Serum anti-Helicobacter pylori antibody titer and its association with gastric nodularity, atrophy, and age: A cross-sectional study.


AIM:To clarify the role of serum anti-Helicobacter pylori (H. pylori) antibody titers in gastric cancer. METHODS:In this cross-sectional study, the effect of patients' baseline characteristics and endoscopic findings on their serum antibody titers were assessed. We evaluated consecutive patients who underwent esophagogastroduodenoscopy and their first evaluation for H. pylori infection using a serum antibody test. We excluded patients with a history of eradication therapy. The participants were divided into four groups according to their E-plate serum antibody titer. Patients with serum antibody titers < 3, 3-9.9, 10-49.9, and ≥ 50 U/mL were classified into groups A, B, C, and D, respectively. RESULTS:In total, 874 participants were analyzed with 70%, 16%, 8.7%, and 5.1% of them in the groups A, B, C, and D, respectively. Patients in group C were older than patients in groups A and B. Gastric open-type atrophy, intestinal metaplasia, enlarged folds, diffuse redness, and duodenal ulcers were associated with a high titer. Regular arrangements of collecting venules, fundic gland polyps, superficial gastritis, and gastroesophageal reflux disease were related to a low titer. Multivariate analysis revealed that nodularity (P = 0.0094), atrophy (P = 0.0076), and age 40-59 years (vs age ≥ 60 years, P = 0.0090) were correlated with a high serum antibody titer in H. pylori-infected patients. Intestinal metaplasia and atrophy were related to age ≥ 60 years in group C and D. CONCLUSION:Serum antibody titer changes with age, reflects gastric mucosal inflammation, and is useful in predicting the risk of gastric cancer.


World J Gastroenterol


Toyoshima O,Nishizawa T,Sakitani K,Yamakawa T,Takahashi Y,Yamamichi N,Hata K,Seto Y,Koike K,Watanabe H,Suzuki H




Has Abstract


2018-09-21 00:00:00












  • Localized type 1 autoimmune pancreatitis superimposed upon preexisting intraductal papillary mucinous neoplasms.

    abstract::A 70-year-old woman was found to have 2 cystic lesions in the head of the pancreas on abdominal ultrasonography during a routine medical examination. Endoscopic ultrasonography (EUS) and magnetic resonance cholangiopancreatography showed multilocular cysts in the head of the pancreas without dilation of the main pancr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Urata T,Naito Y,Izumi Y,Takekuma Y,Yokomizo H,Nagamine M,Fukuda S,Notohara K,Hifumi M

    更新日期:2013-12-21 00:00:00

  • Accumulation of aberrant DNA methylation during colorectal cancer development.

    abstract::Despite the recent advances in the therapeutic modalities, colorectal cancer (CRC) remains to be one of the most common causes of cancer-related death. CRC arises through accumulation of multiple genetic and epigenetic alterations that transform normal colonic epithelium into adenocarcinomas. Among crucial roles of ep...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Sakai E,Nakajima A,Kaneda A

    更新日期:2014-01-28 00:00:00

  • Size does not determine the grade of malignancy of early invasive colorectal cancer.

    abstract:AIM:To clarify the clinicopathological characteristics of small and large early invasive colorectal cancers (EI-CRCs), and to determine whether malignancy grade depends on size. METHODS:A total of 583 consecutive EI-CRCs treated by endoscopic mucosal resection or surgery at the National Cancer Center Hospital between ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Matsuda T,Saito Y,Fujii T,Uraoka T,Nakajima T,Kobayashi N,Emura F,Ono A,Shimoda T,Ikematsu H,Fu KI,Sano Y,Fujimori T

    更新日期:2009-06-14 00:00:00

  • How much helpful is the capsule endoscopy for the diagnosis of small bowel lesions?

    abstract:AIM:To assess the practically usefulness and diagnostic yield of this new method in a group of patients with suspected small bowel lesions. METHODS:Capsule endoscopic (CE) examination by using M2A capsule endoscope TM (Given Imaging, Yoqneam, Israel) was performed in thirty nine patients (26 males, 13 females) with su...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章


    authors: Ersoy O,Sivri B,Arslan S,Batman F,Bayraktar Y

    更新日期:2006-06-28 00:00:00

  • Intra-abdominal drainage following pancreatic resection: A systematic review.

    abstract:AIM:To study all the aspects of drain management in pancreatic surgery. METHODS:We conducted a systematic review according to the PRISMA guidelines. We searched the Cochrane Central Registry of Controlled Trials, EMBASE, Web of Science, and PubMed (MEDLINE) for relevant articles on drain management in pancreatic surge...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Čečka F,Loveček M,Jon B,Skalický P,Šubrt Z,Neoral Č,Ferko A

