Abstract：
:Helicobacter pylori (H. pylori) is the causative agent of gastritis, peptic ulcer disease, mucosa associated lymphoid tissue lymphoma and gastric cancer (GC). While this bacterium infects 50% of the world's population, in Africa its prevalence reach as high as 80% as the infection is acquired during childhood. Risk factors for H. pylori acquisition have been reported to be mainly due to overcrowding, to have infected siblings or parent and to unsafe water sources. Despite this high H. pylori prevalence there still does not exist an African guideline, equivalent to the Maastricht V/Florence Consensus Report of the European Helicobacter and Microbiota Study Group for the management of this infection. In this continent, although there is a paucity of epidemiologic data, a contrast between the high prevalence of H. pylori infection and the low incidence of GC has been reported. This phenomenon is the so-called "African Enigma" and it has been hypothesized that it could be explained by environmental, dietary and genetic factors. A heterogeneity of data both on diagnosis and on therapy have been published. In this context, it is evident that in several African countries the increasing rate of bacterial resistance, mainly to metronidazole and clarithromycin, requires continental guidelines to recommend the appropriate management of H. pylori. The aim of this manuscript is to review current literature on H. pylori infection in Africa, in terms of prevalence, risk factors, impact on human health, treatment and challenges encountered so as to proffer possible solutions to reduce H. pylori transmission in this continent.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Smith S,Fowora M,Pellicano Rdoi
10.3748/wjg.v25.i25.3183subject
Has Abstractpub_date
2019-07-07 00:00:00pages
3183-3195issue
25eissn
1007-9327issn
2219-2840journal_volume
25pub_type
杂志文章,评审abstract：AIM:Glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) genes are involved in the metabolism of a wide range of carcinogens, but deletions of the genes are commonly found in the population. The present study was undertaken to evaluate the association between GSTM1 and GSTT1 gene polymorphisms and hepatocellular ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v11.i2.272
更新日期：2005-01-14 00:00:00
abstract：:Colorectal cancer metastasizes predictably, with liver predominance in most cases. Because liver involvement has been shown to be a major determinant of survival in this population, liver-directed therapies are increasingly considered even in cases where there is (limited) extrahepatic disease. Unfortunately, these pa...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.v22.i11.3127
更新日期：2016-03-21 00:00:00
abstract：:Epidemiologic studies have suggested a relation between hepatitis C virus (HCV) infection and diabetes mellitus. HCV infection is emerging as a metabolic disease, and diabetes mellitus as a risk factor for HCV infection. However, some data on the prevalence of antibodies to HCV in patients with diabetes are conflictin...
journal_title：World journal of gastroenterology
pub_type： 评论,信件
doi：10.3748/wjg.15.5114
更新日期：2009-10-28 00:00:00
abstract：AIM:To examine the clinicopathologic features of elderly patients with gastric carcinoma and to investigate the relationship between prognosis and age. METHODS:We reviewed the hospital records of 2,014 patients with gastric carcinoma retrospectively to compare the clinicopathologic findings in elderly (age >70 years) ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v11.i1.22
更新日期：2005-01-07 00:00:00
abstract：AIM:To determine the effect of chemotherapy on wound healing by giving early preoperative 5-fluorouracil (5-FU) to rats with colonic anastomoses. METHODS:Sixty Albino-Wistar male rats (median weight, 235 g) were used in this study. The rats were fed with standard laboratory food and given tap water ad libitum. The ani...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.15.4156
更新日期：2009-09-07 00:00:00
abstract：AIM:To evaluate the clinical relevance of each cofactor on clinical presentation of chronic hepatitis B. METHODS:Out of 1366 hepatitis B surface antigen (HBsAg) positive subjects consecutively observed in 79 Italian hospitals, 53 (4.3%) showed as the only cofactor hepatitis D virus (HDV) infection [hepatitis B virus (...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,多中心研究
doi：10.3748/wjg.v18.i14.1616
更新日期：2012-04-14 00:00:00
abstract：AIM:To investigate mutation of serine protease 1-cationic trypsinogen (CT, PRSS1) gene in members of a Thai family with hereditary pancreatitis and pancreatic cancer. METHODS:Polymerase chain reaction and direct sequencing were performed to analyze the PRSS1 gene in two members of the family affected by pancreatitis. ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v11.i11.1634
更新日期：2005-03-21 00:00:00
abstract：AIM:To study the effects of drug treatment on hyperplastic gastric polyps infected with Helicobacter pylori (H pylori). METHODS:Forty-eight patients with hyperplastic gastric polyps (3-10 mm in diameter) infected with H pylori were randomly assigned to a treatment group (n = 24) which received proton-pump inhibitor (o...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,随机对照试验
