Impact of comorbidities on the severity of chronic hepatitis B at presentation.

abstract：AIM:To explore the inducing effect of human mutant p27 gene on the apoptosis of the human gastric cancer cell line MKN-45 and its associated mechanisms. METHODS:The recombinant adenovirus Ad-p27mt was constructed to infect the human gastric cancer cell line MKN-45. Using flow cytometry, TUNEL assay and DNA fragment an...

journal_title：World journal of gastroenterology

authors： Zhu JS,Wang L,Cheng GQ,Li Q,Zhu ZM,Zhu L

更新日期：2005-12-21 00:00:00

abstract：:The purpose of this article is to review the evidence regarding transmission of infection during gastrointestinal endoscopy, factors important in endoscope reprocessing and infection control, areas to focus on to improve compliance, and recent developments and advances in the field. ...

journal_title：World journal of gastroenterology

authors： Nelson DB,Muscarella LF

更新日期：2006-07-07 00:00:00

abstract：AIM:To study the therapeutic effectiveness of intra-tumor injection of Xiao-Zhi-Ling(XZL) on transplanted hepatoma in rats. METHODS:Sixty rats were divided into 3 groups (groups S, X and E), 20 in each. Different drugs were injected into the implanted hepatoma (Group S with 0.2 ml saline as control, group X with 0.2 m...

journal_title：World journal of gastroenterology

authors： Lu Y,Wu LQ

更新日期：2003-09-01 00:00:00

abstract：:Neuroendocrine carcinoma (NEC) of the extrahepatic bile duct is rare, and only 22 cases have been reported. Only two of these were large-cell NEC (LCNEC); the vast majority were small-cell NEC. Here, we report a third case of LCNEC of the extrahepatic bile duct. A 76-year-old male presented to a local hospital with pa...

journal_title：World journal of gastroenterology

authors： Sasatomi E,Nalesnik MA,Marsh JW

更新日期：2013-07-28 00:00:00

abstract：AIM:To assess the safety of bismuth used in Helicobacter pylori (H pylori) eradication therapy regimens. METHODS:We conducted a systematic review and meta-analysis. MEDLINE and EMBASE were searched (up to October 2007) to identify randomised controlled trials comparing bismuth with placebo or no treatment, or bismuth ...

journal_title：World journal of gastroenterology

authors： Ford AC,Malfertheiner P,Giguere M,Santana J,Khan M,Moayyedi P

更新日期：2008-12-28 00:00:00

abstract：AIM:To study the inhibitory effects of a Shuangling Fuzheng anticancer preparation (SFAP) on the human gastric cancer cell line SGC-7901 in vitro as well as its immune-modulated effects in a cyclophosphamide-treated murine model. METHODS:MTT experiments and immunocytochemistry ABC experiments were performed for detect...

journal_title：World journal of gastroenterology

authors： Chen HS,Chen J,Cui DL,Zheng YY,Xu AH,Chen G,Jia LC

更新日期：2007-12-28 00:00:00

abstract：AIM:To compare long-term occurrence of gastroesophageal reflux disease (GERD) between two different types of peroral endoscopic myotomy (POEM) for achalasia. METHODS:We included all patients with achalasia who underwent POEM at our hospital from August 2011 to October 2012 and had complete GERD evaluation with ≥ 3 yea...

journal_title：World journal of gastroenterology

authors： Wang XH,Tan YY,Zhu HY,Li CJ,Liu DL

更新日期：2016-11-14 00:00:00

abstract：AIM:To investigate microRNA-133a (miR-133a) expression in colorectal cancer (CRC) and its relationship with tumorigenesis and disease prognosis. METHODS:Quantitative real-time polymerase chain reaction was used to measure levels of miR-133a in tumor samples and adjacent non-cancerous tissues from 169 patients undergoi...

journal_title：World journal of gastroenterology

authors： Wang LL,Du LT,Li J,Liu YM,Qu AL,Yang YM,Zhang X,Zheng GX,Wang CX

更新日期：2014-08-28 00:00:00

abstract：AIM:To evaluate the diagnostic values of serum autoantibodies against matrix metalloproteinase-7 (MMP-7) in patients with esophageal squamous cell carcinoma (ESCC). METHODS:The MMP-7 cDNA was cloned from ESCC tissues, and MMP-7 was expressed and purified from a prokaryotic system. MMP-7 autoantibodies were then measur...

journal_title：World journal of gastroenterology

authors： Zhou JH,Zhang B,Kernstine KH,Zhong L

更新日期：2011-03-14 00:00:00

abstract：:In a recently published letter to the editor, we debated the proposal by Coccolini et al to treat gastrointestinal stromal tumors (GISTs) of the esophagogastric junction with enucleation and, if indicated, adjuvant therapy. We highlighted that, because the prognostic impact of a T1 high-mitotic rate esophageal GIST is...