    更新日期:2015-10-28 00:00:00

  • Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy.

    abstract:AIM:To evaluate the potential use of colonoscopy and endoluminal ultrasonic biomicroscopy (eUBM) to track the progression of mouse colonic lesions. METHODS:Ten mice were treated with a single azoxymethane intraperitoneal injection (week 1) followed by seven days of a dextran sulfate sodium treatment in their drinking ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Soletti RC,Alves KZ,de Britto MA,de Matos DG,Soldan M,Borges HL,Machado JC

    更新日期:2013-11-28 00:00:00

  • Endoscopic full-thickness resection and laparoscopic surgery for treatment of gastric stromal tumors.

    abstract:AIM:To assess the effectiveness of endoscopic full-thickness resection (EFR) and laparoscopic surgery in the treatment of gastric stromal tumors arising from the muscularis propria. METHODS:Out of 62 gastric stromal tumors arising from the muscularis propria, each > 1.5 cm in diameter, 32 were removed by EFR, and 30 w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Huang LY,Cui J,Wu CR,Zhang B,Jiang LX,Xian XS,Lin SJ,Xu N,Cao XL,Wang ZH

    更新日期:2014-07-07 00:00:00

  • Immunohistochemical study on distribution of endocrine cells in gastrointestinal tract of flower fish (Pseudophoxinus antalyae).

    abstract:AIM:To detect distribution and relative frequency of endocrine cells in gastrointestinal tract of flower fish (Pseudophoxinus antalyae). METHODS:The intestinal tract of flower fish was divided into four portions from proximal to distal; the enlarged area after oesophagus and anterior, middle and posterior intestine. I...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Cinar K,Senol N,Ozen MR

    更新日期:2006-11-14 00:00:00

  • Intrahepatic and peripheral T-cell responses in genotype 1b hepatitis C virus-infected patients with persistently normal and elevated aminotransferase levels.

    abstract:AIM:To evaluate whether the cytokine responses in liver and serum differ in chronic hepatitis C patients with normal and high alanine aminotransferase (ALT) levels. METHODS:Thirty-three (16 with normal ALT level as group 1 and 17 with elevated ALT level as group 2) patients infected with genotype 1b hepatitis C virus ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Akyüz F,Polat N,Kaymakoglu S,Aksoy N,Demir K,Beşişik F,Badur S,Cakaloglu Y,Okten A

    更新日期:2005-12-07 00:00:00

  • Relationship between insulin A chain regions and insulin biological activities.

    abstract::AIM:To study the relationship between insulin A chain regions and insulin biological activities, we designed a series of insulin analogues with changes at A21, A12-18 of C terminal helical region and A8-10 located in the region of A6-A11 intra-chain disulphide bond.METHODS:Insulin A-chain analogues were prepared by st...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Yang SZ,Huang YD,Jie XF,Feng YM,Niu JY

    更新日期:2000-06-01 00:00:00

  • New trends in colorectal surgery: single port and natural orifice techniques.

    abstract::Single-incision laparoscopic surgery (SILS) and natural orifice transluminal endoscopic surgery (NOTES) have rapidly gained pace worldwide, potentially replacing conventional laparoscopic surgery (CLS) as the preferred colorectal surgery technique. Currently available data mainly consist of retrospective series analyz...

    journal_title:World journal of gastroenterology

    pub_type: 历史文章,杂志文章,评审


    authors: Daher R,Chouillard E,Panis Y

    更新日期:2014-12-28 00:00:00

  • Impact of comorbidities on the severity of chronic hepatitis B at presentation.

    abstract:AIM:To evaluate the clinical relevance of each cofactor on clinical presentation of chronic hepatitis B. METHODS:Out of 1366 hepatitis B surface antigen (HBsAg) positive subjects consecutively observed in 79 Italian hospitals, 53 (4.3%) showed as the only cofactor hepatitis D virus (HDV) infection [hepatitis B virus (...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究


    authors: Sagnelli E,Stroffolini T,Mele A,Imparato M,Sagnelli C,Coppola N,Almasio PL

    更新日期:2012-04-14 00:00:00

  • Endoscopic papillectomy of minor papillar adenoma associated with pancreas divisum.

    abstract::Tumors of the minor papilla of the duodenum are quite rare. We successfully and safely treated an 18-mm adenoma of the minor papilla associated with pancreas divisum using endoscopic papillectomy. A 64-year-old man was admitted to our hospital for treatment of an asymptomatic mass in the minor papilla detected by uppe...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Kanamori A,Kumada T,Kiriyama S,Sone Y,Tanikawa M,Hisanaga Y,Toyoda H,Kawashima H,Itoh A,Hirooka Y,Goto H