doi：10.3748/wjg.v12.i11.1770
更新日期：2006-03-21 00:00:00
abstract：AIM:To assess the incidence of hepatocellular carcinoma (HCC) in chronic liver disease due to hepatitis B virus (HBV) or hepatitis C virus (HCV) coinfected with human immunodeficiency virus (HIV). METHODS:A retrospective cohort study was performed, including patients with chronic liver disease due to HBV or HCV, with ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v24.i5.613
更新日期：2018-02-07 00:00:00
abstract：AIM:To investigate the prognostic value of the model for end-stage liver disease (MELD) and three new MELD-based models combination with serum sodium in decompensated cirrhosis patients-the MELD with the incorporation of serum sodium (MELD-Na), the integrated MELD (iMELD), and the MELD to sodium (MESO) index. METHODS:...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.14.6546
更新日期：2008-11-14 00:00:00
abstract：AIM:To investigate whether illness severity has an impact on gastric residual volume (GRV) in medical critically ill patients. METHODS:Medical intensive care unit (ICU) patients requiring nasogastric feeding were enrolled. Sequential Organ Failure Assessment (SOFA) score was assessed immediately preceding the start of...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v17.i15.2007
更新日期：2011-04-21 00:00:00
abstract：AIM:To investigate whether ANNs and LDA could recognize patients with ABG in a database, containing only clinical and biochemical variables, of a pool of patients with and without ABG, by selecting the most predictive variables and by reducing input data to the minimum. METHODS:Data was collected from 350 consecutive ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v11.i37.5867
更新日期：2005-10-07 00:00:00
abstract：:Most pancreatic cancer patients present with advanced metastatic disease, resulting in extremely poor 5-year survival, mainly because of the lack of a reliable modality for early detection and limited therapeutic options for advanced disease. Therefore, there is a need for minimally-invasive diagnostic tools for detec...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.v22.i38.8480
更新日期：2016-10-14 00:00:00
abstract：AIM:To determine the genotype distribution of hepatitis B virus (HBV) with a newly oligonucleotide chip assay among the HBV carriers in Eastern China. METHODS:An assay using oligonucleotide chip was developed for detection of HBV genotypes in serum samples from HBV DNA-positive patients in Eastern China. This method i...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,多中心研究
doi：10.3748/wjg.v13.i13.1975
更新日期：2007-04-07 00:00:00
abstract：AIM:To study the expression of a disintegrin and metalloproteinase 17 (ADAM17) mRNA in hepatocellular carcinoma (HCC) and to evaluate the relationship between ADAM17 mRNA expression and clinicopathological features of HCC. METHODS:Hepatocellular carcinomas (HCC) from 31 cases were divided into small HCC (SHCC), nodula...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v10.i18.2735
更新日期：2004-09-15 00:00:00
abstract：AIM:To explore the significance of corticotropin-releasing hormone (CRH)-receptor (R)2 in mucosal healing of dextran sulfate sodium (DSS)-induced colitis and the effect of Tong-Xie-Yao-Fang (TXYF) on CRH-R2 expression and regulation. METHODS:Ulcerative colitis was induced in mice by administration of 3% (w/v) DSS for ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v24.i16.1766
更新日期：2018-04-28 00:00:00
abstract：AIM:To study the response to infliximab in pediatric inflammatory bowel disease (IBD), as reflected in fecal calprotectin levels. METHODS:Thirty-six pediatric patients with IBD [23 Crohn's disease (CD), 13 ulcerative colitis (UC); median age 14 years] were treated with infliximab. Fecal calprotectin was measured at ba...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v17.i47.5166
更新日期：2011-12-21 00:00:00
abstract：AIM:To evaluate whether alcohol dehydrogenase-1B (ADH1B) His47Arg and aldehyde dehydrogenase-2 (ALDH2) Glu487Lys polymorphism is involved in the esophageal squamous cell carcinoma (ESCC) risk in Chinese Han population. METHODS:Seven studies of ADH1B and ALDH2 genotypes in Chinese Han population in 1450 cases and 2459 ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,meta分析
doi：10.3748/wjg.v16.i47.6020
更新日期：2010-12-21 00:00:00
abstract：:Although the lung is the major site for Mycobacterium tuberculosis infection, gastrointestinal involvement can be present as part of multiorgan disease process or, less commonly, can be seen as primary gastrointestinal tuberculosis. In the cases where the culture is negative, it can be difficult to differentiate tuber...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v9.i10.2382
更新日期：2003-10-01 00:00:00
abstract：AIM:To evaluate different methods in differentiating idiopathic neonatal hepatitis from biliary atresia. METHODS:Sixty-five infants with cholestatic jaundice and final diagnosis of idiopathic neonatal hepatitis and biliary atresia were studied prospectively from September 2003 to March 2006. A thorough history and phy...