journal_title：World journal of gastroenterology

authors： Peparini N,Chirletti P

更新日期：2013-03-28 00:00:00

abstract：AIM:To assess the diagnostic value of FIB-4, aspartate aminotransferase-to-platelet ratio index (APRI), and liver stiffness measurement (LSM) in patients with hepatitis B virus infection who have persistently normal alanine transaminase (PNALT). METHODS:We enrolled 245 patients with chronic hepatitis B: 95 in PNALT gr...

journal_title：World journal of gastroenterology

authors： Tan YW,Zhou XB,Ye Y,He C,Ge GH

更新日期：2017-08-21 00:00:00

abstract：AIM:To clarify the role of serum anti-Helicobacter pylori (H. pylori) antibody titers in gastric cancer. METHODS:In this cross-sectional study, the effect of patients' baseline characteristics and endoscopic findings on their serum antibody titers were assessed. We evaluated consecutive patients who underwent esophago...

journal_title：World journal of gastroenterology

authors： Toyoshima O,Nishizawa T,Sakitani K,Yamakawa T,Takahashi Y,Yamamichi N,Hata K,Seto Y,Koike K,Watanabe H,Suzuki H

更新日期：2018-09-21 00:00:00

abstract：AIM:To assess numbers and case fatality of patients with upper gastrointestinal bleeding (UGIB), effects of deprivation and whether weekend presentation affected outcomes. METHODS:Data was obtained from Information Services Division (ISD) Scotland and National Records of Scotland (NRS) death records for a ten year per...

journal_title：World journal of gastroenterology

authors： Ahmed A,Armstrong M,Robertson I,Morris AJ,Blatchford O,Stanley AJ

更新日期：2015-10-14 00:00:00

abstract：AIM:To systematically investigate if cGMP/cGMP-dependent protein kinase G (PKG) signaling pathway may participate in dendroaspis natriuretic peptide (DNP)-induced relaxation of gastric circular smooth muscle. METHODS:The content of cGMP in guinea pig gastric antral smooth muscle tissue and perfusion solution were meas...

journal_title：World journal of gastroenterology

authors： Cai CY,Cai ZX,Gu XY,Shan LJ,Wang YX,Yin XZ,Qi QH,Guo HS

更新日期：2008-09-21 00:00:00

abstract：AIM:To investigate whether α-fetoprotein (AFP) and vascular endothelial growth factor receptor (VEGFR)-1 correlate with early recurrence of hepatoma/hepatocellular carcinoma (HCC). METHODS:From 2000 to 2005, 114 consecutive patients with HCC underwent primary curative hepatectomy. The mean age was 60.7 (8.7) years and...

journal_title：World journal of gastroenterology

authors： Kamiyama T,Takahashi M,Nakanishi K,Yokoo H,Kamachi H,Kobayashi N,Ozaki M,Todo S

更新日期：2012-01-28 00:00:00

abstract：:Hepatoblastoma is the most common primary hepatic tumor of children. However, only a very few cases have been reported in adults. Most studies support treatment with chemotherapy followed by surgical resection. We present the first reported case of adult hepatoblastoma in Taiwan. A 52-year-old female suffered from sud...

journal_title：World journal of gastroenterology

authors： Ke HY,Chen JH,Jen YM,Yu JC,Hsieh CB,Chen CJ,Liu YC,Chen TW,Chan DC

更新日期：2005-10-21 00:00:00

abstract：AIM:To investigate the clinical efficacy and toxic effects of neoadjuvant chemotherapy using docetaxel combined with oxaliplatin and fluorouracil for treating stage III/IV gastric cancer. METHODS:A total of 53 stage III/IV gastric cancer patients were enrolled into the study and treated with neoadjuvant chemotherapy. ...

journal_title：World journal of gastroenterology

authors： Yu YJ,Sun WJ,Lu MD,Wang FH,Qi DS,Zhang Y,Li PH,Huang H,You T,Zheng ZQ

更新日期：2014-12-28 00:00:00

abstract：AIM:To investigate the mechanisms of aspirin increasing the susceptibility of Helicobacter pylori (H pylori) to metronidazole. METHODS:H pylori reference strain 26695 and two metronidazole-resistant isolates of H pylori were included in this study. Strains were incubated in Brucella broth with or without aspirin (1 mm...

journal_title：World journal of gastroenterology

authors： Zhang XP,Wang WH,Tian Y,Gao W,Li J

更新日期：2009-02-28 00:00:00

abstract：:AIM:To study the peripheral mechanism of the inhibitory effect of intra-third ventricular administration (icv) of histamine (HA) on gastric acid secretion in rats.METHODS:Gastric acid was continuously washed with 37&mgr; saline by a perfusion pump in male adrenalectomized SD rats. Drugs were injected intravenously (iv...

journal_title：World journal of gastroenterology

authors： Zhang ZF,Wang ZL,Lu GQ

更新日期：1998-06-01 00:00:00

abstract：:AIM:To study the anticarcinogenic effect and acute toxicity of liver targeting mitoxantrone nanospheres.METHODS:The anticarcinogenic effect of mitoxan-trone polybutylcyanoacrylate nanoparticles (DHAQ-PBCA-NP) was investigated by using heterotopic and orthotopic transplantation models of human hepatocellular carcinoma ...

