Cytotoxic effect of a non-peptidic small molecular inhibitor of the p53-HDM2 interaction on tumor cells.

abstract：AIM:To analyze the literature on the use of Chinese herbal medicines for the treatment of cholecystitis. METHODS:The literature on treatment of cholecystitis with traditional Chinese medicines (TCM) was analyzed based on the principles and methods described by evidence-based medicine (EBM). Eight databases including M...

journal_title：World journal of gastroenterology

authors： Dong ZY,Wang GL,Liu X,Liu J,Zhu DZ,Ling CQ

更新日期：2012-04-14 00:00:00

abstract：AIM:To research the etiology, portal vein thrombosis and other features of Budd-Chiari syndrome (BCS) patients prospectively. METHODS:A total of 75 patients (40 female, 35 male) who were diagnosed between January 2002 and July 2004 as having BCS were studied prospectively. Findings from on physical examination, ultras...

journal_title：World journal of gastroenterology

authors： Uskudar O,Akdogan M,Sasmaz N,Yilmaz S,Tola M,Sahin B

更新日期：2008-05-14 00:00:00

abstract：AIM:To understand CD133 promoter hypermethylation and expression in 32 colorectal cancer cell lines. METHODS:Nucleic acid was isolated from 32 colorectal cancer cell lines and CD133 expression levels were measured by reverse transcription-polymerase chain reaction (RT-PCR) and real-time PCR. Promoter methylation statu...

journal_title：World journal of gastroenterology

authors： Jeon YK,Kim SH,Choi SH,Kim KH,Yoo BC,Ku JL,Park JG

更新日期：2010-07-07 00:00:00

abstract：AIM:To assess the outcome of patients, who underwent transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) and subsequently liver transplantation (OLT) irrespective of tumor size when no tumor progression was observed. METHODS:Records, imaging studies and pathology of 84 patients with HCC were revi...

journal_title：World journal of gastroenterology

authors： Obed A,Beham A,Püllmann K,Becker H,Schlitt HJ,Lorf T

更新日期：2007-02-07 00:00:00

abstract：AIM:To explore the regulator of G-protein signaling 5 (RGS5) expression in gastric carcinoma and its association with differentiation and microvascular density (MVD). METHODS:Expression of RGS5 and CD34 were examined in 76 cases of gastric carcinoma, including 22 cases with lymph node metastasis and 54 cases without l...

journal_title：World journal of gastroenterology

authors： Wang JH,Huang WS,Hu CR,Guan XX,Zhou HB,Chen LB

更新日期：2010-11-28 00:00:00

abstract：AIM:To determine whether increased blood flow of the liver can cause oxidative stress and hepatocyte damage, and to elaborate methods suitable for measuring the antioxidant defence during hepatic surgery on rat model. METHODS:In nembutal narcosis, the left lateral and the medial lobes of the liver were clipped for 45 ...

journal_title：World journal of gastroenterology

authors： Váli L,Taba G,Szentmihályi K,Fébel H,Kurucz T,Pallai Z,Kupcsulik P,Blázovics A

更新日期：2006-02-21 00:00:00

abstract：AIM:To investigate the prognostic value of the expression of connexin (Cx) 26, 32 and 43 messenger RNA (mRNA) in hepatocellular carcinoma (HCC) tissues. METHODS:Using a reverse-transcriptase polymerase chain reaction (RT-PCR), Cx 26, Cx 32 and Cx 43 mRNAs were determined in the liver tissues of 15 controls and in HCC ...

journal_title：World journal of gastroenterology

authors： Sheen IS,Jeng KS,Wang PC,Shih SC,Chang WH,Wang HY,Chen CC,Shyung LR

更新日期：2004-10-01 00:00:00

abstract：:Wireless capsule endoscopy (CE) is a technology developed for the endoscopic exploration of the small bowel. The first capsule model was approved by the Food and Drug Administration in 2001, and its first and essential indication was occult gastrointestinal (GI) bleeding. Over subsequent years, this technology has bee...

journal_title：World journal of gastroenterology

authors： Redondo-Cerezo E,Sánchez-Capilla AD,De La Torre-Rubio P,De Teresa J

更新日期：2014-11-14 00:00:00

abstract：AIM:To determine the effect of chemotherapy on wound healing by giving early preoperative 5-fluorouracil (5-FU) to rats with colonic anastomoses. METHODS:Sixty Albino-Wistar male rats (median weight, 235 g) were used in this study. The rats were fed with standard laboratory food and given tap water ad libitum. The ani...

journal_title：World journal of gastroenterology

authors： Ozel L,Ozel MS,Toros AB,Kara M,Ozkan KS,Tellioglu G,Krand O,Koyuturk M,Berber I

更新日期：2009-09-07 00:00:00

abstract：AIM:To study the effects of Changtai granules (CTG), a traditional compound Chinese medicine, on chronic trinitrobenzene sulfonic acid-induced colitis in rats. METHODS:Healthy adult Sprague-Dawley (SD) rats of both sexes, weighing 250-300 g, were employed in the present study. The rat colitis models were induced by 2,...