    更新日期:2009-03-07 00:00:00

  • A patient with spinal metastasis from hepatocellular carcinoma discovered from neurological findings.

    abstract::Although spinal tumors are uncommon, they may reduce survival or cause serious functional disorders in the extremities. Metastatic spinal tumors from malignant tumors can induce symptoms of spinal cord compression, such as paraplegia, quadriplegia, and vesicorectal disturbance, which are aggravated with progression of...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Tamaki K,Shimizu I,Urata M,Kohno N,Fukuno H,Ito S,Sano N

    更新日期:2007-05-21 00:00:00

  • Differences in endoscopic classification of early colorectal carcinoma between China and Japan: a comparative study.

    abstract:AIM:To compare the differences in the endoscopic classification of early colorectal carcinoma (CRC) between Japan and China. METHODS:Ten cases of early CRC were included in the study. After reviewing the color pictures of these cases, 5 Japanese endoscopists and 5 Chinese endoscopists made their classificatory diagnos...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Zhu RM,Wang FY,Hirata I,Katsu K,Xiao SD,Yu ZL,Zhang ZH,Xu ZM

    更新日期:2003-09-01 00:00:00

  • Peripheral mechanism of inhibitory effect of centrally administrated histamine on gastric acid secretion.

    abstract::AIM:To study the peripheral mechanism of the inhibitory effect of intra-third ventricular administration (icv) of histamine (HA) on gastric acid secretion in rats.METHODS:Gastric acid was continuously washed with 37&mgr; saline by a perfusion pump in male adrenalectomized SD rats. Drugs were injected intravenously (iv...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Zhang ZF,Wang ZL,Lu GQ

    更新日期:1998-06-01 00:00:00

  • Comparison of percutaneous radiofrequency ablation and CyberKnife(®) for initial solitary hepatocellular carcinoma: A pilot study.

    abstract:AIM:To compare therapeutic outcomes and adverse events in initial solitary hepatocellular carcinoma (HCC) treated with radiofrequency ablation (RFA) and CyberKnife(®). METHODS:Seventy three consecutive patients with initial solitary HCC treated with RFA (38 patients; RFA group) and CyberKnife(®) (35 patients; CK group...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Shiozawa K,Watanabe M,Ikehara T,Matsukiyo Y,Kogame M,Kishimoto Y,Okubo Y,Makino H,Tsukamoto N,Igarashi Y,Sumino Y

    更新日期:2015-12-28 00:00:00

  • Genetic polymorphisms predict response to anti-tumor necrosis factor treatment in Crohn's disease.

    abstract:AIM:To investigate genetic factors that might help define which Crohn's disease (CD) patients are likely to benefit from anti-tumor necrosis factor (TNF) therapy. METHODS:This was a prospective cohort study. Patients were recruited from a university digestive disease practice database. We included CD patients who rece...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Netz U,Carter JV,Eichenberger MR,Dryden GW,Pan J,Rai SN,Galandiuk S

    更新日期:2017-07-21 00:00:00

  • Laser ablation of hepatocellular carcinoma--a review.

    abstract::A wide range of local thermal ablative therapies have been developed in the treatment of non resectable hepatocellular carcinoma (HCC) in the last decade. Laser ablation (LA) and radiofrequency ablation (RFA) are the two most widely used of these. This article provides an up to date overview of the role of laser ablat...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Gough-Palmer AL,Gedroyc WM

    更新日期:2008-12-21 00:00:00

  • Cancers in Eastern Libya: first results from Benghazi Medical Center.

    abstract:AIM:To study the pattern of cancer incidence and determine the incidence rates in Eastern Libya (for the first time in a decade). METHODS:A hospital-based registry of cancer patients was formed using records from the primary oncology center in eastern Libya - focusing on those diagnosed in the year 2012. RESULTS:The ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Bodalal Z,Azzuz R,Bendardaf R

    更新日期:2014-05-28 00:00:00

  • Alcoholic liver disease and hepatitis C virus infection.

    abstract::Alcohol consumption and hepatitis C virus (HCV) infection have a synergic hepatotoxic effect, and the coexistence of these factors increases the risk of advanced liver disease. The main mechanisms of this effect are increased viral replication and altered immune response, although genetic predisposition may also play ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Novo-Veleiro I,Alvela-Suárez L,Chamorro AJ,González-Sarmiento R,Laso FJ,Marcos M

    更新日期:2016-01-28 00:00:00

  • The blind men 'see' the elephant-the many faces of fatty liver disease.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is a group of diseases with excess fat in liver in the absence of a poorly defined limit of alcohol consumption. Most common variety, a universal public health problem, is associated with insulin resistance caused by a host of genetic and epigenetic defects modulated by life st...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Sanal MG

