Reduced antioxidant level and increased oxidative damage in intact liver lobes during ischaemia-reperfusion.

Abstract:

AIM:To determine whether increased blood flow of the liver can cause oxidative stress and hepatocyte damage, and to elaborate methods suitable for measuring the antioxidant defence during hepatic surgery on rat model. METHODS:In nembutal narcosis, the left lateral and the medial lobes of the liver were clipped for 45 min to make the total blood supply flow through the other lobes. Total antioxidant status, glutathione peroxidase and superoxide dysmutase activity, as well as the concentrations of diene conjugates and free sulphydril groups, H-donating ability and reducing power of the liver samples were determined. Chemiluminescent intensity of the liver was also measured. Metal ions (Al, Ca, Cu, Fe, Mg, Mn, Zn) and P and S concentrations of the liver were determined with an inductively coupled plasma optical emission spectrometer and Se content was measured by cathodic stripping voltammetry. RESULTS:Glutathione peroxidase and superoxide dysmutase activities of the liver decreased significantly in the hyperemia group compared to those observed in the sham operated group. The level of total antioxidant status was also significantly lower in the hyperemia group. H-donating ability, reducing power and free sulphydril group concentration showed the same tendency. A significant correlation (P<0.05) was found between the changes in non-specific antioxidant activities. This pointed to simultaneous activity of the antioxidant defence system. Al, Cu, Mn, Zn, and S were lower in the hyperemia group than in the sham operated group when the levels of Ca, Fe, Mg, Se and P ions were higher during hyperemia. CONCLUSION:Oxidative stress is one of the main factors for the injury of intact liver lobes during ischaemia-reperfusion.

journal_name

World J Gastroenterol

authors

Váli L,Taba G,Szentmihályi K,Fébel H,Kurucz T,Pallai Z,Kupcsulik P,Blázovics A

doi

10.3748/wjg.v12.i7.1086

keywords:

subject

Has Abstract

pub_date

2006-02-21 00:00:00

pages

1086-91

issue

7

eissn

1007-9327

issn

2219-2840

journal_volume

12

pub_type

杂志文章
  • Behçet's disease complicated by multiple aseptic abscesses of the liver and spleen.

    abstract::Aseptic abscesses are an emergent entity and have been described in inflammatory bowel disease, especially in Crohn's disease, and in other diseases. However, aseptic abscesses associated with Behçet's disease are extremely rare. We report a Japanese male diagnosed with an incomplete type of Behçet's disease who devel...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i20.3165

    authors: Maeshima K,Ishii K,Inoue M,Himeno K,Seike M

    更新日期:2013-05-28 00:00:00

  • Circulating miR-125a but not miR-125b is decreased in active disease status and negatively correlates with disease severity as well as inflammatory cytokines in patients with Crohn's disease.

    abstract:AIM:To determine the association of circulating miR-125a/b expression with the risk and disease severity of Crohn's disease (CD), and with inflammatory cytokines. METHODS:Plasma samples were collected from patients with active CD (A-CD), or CD in remission (R-CD) and from healthy controls (HCs). The levels of the infl...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v23.i44.7888

    authors: Sun CM,Wu J,Zhang H,Shi G,Chen ZT

    更新日期:2017-11-28 00:00:00

  • Primary sclerosing cholangitis--what is the difference between east and west?

    abstract::Primary sclerosing cholangitis (PSC) is a chronic, progressive, cholestatic liver disease characterized by inflammation and fibrotic obliteration of the hepatic biliary tree. It is commonly associated with inflammatory bowel disease (IBD). A number of complications can occur which require special consideration, the mo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.3974

    authors: Shorbagi A,Bayraktar Y

    更新日期:2008-07-07 00:00:00

  • 1alpha, 25-dihydroxyvitamin D3 prevents DNA damage and restores antioxidant enzymes in rat hepatocarcinogenesis induced by diethylnitrosamine and promoted by phenobarbital.