journal_title：World journal of gastroenterology

authors： Cao YB,Zhang JD,Diao YY,Yan L,Wang DJ,Jia XM,Gao PH,Cheng MH,Xu Z,Wang Y,Jiang YY

更新日期：2005-06-21 00:00:00

abstract：:Inflammatory bowel disease (IBD) is associated with increased risk of colorectal cancer (CRC). The risk is known to increase with longer duration of the disease, family history of CRC, and history of primary sclerosing cholangitis. The diagnosis of the neoplastic changes associated with IBD is difficult owing to the h...

journal_title：World journal of gastroenterology

authors： Althumairi AA,Lazarev MG,Gearhart SL

更新日期：2016-01-21 00:00:00

abstract：AIM:To estimate the effect of a therapeutic vaccine against pancreatic carcinoma based on dendritic cell (DC) vaccine modified with tumor lysate and Interleukin-18 gene. METHODS:The BALB/C mice model of pancreatic carcinoma was induced with DMBA. DC vaccine was constructed through pulsed with tumor lysate and transfec...

journal_title：World journal of gastroenterology

authors： Tang ZH,Qiu WH,Wu GS,Yang XP,Zou SQ,Qiu FZ

更新日期：2002-10-01 00:00:00

abstract：:Despite major improvements concerning its diagnosis and treatment, pancreatic ductal adenocarcinoma (PDAC) remains an aggressive disease with an extremely poor prognosis. Pathology, as interface discipline between basic and clinical medicine, has substantially contributed to the recent developments and has laid the ba...

journal_title：World journal of gastroenterology

authors： Esposito I,Konukiewitz B,Schlitter AM,Klöppel G

更新日期：2014-10-14 00:00:00

abstract：:We report a patient with HBV-related hepatocellular carcinoma (HCC) and refractory ascites who had received a peritoneal-venous shunt (PVS) 1 year before liver transplantation. Urgent surgical intervention following bowel obstruction and failure of immunosuppression therapy. No intestinal obstruction was found during ...

journal_title：World journal of gastroenterology

authors： Lin CH,Yu JC,Chen TW,Chan DC,Chen CJ,Hsieh CB

更新日期：2005-09-14 00:00:00

abstract：:Tumor necrosis factor-α (TNF-α) inhibitors are known to increase reactivation of concurrent chronic hepatitis B, but their impact on the hepatitis C virus (HCV) is controversial. Some conditions of immunosuppression, such as liver transplantation, typically cause an increase in the rate of HCV evolution. Inhibition of...

journal_title：World journal of gastroenterology

authors： Pompili M,Biolato M,Miele L,Grieco A

更新日期：2013-11-28 00:00:00

abstract：AIM:To study the characteristics of upper digestive tract diseases (UDTDs) in fishermen who live in Bohai Bay. METHODS:An investigation was carried out in 1488 fishermen with symptoms of UDTDs (aside from liver, biliary and pancreatic diseases) during the time period between December 1991 and February 1995. This inves...

journal_title：World journal of gastroenterology

authors： Wang YB,Wang YP,Zou J,Bai BJ,Ren GC,Cai BQ

更新日期：1997-09-15 00:00:00

abstract：:Inflammatory bowel disease is an important cause of gastrointestinal pathology in children and adolescents. The incidence of pediatric inflammatory bowel disease is increasing; therefore, it is important for the clinician to be aware of the presentation of this disease in the pediatric population. Laboratory tests, ra...

journal_title：World journal of gastroenterology

authors： Diefenbach KA,Breuer CK

更新日期：2006-05-28 00:00:00

abstract：:Acute pancreatitis (AP) is an acute inflammatory disease of the exocrine pancreas. In Japan, nationwide epidemiological surveys have been conducted every 4 to 5 years by the Research Committee of Intractable Pancreatic Diseases, under the support of the Ministry of Health, Labour, and Welfare of Japan. We reviewed the...

journal_title：World journal of gastroenterology

authors： Hamada S,Masamune A,Shimosegawa T

更新日期：2016-07-28 00:00:00

abstract：:Metastases of esophageal carcinoma to the skeletal muscle are rare, but the incidence may be increasing because of better diagnosis resulting from widespread use of positron emission tomography/computed tomography (PET/CT). A cohort of 205 patients with esophageal carcinoma treated at our center who had PET/CT between...

journal_title：World journal of gastroenterology

authors： Cincibuch J,Mysliveček M,Melichar B,Neoral C,Metelková I,Zezulová M,Procházková-Študentová H,Flodr P,Zlevorová M,Aujeský R,Cwiertka K

更新日期：2012-09-21 00:00:00

abstract：AIM:H101, an E1B 55 kD gene deleted adenovirus, has been shown to possess oncolysis activity experimentally and proved to be safe in preliminary phase I study. The current study was designed to evaluate its anti-tumor activity and toxicity in combination with chemotherapy in patients with late stage cancers. METHODS:H...