journal_title：World journal of gastroenterology

authors： Zhang ZR,He Q,Liao GT,Bai SH

更新日期：1999-12-01 00:00:00

abstract：AIM:To analyze the associations of pancreatic fat with other fat depots and β-cell function in pediatric nonalcoholic fatty liver disease (NAFLD). METHODS:We examined 158 overweight/obese children and adolescents, 80 with NAFLD [hepatic fat fraction (HFF) ≥ 5%] and 78 without fatty liver. Visceral adipose tissue (VAT)...

journal_title：World journal of gastroenterology

authors： Pacifico L,Di Martino M,Anania C,Andreoli GM,Bezzi M,Catalano C,Chiesa C

更新日期：2015-04-21 00:00:00

abstract：AIM:To investigate the role of single nucleotide polymorphisms (SNPs) in CD24 gene in susceptibility and overall survival of gastric cancer (GC). METHODS:We genotyped 3 tagging SNPs of CD24-P-534 in the promoter region, P170 in the coding region of exon 2 and P1527 in the 3' untranslated region - using polymerase chai...

journal_title：World journal of gastroenterology

authors： Jia ZF,Wang LZ,Cao XY,Wang C,Cao DH,Wu X,You LL,Jin MS,Wang YP,Zhou BS,Jiang J

更新日期：2016-02-21 00:00:00

abstract：AIM:To elucidate the molecular mechanisms leading to development of functionally impaired dendritic cells (DCs) in chronic hepatitis C (CHC) patients infected with genotype 3 virus. METHODS:This prospective study was conducted on the cohorts of CHC individuals identified as responders or non-responders to antiviral th...

journal_title：World journal of gastroenterology

authors： Tomer S,Chawla YK,Duseja A,Arora SK

更新日期：2016-06-14 00:00:00

abstract：:Acute hepatic failure due to hepatitis B virus (HBV) can occur both during primary infection as well as after reactivation of chronic infection. Guidelines recommend considering antiviral therapy in both situations, although evidence supporting this recommendation is weak. Since HBV is not directly cytopathic, the mec...

journal_title：World journal of gastroenterology

authors： Bockmann JH,Dandri M,Lüth S,Pannicke N,Lohse AW

更新日期：2015-02-21 00:00:00

abstract：:Innate lymphoid cells (ILCs) are defined as a distinct arm of innate immunity. According to their profile of secreted cytokines and lineage-specific transcriptional factors, ILCs can be categorized into the following three groups: group 1 ILCs (including natural killer (NK) cells and ILC1s) are dependent on T-bet and ...

journal_title：World journal of gastroenterology

authors： Shen Y,Li J,Wang SQ,Jiang W

更新日期：2018-05-14 00:00:00

abstract：AIM:To clarify the association of glypican-3 (GPC3) expression with Wnt and other growth signaling molecules in hepatocellular carcinoma (HCC). METHODS:Expression of GPC3, Wnt, matrix metalloproteinases (MMPs), sulfatase (SULF)1, SULF2, and other growth signaling molecules was analyzed in HCC cell lines and tissue sam...

journal_title：World journal of gastroenterology

authors： Akutsu N,Yamamoto H,Sasaki S,Taniguchi H,Arimura Y,Imai K,Shinomura Y

更新日期：2010-07-28 00:00:00

abstract：AIM:Positioning of interventional devices in liver lesions is a challenging task if only CT is available. We investigated the potential benefit of combined PET/CT images for localization of interventional devices in interventional liver studies. METHODS:Thirty lesions each of hyperdense, isodense and hypodense attenua...

journal_title：World journal of gastroenterology

authors： Veit P,Kuehle C,Beyer T,Kuehl H,Bockisch A,Antoch G

更新日期：2006-04-21 00:00:00

abstract：AIM:To study the effect of nicotine on the migration and invasion of human esophageal squamous carcinoma cells and to investigate whether nimesulide can inhibit the effect of nicotine. METHODS:The esophageal squamous carcinoma cell line (TE-13) was treated with different concentrations of nicotine (100 microg/mL and 2...

journal_title：World journal of gastroenterology

authors： Zong Y,Zhang ST,Zhu ST

更新日期：2009-05-28 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most lethal cancers, and its rate of incidence is rising annually. Despite the progress in diagnosis and treatment, the overall prognoses of HCC patients remain dismal due to the difficulties in early diagnosis and the high level of tumor invasion, metastasis and recurrence...

journal_title：World journal of gastroenterology

authors： Shang RZ,Qu SB,Wang DS

更新日期：2016-12-07 00:00:00

abstract：:The incidence of gastric cancer remains high in South Korea. Upper gastrointestinal (GI) endoscopy, i.e., esophagogastroduodenoscopy (EGD), has a higher diagnostic specificity and sensitivity than the upper GI series. Additionally, EGD has the ability to biopsy, through taking a tissue of the pathologic lesion. Succes...

journal_title：World journal of gastroenterology

authors： Lee SH,Park YK,Cho SM,Kang JK,Lee DJ

更新日期：2015-01-21 00:00:00