    abstract:AIM:To investigate the chemopreventive effects of 1alpha, 25-dihydroxyvitamin D(3) in diethylnitrosamine induced, phenobarbital promoted rat hepatocarcinogenesis. METHODS:The rats were randomly divided into 6 different groups (A-F). Groups A, C and E rats received a single intraperitoneal (i.p.) injection of diethylni...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i9.1268

    authors: Banakar MC,Paramasivan SK,Chattopadhyay MB,Datta S,Chakraborty P,Chatterjee M,Kannan K,Thygarajan E

    更新日期:2004-05-01 00:00:00

  • Tuberculous esophagomediastinal fistula with concomitant mediastinal bronchial artery aneurysm-acute upper gastrointestinal bleeding: A case report.

    abstract:BACKGROUND:Esophagomediastinal fistula is a very rare complication of tuberculosis in otherwise healthy adults, and mediastinal bronchial artery aneurysm is even rarer. In this case report, we describe a rare case of tuberculosis complication that presented with acute upper gastrointestinal (GI) bleeding. It also highl...

    journal_title:World journal of gastroenterology

    pub_type:

    doi:10.3748/wjg.v25.i17.2144

    authors: Alharbi SR

    更新日期:2019-05-07 00:00:00

  • Collision tumor of hepatocellular carcinoma and neuroendocrine carcinoma involving the liver: Case report and review of the literature.

    abstract::Primary hepatic neuroendocrine carcinoma (NEC) with concurrent occurrence of hepatocellular carcinoma (HCC) of the liver is very rare. Only 8 cases have been reported in the literature. Concurrent occurrence of HCC and NEC in the liver is classified as combined type or collision type by histological distributional pat...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i41.9229

    authors: Choi GH,Ann SY,Lee SI,Kim SB,Song IH

    更新日期:2016-11-07 00:00:00

  • Hypoestoxide inhibits tumor growth in the mouse CT26 colon tumor model.

    abstract:AIM:To evaluate the effect of the natural diterpenoid, hypoestoxide (HE) on the growth of established colon cancer in mice. METHODS:The CT26.WT mouse colon carcinoma cell line was grown and expanded in vitro. Following the expansion, BALB/c mice were inoculated s.c. with viable tumor cells. After the tumors had establ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i34.4586

    authors: Ojo-Amaize EA,Cottam HB,Oyemade OA,Okogun JI,Nchekwube EJ

    更新日期:2007-09-14 00:00:00

  • A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes.

    abstract:AIM:To investigate the effectiveness of antioxidant compounds in modulating mitochondrial oxidative alterations and lipids accumulation in fatty hepatocytes. METHODS:Silybin-phospholipid complex containing vitamin E (Realsil(®)) was daily administered by gavage (one pouch diluted in 3 mL of water and containing 15 mg ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i20.3007

    authors: Grattagliano I,Diogo CV,Mastrodonato M,de Bari O,Persichella M,Wang DQ,Liquori A,Ferri D,Carratù MR,Oliveira PJ,Portincasa P

    更新日期:2013-05-28 00:00:00

  • Air leak syndrome after endoscopic retrograde cholangiopancreatography: a rare and fatal complication.

    abstract::Endoscopic retrograde cholangiopancreatography (ERCP) is a state of the art diagnostic and therapeutic procedure for various pancreatic and biliary problems. In spite of the well-established safety of the procedure, there is still a risk of complications such as pancreatitis, cholangitis, bleeding and perforation. Air...

    journal_title:World journal of gastroenterology

    pub_type: 信件

    doi:10.3748/wjg.v21.i15.4770

    authors: Yilmaz B,Roach EC,Koklu S,Aydin O,Unlu O,Kilic YA

    更新日期:2015-04-21 00:00:00

  • Noninvasive assessment of liver fibrosis with combined serum aminotransferase/platelet ratio index and hyaluronic acid in patients with chronic hepatitis B.