journal_title：World journal of gastroenterology

authors： Lu W,Zheng S,Li XF,Huang JJ,Zheng X,Li Z

更新日期：2004-12-15 00:00:00

abstract：AIM:To investigate the risk association and compare the onset age of hepatocellular carcinoma (HCC) patients in Taiwan with different genotypes of MDM2-SNP309. METHODS:We analyzed MDM2-SNP309 genotypes from 58 patients with HCC and 138 cancer-free healthy controls consecutively. Genotyping of MDM2-SNP309 was conducted...

journal_title：World journal of gastroenterology

authors： Leu JD,Lin IF,Sun YF,Chen SM,Liu CC,Lee YJ

更新日期：2009-11-28 00:00:00

abstract：:The occurrence of adult intussusception from small intestinal lymphoma is quite rare. We present an 82-year-old man with a two-month history of intermittent abdominal pain, nausea and fatigue. Clinical symptoms included moderate abdominal tenderness in the right lower abdomen. Computed tomography scan of the abdomen r...

journal_title：World journal of gastroenterology

authors： Xu XQ,Hong T,Li BL,Liu W

更新日期：2013-12-07 00:00:00

abstract：AIM:To explore the effects of the nucleoside analogues beta-L-D4A and beta-LPA on hepatitis B virus (HBV) promoters. METHODS:Four HBV promoters were amplified by polymerase chain reaction (PCR) and subcloned into the expression vector pEGFP-1. The four recombinants controlled by HBV promoters were confirmed by restric...

journal_title：World journal of gastroenterology

authors： He XX,Lin JS,Chang Y,Zhang YH,Li Y,Wang XY,Xu D,Cheng XM

更新日期：2008-03-28 00:00:00

abstract：:Pernicious anemia (PA) is a macrocytic anemia that is caused by vitamin B(12) deficiency, as a result of intrinsic factor deficiency. PA is associated with atrophic body gastritis (ABG), whose diagnosis is based on histological confirmation of gastric body atrophy. Serological markers that suggest oxyntic mucosa damag...

journal_title：World journal of gastroenterology

authors： Lahner E,Annibale B

更新日期：2009-11-07 00:00:00

abstract：AIM:The use of low-dose aspirin to prevent cardiovascular disease events is well established. However, the incidence and predictors of upper gastrointestinal bleeding (UGIB) with its use are unknown. We studied prospectively the incidence and outcome of peptic ulceration in low-dose aspirin users. METHODS:A total of 9...

journal_title：World journal of gastroenterology

authors： Ng W,Wong WM,Chen WH,Tse HF,Lee PY,Lai KC,Li SW,Ng M,Lam KF,Cheng X,Lau CP

更新日期：2006-05-14 00:00:00

abstract：AIM:To assess the utility of contrast-enhanced ultrasonography (CEUS) with a second-generation contrast medium in the differential diagnosis between mass-forming pancreatitis and pancreatic carcinoma. METHODS:From our radio-pathology database, we retrieved all the patients affected by mass-forming pancreatitis or panc...

journal_title：World journal of gastroenterology

authors： D'Onofrio M,Zamboni G,Tognolini A,Malago R,Faccioli N,Frulloni L,Pozzi Mucelli R

更新日期：2006-07-14 00:00:00

abstract：:Colorectal cancer (CRC) is one of the commonest cancers with 1.2 million new cases diagnosed each year in the world. It remains the fourth most common cause of cancer-related mortality in the world and accounts for > 600000 cancer-related deaths each year. There have been significant advances in treatment of metastati...

journal_title：World journal of gastroenterology

authors： Khan K,Wale A,Brown G,Chau I

更新日期：2014-09-21 00:00:00

abstract：AIM:To achieve a better understanding of the pathogenesis of new type gosling viral enteritis virus (NGVEV) and the relationship between NGVEV and host cells. METHODS:The apoptosis of duck embryo fibroblasts (DEF) induced by NGVEV was investigated by fluorescence-activated cell sorter (FACS) and fluorescence microscop...

journal_title：World journal of gastroenterology

authors： Chen S,Cheng AC,Wang MS,Peng X

更新日期：2008-04-14 00:00:00

abstract：AIM:To investigate the effect of a fat rich diet on non-steroidal anti-inflammatory drug (NSAID)-induced mucosal damage in the murine small intestine. METHODS:C57BL6 mice were fed 4 types of diets with or without indomethacin. One group was fed standard laboratory chow. The other groups were fed a fat diet consisting ...

journal_title：World journal of gastroenterology

authors： Ueda T,Hokari R,Higashiyama M,Yasutake Y,Maruta K,Kurihara C,Tomita K,Komoto S,Okada Y,Watanabe C,Usui S,Nagao S,Miura S

更新日期：2015-01-07 00:00:00

abstract：BACKGROUND:Epithelioid angiosarcoma is a vascular neoplasm that is among the most aggressive subtypes of sarcomas. Its involvement in the gastrointestinal tract is rare. We here report a case of multifocal gastrointestinal epithelioid angiosarcomas presenting with gastrointestinal bleeding. CASE SUMMARY:A 77-year-old ...

journal_title：World journal of gastroenterology

authors： Chen YW,Dong J,Chen WY,Dai YN

更新日期：2020-08-07 00:00:00