journal_title：World journal of gastroenterology
pub_type： 临床试验,杂志文章
doi：10.3748/wjg.v12.i36.5893
更新日期：2006-09-28 00:00:00
abstract：:The term "hemangioma" refers to the common tumor of infancy that exhibits rapid postnatal growth and slow regression during childhood. It may cause confusion with venous malformations that are often incorrectly called "cavernous hemangioma". Venous malformations comprise abnormally formed channels that are lined by qu...
journal_title：World journal of gastroenterology
pub_type： 评论,信件
doi：10.3748/wjg.15.5242
更新日期：2009-11-07 00:00:00
abstract：AIM:To review the usefulness of endoscopic biliary stenting for obstructive jaundice caused by hepatocellular carcinoma and identify problems that may need to be addressed. METHODS:The study population consisted of 36 patients with obstructive jaundice caused by hepatocellular carcinoma (HCC) who underwent endoscopic ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v20.i22.6968
更新日期：2014-06-14 00:00:00
abstract：AIM:To compare molecular profiles of proximal colon, distal colon and rectum in large adenomas, early and late carcinomas. To assess feasibility of testing directed at molecular markers from this study in routine clinical practice. METHODS:A prospective 3-year study has resulted in the acquisition of samples from 159 ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v22.i20.4936
更新日期：2016-05-28 00:00:00
abstract：AIM:To investigate the relationship between the methylation status in the SLIT2 and TGFB2 promoters and colonic inflammation in inflammatory bowel disease patients. METHODS:We evaluated the methylation status of 2 genes (SLIT2 and TGFB2) in 226 biopsies taken from 62 colonoscopies of 38 patients (29 ulcerative colitis...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v20.i30.10591
更新日期：2014-08-14 00:00:00
abstract：AIM:To determine whether efflux systems contribute to multidrug resistance of H pylori. METHODS:A chloramphenicol-induced multidrug resistance model of six susceptible H pylori strains (5 isolates and H pylori NCTC11637) was developed. Multidrug-resistant (MDR) strains were selected and the minimal inhibitory concentr...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.14.5217
更新日期：2008-09-07 00:00:00
abstract：AIM:To investigate the efficacy and potential mechanism of Xiaotan Tongfu granules (XTTF) in stress ulcers. METHODS:One hundred sixty rats were randomly divided into 4 groups (n = 10) as follows: the model group (MP group), the control group (CP group), the ranitidine group (RP group) and the XTTF granule group (XP gr...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v19.i33.5473
更新日期：2013-09-07 00:00:00
abstract：:Third generation of quinolones, such as levofloxacin and moxifloxacin, -containing regimens are often used in second-line or rescue treatment of Helicobacter pylori infection. However, the increasing antibiotic resistance to quinolones affects the efficacies of quinolones-containing therapies in recent years. Therefor...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.v26.i15.1733
更新日期：2020-04-21 00:00:00
abstract：:RNA sequencing is the use of high throughput next generation sequencing technology to survey, characterize, and quantify the transcriptome of a genome. RNA sequencing has been used to analyze the pathogenesis of several malignancies such melanoma, lung cancer, and colorectal cancer. RNA sequencing can identify differe...
journal_title：World journal of gastroenterology
pub_type： 社论,评审
doi：10.3748/wjg.v23.i16.2819
更新日期：2017-04-28 00:00:00
abstract：AIM:To identify the predictive clinicopathological factors for lymph node metastasis (LNM) in poorly differentiated early gastric cancer (EGC) and to further expand the possibility of using endoscopic mucosal resection (EMR) for the treatment of poorly differentiated EGC. METHODS:Data were collected from 85 poorly-dif...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.14.4222
更新日期：2008-07-14 00:00:00
abstract：AIM:To explore risk factors for lymph node metastases in early gastric cancer (EGC) and to confirm the appropriate range of lymph node dissection. METHODS:A total of 202 patients with EGC who underwent curative gastrectomy with lymphadenectomy in the Department of Surgery, Xinhua Hospital and Ruijin Hospital of Shangh...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v19.i20.3096
更新日期：2013-05-28 00:00:00