    更新日期:2008-02-14 00:00:00

  • Liposome transfected to plasmid-encoding endostatin gene combined with radiotherapy inhibits liver cancer growth in nude mice.

    abstract:AIM:To evaluate whether intratumoral injection of liposome-endostatin complexes could enhance the antitumor efficacy of radiation therapy in human liver carcinoma (BEL7402) model. METHODS:Recombinant plasmid pcDNA3.End was transfected into human liver carcinoma cell line (BEL7402) with lipofectamine to produce conditi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Zheng AQ,Song XR,Yu JM,Wei L,Wang XW

    更新日期:2005-07-28 00:00:00

  • Evidence of human papilloma virus infection and its epidemiology in esophageal squamous cell carcinoma.

    abstract:AIM:To look for the evidence of human papilloma virus (HPV) infection in esophageal squamous cell carcinomas (ESCC) and to investigate the potential role and epidemiology of HPV infection in the pathogenesis of esophageal carcinomas in Henan emigrants. METHODS:Papilloma virus(PV) and HPV were determined by Ultrasensiv...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Yao PF,Li GC,Li J,Xia HS,Yang XL,Huang HY,Fu YG,Wang RQ,Wang XY,Sha JW

    更新日期:2006-03-07 00:00:00

  • Golimumab in real-world practice in patients with ulcerative colitis: Twelve-month results.

    abstract:BACKGROUND:The introduction of biologics has revolutionized the management of the chronic inflammatory bowel disease, ulcerative colitis (UC), with many patients experiencing significant improvements not only in their symptoms but in other outcomes relevant to individuals and society as a whole. In Germany, there are n...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Teich N,Grümmer H,Jörgensen E,Liceni T,Holtkamp-Endemann F,Fischer T,Hohenberger S

    更新日期:2020-06-07 00:00:00

  • Expression of gastrointestinal nesfatin-1 and gastric emptying in ventromedial hypothalamic nucleus- and ventrolateral hypothalamic nucleus-lesioned rats.

    abstract:AIM:To determine the expression levels of gastrointestinal nesfatin-1 in ventromedial hypothalamic nucleus (VMH)-lesioned (obese) and ventrolateral hypothalamic nucleus (VLH)-lesioned (lean) rats that exhibit an imbalance in their energy metabolism and gastric mobility. METHODS:Male Wistar rats were randomly divided i...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Tian ZB,Deng RJ,Sun GR,Wei LZ,Kong XJ,Ding XL,Jing X,Zhang CP,Ge YL

    更新日期:2014-06-14 00:00:00

  • Colonoscopy can miss diverticula of the left colon identified by barium enema.

    abstract:AIM:To identify the diagnostic value of colonoscopy for diverticulosis as determined by barium enema. METHODS:A total of 65 patients with hematochezia who underwent colonoscopy and barium enema were analyzed, and the diagnostic value of colonoscopy for diverticula was assessed. The receiver operating characteristic ar...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Niikura R,Nagata N,Shimbo T,Akiyama J,Uemura N

    更新日期:2013-04-21 00:00:00

  • Ambiguous roles of innate lymphoid cells in chronic development of liver diseases.

    abstract::Innate lymphoid cells (ILCs) are defined as a distinct arm of innate immunity. According to their profile of secreted cytokines and lineage-specific transcriptional factors, ILCs can be categorized into the following three groups: group 1 ILCs (including natural killer (NK) cells and ILC1s) are dependent on T-bet and ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Shen Y,Li J,Wang SQ,Jiang W

    更新日期:2018-05-14 00:00:00

  • Intravenous vs intraperitoneal mesenchymal stem cells administration: what is the best route for treating experimental colitis?

    abstract:AIM:To investigate the therapeutic effects of mesenchymal stem cells (MSCs) transplanted intraperitoneally and intravenously in a murine model of colitis. METHODS:MSCs were isolated from C57BL/6 mouse adipose tissue. MSC cultures were analyzed according to morphology, cellular differentiation potential, and surface mo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Gonçalves Fda C,Schneider N,Pinto FO,Meyer FS,Visioli F,Pfaffenseller B,Lopez PL,Passos EP,Cirne-Lima EO,Meurer L,Paz AH

    更新日期:2014-12-28 00:00:00

  • Evaluation of the role of H pylori infection in pathogenesis of gastric cancer by immunoblot assay.

    abstract:AIM:To elucidate the different serological reactions to H pylori using the immunoblotting technique for further understanding of its pathogenic role in gastric cancer. METHODS:A total of 54 patients were divided into two groups after upper gastrointestinal endoscopy: normal control group (25 patients) and gastric canc...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Yang KC,Chu A,Liao CS,Lin YM,Wang GM

    更新日期:2006-11-21 00:00:00