    abstract:AIM:To construct a noninvasive assessment model consisting of routine laboratory data to predict significant fibrosis and cirrhosis in patients with chronic hepatitis B (CHB). METHODS:A total of 137 consecutive patients with CHB who underwent percutaneous liver biopsy were retrospectively analyzed. These patients were...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.7117

    authors: Zhang YX,Wu WJ,Zhang YZ,Feng YL,Zhou XX,Pan Q

    更新日期:2008-12-14 00:00:00

  • Emodin and baicalein inhibit sodium taurocholate-induced vacuole formation in pancreatic acinar cells.

    abstract:AIM:To investigate the effects of combined use of emodin and baicalein (CEB) at the cellular and organism levels in severe acute pancreatitis (SAP) and explore the underlying mechanism. METHODS:SAP was induced by retrograde infusion of 5% sodium taurocholate into the pancreatic duct in 48 male SD rats. Pancreatic hist...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v24.i1.35

    authors: Li J,Zhou R,Bie BB,Huang N,Guo Y,Chen HY,Shi MJ,Yang J,Zhang J,Li ZF

    更新日期:2018-01-07 00:00:00

  • Identification of antigens by monoclonal antibody PD4 and its expression in Escherichia coli.

    abstract:AIM:To clone and express the antigen of monoclonal antibody (MAb) PD4 for further investigation of its function. METHODS:MGC803 cDNA expression library was constructed and screened with PD4 as probes to clone the antigen. After failed in the library screening, immunoprecipitation and SDS-polyacrylamide gel electrophor...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i10.2164

    authors: Ning JY,Sun GX,Huang S,Ma H,An P,Meng L,Song SM,Wu J,Shou CC

    更新日期:2003-10-01 00:00:00

  • Functional activity of the rectum: A conduit organ or a storage organ or both?

    abstract:AIM:To investigate whether the degree of rectal distension could define the rectum functions as a conduit or reservoir. METHODS:Response of the rectal and anal pressure to 2 types of rectal balloon distension, rapid voluminous and slow gradual distention, was recorded in 21 healthy volunteers (12 men, 9 women, age 41....

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i28.4549

    authors: Shafik A,Mostafa RM,Shafik I,Ei-Sibai O,Shafik AA

    更新日期:2006-07-28 00:00:00

  • Extra-intestinal manifestations of non-celiac gluten sensitivity: An expanding paradigm.

    abstract::Non celiac gluten sensitivity (NCGS) is a syndrome characterized by a cohort of symptoms related to the ingestion of gluten-containing food in subjects who are not affected by celiac disease (CD) or wheat allergy. The possibility of systemic manifestations in this condition has been suggested by some reports. In most ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v24.i14.1521

    authors: Losurdo G,Principi M,Iannone A,Amoruso A,Ierardi E,Di Leo A,Barone M

    更新日期:2018-04-14 00:00:00

  • Differences in characteristics of colorectal neoplasm between young and elderly Thais.

    abstract:AIM:To analyze the differences of clinical characteristics of colorectal neoplasm including polyps between the elderly and young Thai patients. METHODS:Colonoscopy database from December 2000 to October 2004 was retrospectively analyzed. There were 1822 eligible patients who underwent colonoscopy (with a mean age of 5...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i47.7684

    authors: Rerknimitr R,Ratanapanich W,Kongkam P,Kullavanijaya P

    更新日期:2006-12-21 00:00:00

  • Virulence and potential pathogenicity of coccoid Helicobacter pylori induced by antibiotics.

    abstract:AIM:To explore the virulence and the potential pathogenicity of coccoid Helicobacter pylori (H. pylori) transformed from spiral form by exposure to antibiotic. METHODS:Three strains of H. pylori, isolated from gastric biopsy specimens of confirmed peptic ulcer, were converted from spiral into coccoid from by exposure ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v7.i2.254

    authors: She FF,Su DH,Lin JY,Zhou LY

    更新日期:2001-04-01 00:00:00

  • Sixty-four-slice computed tomography in surgical strategy of portal vein cavernous transformation.

