Kochhar R

更新日期：2015-12-28 00:00:00

abstract：:We report a rare case of hypereosinophilic syndrome (HES) presenting with intractable gastric ulcers. A 71-year-old man was admitted with epigastric pain. Initial endoscopic findings revealed multiple, active gastric ulcers in the gastric antrum. He underwent Helicobacter pylori (H pylori) eradication therapy followed...

journal_title：World journal of gastroenterology

authors： Park TY,Choi CH,Yang SY,Oh IS,Song ID,Lee HW,Kim HJ,Do JH,Chang SK,Cho AR,Cha YJ

更新日期：2009-12-28 00:00:00