Alverine citrate induced acute hepatitis.

Abstract:

:Alverine citrate is a commonly used smooth muscle relaxant agent. A MEDLINE search on January 2004 revealed only 1 report implicating the hepatotoxicity of this agent. A 34-year-old woman was investigated because of the finding of elevated liver function tests on biochemical screening. Other etiologies of hepatitis were appropriately ruled out and elevated enzymes were ascribed to alverine citrate treatment. Although alverine citrate hepatotoxicity was related to an immune mechanism in the first case, several features such as absence of predictable dose-dependent toxicity of alverine citrate in a previous study and absence of hypersensitivity manifestations in our patient are suggestive of a metabolic type of idiosyncratic toxicity.

journal_name

World J Gastroenterol

authors

Arhan M,Koklu S,Koksal AS,Yolcu OF,Koruk S,Koruk I,Kayacetin E

doi

10.3748/wjg.v10.i15.2303

keywords:

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

2303-4

issue

15

eissn

1007-9327

issn

2219-2840

journal_volume

10

pub_type

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