    abstract:AIM:To investigate the role of 64-slice computed tomography (CT) in portal vein cavernous transformation to determine surgical strategy. METHODS:The site of lesions and extent of collateral circulation in 12 pediatric cases of cavernous transformation of the portal vein with surgical treatment were analyzed. RESULTS:...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i38.4334

    authors: Zhang MM,Pu CL,Li YC,Guo CB

    更新日期:2011-10-14 00:00:00

  • Expression of E-selectin, integrin beta1 and immunoglobulin superfamily member in human gastric carcinoma cells and its clinicopathologic significance.

    abstract:AIM:To study the expression levels of E- selectin, integrin beta1 and immunoglobulin superfamily member-intercellular adhesion molecule-1 (ICAM-1) in human gastric carcinoma cells, and to explore the relationship between these three kinds of cell adhesion molecules and gastric carcinoma. METHODS:The serum contents of ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i22.3609

    authors: Ke JJ,Shao QS,Ling ZQ

    更新日期:2006-06-14 00:00:00

  • Current status and future strategies of cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis.

    abstract::This article is to offer a concise review on the use of cytoreductive surgery (CRS) plus intraperitoneal hyperthermic chemotherapy (IPHC) for the treatment of peritoneal carcinomatosis (PC). Traditionally, PC was treated with systemic chemotherapy alone with very poor response and a median survival of less than 6 mo. ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.1159

    authors: Al-Shammaa HA,Li Y,Yonemura Y

    更新日期:2008-02-28 00:00:00

  • Proton pump inhibitors therapy vs H2 receptor antagonists therapy for upper gastrointestinal bleeding after endoscopy: A meta-analysis.

    abstract:AIM:To compare the therapeutic effects of proton pump inhibitors vs H₂ receptor antagonists for upper gastrointestinal bleeding in patients after successful endoscopy. METHODS:We searched the Cochrane library, MEDLINE, EMBASE and PubMed for randomized controlled trials until July 2014 for this study. The risk of bias ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v21.i20.6341

    authors: Zhang YS,Li Q,He BS,Liu R,Li ZJ

    更新日期:2015-05-28 00:00:00

  • Actinomycosis mimicking recurrent carcinoma after Whipple's operation.

    abstract::Actinomycosis is a rare, chronic, spreading, suppurative, granulomatous and fibrosing infection. Actinomyces are normal inhabitants of the oral cavity and gastrointestinal tract. They rarely cause disease and are seldom reported as pathogens. Herein, we reported on a 69-year-old male patient who had undergone Whipple'...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i11.1722

    authors: Hsu JT,Lo HC,Jan YY,Chen HM

    更新日期:2005-03-21 00:00:00

  • Two novel VPS33B mutations in a patient with arthrogryposis, renal dysfunction and cholestasis syndrome in mainland China.

    abstract::Arthrogryposis, renal dysfunction and cholestasis (ARC) syndrome is a rare genetic disorder and has not been described in China. We present a female infant with neonatal intrahepatic cholestasis from a Chinese family with ARC syndrome. All 23 coding exons and flanking introns of the VPS33B gene were amplified and sequ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i1.326

    authors: Li LT,Zhao J,Chen R,Wang JS

    更新日期:2014-01-07 00:00:00

  • TP53 Arg72Pro polymorphism is associated with esophageal cancer risk: a meta-analysis.

    abstract:AIM:To investigate the association between TP53 Arg72Pro polymorphism and esophageal cancer (EC) risk using meta-analysis. METHODS:All eligible studies published before March 1, 2010 were selected by searching PubMed using keywords "p53" or "TP53", "polymorphism" or "variation", "esophageal" and "cancer" or "carcinoma...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.3748/wjg.v17.i9.1227

    authors: Jiang DK,Yao L,Wang WZ,Peng B,Ren WH,Yang XM,Yu L

    更新日期:2011-03-07 00:00:00

  • Vaccines and recommendations for their use in inflammatory bowel disease.

