Locoregional treatments for hepatocellular carcinoma: Current evidence and future directions.

Abstract:

:Liver cancers are the second most frequent cause of global cancer-related mortality of which 90% are attributable to hepatocellular carcinoma (HCC). Despite the advent of screening programmes for patients with known risk factors, a substantial number of patients are ineligible for curative surgery at presentation with limited outcomes achievable with systemic chemotherapy/external radiotherapy. This has led to the advent of numerous minimally invasive options including but not limited to trans-arterial chemoembolization, radiofrequency/microwave ablation and more recently selective internal radiation therapy many of which are often the first-line treatment for select stages of HCC or serve as a conduit to liver transplant. The authors aim to provide a comprehensive overview of these various image guided minimally invasive therapies with a brief focus on the technical aspects accompanied by a critical analysis of the literature to assess the most up-to-date evidence from comparative systematic reviews and meta-analyses finishing with an assessment of novel combination regimens and future directions of travel.

journal_name

World J Gastroenterol

authors

Inchingolo R,Posa A,Mariappan M,Spiliopoulos S

doi

10.3748/wjg.v25.i32.4614

subject

Has Abstract

pub_date

2019-08-28 00:00:00

pages

4614-4628

issue

32

eissn

1007-9327

issn

2219-2840

journal_volume

25

pub_type

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