Efficacy of docetaxel combined with oxaliplatin and fluorouracil against stage III/IV gastric cancer.

Abstract:

AIM:To investigate the clinical efficacy and toxic effects of neoadjuvant chemotherapy using docetaxel combined with oxaliplatin and fluorouracil for treating stage III/IV gastric cancer. METHODS:A total of 53 stage III/IV gastric cancer patients were enrolled into the study and treated with neoadjuvant chemotherapy. Two of the cases were excluded. The program was as follows: 75 mg/m(2) docetaxel and 85 mg/m(2) oxaliplatin on day 1 and 1500 mg/m(2) fluorouracil on days 1 to 3 for three weeks. RESULTS:The tumour changes, postoperative remission rate, changes in the symptoms and adverse reactions were observed. The overall clinical efficacy (complete remission + partial remission) of the neoadjuvant chemotherapy was 62.7%. R0 radical resection was performed on 60.8% of the patients, with a remission rate (pathological complete response + pathological subtotal response + pathological partial response) of 74.2%. The Karnofksy score improved in 42 cases. The toxicity reactions mostly included myelosuppression, followed by gastrointestinal mucosal lesions, nausea, vomiting and diarrhoea. CONCLUSION:Neoadjuvant chemotherapy consisting of docetaxel combined with oxaliplatin and fluorouracil is effective for stage III/IV gastric cancer. However, the treatment is associated with a high incidence of bone marrow suppression, which should be managed clinically.

journal_name

World J Gastroenterol

authors

Yu YJ,Sun WJ,Lu MD,Wang FH,Qi DS,Zhang Y,Li PH,Huang H,You T,Zheng ZQ

doi

10.3748/wjg.v20.i48.18413

subject

Has Abstract

pub_date

2014-12-28 00:00:00

pages

18413-9

issue

48

eissn

1007-9327

issn

2219-2840

journal_volume

20

pub_type

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