    abstract::The patient with inflammatory bowel disease will be predisposed to numerous infections due their immune status. It is therefore important to understand the immune and serologic status at diagnosis and to put the patient into an adapted vaccination program. This program would be applied differently according to two pat...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v19.i9.1354

    authors: Sánchez-Tembleque MD,Corella C,Pérez-Calle JL

    更新日期:2013-03-07 00:00:00

  • Mutations in components of the Wnt signaling pathway in gastric cancer.

    abstract:AIM:To explore the contribution of AXIN1, AXIN2 and beta-catenin, components of Wnt signaling pathway, to the carcinogenesis of gastric cancer (GC), we examined AXIN1, AXIN2 exon7 and CTNNB1 (encoding beta-catenin) exon3 mutations in 70 GCs. METHODS:The presence of mutations was identified by polymerase chain reaction...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.1570

    authors: Pan KF,Liu WG,Zhang L,You WC,Lu YY

    更新日期:2008-03-14 00:00:00

  • Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers.

    abstract:AIM:To clarify the expression and role of Ephrin receptor A4 (EphA4) in gastric cancer in relation to clinicopathological characteristics and the expression of fibroblast growth factor receptor 1 (FGFR1) and ephrin ligands. METHODS:Eleven gastric carcinoma cell lines, 24 paired surgical fresh specimens of gastric aden...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.5650

    authors: Oki M,Yamamoto H,Taniguchi H,Adachi Y,Imai K,Shinomura Y

    更新日期:2008-10-07 00:00:00

  • Intra-tumor injection of H101, a recombinant adenovirus, in combination with chemotherapy in patients with advanced cancers: a pilot phase II clinical trial.

    abstract:AIM:H101, an E1B 55 kD gene deleted adenovirus, has been shown to possess oncolysis activity experimentally and proved to be safe in preliminary phase I study. The current study was designed to evaluate its anti-tumor activity and toxicity in combination with chemotherapy in patients with late stage cancers. METHODS:H...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v10.i24.3634

    authors: Lu W,Zheng S,Li XF,Huang JJ,Zheng X,Li Z

    更新日期:2004-12-15 00:00:00

  • Protective effect and mechanism of stronger neo-minophagen C against fulminant hepatic failure.

    abstract:AIM:To investigate the protective effect of stronger neo-minophafen C (SNMC) on fulminant hepatic failure (FHF) and its underlying mechanism. METHODS:A mouse model of FHF was established by intraperitoneal injection of galactosamine (D-Gal N) and lipopolysaccharide (LPS). The survival rate, liver function, inflammator...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i3.462

    authors: Yang BS,Ma YJ,Wang Y,Chen LY,Bi MR,Yan BZ,Bai L,Zhou H,Wang FX

    更新日期:2007-01-21 00:00:00

  • Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma.

    abstract:BACKGROUND:Extrahepatic metastasis (EHM) of hepatocellular carcinoma (HCC) is associated with poor outcomes. However, the clinical features and risk factors of EHM of HCC after radiofrequency ablation (RFA) remain unclear. AIM:To elucidate the characteristics and risk factors of EHM after RFA for HCC. METHODS:From Ja...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i32.4833

    authors: Yoon JH,Goo YJ,Lim CJ,Choi SK,Cho SB,Shin SS,Jun CH

    更新日期:2020-08-28 00:00:00

  • Relationship between the expression of human telomerase reverse transcriptase gene and cell cycle regulators in gastric cancer and its significance.

    abstract:AIM:To investigate the expression of human telomerase reverse transcriptase gene (hTRT) in gastric cancer (GC) and its relevance with cell cycle regulators including P16INK4, cyclin and P53. METHODS:In situ hybridization (ISH) for hTRT mRNA was performed in 53 cases of gastric cancer and adjacent cancerous tissues. Im...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i3.427

    authors: Shao JC,Wu JF,Wang DB,Qin R,Zhang H

    更新日期:2003-03-01 00:00:00